This document discusses factors that determine prognosis in periodontal disease treatment. It defines prognosis as predicting the course and outcome of a disease based on general knowledge of pathogenesis and risk factors. Prognosis depends on overall factors like type and severity of periodontitis, age, systemic conditions, and individual factors like percentage of bone loss, pocket depth, and furcation involvement. A patient's prognosis can range from excellent to hopeless depending on these factors. The document provides details on how factors affect prognosis and clinical implications for determining prognoses as good, fair, poor, questionable or hopeless.