Monitoring of concrete structures by electro mechanical impedance technique IEI GSC
By Dr. S.N.Khante Associate Professor & Bhagyashri Sangai
at 31st National Convention of Civil Engineers
organised by
Gujarat State Center, The Institution of Engineers (India) at Ahmedabad
Plazma-Sk Ltd. Nanosized carbon coating to supress the multipactor effectIgor_Kossyi
Technology of creation nanostructured carbon coating on metal parts of transceiver tract of UHF communications equipment of the spacecraft, suppressing the emergence of effect of secondary emission discharge in vacuum conditions, which is, in the opinion of the community of scientists and engineers, the main cause of the destruction of on-board equipment of communications satellites.
Monitoring of concrete structures by electro mechanical impedance technique IEI GSC
By Dr. S.N.Khante Associate Professor & Bhagyashri Sangai
at 31st National Convention of Civil Engineers
organised by
Gujarat State Center, The Institution of Engineers (India) at Ahmedabad
Plazma-Sk Ltd. Nanosized carbon coating to supress the multipactor effectIgor_Kossyi
Technology of creation nanostructured carbon coating on metal parts of transceiver tract of UHF communications equipment of the spacecraft, suppressing the emergence of effect of secondary emission discharge in vacuum conditions, which is, in the opinion of the community of scientists and engineers, the main cause of the destruction of on-board equipment of communications satellites.
Ion Beam Analytical Technique PIXE for Pollution Study at Dhaka Van de Graaff...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Application of non destructive test for structural health monitoring - state ...eSAT Journals
Abstract
The concept of non-destructive testing (NDT) is to obtain material properties “in place” specimens without the destruction of the specimens and to do the structural health monitoring. NDT using Rebound hammer, Ultra pulse velocity, Half-cell potential, core cutter, carbonation depth, rebar locator, Rapid chloride penetration test, electric resistivity meter test and vibration base analysis by data analoger are very popular and highly effective in conducting structural health monitoring. The structure can be investigated by using a visual inspection, NDT, laboratory and field test performance. In this article a review of these tests have been provided to conduct effective structural health monitoring of a RCC structure
Keywords: Non-destructive test, visual inspection, corrosion, compressive strength
In these work, new nano and micro thermoplastic based composite is prepared with zeolite filler, The method involves using zeolite in powder form, the preparation of zeolite powder from ores by crushing it into small - sized granules. The characteristics of the zeolite powder are determined. The physical properties and chemical composition (XRD) are evaluated before impeding it into the thermoplastic. Thermoplastics powder are added to the zeolite powder as granules in different sizes, The particles sizes ranging from the size of a millimeter to nanometer. The manufacturing quality parameters are optimized at volume percentages of filler in the range 20 to 25 % , composite material is formed into molds. New Composite material is characterized by easy deformation into different shapes beside machine ability. The characteristics of new composite such as SEM, EDX,FTIR in absorption and transmission mode are evaluated and compared with the standard characteristics of Zeolite ores. The performance and characteristics of the new composite are completely different. The new composite is hard, solid and does not absorb water. The work end with list of recommendation about the new field and expected application of Zeolite when using it as filler in thermoplastic based micro and nano composites.
To get an insight into the radiological features of potentially reusable by-products can be reused in building materials industry a review of the reported scientific data is necessary. This study is based on the continuously growing database of the By-BM (H2020-MSCA-IF-2015) project (By-products for Building Materials). Currently, the By-BM database contains individual data of about 431 by-products and 1095 building and raw materials. It was found that in case of the construction materials the natural isotope content varied widely (Ra-226: <dl-27851 /><dl-906 /><dl-17922 /><dl-1350 /><DL-3001 Bq/kg). The average Ra-226, Th-232 and K-40 content of reported by-products were 2.52, 2.35 and 0.39 times higher than the building materials respectively. The gamma exposure of bulk building products was calculated according to IAEA Specific Safety Guide No. SSG-32 and European Commission Radiation Protection 112 based I-index (EU BSS). It was found that in most cases the I-index without density consideration provides a significant overestimation in excess effective dose.
Nanostructured carbon coating for multipactor effect preventing on metal surf...Aleksei Lavrin
Technology of creation of nanostructured carbon coating on metal parts of transceiver tract of UHF communications equipment of the spacecraft, suppressing the emergence of effect of secondary emission discharge in vacuum conditions.
