Biological Aging VS. Chronological Aging - How to Build a Healthy Longevity - An Important Role for the Mitochondria
Part I
Professor Serge Jurasunas, M.D. (hc) N.D. M.D (Hom)
Topics in Part 1:
A Longer Lifespan No Longer Means a Healthier Lifespan
What are the Causes of Normal Aging or Premature Aging?
Mitochondria, Oxidative Stress, and Premature Aging
What are Mitochondria?
Brain Neurons
The Brain and Alzheimer’s
Abstract On Peer Pressure
Abstract Paper On Stress
Abstract On Depression
Abstract On Water Pollution
Abstract Of Alcohol
Abstract Of Cloning
The Holocaust : An Abstract
Abortion Research Paper
Preview - Health and Disease Begin in the ColonSheldon Stein
Health and Disease Begin in the Colon A preview of Professor Serge Jurasunas' new book, now available on Amazon in eBook and paperback formats. www.sergejurasunas.com
Inquiries: sergejurasunas@hotmail.com
Abstract On Peer Pressure
Abstract Paper On Stress
Abstract On Depression
Abstract On Water Pollution
Abstract Of Alcohol
Abstract Of Cloning
The Holocaust : An Abstract
Abortion Research Paper
Preview - Health and Disease Begin in the ColonSheldon Stein
Health and Disease Begin in the Colon A preview of Professor Serge Jurasunas' new book, now available on Amazon in eBook and paperback formats. www.sergejurasunas.com
Inquiries: sergejurasunas@hotmail.com
Growing old in a society that has been obsessed with youth may have a critical impact on the mental health of many people. This situation has serious implications for psychiatric nursing.
This chapter focuses on physical and psychological changes associated with the aging process, as well as special concerns of the elderly population, such as retirement, long-term care, elder abuse, and rising suicide rates. The nursing process is presented as the vehicle for delivery of nursing care to elderly individuals.
The Interface of Loneliness, Hospitalization and Illness | Crimson PublishersCrimsonpublishersPPrs
This article reviews the experience of loneliness and how it is influenced, and influences, the ill person and the hospitalized individual. Social ties enhance the immune system and help individuals cope with stress and illness. Loneliness has physical, emotional, and cognitive negative effects. Loneliness, which can involve both excruciating physical and mental suffering, is an ancient nemesis. Loneliness is implicated in numerous somatic, psychosomatic, and psychiatric diseases [1]. It is a mundane yet arcane human affliction that is often hazardous to health and hostile to happiness [2]. In this article, I review the experience of loneliness as it affects us when we are not doing well, such as when we are ill or hospitalized.
Australian Journal of Adult LearningVolume 57, Number 3, Nov.docxcelenarouzie
Australian Journal of Adult Learning
Volume 57, Number 3, November 2017
Learning to live with chronic illness in later life:
Empowering myself
Alexandra Withnall
University of Warwick, UK
Type 2 Diabetes is both an incurable illness and a hidden disability that
has reached epidemic proportions on a global scale. It has obviously
spawned a huge clinical literature, but no scholarly accounts of learning
to live with the illness on a daily basis from a feminist perspective.
As an older woman, I have made use of a somewhat controversial
autoethnographical approach to explore how far I consider myself
empowered to live with, and manage this condition for the rest of
my life. Self-management is an idea that is central to both the United
Kingdom (UK) National Health Service (NHS) philosophy of supporting
patient choice and within a feminist perspective on health care. Learning
to identify, access and use the necessary resources to manage my
condition suggests that there are regional differences within the UK as to
how much practical care diabetes patients are offered or can access. The
paternalistic nature of the health care team/patient relationship appears
to militate against the concept of patient empowerment.
Keywords: diabetes, autoethnography, feminism, learning, self-care,
lifestyle.
