Recording Facial EMG with New Amplifier Technology

•

1 like•1,011 views

In this training session, Frazer Findlay, CEO of BIOPAC, demonstrates how fEMG with Smart Amplifiers can be used to track emotions and for a variety of other studies involving visual, auditory and haptic stimuli, startle response, emotional response, unconscious learning and more. Presented as a live demo, Frazer discusses optimal electrode placement and best practices for collecting fEMG signals from the zygomaticus and corrigator supercilii muscles. Discussion topics include: - How to optimize subject preparation and electrode placement - Critical factors to improve data quality - Current wired and wireless options - Live demo of hardware and software, including live data recording and analysis

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2018 Registered to ISO 9001:2015
1
Click to edit Master title style
Registered to ISO 9001:2015

Frazer Findlay
CEO
BIOPAC Systems, Inc.
How to Record Great Facial
EMG Data

© BIOPAC Systems, Inc. 2017 www.biopac.com 3
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
3

© BIOPAC Systems, Inc. 2017 www.biopac.com 4
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
4
Over 99% of top universities run BIOPAC Systems
THE WORLD DISCOVERS
WITH BIOPAC
Solutions for life science research and education

© BIOPAC Systems, Inc. 2017 www.biopac.com 5
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
5
THE WORLD DISCOVERS
WITH BIOPAC
BIOPAC systems cited 34,000
times

© BIOPAC Systems, Inc. 2017 www.biopac.com 6
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
6

© BIOPAC Systems, Inc. 2017 www.biopac.com 7
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
7
•Subject setup
•Hardware setup
•Recording data
•Analysis
Agenda

© BIOPAC Systems, Inc. 2017 www.biopac.com 8
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
8

© BIOPAC Systems, Inc. 2017 www.biopac.com 9
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
9
Subject Setup

© BIOPAC Systems, Inc. 2017 www.biopac.com 10
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
10
Zygomaticus Major

© BIOPAC Systems, Inc. 2017 www.biopac.com 11
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
11
Corrugator Supercilii

© BIOPAC Systems, Inc. 2017 www.biopac.com 12
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
12
Subject Preparation
ELPREP
GEL100
EL-CHECK
ALCPAD
AND/OR

© BIOPAC Systems, Inc. 2017 www.biopac.com 13
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
13
100C–Series Electrodes and Leads
LEAD115 Lighter Lead Series EL254S Shielded 4mm ElectrodeEL654 Ag/AgCl 4mm Electrode

© BIOPAC Systems, Inc. 2017 www.biopac.com 14
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
14
BioNomadix Leads

© BIOPAC Systems, Inc. 2017 www.biopac.com 15
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
15
EL513 Disposable Cloth Electrodes

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
16
New Smart Amplifiers
fEMG

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
17
100D-
Series
Smart
Amplifiers
Provide high quality low noise signals
Small, light form factor to be comfortable for the
subject
Connect directly to the new interface – AIM100D
Co-exist with other connected C series modules,
including wireless BioNomadix
Detect and warn users when amplifiers are not
connected properly

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
18
100D-Series Smart
Amplifiers
• Provide signal type information and software
options to automatically define derived signals
(e.g. heart rate)
• Automate initial hardware setup to match
connected amplifiers
• Reuse BioNomadix electrode leads and
transducers
• MEC104D 4-channel extension cable to extend
distance beyond standard 3m cables

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
20

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
22
Amplifier Types
ECG
01
EOG
02
EMG – Large
Muscle
03
EMG – Facial
04
EGG
05
EEG
06
ERS Evoked
Response
07
RSP –
Resp belt
08
PPG
09
EDA
10
Skin temp
11

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
23
MP160 and
AMI100D

© BIOPAC Systems, Inc. 2017 www.biopac.com 24
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
24
Hardware Options

www.biopac.com
BIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019 Registered to ISO 9001:2015
25
New Smart Amplifiers

© BIOPAC Systems, Inc. 2017 www.biopac.com 26
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
26
MP160 and
Smart Amplifiers

© BIOPAC Systems, Inc. 2017 www.biopac.com 27
BIOPAC—Inspiring people and enabling discovery about lifeBIOPAC—Inspiring people and enabling discovery about life
© BIOPAC Systems, Inc. 2019
www.biopac.com
27
BioNomadix Wireless EMG100C Tethered EMG100C-MRI Tethered

© BIOPAC Systems, Inc. 2018 www.biopac.com 28
BIOPAC—Inspiring people and enabling discovery about life
Transmitter
Logger
Smart Center

Please complete our survey upon
exiting the webinar.
Thank you for attending!
For more information:
www.biopac.com
info@biopac.com
View upcoming and on-demand webinars at:
www.biopac.com/webinars
Thank you for your time and attention!

Functional Near-Infrared Optical Imaging (fNIR) is a promising neuroimaging technology which measures hemodynamics of the brain in response to neural activity. Applications for this technology are broad and include optical brain imaging, cognition (e.g. working memory, decision making processes, mental fatigue), neuroergonomics, neuromarketing, and muscle oxygenation studies. Like fMRI, the technology is noninvasive and has a high temporal resolution. However, unlike fMRI, fNIR is portable, affordable and much less sensitive to motion. Modern devices are increasingly miniaturized, allowing them to be used in a wide range of experimental conditions, including outside and in moving subjects. In this webinar hosted by BIOPAC, Alex Dimov of BIOPAC and Davood Tashayyod of fNIR Devices discuss the strengths, best practices and applications of fNIR technology for neuroscience research. They also present a live demo showcasing the latest fNIR equipment—including the new Mobile System and Through-the-Hair Sensor—and show how they can be used to study human cognition and brain function. Watch this webinar to learn: - Applications of fNIR technology - Proper setup of equipment for optimal data collections in each application area - Prefrontal cortex vs. whole brain studies - fNIR and muscle oxygenation - Whole head imaging

Integrating Noninvasive Blood Pressure Monitoring with Human Physiology Measu...