Material Characterization Testing, Unit IV; OML751 Testing of Materials Dr.S.Thirumalvalavan
Material Characterization Testing, Unit-IV
Subject Name: OML751 Testing of Materials
Topics: Material Characterization Testing [Optical microscopy, Electron microscopy-SEM, TEM. Diffraction techniques, Spectroscopy techniques. Electrical and Magnetic techniques.
B.E. Mechanical Engineering
Final Year, VII Semester, Open Elective Subject
[As per Anna University R-2017]
Ion Beam Analytical Technique PIXE for Pollution Study at Dhaka Van de Graaff...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Application of non destructive test for structural health monitoring - state ...eSAT Journals
Abstract
The concept of non-destructive testing (NDT) is to obtain material properties “in place” specimens without the destruction of the specimens and to do the structural health monitoring. NDT using Rebound hammer, Ultra pulse velocity, Half-cell potential, core cutter, carbonation depth, rebar locator, Rapid chloride penetration test, electric resistivity meter test and vibration base analysis by data analoger are very popular and highly effective in conducting structural health monitoring. The structure can be investigated by using a visual inspection, NDT, laboratory and field test performance. In this article a review of these tests have been provided to conduct effective structural health monitoring of a RCC structure
Keywords: Non-destructive test, visual inspection, corrosion, compressive strength
In these work, new nano and micro thermoplastic based composite is prepared with zeolite filler, The method involves using zeolite in powder form, the preparation of zeolite powder from ores by crushing it into small - sized granules. The characteristics of the zeolite powder are determined. The physical properties and chemical composition (XRD) are evaluated before impeding it into the thermoplastic. Thermoplastics powder are added to the zeolite powder as granules in different sizes, The particles sizes ranging from the size of a millimeter to nanometer. The manufacturing quality parameters are optimized at volume percentages of filler in the range 20 to 25 % , composite material is formed into molds. New Composite material is characterized by easy deformation into different shapes beside machine ability. The characteristics of new composite such as SEM, EDX,FTIR in absorption and transmission mode are evaluated and compared with the standard characteristics of Zeolite ores. The performance and characteristics of the new composite are completely different. The new composite is hard, solid and does not absorb water. The work end with list of recommendation about the new field and expected application of Zeolite when using it as filler in thermoplastic based micro and nano composites.
To get an insight into the radiological features of potentially reusable by-products can be reused in building materials industry a review of the reported scientific data is necessary. This study is based on the continuously growing database of the By-BM (H2020-MSCA-IF-2015) project (By-products for Building Materials). Currently, the By-BM database contains individual data of about 431 by-products and 1095 building and raw materials. It was found that in case of the construction materials the natural isotope content varied widely (Ra-226: <dl-27851 /><dl-906 /><dl-17922 /><dl-1350 /><DL-3001 Bq/kg). The average Ra-226, Th-232 and K-40 content of reported by-products were 2.52, 2.35 and 0.39 times higher than the building materials respectively. The gamma exposure of bulk building products was calculated according to IAEA Specific Safety Guide No. SSG-32 and European Commission Radiation Protection 112 based I-index (EU BSS). It was found that in most cases the I-index without density consideration provides a significant overestimation in excess effective dose.
Nanostructured carbon coating for multipactor effect preventing on metal surf...Aleksei Lavrin
Technology of creation of nanostructured carbon coating on metal parts of transceiver tract of UHF communications equipment of the spacecraft, suppressing the emergence of effect of secondary emission discharge in vacuum conditions.
Material Characterization Testing, Unit IV; OML751 Testing of Materials Dr.S.Thirumalvalavan
Material Characterization Testing, Unit-IV
Subject Name: OML751 Testing of Materials
Topics: Material Characterization Testing [Optical microscopy, Electron microscopy-SEM, TEM. Diffraction techniques, Spectroscopy techniques. Electrical and Magnetic techniques.
B.E. Mechanical Engineering
Final Year, VII Semester, Open Elective Subject
[As per Anna University R-2017]
These are the slides I made for the Micro Systems and Nano technology course that I gave for Mikro centrum for some years, a little old but not outdated i think. Already the current converge of hardware technology, software technology and biology becomes visible.