Learning to live with chronic illness in later life: Empowering myself 475
Introduction
As awareness of ageing populations grows across the world, enjoying a
sense of physical and mental well-being by remaining active in society
and retaining independence for as long as possible have come to be
seen as desirable aims. Adult educators have been especially persuasive
in emphasising the importance of continuing to learn throughout life
as an essential ingredient of healthy ageing. Indeed, there is growing
international evidence that learning in later life offers a whole range
of benefits not only to individual learners as they age but also to their
families, their communities and to the societies in which they live. Yet
we know that for many people, the later years can bring varying degrees
of ill health and the chances of growing older in good health vary greatly
between countries. From a European perspective, it is fortunate that
most people can generally still expect a good standard of health care in
later life. Nevertheless, poor health in later life can be compounded by
isolation or increasing poverty as well as by inequalities in accessing
good quality health care.
What is surprising is that those involved in researching or facilitating
later life learning rarely contemplate their own ageing or consider what
it might mean to be forced to live with an illness or disability as they
grow older. Yet as people approach their later years, some degree of
change in well-being is inevitable. Understanding the nature of such
changes is important in helping to cope with the challenges of daily life
and with maintaining a.
Prof. Serge Jurasunas Biological Aging vs. Chronobiological Aging Part 2.pdfSheldon Stein
Prof. Serge Jurasunas Biological Aging vs. Chronobiological Aging Part 2.pdf
Topics in Part 2:
Food Diet and Healthy Lifespan
The Okinawa Food Model
List of the Best Anti-Aging Foods
Supplements that enhance Anti-Aging and Mitochondria
Professor Serge Jurasunas' upcoming presentation: "A New Way to Approach Cancer". This presentation is for the Medicine Week Congress in Baden Baden Germany, October 30 thru November 3rd, 2019.
How to Understand and Treat Cancer with Modern Methods. Public Presentation B...Sheldon Stein
Professor Serge Jurasunas' Public Presentation on the New Modern Way to Treat Cancer - Strategic Immunotherapy, Apoptosis, Angiogenesis at the Biobran Workshop in Zagreb, Croatia, 2-27-2018.
Professor Serge Jurasunas - New Modern Way to Approach Cancer - Biobran Works...Sheldon Stein
How to Treat Cancer with Immunotherapy Utilizing Biobran through the Microbiome. Professional Presentation for Medical Practitioners with Clinical Cases By Professor Serge Jurasunas.
Can Food Diet Prevent and Be Efficient In Cancer Treatment?Sheldon Stein
In this paper Professor Jurasunas writes about food diet and nutrition in cancer prevention and treatment. He shares his knowledge about what he has learned about the role of food diet from his 50 years of clinical experience in cancer treatment, emphasizing the role of diet, nutrition, and antioxidants in naturopathic oncology. He also gives recipes for a juice cocktail, special soup and an energy drink. Good nutrition and a healthy food diet a useful adjunct and foundation for cancer prevention and treatment.
New Modern Way to Approach Cancer - 5th International Biobran WorkshopSheldon Stein
New Modern Way to Approach Cancer - 5th International Biobran Workshop Krakow , Poland June 9-11, 2017. Professor Jurasunas discusses the problems of conventional oncology and offers insight into less toxic and more efficient methods of cancer treatment. He offers case histories and reviews protocols
using Biobran and other modern methods against cancer, focusing on Strategic Immunotherapy, Apoptosis and Angiogenesis. He shows how Biobran improves cancer survival rates and metastases prevention and disease recurrence.
Protocol for the Treatment Prostate Cancer - Dr Serge JurasunasSheldon Stein
Dr. Serge Jurasunas shares his Prostate Cancer Protocol in this paper, explaining the nature and treatment of Prostate Cancer from a Naturopathic Oncology Perspective. Professor Jurasunas is located in Lisbon Portugal and has lectured worldwide throughout his 50 years as a clinician.
He explains what can be done about the #1 cause of death in males even before lung cancer and what can be done, from the new perspective of Naturopathic Oncology.He offers an example, explains diagnostic procedures with Molecular markers and addresses detox, supplements and treatment.
Further information may be found in his new book, Health and Disease Begin in the Colon" and in his Blog: Naturopathiconcology.blogspot.com .
Professor Jurasunas explains what is cancer and how it develops. He explains the nature of this disease, and why cells mutate, elaborating on P53 and apoptosis. He explains why Cancer is a silent killer, while addressing the cellular cycle.