InsideScientific

Experts discuss the fundamentals of real-time, beat-to-beat noninvasive blood pressure (NIBP) monitoring and present new research capabilities enabled through the integration of NIBP technology and physiological recording systems. In this webinar sponsored by BIOPAC Systems and CNSystems, Frazer Findlay and Walter Habenbacher discuss study design and demonstrate correct equipment set up and operation when recording NIBP with additional physiological signals. Specifically, Mr. Habenbacher explains the application of the NIBP100D-HD to measure noninvasive continuous blood pressure. He demonstrates setup & measurement and shows how scientific findings can benefit your research with advanced hemodynamic monitoring. Following, Mr. Findlay demonstrates how to interface the NIBP100D Continuous Noninvasive Blood Pressure Monitor with the BIOPAC MP160 Data Acquisition and Analysis System and simultaneously recorded measurements of NIBP, ECG and respiration. In addition, Mr. Findlay discusses important data analysis processes such as computing cardiac output and stroke volume, and demonstrates how scientists can use the “Focus Areas” feature in AcqKnowledge Software to simplify their data review.

Iriscopio de 5.0 megapíxeles ir 9915 u advantage,supplier

changyun luo

OPTIM Incorporated

optim_inc

OPTIM Incorporated designs and manufactures optical imaging tools for industrial, medical, and security markets. It produces several medical endoscope models for private-label customers and branded products. Key products include the ENTity NasoView Nasopharyngoscope for nasal and throat examinations, and the PLS Portable LED Light Source for use with flexible and rigid endoscopes. OPTIM also manufactures insertion tubes, light guides, and other endoscope components and offers industrial fiberscopes for non-intrusive inspections.

Motion Tracking

MenghengXue

The document discusses NICTA's work developing portable motion analysis technologies using inertial measurement units (IMUs). It summarizes several applications including monitoring arm movements in stroke patients, detecting gait events in Parkinson's disease patients, measuring sway in epilepsy patients, and assessing surgeons' proficiency. For each application, it describes the customer problem, NICTA's technical approach using IMUs, results compared to existing technologies, and benefits of NICTA's solution such as low-cost portable monitoring of patients in their natural environments.

BIOPAC Webinar.pptx

aiimssks

BIOPAC Systems provides life science research and education solutions, including data acquisition systems, that are used in over 99% of top universities. BIOPAC systems have been cited over 50,000 times in research. The document appears to be promoting BIOPAC Systems products such as their MP160 and MP36R data acquisition systems, smart amplifiers, and BioNomadix wireless logging system for enabling discovery about life.

How to Synchronize Participant Video With Physiology Data

InsideScientific

BIOPAC is a company that develops physiological data acquisition systems. It provides various solutions for measuring and recording physiological signals, including standalone systems, integrated recording platforms, and a modular lab system called BioCube. BioCube allows for simultaneous measurement and monitoring of up to four participants in isolated rooms, with an optional expansion to accommodate more. It includes all necessary equipment in one package. BIOPAC also offers multi-camera video systems that can synchronize video recordings with physiological data acquisition.

Recording High-Quality Metabolic Data in Humans

InsideScientific

LIVE WEBINAR: Nov 30, 2017 Sponsor: BIOPAC Systems (www.biopac.com) During this webinar, Frazer Findlay and William McMullen introduce a new gas analysis solution, titled GASSYS 3, and review fundamental principles for human metabolic studies. Specifically, they discuss basic principles on how to determine a participant's Metabolic Rate (energy expended), Oxygen Consumption (VO2), Carbon Dioxide production (VCO2), Respiratory Exchange Ratio (RER), and other useful metabolic data. In addition, they show correct equipment setup for measuring expired airflow, O2 and CO2 with simultaneous ECG recordings, all while minimizing EMG artifact. Finally, they demonstrate valuable automated software calculations to obtain VO2, VCO2, RER, Heart Rate from ECG and Respiration rate from airflow.

This document summarizes a webinar about recording high-quality metabolic data from human research participants. It introduces the new BIOPAC GASSYS3 system, which was designed to more affordably measure oxygen and carbon dioxide levels in expired air. The webinar demonstrates setup and use of the GASSYS3, and discusses techniques for measuring metabolic data at rest and during exercise to determine values like metabolic rate, fuel usage, and cardiorespiratory fitness. Live analysis of sample data is also shown.

EPs.pptx

aiimssks

BIOPAC Systems provides physiological data acquisition and analysis equipment and software used in over 40 research fields including cardiovascular, respiratory, neurophysiology and exercise physiology research. Over 99% of top universities use BIOPAC Systems. BIOPAC systems have been cited in over 48,000 research publications. The document provides information on BIOPAC recording platforms and tutorials for recording and analyzing event-related potentials including an auditory oddball paradigm.

webinar-ppt-water-steam-baseline-guide-final-watermarked-locked-reduced.pdf

Dattatray25

The document summarizes a webinar on water and steam systems for pharmaceutical manufacturing. It introduces the two speakers - Nissan Cohen and Gary Zoccolante, who have decades of experience in water systems. The webinar covered an introduction to revising the ISPE Water and Steam Systems Guide, including changes made to update and expand the guide to global standards. It also highlighted key points about system planning, treatment options, and microbial control.