Progress of Integration in MEMS and New Industry CreationSLINTEC
Progress of Integration in MEMS and New Industry Creation
Prof. Susumu Sugiyama
Scientific Expert, JSPS/JAICA
Director, Research Institute for Nanomachine System Technology
Professor, Ritsumeikan Global Innovation Research Organization
Ritsumeikan University
Japan
Delivered @ SLINTEC September 2009
This article discusses MEMS, i.e. Micro-Electro Mechanical Systems.
It gives a rudimentry idea of MEMS technology, its block diagram, applications, advantages and disadvantages. It also gives a brief idea on the working principle of MEMS devices.
Micro-electro-mechanical systems (MEMS) have been identified as one of the most promising technologies and will continue to revolutionize the industry as well as the industrial and consumer products by combining silicon-based microelectronics with micro-machining technology. All the spheres of industrial application including robots conception and development will be impacted by this new technology. If semiconductor microfabrication was contemplated to be the first micro-manufacturing revolution, MEMS is the second revolution. The paper reflects the results of a study about the state of the art of this technology and its future influence in the development of the construction industry. The interdisciplinary nature of MEMS utilizes design, engineering and manufacturing expertise from a wide and diverse range of technical areas including integrated circuit fabrication technology, mechanical engineering, materials science, electrical engineering, chemistry and chemical engineering, as well as fluid engineering, optics, instrumentation and packaging.
DeltaTi Consortium research activities focuses on deployment on the market new embedded system with thermoelectrical property based on nanostructured Si-based Alloy for cooling\thermogenerations into embedded ICs
Finanziare Ricerca ed Innovazione: Il caso della trasformazione digitale dell...Danilo Mascolo
Aggiornamento sugli strumenti di finanziamento disponibili per sostenere ricerca ed innovazione in ambito nazionale regionale ed europeo. Confronto fra strumenti che danno accesso a liquidità e fondo perduto. Bandi Porfesr, H2020 a confronto. Strumenti per PMI e GI: SME, Fast-Track-to-Innovation, Open FET. L'impatto delle tecnologie abilitanti nella generazione del valore. Comodizzazione digitale: la modifica delle value chain per effetto delle tecnologie digitali. Consumerizzazione digitale. Le Comodity digitali. Trasformazione delle industrie e maturità digitale. da Industria 4.a a impresa 4.0 e prodotti 4.0, Vortice digitale e caratteristiche dei settori digitalizzati. Best pratcice operative. Big Data, Analitycs, AI, Deep learning come motore della trasformazione del manifatturiero. L'insostenibilità della competition in caso di ritarti in digitalizzazione. Assessment e supporto alla trasformazione su customers, competition, value, innovation, managment capabilities.
Verso industria 4.0 big data manufactoring - modena 24 ottobre 2017Danilo Mascolo
“BIG DATA MANUFACTURING NELLA TRASFORMAZIONE DIGITALE DEI PROCESSI AZIENDALI” che si terrà martedì 24 ottobre 2017 a Modena, con inizio alle ore 9.30, presso la sede di Confindustria Emilia Area Centro.
Bando innovazione 2017 (por fesr 2014-2020 rev-1 0)Danilo Mascolo
POR-FESR 2014-2020 dell’ Asse 1 - Ricerca e Innovazione:
Azione 1.1.2 - Sostegno a progetti di innovazione e diversificazione di prodotto o servizio per le PMI.
Sostenere percorsi di innovazione tecnologica e diversificazione, con l'obiettivo di accrescere la quota di mercato o di penetrare in nuovi mercati.
Sostenere PMI che necessitano di acquisire all'esterno i servizi innovativi e le competenze per completare, anche dal punto di vista manageriale, i percorsi per la loro introduzione sul mercato.
Confindustria Emilia-Romagna Ricerca (CERR) is the company of Confindustria System (the Federation of 9 industrial association of the Emilia-Romagna region, counting 9.000 members working over the main manufacturing and services sectors) created to assist companies in the field of research, innovation and technology transfer.
CERR supports firms alongside the whole innovation processes developing customized programs to address technological and organizational challenges.
CERR promotes collaboration, dissemination of ideas and the exploitation of knowledge to experiment and find new way to the Open Innovation paradigm, looking to Europe as reference path.