More Related Content
Similar to Prof. Serge Jurasunas Biological Aging vs. Chronological Aging Part 1.pdf
Growing old in a society that has been obsessed with youth may have a critical impact on the mental health of many people. This situation has serious implications for psychiatric nursing.
This chapter focuses on physical and psychological changes associated with the aging process, as well as special concerns of the elderly population, such as retirement, long-term care, elder abuse, and rising suicide rates. The nursing process is presented as the vehicle for delivery of nursing care to elderly individuals.
The Interface of Loneliness, Hospitalization and Illness | Crimson PublishersCrimsonpublishersPPrs
This article reviews the experience of loneliness and how it is influenced, and influences, the ill person and the hospitalized individual. Social ties enhance the immune system and help individuals cope with stress and illness. Loneliness has physical, emotional, and cognitive negative effects. Loneliness, which can involve both excruciating physical and mental suffering, is an ancient nemesis. Loneliness is implicated in numerous somatic, psychosomatic, and psychiatric diseases [1]. It is a mundane yet arcane human affliction that is often hazardous to health and hostile to happiness [2]. In this article, I review the experience of loneliness as it affects us when we are not doing well, such as when we are ill or hospitalized.
Australian Journal of Adult LearningVolume 57, Number 3, Nov.docxcelenarouzie
Australian Journal of Adult Learning
Volume 57, Number 3, November 2017
Learning to live with chronic illness in later life:
Empowering myself
Alexandra Withnall
University of Warwick, UK
Type 2 Diabetes is both an incurable illness and a hidden disability that
has reached epidemic proportions on a global scale. It has obviously
spawned a huge clinical literature, but no scholarly accounts of learning
to live with the illness on a daily basis from a feminist perspective.
As an older woman, I have made use of a somewhat controversial
autoethnographical approach to explore how far I consider myself
empowered to live with, and manage this condition for the rest of
my life. Self-management is an idea that is central to both the United
Kingdom (UK) National Health Service (NHS) philosophy of supporting
patient choice and within a feminist perspective on health care. Learning
to identify, access and use the necessary resources to manage my
condition suggests that there are regional differences within the UK as to
how much practical care diabetes patients are offered or can access. The
paternalistic nature of the health care team/patient relationship appears
to militate against the concept of patient empowerment.
Keywords: diabetes, autoethnography, feminism, learning, self-care,
lifestyle.
Learning to live with chronic illness in later life: Empowering myself 475
Introduction
As awareness of ageing populations grows across the world, enjoying a
sense of physical and mental well-being by remaining active in society
and retaining independence for as long as possible have come to be
seen as desirable aims. Adult educators have been especially persuasive
in emphasising the importance of continuing to learn throughout life
as an essential ingredient of healthy ageing. Indeed, there is growing
international evidence that learning in later life offers a whole range
of benefits not only to individual learners as they age but also to their
families, their communities and to the societies in which they live. Yet
we know that for many people, the later years can bring varying degrees
of ill health and the chances of growing older in good health vary greatly
between countries. From a European perspective, it is fortunate that
most people can generally still expect a good standard of health care in
later life. Nevertheless, poor health in later life can be compounded by
isolation or increasing poverty as well as by inequalities in accessing
good quality health care.
What is surprising is that those involved in researching or facilitating
later life learning rarely contemplate their own ageing or consider what
it might mean to be forced to live with an illness or disability as they
grow older. Yet as people approach their later years, some degree of
change in well-being is inevitable. Understanding the nature of such
changes is important in helping to cope with the challenges of daily life
and with maintaining a.
Prof. Serge Jurasunas Biological Aging vs. Chronobiological Aging Part 2.pdfSheldon Stein
Prof. Serge Jurasunas Biological Aging vs. Chronobiological Aging Part 2.pdf
Topics in Part 2:
Food Diet and Healthy Lifespan
The Okinawa Food Model
List of the Best Anti-Aging Foods
Supplements that enhance Anti-Aging and Mitochondria
Professor Serge Jurasunas' upcoming presentation: "A New Way to Approach Cancer". This presentation is for the Medicine Week Congress in Baden Baden Germany, October 30 thru November 3rd, 2019.