Integrating Eye Tracking Data with Physiological Measurements

InsideScientific

In this exclusive webinar sponsored by BIOPAC Systems and SensoMotoric Instruments (SMI), experts present user case studies to demonstrate new research capabilities made possible by the plug & play integration of eye tracking technology with physiological recording systems. Dr. Meike Mischo provides an overview of eye tracking application types and important considerations pertaining to the integration with physiological measurements such as GSR, HR and ECG. Following, Frazer Findlay presents key considerations in recording and analyzing physiological data, showing a live demonstration of a screen-based study. In closing, Dr. Arnd Rose presents a user case study for mobile eye tracking applications using examples from the study of human factors.

Biologics Modular Offering Presentation Series D

jkarras0434

WTF@OIS: WHAT’S THE FUTURE @OIS?

Healthegy

SCIEX Overview Presentation (no movie)

PJ Moloney

SCIEX is a provider of analytical tools and technologies for life science research and clinical diagnostics. Its vision is to provide integrated solutions to advance scientific understanding and safeguard health. It serves markets including pharmaceuticals and biopharma, clinical diagnostics, forensics, food and environment, and life science research. SCIEX offers a range of mass spectrometry, liquid chromatography, and capillary electrophoresis instruments, as well as software and services. It has over 40 years of experience innovating new technologies and has operations worldwide.

Innovation in biopharmaceutical production

GBX Summits

10th— 11th - February 2015 – Radisson Blu, Heathrow Airport, Hayes, London, UK Annual BIOINNOVATION | Seamless, Integrated & Innovative BioManufacturing http://www.bioinnovation.gb.com/ Annual PIMS | 2015 |Pharmaceutical Innovation, Operational Excellence & Manufacturing Strategies Summit http://www.pims.gb.com/ 16th & 17th September 2015 | Boston Marriott Cambridge, MA | USA Annual ManuBIO | 2015 Flexible, Integrated & Innovative Biological Manufacturing Excellence USA http://www.manubio.com/ VIDEO WATCH

Biocon Company Profile

Akash Deep Sharma

Dr. Kiran Mazumdar Shaw founded Biocon in 1978 with Rs. 10,000 in capital. She has received many prestigious awards for her achievements. Biocon is now India's largest biopharmaceutical company and Dr. Shaw is one of India's richest women. Biocon uses a split business technique to divide its business into subsidiaries that collaborate on pre-clinical discovery, clinical development, and commercialization of health products. This structure drives innovation and provides multiple revenue streams. Biocon employs over 3,600 people and has strategic collaborations with global companies. Its objective is to become a globally distinguished integrated biotechnology enterprise.

Roadshow:Health & Life Science

The document outlines an agenda for seminars focused on different sectors including energy, chemistry, materials, healthcare and life science, and smart human capital. The dates and focus areas of each seminar are listed. Additionally, the document provides statistics on assignments per sector from 2007 to 2017, with the top sectors being production food, FMCG, services, pharma and healthcare, and construction. It encourages business transformation and upcycling through these seminars.

ACIB - Biotech Stories

Martin Trinker

The document discusses how researchers at the Austrian Centre of Industrial Biotechnology (acib) used biocatalysis to produce a valuable fragrance compound called lysmeral/LilialTM that is found in lily of the valley in a sustainable way. Previously this compound could only be obtained directly from the plants in small amounts and poor yield. The acib researchers were able to selectively produce only one of the two possible chiral products of the fragrance compound using an enzymatic approach. This provided a renewable and environmentally friendly method for producing this high-value fragrance component for use in perfumes like Chanel No. 5 on an industrial scale.

culture cellular

Andrea José Fuentes Bisbal

This document provides an overview of microcarrier cell culture principles and methods. Microcarriers allow for increased surface area for cell attachment and growth compared to traditional cell culture methods. They enable higher cell densities and product yields by separating cells from culture medium, improving process control and scalability. Various microcarrier types made from different materials are available for culturing different cell types like mammalian, insect and plant cells. Microcarriers are used to produce vaccines, proteins, antibodies and more in small-scale equipment like spinners and roller bottles as well as large-scale bioreactors like stirred tanks, packed beds and fluidized beds. Careful selection of microcarrier properties, culture conditions and control strategies are required to optimize microcarrier cell culture

Implementing Agile in an FDA Regulated Environment

TechWell

Developing medical devices that are subject to FDA approval has traditionally followed the waterfall methodology, largely due to the structure of the regulations that govern development practices. But we know from myriad case studies in different industries that agile methodologies are far superior in providing the highest value to customers in the shortest time to market. Neal Herman shares how one developer of complex medical devices embraced agile software development practices and proved that it could not only develop software faster with higher quality but also meet all regulatory requirements. Convincing the internal quality management, systems engineering, and regulatory departments was difficult, but the software department was able to overcome these obstacles and fundamentally change the company’s philosophy on product development. Since 2012, software development productivity is up 100 percent, and quality is up 200 percent. Now, after seeing these gains from the software department, agile is being rolled out to all areas of R&D including hardware.

Pharma Presentation

emarcellin

Boccard is a global turnkey constructor with over 3000 employees across 18 countries. They have over 100 years of experience in designing, building, and maintaining process facilities for industries like pharmaceutical, food, beverage, and more. Boccard offers full lifecycle services from engineering and fabrication to automation, validation, and long-term maintenance. They have significant experience and references in pharmaceutical and biotech industries for projects like vaccine production, enzyme manufacturing, chromatography systems, and complete turnkey biotech facilities.