Courier management system project report.pdfKamal Acharya
It is now-a-days very important for the people to send or receive articles like imported furniture, electronic items, gifts, business goods and the like. People depend vastly on different transport systems which mostly use the manual way of receiving and delivering the articles. There is no way to track the articles till they are received and there is no way to let the customer know what happened in transit, once he booked some articles. In such a situation, we need a system which completely computerizes the cargo activities including time to time tracking of the articles sent. This need is fulfilled by Courier Management System software which is online software for the cargo management people that enables them to receive the goods from a source and send them to a required destination and track their status from time to time.
COLLEGE BUS MANAGEMENT SYSTEM PROJECT REPORT.pdfKamal Acharya
The College Bus Management system is completely developed by Visual Basic .NET Version. The application is connect with most secured database language MS SQL Server. The application is develop by using best combination of front-end and back-end languages. The application is totally design like flat user interface. This flat user interface is more attractive user interface in 2017. The application is gives more important to the system functionality. The application is to manage the student’s details, driver’s details, bus details, bus route details, bus fees details and more. The application has only one unit for admin. The admin can manage the entire application. The admin can login into the application by using username and password of the admin. The application is develop for big and small colleges. It is more user friendly for non-computer person. Even they can easily learn how to manage the application within hours. The application is more secure by the admin. The system will give an effective output for the VB.Net and SQL Server given as input to the system. The compiled java program given as input to the system, after scanning the program will generate different reports. The application generates the report for users. The admin can view and download the report of the data. The application deliver the excel format reports. Because, excel formatted reports is very easy to understand the income and expense of the college bus. This application is mainly develop for windows operating system users. In 2017, 73% of people enterprises are using windows operating system. So the application will easily install for all the windows operating system users. The application-developed size is very low. The application consumes very low space in disk. Therefore, the user can allocate very minimum local disk space for this application.
Immunizing Image Classifiers Against Localized Adversary Attacksgerogepatton
This paper addresses the vulnerability of deep learning models, particularly convolutional neural networks
(CNN)s, to adversarial attacks and presents a proactive training technique designed to counter them. We
introduce a novel volumization algorithm, which transforms 2D images into 3D volumetric representations.
When combined with 3D convolution and deep curriculum learning optimization (CLO), itsignificantly improves
the immunity of models against localized universal attacks by up to 40%. We evaluate our proposed approach
using contemporary CNN architectures and the modified Canadian Institute for Advanced Research (CIFAR-10
and CIFAR-100) and ImageNet Large Scale Visual Recognition Challenge (ILSVRC12) datasets, showcasing
accuracy improvements over previous techniques. The results indicate that the combination of the volumetric
input and curriculum learning holds significant promise for mitigating adversarial attacks without necessitating
adversary training.
Water scarcity is the lack of fresh water resources to meet the standard water demand. There are two type of water scarcity. One is physical. The other is economic water scarcity.
CFD Simulation of By-pass Flow in a HRSG module by R&R Consult.pptxR&R Consult
CFD analysis is incredibly effective at solving mysteries and improving the performance of complex systems!
Here's a great example: At a large natural gas-fired power plant, where they use waste heat to generate steam and energy, they were puzzled that their boiler wasn't producing as much steam as expected.
R&R and Tetra Engineering Group Inc. were asked to solve the issue with reduced steam production.
An inspection had shown that a significant amount of hot flue gas was bypassing the boiler tubes, where the heat was supposed to be transferred.
R&R Consult conducted a CFD analysis, which revealed that 6.3% of the flue gas was bypassing the boiler tubes without transferring heat. The analysis also showed that the flue gas was instead being directed along the sides of the boiler and between the modules that were supposed to capture the heat. This was the cause of the reduced performance.
Based on our results, Tetra Engineering installed covering plates to reduce the bypass flow. This improved the boiler's performance and increased electricity production.
It is always satisfying when we can help solve complex challenges like this. Do your systems also need a check-up or optimization? Give us a call!
Work done in cooperation with James Malloy and David Moelling from Tetra Engineering.
More examples of our work https://www.r-r-consult.dk/en/cases-en/
Forklift Classes Overview by Intella PartsIntella Parts
Discover the different forklift classes and their specific applications. Learn how to choose the right forklift for your needs to ensure safety, efficiency, and compliance in your operations.
