3. Risk Factors for EDs
Perfectionism for AN
Early Puberty
Failed attempts to lose weight
Athletics
Beginning a diet
Family history of eating disorder, substance abuse or
mood disorder
4. Diagnosis of Anorexia Nervosa
DSM IV
Refusal to maintain 85% of ideal body weight
Intense fear of becoming fat
Body image distortion; undue influence of weight
on self evaluation; denial of risks of low weight
Amenorrhea (in post-menarchal females)
Purging-type
Restricting-type
5. Proposed DSM V changes
“less than minimally expected” instead of 85% ideal
body weight
Remove “refusal” (pejorative)
Add “behavior” to avoid weight gain, since many
patients deny fear of gaining weight
Remove amenorrhea
Subtyping be for current episode
6. Diagnosis AN (DSM-5):
Restriction of energy intake relative to
requirements leading to a significantly low body
weight in the context of age, sex.
Intense fear of gaining weight or becoming fat,
or persistent behavior that interferes
with weight gain.
Disturbance in one's body weight or shape ,
persistent lack of recognition of the seriousness
of low body weight
Specify:
Restricting type
Purging type/Binge Eating.
7. Subtypes AN (DSM-5):
Restricting Type: during last 3months, the person has
not engaged in recurrent episodes of binge eating or
purging behavior
Binge-Eating/Purging Type: during last 3 months, the
person engaged in
recurrent episodes of binge eating or purging behavior
8. Epidemiology:
Life time prevalence 0.5- 3.7%
Girls from 14- 18ys 0.5- 1%
AN and BN 30 - 50%
Death 3-8%
Age: 10-30years.
Risk : Sp. After stress
M:F ratio 1: 20
In professions modeling –
ballet dancers.
9. Medical Complication
Death (hypokalemia , starvation, sudden cardiac death)
Hypometabolic state (bradycardia, hypotension, hypothermia)
Dehydration
Arrhythmia, heart failure.
Bone loss
Peripheral edema
Delayed sexual maturity
Hair loss, brittle hair, Lanugo.
On recovery: Re-feeding syndrome
11. Eating Disorder Inventory (EDI)
The EDI is a 64 item, self-report for the
assessment of psychological and behavioral traits
common in anorexia nervosa (AN) and bulimia.
EDI consists of eight sub-scales measuring: 1)
Drive for Thinness, 2) Bulimia, 3) Body
Dissatisfaction, 4) Ineffectiveness, 5)
Perfectionism, 6) Interpersonal Distrust, 7)
Interoceptive Awareness ,8) Maturity Fears
12. Anorexia Nervosa: Treatment
Determine inpatient vs. day treatment vs. outpatient
Multidisciplinary teams are ESSENTIAL!
Primary care provider
Psychiatrist
Individual therapist
Family therapist
Nutritionist
1st
: weight restoration
2nd
: psychological
3rd
: maintinance (long-term)
13. Medical Admission Criteria
<75% ideal body weight
Hypothermia T<36
Bradycardia HR<50 while awake, <45 asleep
Orthostasis-drop in sbp >10, increase in
HR>35
Dehydration
Severe hypokalemia (<2-3 mmol/L) or other
electrolyte abnormality
Acute medical complication
Severe depression/suicidality– Psychiatric
admit
Refractory to outpatient treatment
14. Anorexia Nervosa: Therapy
Best evidence is for family-based treatment
(Maudsley approach)
Who: younger patients who live at home, intact family
Philosophy: no-blame, family did not cause anorexia; family
is the best resource to help her get better
Elevate family’s anxiety about the gravity of the illness.
Empower parents to do whatever they need to do to get the
anorexic to eat. Align siblings with the patient for support.
Externalize the anorexia.
“Family Meal”
Once weight-restored: explore the family dynamics and
psychological issues.
15. Anorexia Nervosa: Medications
No approved medication treatments for Anorexia Nervosa
Prozac (or other SSRI) for co-morbid depression or anxiety
Low-dose Atypical Antipsychotics off-label for near-
psychotic thinking that is characteristic of anorexia,
Zyprexa may help with weight gain
- problem: informed consent for risks of weight gain
16. ANOREXIA NERVOSA
Prognosis:
40% → recover.
30% → continue with milder course.
30% → chronic cases.