Biotechnology Session conference .pdf

smartmmm

The document discusses biotechnology and its applications. It begins with defining biotechnology as the use of living organisms or their components to develop useful products. It then discusses the history of biotechnology, including early applications of fermentation in winemaking and yogurt production. The document outlines various types and applications of biotechnology in areas like agriculture, food science, genetics, and medicine. It provides examples of how biotechnology benefits human welfare such as developing new vaccines and treatments.

thermo fisher 2005

finance40

Fisher Scientific is a leading provider of products and services to the scientific community. In 2005, Fisher had revenues of $5.6 billion and approximately 19,500 employees worldwide. Fisher facilitates scientific discovery by supplying researchers and clinicians with the tools they need to enhance and prolong life. Key accomplishments in 2005 included strategic acquisitions that expanded Fisher's offerings in areas like biopharma services and life sciences, as well as operational initiatives that increased cost savings and production capabilities. Fisher is well-positioned for continued growth by meeting the evolving needs of customers in research, healthcare, and drug development.

thermo fisher 2005

finance40

Fisher Scientific is a leading provider of products and services to scientific researchers around the world. In 2005, Fisher had revenues of $5.6 billion and approximately 19,500 employees worldwide. The company facilitates scientific discovery by supplying researchers with over 600,000 products and services. Fisher aims to make its 350,000 customers more efficient and effective through its integrated supply chain and sales/marketing capabilities.

ERIKS Know+How Issue 18 - Food and Beverage

ERIKS UK

Miray Tayfun - Vivoo - Wellness Startups in Turkey & Silicon Valley - Stanfor...

Burton Lee

Know how 30

ERIKS UK

Next-Generation Safety Assessment Tools for Advancing In Vivo to In Vitro Tra...

InsideScientific

Join Prof. Victoria Hutter and Dr. Louis Scott as they showcase the application of high-content imaging and advanced cell lines for drug safety assessment. Safety concerns play a significant role in the unsuccessful progression of candidate compounds in the later stages of drug development. Establishing the connection between in vitro endpoints and human health outcomes is essential. In this webinar, Prof. Victoria Hutter and Dr. Louis Scott present a novel tool for in vitro safety assessment in drug development. The morph_ONE™ assay provides a human-centric approach to potentially fill specific regulatory gaps concerning safety issues. This tool is capable of profiling both human and rat alveolar macrophages, offering valuable insights for hazard identification and toxicity assessments. By bridging the divide between cellular effects and overall risk, it has the potential to enhance our understanding of safety-related aspects in drug development. Key Topics Include: - Explore distinct in vitro screening techniques for evaluating the safety of emerging inhaled products, facilitating early and informed decisions in compound selection and development. - How high-content image analysis (HCIA) cell painting assays can be used as a forward-looking high-throughput screening tool, distinguishing unique response patterns in alveolar macrophages. - Understand the use of the ImmuPHAGE™ and ImmuLUNG™ models in conducting customized evaluations focused on inhalation safety.

A Ready-to-Analyze High-Plex Spatial Signature Development Workflow for Cance...

InsideScientific

In this webinar, Aditya Pratapa and Lorcan Sherry present a new workflow for analyzing multiplex immunoflurescence images. Spatial Signatures are a new class of highly predictive biomarkers that measure the interactions and cellular densities of tumor and immune cells that compose the tumor microenvironment. Based on multiplex immunofluorescence, spatial signatures provide a deeper understanding of complex interactions between tumors and the immune system, enabling improved patient stratification for immunotherapies. A significant hurdle to date has been in developing a data analysis workflow that is straightforward and user-friendly to transform the data rich images into meaningful quantitative spatial signatures. In this webinar, Aditya and Lorcan review the key features of the new PhenoImager HT 2.0 data analysis workflow. This workflow introduces a simplified framework from scanning to analyzing spectrally unmixed multiplex immunofluorescence images generated on the PhenoImager HT platform. The ready-to-analyze data can be directly imported into image analysis software such as Visiopharm. This presentation covers key aspects of data analysis elements such as image QC, segmentation, phenotyping, and verification – all essential for creating outputs that support the development of a spatial signature. Key Topics Include: - Understand Akoya’s new HT 2.0 data analysis workflow - The challenges in multiplex immunofluorescence analysis and the use of AI and cell lineage segmentation considerations - Explore OracleBio’s image analysis workflow incorporating Visiopharm - Evaluation of analysis data to facilitate spatial profiling and interpretation

Similar to Recording Facial EMG with New Amplifier Technology

Recording High-Quality Metabolic Data in Humans

InsideScientific

EPs.pptx

aiimssks

webinar-ppt-water-steam-baseline-guide-final-watermarked-locked-reduced.pdf

Dattatray25

Integrating Eye Tracking Data with Physiological Measurements

InsideScientific

Biologics Modular Offering Presentation Series D

jkarras0434

WTF@OIS: WHAT’S THE FUTURE @OIS?

Healthegy

SCIEX Overview Presentation (no movie)

PJ Moloney

Innovation in biopharmaceutical production

GBX Summits

Biocon Company Profile

Akash Deep Sharma

Roadshow:Health & Life Science

ACIB - Biotech Stories

Martin Trinker

culture cellular

Andrea José Fuentes Bisbal

Implementing Agile in an FDA Regulated Environment

TechWell

Pharma Presentation

emarcellin

Biotechnology Session conference .pdf

smartmmm

thermo fisher 2005

finance40

thermo fisher 2005

finance40

ERIKS Know+How Issue 18 - Food and Beverage

ERIKS UK

Miray Tayfun - Vivoo - Wellness Startups in Turkey & Silicon Valley - Stanfor...