For more technical information, visit our website https://intellaparts.com
Quality defects in TMT Bars, Possible causes and Potential Solutions.PrashantGoswami42
Maintaining high-quality standards in the production of TMT bars is crucial for ensuring structural integrity in construction. Addressing common defects through careful monitoring, standardized processes, and advanced technology can significantly improve the quality of TMT bars. Continuous training and adherence to quality control measures will also play a pivotal role in minimizing these defects.
Sachpazis:Terzaghi Bearing Capacity Estimation in simple terms with Calculati...Dr.Costas Sachpazis
Terzaghi's soil bearing capacity theory, developed by Karl Terzaghi, is a fundamental principle in geotechnical engineering used to determine the bearing capacity of shallow foundations. This theory provides a method to calculate the ultimate bearing capacity of soil, which is the maximum load per unit area that the soil can support without undergoing shear failure. The Calculation HTML Code included.
NO1 Uk best vashikaran specialist in delhi vashikaran baba near me online vas...Amil Baba Dawood bangali
Contact with Dawood Bhai Just call on +92322-6382012 and we'll help you. We'll solve all your problems within 12 to 24 hours and with 101% guarantee and with astrology systematic. If you want to take any personal or professional advice then also you can call us on +92322-6382012 , ONLINE LOVE PROBLEM & Other all types of Daily Life Problem's.Then CALL or WHATSAPP us on +92322-6382012 and Get all these problems solutions here by Amil Baba DAWOOD BANGALI
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About
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
Technical Specifications
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
Key Features
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface
• Compatible with MAFI CCR system
• Copatiable with IDM8000 CCR
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
Application
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
2. 2
May 2009
Key Competencies
Post Silicon Technology (PST) is an R&D group leading the development
of a new technology paradigm focused on the combination of the following
key competencies:
Low-cost manufacturing technologies based on stamps, Soft and Nano-
Imprint lithography (down to 50nm), Ink-jet Printing and Surface
Functionalization as enabling techniques for printed organic and
molecular electronics
Design and modeling of printed organic electronic devices and circuits
Design, optimization and characterization of functional organic/hybrid
materials
Multi-scale and Multi-objective optimization – Neural Net (proprietary
algorithms)
3. 3
May 2009
Printed Molecular Electronics -Technology Platform
Mission:
Integrate organic molecules in and onto solid state devices as
functional units through a low-cost manufacturing technology and
pave the way to new profitable applications
Killer application
Functionalized printed sensors for the electrical detection of
biomarker proteins (i.e. cancer)
Medical Diagnostics and Personalized Therapeutics
Strategic via: The Pharmaceutical/BioMed Industry
5. 5
May 2009
Printed Molecular Electronics: Some driving forces
Intrinsic potentiality
Assign the desired properties to functional molecules by specific design, modeling and
synthesis
Tailor the molecular structure to match processes issues
Potentially cost effective (10-13
-10-14
$† v.s. 10-9
$ per active elements @2014*)
Boost the performances of standard applications
Logics
- Intrinsic switching frequency >GHz
- Very low power consumption
– Memory (Both NV and DRAM possible)
- Retention time can be tuned ~ 1.5eV : 1015
s -108
s (20 C, 130 C)
-Read voltage ~ 0.15V, Write voltage ~ 0.3V (high frequency)
Pave the way to new profitable applications
Printed Functionalized Nano scale Sensors for the electrical detection of
chemicals and bio-molecules (Proteins, DNA, Cancer Bio-Markers….)
mEMS and Functionalized MEMS/NEMS
† not-including the silicon
*as per ITRS projection
6. 6
May 2009
TR&D Roadmaps
Vision: Ultra-low cost Printed System-on-Plastic, including
Printed Sensors for the electrical detection of chemicals/bio-
molecules
- Printed array of functionalized sensors (Demonstrated ~ 100nm)
- Test case: ssDNA-functionalized Si sensors (Demonstrated)
- 1st
plastic array planned by 2010
Printed RF-powered system (planned by 2010)
- New polymer composite materials and low-cost technology for
antenna and diodes
Printed Electro-wetting Micro-fluidic devices (planned by 2010)
- Printed Electro-wetting Technology as ultra low cost micro fluidic
solutions compatible with Printed Electronics.