How to Understand and Treat Cancer with Modern Methods. Public Presentation B...Sheldon Stein
Professor Serge Jurasunas' Public Presentation on the New Modern Way to Treat Cancer - Strategic Immunotherapy, Apoptosis, Angiogenesis at the Biobran Workshop in Zagreb, Croatia, 2-27-2018.
Professor Serge Jurasunas - New Modern Way to Approach Cancer - Biobran Works...Sheldon Stein
How to Treat Cancer with Immunotherapy Utilizing Biobran through the Microbiome. Professional Presentation for Medical Practitioners with Clinical Cases By Professor Serge Jurasunas.
Can Food Diet Prevent and Be Efficient In Cancer Treatment?Sheldon Stein
In this paper Professor Jurasunas writes about food diet and nutrition in cancer prevention and treatment. He shares his knowledge about what he has learned about the role of food diet from his 50 years of clinical experience in cancer treatment, emphasizing the role of diet, nutrition, and antioxidants in naturopathic oncology. He also gives recipes for a juice cocktail, special soup and an energy drink. Good nutrition and a healthy food diet a useful adjunct and foundation for cancer prevention and treatment.
New Modern Way to Approach Cancer - 5th International Biobran WorkshopSheldon Stein
New Modern Way to Approach Cancer - 5th International Biobran Workshop Krakow , Poland June 9-11, 2017. Professor Jurasunas discusses the problems of conventional oncology and offers insight into less toxic and more efficient methods of cancer treatment. He offers case histories and reviews protocols
using Biobran and other modern methods against cancer, focusing on Strategic Immunotherapy, Apoptosis and Angiogenesis. He shows how Biobran improves cancer survival rates and metastases prevention and disease recurrence.
Protocol for the Treatment Prostate Cancer - Dr Serge JurasunasSheldon Stein
Dr. Serge Jurasunas shares his Prostate Cancer Protocol in this paper, explaining the nature and treatment of Prostate Cancer from a Naturopathic Oncology Perspective. Professor Jurasunas is located in Lisbon Portugal and has lectured worldwide throughout his 50 years as a clinician.
He explains what can be done about the #1 cause of death in males even before lung cancer and what can be done, from the new perspective of Naturopathic Oncology.He offers an example, explains diagnostic procedures with Molecular markers and addresses detox, supplements and treatment.
Further information may be found in his new book, Health and Disease Begin in the Colon" and in his Blog: Naturopathiconcology.blogspot.com .
Professor Jurasunas explains what is cancer and how it develops. He explains the nature of this disease, and why cells mutate, elaborating on P53 and apoptosis. He explains why Cancer is a silent killer, while addressing the cellular cycle.
Health and Disease by Iridology Examination - Professor Serge JurasunasSheldon Stein
Professor Jurasunas offers an introductory overview to the history and practice of Iridology. He draws from his 50 years of clinical practice and offers real life cases, emphasizing the value of Iridology as a diagnostic tool, explaining the relationship between the iris, nervous system, and body's organs, as well as embryological development.
Protocol for the Treatment of Prostate CancerSheldon Stein
Professor of Naturopathic Oncology, Serge Jurasunas explains the nature of prostate cancer and outlines the unique protocols he utilizes at his Lisbon clinic. Additional information is available on his website: www.sergejurasunas.com
IRIDOLOGY RESEARCH BY GAEL RIVERZ N.D., IRIDOLOGISTSheldon Stein
A Presentation of the Work of Professor Serge Jurasunas in the Field of Cancer Detection through Iridology Profiling
(As Described his Last Important Book "Health and Disease Begin in the Colon, Featuring Prof. Serge Jurasunas’ Natural Medicine)
Breast Cancer Theory, Profiling Through Iridology & TherapiesSheldon Stein
Professor Serge Jurasunas offers an in-depth understanding of breast cancer theory, its development, history and treatment. He discusses environmental factors, risk evaluation, genetics and family risk, cellular respiration and treatment innovations back in 2003. You can ask yourself what has happened over the past 13 years since then?
