Proton pump inhibitors are among the most frequently prescribed drugs in the world and are generally considered safe. However, there is growing concern regarding their safety. World's leading journals say PPIs are not as safe as thought to be. Proton-pump inhibitors (PPIs) are a widely prescribed class of medications used to treat acid-related disorders and its use has significantly increased over the last few decades. PPIs are often inappropriately prescribed; since they have been in the market. According to one study, it was observed that 46.7% of patients taking PPIs were ≥ 65 years of age who have compromised renal functions. Additionally, in approximately 40% of older adults, there was no indication for long-term PPI use identified. Adding to it, patients continue consuming PPIs way beyond the doctor’s advice. A number of post-marketing studies have been published in the past demonstrating associations between longer duration of PPI therapy and a number of adverse effects that are a concern. PPIs have been associated with an increased risk of a number of adverse effects including AIN, CKD, KIDNEY DISEASE, ESRD osteoporotic-related fractures, Clostridium difficile infection, community-acquired pneumonia, vitamin B12 deficiency.