Burton Lee

Know how 30

ERIKS UK

Similar to Recording Facial EMG with New Amplifier Technology (20)

Recording High-Quality Metabolic Data in Humans

EPs.pptx

webinar-ppt-water-steam-baseline-guide-final-watermarked-locked-reduced.pdf

Integrating Eye Tracking Data with Physiological Measurements

Biologics Modular Offering Presentation Series D

WTF@OIS: WHAT’S THE FUTURE @OIS?

SCIEX Overview Presentation (no movie)

Innovation in biopharmaceutical production

Biocon Company Profile

Roadshow:Health & Life Science

ACIB - Biotech Stories

culture cellular

Implementing Agile in an FDA Regulated Environment

Pharma Presentation

Biotechnology Session conference .pdf

thermo fisher 2005

ERIKS Know+How Issue 18 - Food and Beverage

Miray Tayfun - Vivoo - Wellness Startups in Turkey & Silicon Valley - Stanfor...

Know how 30

More from InsideScientific

Next-Generation Safety Assessment Tools for Advancing In Vivo to In Vitro Tra...

InsideScientific

A Ready-to-Analyze High-Plex Spatial Signature Development Workflow for Cance...

InsideScientific

Molecule Transport across Cell Membranes: Electrochemical Quantification at t...

InsideScientific

In this webinar, Dr. Sabine Kuss will discuss the importance of transmembrane molecule exchange and how to detect and quantify membrane transport of molecules in cells. Complex biological processes, such as the transport of molecules across cell membranes, are difficult to understand using purely biological methodologies. Investigating cellular transport processes is challenging, because of the highly complex chemical composition of cells and the diffusion of molecules in and around cells at low concentrations. The development and advancement of electroanalytical methods over the last two decades has enabled the monitoring of living cells and their interaction with the environment, including external stimuli, such as pharma-molecules. This presentation emphasizes electrochemical and electrophysiological methods of detection and quantification but also makes a comparison to other bioanalytical approaches. Join us to discover a substantial diversity in methods used to monitor the transport of cell metabolites, crucial for cell survival, and pharmaceutical compounds, involved in cell characteristics such as drug resistance. Key Topics Include: - Understanding transmembrane molecule transport through bioanalytical methods - Electrochemical approaches to monitor molecule transport across cell membranes - What bioanalytical and especially electrochemical approaches can reveal - Challenges associated with instrument limitations

Exploring Predictive Biomarkers and ERK1/2 Phosphorylation: A New Horizon in ...

InsideScientific

In this webinar, Dr. Victor Arrieta highlights the link between p-ERK activation and improved survival in rGBM patients using anti-PD-1 immunotherapy. Recurrent glioblastoma (rGBM) has displayed a varied response to anti-PD-1 immunotherapy, necessitating the identification of predictive biomarkers. Through extensive analyses and 3 clinical studies, we have identified that activation of the MAPK/ERK signaling pathway, particularly ERK1/2 phosphorylation (p-ERK), is associated with longer overall survival (OS) in rGBM patients receiving PD-1 blockade. Initially, enrichment of BRAF/PTPN11 mutations was reported in 30% of responsive rGBM patients, prompting the investigation of p-ERK as a potential marker beyond these mutations. Our research has unraveled an association between p-ERK abundance and better clinical outcomes following PD-1 blockade, with p-ERK mainly localized in tumor cells. Notably, high p-ERK GBMs contained unique microglia and macrophage phenotypes with elevated MHC class II expression, suggesting a novel interplay between MAPK activation and the tumor immune microenvironment. While these insights establish a pivotal role for p-ERK in predicting PD-1 blockade response in rGBM, the implementation in clinical settings calls for further validation and accuracy. Nonetheless, these findings pave the way for more personalized and effective immunotherapy strategies, emphasizing the significance of the tumor microenvironment and its interaction with therapeutic interventions in GBM. Key Topics Include: - The activation of the MAPK signaling pathway, specifically ERK1/2 phosphorylation (p-ERK), is identified as a predictive biomarker for longer overall survival in recurrent glioblastoma (eGBM) patients undergoing PD-1 blockade - High p-ERK tumors in rGBM present a distinct myeloid cell phenotype with elevated MHC class II expression, signifying a connection between MAPK pathway activation and the immune microenvironment - The implementation of p-ERK as a predictive biomarker in clinical settings requires further validation and exploration of variables impacting its evaluation

Exploring Estrogen’s Role in Metabolism and the Use of 13C-Labeled Nutrients ...

InsideScientific

Dr. Reilly Enos and Dr. Eran Levin discuss estrogen's metabolic impact and how isotopic labeling and 13C-labeled nutrients can be used for animal physiology and nutrition research. Reilly Enos, PhD – Harnessing the power of estrogen to regulate metabolic processes Dr. Reilly Enos’ research focuses on the role that sex steroids and their receptors play in regulating metabolic processes, particularly in the setting of obesity. In this webinar, Dr. Enos will discuss his research on tissue-specific fluctuations of sex steroids throughout the estrous cycle in mice, provide insights into the importance of the quantity of estrogen necessary to impact physiological processes, as well as an understanding of the central versus peripheral effects of estrogen action. Eran Levin, PhD – Unlocking Insights: Utilizing 13C Labeled Nutrients for Cutting-Edge Physiology and Nutrition Research Dr. Eran Levin will discuss the potential of using 13C-labeled nutrients in physiology and nutrition research in animal models. Specifically, he will share practical tips for designing and conducting experiments using isotopic labeling techniques and demonstrate how they can provide unprecedented insights into metabolic pathways, nutrient utilization, and behaviors in both vertebrate and invertebrate models including insects, reptiles, and mammals. Key Topics Include: - The role that estrogen plays in regulating metabolic and behavioral processes in males and females - The tissue-specific fluctuations of sex steroids throughout the estrous cycle - Insight into the importance of tissue-specificity in developing hormonal therapies - The importance of estrogen quantity in regulating physiological processes - Understand the diverse range of 13C labeled nutrients available - Specific applications of labeled amino acids in studies of protein metabolism, cellular signaling, and typical nutrient utilization - How to integrate 13C labeling techniques with respirometry for a comprehensive assessment of metabolic processes, energy expenditure, and substrate utilization in animal models - How to calculate metabolic rates in free-flying animals using 13C bicarbonate