Risk of death
Suicide
Cardiac arrest
Malnutrition
> 3 years of illness: prognosis is poor
17. Bulemia Nervosa – DSM IV
Recurrent episodes of binge-eating (eating larger
amounts of food than others would eat in a
discrete- 2 hour- period of time, with a sense of lack
of control)
recurrent inappropriate compensatory behavior
(vomitting, laxatives, excessive exercise, etc)
Both occur at least 2x/wk for 3 months
Self-evaluation is unduly influenced by body
shape or weight
(purging type, non-purging type)
18. Proposed DSM V changes
Change frequency of compensatory behaviors from
2x/week to 1x/week
Deletion of non-purging subtype, because it more
closely resembles binge-eating disorder
19. Diagnostic Criteria for Bulemia Nervosa DSM-5
A. Recurrent episodes of binge eating:
(1) Eating large amount in a discrete period of time
(2) lack of control over eating
B. Recurrent compensatory behavior in order to
prevent weight gain.
C. Binge eating and inappropriate compensatory
behaviors is at least once a week for 3 months.
22. Medical Complication
Electrolyte abnormalities
Dental – loss of enamel, chipped teeth, cavities
Parotid enlargement
Conjunctival hemorrhages
Calluses on dorsal side of hand (Russel’s sign)
Esophagitis
hematemesis
Latxative-dependent: cathartic colon, melena, rectal
prolapse
23. Bulemia: Treatment
Multidisciplinary team
Primary care provider
Psychiatrist
Family therapist
Nutritionist
Evidence based : CBT + Antidepressant (SSRI)
24. Bulemia: Treatment (Therapy)
Family therapy is a good option if patient is young
and still lives at home (But not as much evidence as
for Anorexia)
Interpersonal therapy (IPT) (short-term treatment
focused on life transitions)
Psychodynamic Psychotherapy (good for long-term
results in people with chronic depressive and
personality symptoms)
Nutrition plan, exercise, physical activity
25. Bulemia: Medicaions
High-dose Fluoxetine/Prozac (SSRI) – very good
evidence!
Sertraline/Zoloft (SSRI) – some good evidence
Buproprion/Wellbutrin (other antidepressant) –
contraindicated! (risk of seizures if history of
purging)
Topiramate/Topomax (mood stabalizer, promotes
weight loss) – some good evidence, but use with
caution esp if low-weight
26. Bulemia: Prognosis
33% remit every year
But another 33% relapse into full criteria
Adolescent-onset better prognosis than adult-onset
Death-rate = 1%
27. Binge Eating Disorder – DSM IV (only in
appendix)
Episodic intakes of larger than typical amounts of
food
Episodes occur in brief (<2 hrs) periods of time
Subjectively, sense of loss of control while eating
At least 2 days/week for 6 months
28. Binge Eating Disorder- Diagnosis
Also needs 3 of the following:
Eating much more rapidly than normal
Getting uncomfortably full
Large amounts of food when not physically
hungry
Eating alone because embarrassed about how
much one is eating
Feeling disgusted with oneself, depressed, or
guilty when over-eating
29. Proposed DSM-V changes
That binge eating disorder should become a free-
standing diagnosis, rather than only in the appendix
Less Frequency: once a week for 3 months
30. DSM-5 Diagnostic Criteria for Binge Eating
Disorder
Eating, in a discrete period of time , large amount
Lack of control over eating during the episode
Binge eating occurs, on average, at least once a week
for three month
31. DSM-5 Diagnostic Criteria for Binge Eating
Disorder
BE are associated WITH :
1. Eating much more rapidly than normal
2. Eating until feeling uncomfortably full
3. Eating large amounts of food when not feeling
hungry
4. feeling disgusted with oneself, depressed, or very
guilty afterwards
33. Binge Eating Disorder:
Medical Risks
Less acute risk than with restrictive eating patterns
Long-term risks significant: the many organ systems
affected by obesity, shortened life-span, etc
34. Binge Eating Disorder: Etiology
Media factors
genetic
Individual
Temperament
(ie. impulsive)
biological
Family dynamics
Societal, cultural
35. Binge Eating Disorder:
Treatment (Medication)
SSRI
high dose reduces binge behavior short-term
but doesn’t help weight loss
Topomax, Zonisamide (anticonvulsants, mild
mood stabalizer)
Helps binge reduction
Helps weight loss
Caution for adverse effects, high discontinuation rates
36. Binge Eating Disorder:
Treatment (Therapy)
Therapies either prioritize…
Weight loss
Binge-reduction
Neither (ie. relationships, depression etc)
Group psychotherapy
There is little evidence that obese individuals who
binge should receive different therapy than obese
individuals who do not binge
37. Binge Eating Disorder:
Psychosocial Support
Family need help with co-dependency
Weight loss programs
Weight watchers, Jenny Craig, etc.
12-step Self help groups
Food Addicts in Recovery Anonymous
Overeaters Anonymous