7. 7
May 2009
Vision: Printed System-on-Plastic
Killer application
Early detection of disease biomarkers (i.e. proteins)
Energy scavenging from RF field to power on the System-on-Plastic
Pharmaceutical
BioMed Industry
8. 8
May 2009
The Process integration and expertise
Expertise & Achievements
• Provide the surface with suitable terminations (surface preparation)
• Graft of functional molecules by hydrosilation, silanization… (grafting+rinsing)
• A unique set of algorithms to extract quantitative indicators on reaction yields
• Integration of functional molecules into Si- X-bar devices Hybrid Si-Mol-Si NV Memory
• Surface functionalization giving new properties antistiction, hydrophobic, corrosion resistance to
acid/basic or buffer bio-solution.
• Manufacture proprietary molds (with sub-µm features) to produce by printed devices
Printed array of functionalized sensors
CH2 CH2RSi H CH2 CHR+
T <200°C
Si
R – functional group
Micro-wave enhanced Hyrdosilation
Strategy
Hydrogen-terminated Si surface can be functionalized by exposure to alkene-alkyne-
terminated molecules to form a chemically robust, environmentally stable, Si-C
30 min 60 min30 min 60 min30 min 60 min30 min 60 min
9. 9
May 2009
Si+4
Si+4
Si+3
Si+3
Si+2
Si+2
Si+1
Si+1
SiH3
SiH2SiH2
SiHSiH
Si-Si-
SiH3
SiH2
SiH
SiH3
SiH2
SiH
Chem. Phys. Characterization of Surface
AFM: 0.18 nm
H
O
+
HH
O
H
Si
H
O
+
H O
Si
H
Si
Si
H
Si
Si Si
SiSi
Si
Si
H
Si
Si
Si
H
Si
Si
H
H
Si
Si
Si Si
Si
Si
H
Si
Si
SiSi
Si
Si
H
O
Si
H
Si
H
Si
Si
Si
Si Si
H
Si
Si
H
Si
Si Si
Si
H
[100]
[111]
Development of proprietary strategy and
algorithms to fully quantify the results of
surface treatments in terms of surface
species
ATR-FTIR AR-XPS
Decomposition of surface species
(PST own algorithms)
10. 10
May 2009
Stability after 6 months
Native Oxide islands growth on defect sites
Highly robust/stability of the surface after grafting
Contact angles ~ 102 degree
preserved after 6 months
Si-CSi-CSi-C
30 min 60 min30 min 60 min
AR-XPS decomposition by
proprietary algorithms giving evidence of Si-C
11. 11
May 2009
Poly-Si surface after grafting – some features
Data Physics Instruments OCA20 Method: sessile drop
CA: 33,8, Vs Si(100) CA: 36 CA: 103.1 Vs Si(100) CA: 106.7CA:80.4 Vs Si(100) CA: 76.4
Improved resistance versus harsh environment: aqueous NH4OH, KOH, HCl, HF
unique possibility for silicon devices
High stability to thermal treatment. The contact angles decreases after 30min
annealing in air at 350 C (commercially-available)
It is possible to design molecule with the functionality to resist temperature as
high as 450 C If oxygen is removed from the atmosphere.
CA: 33,8 CA: 80,4 CA: 106,7
As received after HF+rinsing
after grafting of
1-octadecene
12. 12
May 2009
Examples of surface treatments 1/2
Ultra-hydrophobic self-cleaning surface Particular suitable to handle with biological samples
179.8
102.8
Silicon
Ready to sense chemicals
13. 13
May 2009
Examples of anti-sticking 2/2
CA 142
High resolution molds for NIL
Down to 50nm
MEMS
Not treated devices exposed to water vapor Grafted surface
14. 14
May 2009
The very 1st
X-bar hybrid Si-organic-Si IC
Silicon host for sense, address and control operations
Molecule guest functionality
Xbar-device
Cross section
Q107
Q307
Feb08X-bar devices as
core element of
general-purpose
architecture.
Oxide tuned
on molecular length
scale
15. 15
May 2009
TEM analysis and IV
26.8 nm
Bottom electrode
Top electrode
oxide
27.1 nm
After HF
Pristine device
0.00E+00
5.00E-06
1.00E-05
1.50E-05
2.00E-05
2.50E-05
0.0
0.4
0.7
1.1
1.4
1.8
2.2
2.5
2.9
3.2
3.6
4.0
4.3
4.7
5.0
5.4
5.8
6.1
6.5
6.8
7.2
7.6
7.9
A
V
After grafting
27.1 nm
4.8 nm
ResultsResults
- The HF + CH3CN produces superior etching uniformity
- The TEM analysis give a gap of ~ 26.9 nm + molecules
completely filling the area.