Longitudinal Plasma Samples: Paving the Way for Precision Oncology

InsideScientific

Experts present a cell-free plasma biobank and describe the role of longitudinal plasma samples for cancer research, disease monitoring, and biomarker development. Through liquid biopsies, it is now possible to repeatedly and non-invasively interrogate the molecular landscape of solid tumors via a blood draw over the whole treatment course. Until now, liquid biopsies can be used for screening, disease monitoring and prognosis. Circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) have been the most explored targets in this technology for commercial applications up to the present time. In collaboration with a continuously expanding oncology network, Indivumed Services has established a unique high-quality cell-free plasma biobank that is exclusively focused on collecting longitudinal whole blood samples from cancer patients. This allows molecular insight by providing quick access to longitudinal plasma from cancer patients that have undergone treatment. ctDNA can then be isolated from longitudinal cell-free plasma to allow for monitoring of disease progression by providing diagnostic and prognostic information, potentially in real time. Key Topics Include: - Gain insights into Indivumed Services’ longitudinal plasma collection process - Understand the advantages and benefits of utilizing longitudinal plasma samples for cancer research - Explore applications of longitudinal plasma samples for biomarker research and development of companion diagnostics

Fully Characterized, Standardized Human Induced Pluripotent Stem Cell Line an...

InsideScientific

This document summarizes a webinar presented by Andrew Gaffney and Erin Knock of STEMCELL Technologies. They discussed STEMCELL's development of the healthy control human iPSC line SCTi003-A and single-use iPSCdirect product, which were manufactured to high quality standards. They also discussed STEMCELL's neural progenitor cells derived from SCTi003-A, which can be expanded over multiple passages while maintaining their ability to differentiate into neurons and astrocytes. The neural progenitor cells demonstrate expected marker expression and can be cryopreserved and re-thawed while retaining their differentiation potential.

How to Create CRISPR-Edited T Cells More Efficiently for Tomorrow's Cell Ther...

InsideScientific

Ian Foster and Steven Loo-Yong-Kee discuss Artisan Bio's STAR-CRISPR system for optimized gene editing in cell therapy, with a focus on the genetifc modification of T cells for cancer immunotherapy. Cell therapy is an emerging field with great promise for the treatment of various diseases. One of the most exciting areas of cell therapy is the use of T cells that have been genetically modified to recognize and kill cancer cells. While the use of T cells for cancer immunotherapy has tremendous promise, there is still room for improvement. The efficiency, expansion, and functionality of T cells can be enhanced by genetic modification using the STAR-CRISPR system. Artisan Bio is a biotechnology company focused on developing a CRISPR-mediated editing platform to improve the efficacy and safety of cell therapy products. In this webinar, we will provide a comprehensive overview of Artisan Bio’s STAR-CRISPR system, which is designed to improve the specificity and efficiency of gene editing for cell therapies. We will explain the system’s key components and how we are using a risk-based approach to optimize and validate the editing platform. The webinar will focus on Artisan Bio’s approach to building T cell OS/APPS through iterative improvements to achieve best-in-class editing capabilities and improved cell health metrics. Key Topics Include: - Learn about Artisan Bio’s proprietary high-performance STAR-CRISPR system for improving the specificity and efficiency of gene editing for cell therapies - Explore Artisan Bio’s risk-based, systems approach to technology development, including how to implement Design of Experiments (DoE) and Quality by Design (QbD) principles to optimize and validate any process - Case study of the application of QbD to Artisan Bio’s STAR-CRISPR platform to edit T cells for cancer immunotherapy with preliminary data showing improved efficacy, expansion, and functionality

Peripheral and Cerebral Vascular Responses Following High-Intensity Interval ...

InsideScientific

Dr. Bert Bond and Max Weston will present an overview on their study investigating the effects high-intensity interval exercise has on cerebrovascular health. Physical activity reduces the risk of developing cardiovascular diseases (CVD) and dementia. This benefit cannot be explained by changes in traditional CVD risk factors alone, and direct improvements in vascular health are thought to play a key role. However, our understanding of how exercise can be optimized for improvements in blood-vessel health is limited. High-intensity interval exercise (HIIE) is known to improve peripheral vascular function, and there is a growing interest in the effects of HIIE on cerebrovascular health. However, it is not clear whether the acute improvements in peripheral vascular function following HIIE are also seen in the major blood-vessels of the brain. In the Bond lab’s study, 30 minutes of HIIE completed at both 75% and 90% V̇O2max improved peripheral vascular function 1 and 3h following exercise in healthy young adults, compared with work-matched continuous moderate-intensity exercise and a sedentary control condition. By contrast, cerebrovascular function was unchanged following all conditions. This is the first study to identify that acute improvements in peripheral vascular function following high-intensity interval exercise are not mirrored by improvements in cerebrovascular function in healthy young adults.

Leveraging Programmable CRISPR-Associated Transposases for Next-Generation Ge...

InsideScientific

Dr. Sam Sternberg discusses a novel CRISPR-Cas9 system using programmable, RNA-guided transposase, and highlights its implications for kilobase-scale genome engineering in cell and gene therapies. The utility of programmable, RNA-guided CRISPR-Cas systems in genome engineering continues to evolve. Nature has afforded scientists novel and diverse gene editing functionality, from nuclease-dependent CRISPR-Cas9 to second-generation base and prime editors that do not produce double-strand breaks. In this webinar, Dr. Sam Sternberg describes a new CRISPR-Cas9 paradigm relying on nuclease-deficient bacterial transposons that catalyze RNA-guided integration of mobile genetic elements into the genome. The discovery of a fully programmable, RNA-guided transposase lays the foundation for kilobase-scale genome engineering with broad applications for developing cell and gene therapies. Key Topics Include: - The basics of first- and second-generation CRISPR-Cas technologies from a scientist at the forefront of their development - Mechanisms, accommodation, and cell type diversity of CRISPR-Cas programmable transposition - How transposase factor coordination enables highly specific, genome-wide DNA integration to target sites - Implications of programmable transposases that obviate the need for DNA double-strand breaks and homologous recombination

Simple Tips to Significantly Improve Rodent Surgical Outcomes

InsideScientific

Dr. Marcel Perret-Gentil presents six simple-to-implement techniques to significantly improve surgical outcomes. You may feel proficient, even confident in performing rodent surgery; however, you may be surprised how simple improvements can have a huge impact to your animal’s recovery and data. The presentation is designed for individuals who have minimal or no rodent surgical skills but is also a great opportunity for those with considerable experience wanting to improve outcomes as well as teach such key principles. Key Topics Include: - Improve surgical outcomes that will lessen post-op morbidity and mortality - Improve data yield after rodent surgery - Implementation of key principles into a rodent surgical program

Cardiovascular Autonomic Dysfunction in the Post-COVID Landscape: Detection a...

InsideScientific

This document discusses cardiovascular autonomic dysfunction in post-COVID patients. It begins with a case study of a 41-year-old woman who developed post-COVID symptoms like fatigue, palpitations and orthostatic intolerance. Tests showed she had postural orthostatic tachycardia syndrome (POTS). Between 10-15% of COVID patients develop long COVID, and 30% of highly symptomatic long COVID patients have POTS. Tilt testing, active standing tests and Holter monitoring can help diagnose POTS and other forms of autonomic dysfunction. Treatment focuses on lifestyle changes, compression garments, increasing fluids and salts, and regulating heart rate and blood pressure with medications. Further research is still

Creating Better Gene-Edited Cell Lines with the FAST-HDR System

InsideScientific

Cell lines are the core of biological research. Scientists need cell lines for drug development, basic biology research, safety testing, and biologic therapeutic production. Since the 1980s, genetic manipulation has allowed researchers to tailor cell lines to the experiment or production purpose. Over time, the requirements for these cell lies have risen. In many cases, the cells require multiple genetic edits and must produce data that passes FDA. Moreover, the current funding environment often requires rapid delivery of these cells so scientists can produce data to support further budget and/or investment. This is particularly acute for knock-in cell lines. Current technologies may take months to complete a cell line, allow a limited number of edits, and often have off-target effects that are not suitable for FDA filings. ExpressCells uses its patented FAST-HDR plasmid--along with CRISPR, to address these problems. The FAST-HDR process can precisely knock-in multiple genes (while supporting other types of genetic modifications), ensure precise placement of these edits, and deliver them months faster than competing technologies. This webinar will discuss the basis of the FAST-HDR technology and illustrate several uses. The first part is a presentation by Oscar Perez-Leal, MD, the inventor of the technology. Oscar will discuss the problems he faced as a researcher and how FAST-HDR was designed to address them. He will outline the details of the technology, the history of its development, and several examples where he used FAST-HDR. The second part is a conversation with Jon Weidanz, PhD. Jon will outline the challenges he faced at AbeXXa and how he selected a FAST-HDR custom cell line for his project. He'll outline the learnings from using this cell line, some of which were unexpected, but valuable to future development. By attending this program, attendees will: - Understand the current challenges in creating custom gene-edited cell lines - Know the technology underlying the FAST-HDR gene-editing system, including its use with CRISPR - Be able to describe the advantages of the FAST-HDR system - Learn about several case studies using gene-edited cell lines

Functional Recovery of the Musculoskeletal System Following Injury - Leveragi...

InsideScientific

Watch Dr. Sarah Greising discuss the current pathophysiologic understanding of the skeletal muscle remaining following traumatic musculoskeletal injuries. Volumetric muscle loss (VML) injuries result in the abrupt loss of skeletal muscle fibers, causing chronic functional disability in part due to limited muscle regeneration and vast co-morbidities. With a focus on clinically relevant outcome measurements for skeletal muscle function in both small and large animal models of VML injury, this webinar presents various near-term interventions for the restoration of tissue function following complex injuries. Interventions evaluated focus on regenerative rehabilitation approaches using regenerative pharmaceuticals to correct underlying muscle pathophysiology.

Designing Causal Inference Studies Using Real-World Data

InsideScientific

In this webinar, experts provide an overview of causal inference, along with step-by-step guidance to designing these studies using real-world healthcare data. Causal inference is used to answer cause and effect research questions and yield estimates of effect. Causal study design considerations and statistical methods address the effects of confounding variables and other potential biases and allow researchers to answer questions such as, “Does treatment A produce better patient outcomes compared to Treatment B?” Causal study interpretations have traditionally been restricted to randomized controlled trials; however, causal inference applied to observational healthcare data is growing in importance, driven by the need for generalizable and rapidly delivered real-world evidence to inform regulatory, payer, and patient/provider decision making. The application of causal inference methods leads to stronger and more powerful evidence. When these techniques are applied to observational data, the results generated are both from and for the real world. Presenters walk through several real-world case studies including the PCORI-funded BESTMED study and a collaborative study with a prominent pharmacy payer.