The covalently-bonded molecules are responsible for
the NV memory effect (hysteretic)
16. 16
May 2009
A write-Read-Reset Cycle at room-
temperature in air
P-type
n-type
5.8nm
1.8nm
~ 20 nm
The tunnel junction is controlled by
grafted functional molecule in a
~50nm linear gap
18. 18
May 2009
The main Challenges
Detect bio-markers diseases sensing their unique proteomic expression within others similar bio-
molecules in fluids/air. (<<ng/ml in early stages)
Basic Requirements for detection:
– Very high selectivity (capacity to give a response only to selected targets)
– Very high sensitivity (capacity to sense extremely low amount of targets)
– Parallel approach for protein/antibodies sets detection
Mission
Develop printed array of specialized nanoscale sensors to recognize selected antigen or other molecular
species (antibody fragments, globular proteins, cancer bio-markers....) by means of electrical detection
after specific interaction
Key features
– Extremely high sensitive << ng /ml
– Unique selective to specific targets by suitable functionalization
– Suitable for highly thought-put analysis
– Fast screening and cheap technology (plastic)
Electrical detection of bio-marker proteins by
nano-scale printed sensors
19. 19
May 2009
Process definition &
integration
Printed Array of Functionalized Nano-Sensors
Printed functionalized devices
Task1: Surface functionalization
Task 2: Printed Devices - sensors
20. 20
May 2009
Strategy:
Graft a carboxyl terminated molecule to gain access to the bio-cross linker chemistry
Grafting of a selected binary mixtures (a/b) characterized by:
– Molecule (a): terminal alkene, C atoms <10
(Molecular Spacer + insulating layer)
– Molecule (b): terminal alkene, C atoms >10 + a suitable reactive group
(Molecular linker to catch bio-molecules)
– Rinsing treatments
Immobilization of target bio-molecules on sensor for electrical sensing
Identification of a general-purpose strategy
for bio-functionalization of the Nano-devices
Sensors
C
O
H
(a) - insulator
(b) - linker
The strategy can be adapted to Antibodies, enzymes, DNA…
C
O
H C
O
H C
O
H
C
O
H
22. 22
May 2009
General Structure of bio-hunter
A biological hunter is antibody-modified molecules with a
synthetic sequence of ssDNA
Strategy for bio-functionalization
– Primary amine groups (–NH2) on lysine sidechains and at the amino
terminus of each polypeptide chain.
– Sulfhydryl groups (–SH) can be generated by reducing disulfide
bonds in the hinge region.
Selective
Bio-Hunters
AGGATCCA -
CTGAACTA -
Complementary
DNA-functionalized
devices
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
NH
2
Targets
Device 1 Device 1
Self Recognition
Head Tail
linkage
23. 23
May 2009
Silicon bio-functionalization
Si-CSi-C
1
2
COOHCOOH
High-lights
Silicon and poly-silicon surface has been
functionalized by UME linker and modified
in terms of –COOH terminations
– AR-XPS:
- Stable functionalization of the Si surface
- Persistence of the C.A.s over 1 Month
under Lab condition
- The decomposition of the C 1s peak
Si-C in both the samples
Activation of carboxyl (- COOH)
– Microwave-assisted grafting showed
• Improved selectivity
• Reduced reaction time
• Improved yields and monolayer quality
CA: 72,4
after grafting of bio-linker precursor
Si-(CH2)12-COCH3
CA: 34
after bio-linker activation
Si-(CH2)12-COOH
hydrolisis
24. 24
May 2009
ss-DNA-functionalized Silicon surfaces
5 nm
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
C1s
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OCH3
CH2
O
OCH3
CH2
Methyl10undecenoate10-undecenoicacid
Hydrolysis
1.Boilingacidified
water
2.Microwave
200W/10’
O
OH
CH2
O
OH
CH2
N1s
Carboxylated Si surface ssDNA-functionalized Si
– AR-XPS showed Si functionalized by ss-DNA when the EDC/NHS