Social Media Data: Opportunities and Insights for Clinical Research

InsideScientific

Many new data are emerging in recent years - real time data is collected through digital health technologies, including apps and wearables, monitoring data, social media data, public datasets, and patient organization data, in addition to primary and secondary datasets. Real life data are highly informative and can be used to address a range of challenges throughout the product life cycle. Data from social media can generate valuable insights as patients often gather in digital communities to get answers and share their experiences. Conversations on social networks merit special consideration as they can have real world influence over treatment management decisions. Social media data can reveal the motivations that impact patient healthcare decisions and behaviors through each stage of the care pathway. These data provide both the patient and caregiver perspectives at the same time. For this reason, conversations on social networks offer an opportunity to deepen our understanding on: - The fears and hopes associated with patient treatments - Daily needs and difficulties patients are facing in managing their disease - The impact of disease on patient health related quality of life - Identification in real life of the stages of the care pathway and patient perceptions - Reactions to health policies Watch this webinar for insights on how to collect, use, analyze, and interpret social media data in different contexts. Our experts share knowledge from over fifteen years of successfully developing and adapting algorithms to treat this kind of data.

We Are More Than What We Eat Dietary Interventions Depend on Sex and Genetic ...

InsideScientific

To learn more visit: https://insidescientific.com/webinar/we-are-more-than-what-we-eat-dietary-interventions-depend-on-sex-and-genetic-background/ Despite evidence that sex and genetic background are key factors in the response to diet, most studies of how diet regulates metabolic health and even longevity in mice examine only a single strain and sex. Using multiple strains and both male and female mice, Dr Lamming's team has found that improvements in metabolic health and in longevity in response to reduced levels of protein or specific amino acids strongly depend on sex and strain. While some phenotypes were conserved across strains and sexes, including increased glucose tolerance and energy expenditure, they observed high variability in adiposity, insulin sensitivity, and circulating hormones. Using a multi-omics approach, they identified mega-clusters of differentially expressed hepatic genes, metabolites, and lipids associated with each phenotype, gaining new insight into role of the energy balance hormone FG21 in the response to protein restriction.

Antibody Discovery by Single B Cell Screening on Beacon®

InsideScientific

Amy Sheng, PhD provides an overview of antibody screening platforms and presents applications and case studies using the Beacon® platform for antibody discovery. Single B cell screening is a powerful and efficient strategy for generating antigen-specific monoclonal antibodies. Distinguished with fluorescence-activated B cell sorting, the Beacon® platform is based on plasma cell screening, making it easier to obtain antibody genes. The Beacon® single-cell optofluidic system combines a unique optoelectro positioning (OEP) technology with novel microfluidic technology. It can be used to accurately select single cells on a chip, perform multiple single-cell assays, and export target cells based on specific results. The Beacon® optofluidic platform preserves the diversity of B cells, generating high-quality positive hits at an early stage of discovery and avoiding the loss of “good clones”. Key Topics Include: - B cell differentiation and development - Pros and cons of mainstream antibody screening platforms - Mechanisms, applications, and case studies using the Beacon® platform for antibody screening - Sino Biological’s capacity using the Beacon® platform

Experimental Design Considerations to Optimize Chronic Cardiovascular Telemet...

InsideScientific

Phil Griffiths, PhD, presents a summary of chronic cardiovascular telemetry studies and considerations for experimental design. Ensuring you collect the best and most physiologically accurate data from your chronic telemetry experiments requires careful planning and experimental design. This webinar will give an insight into the practical aspects of designing chronic animal experiments to set you on the best path for success. The benefits of chronic studies, how to select the most appropriate sample size for your study, some basic tips and tricks for data acquisition and handling, and how to ensure high animal welfare are discussed. Key Topics Include: - What are the benefits of chronic over acute studies? - How to decide the best sample sizes and the length of experiments? - Basic tips for data acquisition and handling - How to maintain high animal welfare standards

Strategic Approaches to Age-Related Metabolic Insufficiency and Transition in...

InsideScientific

In this webinar, Dr. Dennis Turner delves into dementia syndrome, the metabolic changes that occur, and the importance of proper physiological monitoring of animal models. Brain metabolism transforms with normal aging, and transient, dynamic metabolic insufficiency may underlie critical progression from aging into dementia syndrome and Alzheimer’s disease (AD). Age-related brain metabolism balances vascular-related substrate supply and transport mechanisms into extracellular space to neurons with cellular metabolic needs and utilization. Dynamic metabolic insufficiency can occur when there is intermittent supply-demand mismatch. Adequacy of neurovascular coupling to provide sufficient cerebral blood flow (CBF) to meet neuronal demand in vivo in a mouse AD model, compared to aged controls were studied. Dr. Turner’s lab analyzed the response to maximal neuronal metabolic demands, spreading depression and anoxia, using imaging, CBF measurements, and oxygen and glucose levels. These in vivo studies require human-similar anesthesia conditions, through monitoring temperature, blood pressure/pulse oximetry, and respiration, to maintain homeostasis. The lab confirmed abnormal neurovascular coupling in a mouse model of AD in response to these metabolic challenges, showing disruption much earlier in dementia than in equivalently aged individuals. Chronic metabolic treatments could influence dementia syndrome progression.

More from InsideScientific (20)