strategy is applied to –COOH terminating Si surface
– When applied to Si-H surface:
- no N1s was detected on the Si surface
- the C1s spectra was noisy without components at higher B.E
- The Si2p showed significant oxidation
– When applied to –COCH3 Si surface:
- no N1s was detected on the Si surface
- the C1s spectra remains un-changed
– When applied to –COOH Si surface without NHS:
- no N1s was detected on the Si surface
- the C1s spectra remains un-changed
The strategy
Oligo-DNA: 5'–NH2–C6-AAAAAAAAAA-CgTgACATCATgCATg- 3‘
25. 25
May 2009
Molds Manufacturing – Process scheme
Si
Si
2) Photo Resist
deposition
3) Resist
exposure
1) cleaning
4) Resist
development
5) Deposition of
metal
6) Lift-off
Si
Si
Si
Si
SiSi
Si
2) Photo Resist
deposition
3) Resist
exposure
1) cleaning
4) Resist
development
5) Deposition of
metal
6) Lift-off
SiSi
SiSi
SiSi
SiSi
7) Resist
deposition
e-
8) Resist
exposure by
e-beam
9) Resist
development
10) Deposition
of metal
11) Lift-off
11) Dry etching
Si
Si
Si
Si
Si
Si
7) Resist
deposition
e-
8) Resist
exposure by
e-beam
9) Resist
development
10) Deposition
of metal
11) Lift-off
11) Dry etching
SiSi
SiSi
SiSi
SiSi
SiSi
SiSi
12) Removing of
Metallic Mask
13) Antisticking
Mold
Si
Optical Litho E-beam Litho
29. 29
May 2009
Printing active polymer – Test case
1.3 µm
Feature size
100 nm
Feature size
80 nm
1.60 um
L=100
nm
L= 80
nm
1.32 um
0.8 um
L= 50
nm
30. 30
May 2009
Printed Electrowetting Tech.
Electro-wetting as ultra low cost paradigm for printable
micro fluidic system based on manipulation of discrete
droplets electrically: moved, mixed, pumped….
Main advantages
No pumps or valves, Reconfigurable via SW.
Works with a large variety of liquids.
Extremely energy efficient
Demonstrated:
Surface finishing
Proprietary mold done to print test EW devices
Printed EW devices
Target voltages: 1. 5 V
Next Challenges:
Functionalization of printed EW devices
Sub-picoliter droplet movement
Printed EW Device
C.A ~ 119 C.A ~ 72
V=0 V=25 V
C.A ~ 119 C.A ~ 72
V=0 V=25 V
31. 31
May 2009
System Integration
To be implemented on Silicon or on plastic as well
Cartage
Mix of Bio-Hunter
Cartage
Mix for selective
sequestration
SensingSensing
Rinsing
I/Oapplicationdependent
Sequestration
Detection
Trash
sample
Applicationdependent
• A new proprietary algorithm enhancing the performances in detection has been developed.
Tests demonstrate its ability in very fast operations improving all the known tested
strategies
Pharmaceutical
BioMedIndustry
Editor's Notes
Stiamo lavorando per sviluppare un paradigma basato su tecnologie di Low-cost,
manufactoring e nuovi materiali funzionali e funzionalizzati
Obiettivo rendere abilitare un elettronica organica stampata ultra-low cost su substrato polimerici
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La realizzazione di un dispositivo printato passa per la realizzazione di uno stampini
Che richiede uno sviluppo in termin in termini di CAD.
La tecnica utilizzata prevede la realizzazione di pattern mediante azione combinata di litografia ottica per I
Pattern micrometrici e EBl per I pattern sub micrometrici. Il mold realizzato viene poi trattato per garantire
Che il polimero/resist con il quale entrera incontatto non resti adeso alle pareti del master.
In funzione dello schema di printing, il mold viene usato per replicare la struttura in silicio oppure in polymero.
- Primo step che abbiamo deciso di affrontare e la bio-funzionalizzazione di sensori di Si in scala nanometrica
questo per 2 motivi:
- 1st di carattere tecnologico – capitalizzare sull’esperienza elettronica molecolare e le tecniche di funzionalizzazione superficiali del Silicio cristallino e poly-cristallino
- 2nd di carattere strategio – time-to-market ST e silicio
Risultati visibili nella slides