He offers detoxification drinks and formulas, discusses the reversal of mitochondrial damage as well as the need for psychological counseling and support. He then offers several cases.
Please note his new address:
Professor Serge Jurasunas
R.coelho 93 QTA Marinha
2750-008 Cascais
Portugal
Sergejurasunas@hotmail.com
Serge Jurasunas: A Complementary Approach to Breast Cancer - A Case with Mult...Sheldon Stein
A Complementary Approach to Breast Cancer - A Case with Multiple Liver Metastases is Free from Disease . In this paper Professor Jurasunas explains breast cancer, it's development
and treatment. He offers illustrations with Live Blood Microscopy, Oxidative Dried Layer Blood Testing, and his protocol for a successful outcome.
Serge Jurasunas: Oxygen, Mitochondria and CancerSheldon Stein
Oxygen, Mitochondria and Cancer - In this well documented paper Professor Jurasunas explains the role of Mitochondria and Oxygen play in cancer development and treatment, discussing ATP, genetic mutation, treatment protocol and nutrition.
Serge Jurasunas: Clinical Evidence of Cellular Respiration to Target CancerSheldon Stein
In this paper, Professor Jurasunas discusses clinical evidence on cellular respiration and its use in treating cancer. He offers documentation, dietary advice and documentation, along with protocols.
Integrative Cancer - New theories and Advances in Treatment From Hippocrates ...Sheldon Stein
Professor Serge Jurasunsas' recent paper on Integrative Cancer, From Hippocrates to the Human Genome - posted on his behalf. Discusses testing, protocols and case discussion.
Naturopathic Oncology-Health Begins In The Colon As Seen through Iridology-Ho...Sheldon Stein
Naturopathic Oncology-Health Begins In The Colon As Seen through Iridology - How To Detoxify - Professor Serge Jurasunas
Professor Serge Jurasunas' Presentation for the International Physician Round Table in Tampa Fl. , January 2016
www.sergejurasunas.com
P53 Tumor Suppressor Gene: Understanding P53 Based Dietary Anti Cancer Thera...Sheldon Stein
The P53 tumor suppressor gene which has been dubbed both the “Guardian of the Genome” (Lane 1992) and Science “Molecule of the Year”, is directly involved in the initiation of apoptosis and programmed cell death, to prevent an accumulation of abnormal cells. However apoptosis evasion is a characteristic feature of human cancers that promote tumor formation and progression (1). Presently, P53 is known to play a key role in practically all types of human cancers, and the mutation or loss of P53 gene function, can be identified in more than 50% of all human cancer cases worldwide.
This paper was uploaded on behalf of Professor Serge Jurasunas of Lisbon Portugal, www.sergejurasunas.com
The paper goes on to explain the role of the P53 gene and its relationship to Cancer and Apoptosis. It then elaborates on the importance of dietary agents can have a beneficial impact in cancer treatment, and provides a number of case studies. He addresses the importance of the P53 gene and DNA repair, as well as his use of Molecular Markers testing.
Professor Jurasunas believes:
We urgently need to put into clinical practice what we have discovered and learned. Targeting P53 and other genes remain one of the greatest challenges in the treatment of cancer. We have been working now for over 8 years with molecular markers as a diagnostic, prognosis, and follow up to treatment, selected the appropriate bioactive dietary compounds or anticancer agents, exceeding 1000 cases, blood tests, and successes. This may be an incentive for more doctors to venture into this new direction in order to achieve more beneficial results with their patient treatment, especially in cases where we can verify the ones who would be refractory to chemotherapy and have a poor response. It is always best to first check through patient testing, to determine whether or not chemotherapy would be beneficial.
Naturopathic Oncology - Nutritional Treatment - Third in a SeriesSheldon Stein
In this workshop given by Professor Serge Jurasunas, N.D., M.D. (Hom.) on Naturopathic Oncology, covering nutrition, diet and lifestyle, especially after remission or cure, as well as dietary prevention. This workshop was given at the 2008 Anti-Aging World Congress in Paris, France. Even more so these nutritional principles hold true today. Please visit: www.sergejurasunas.com , for more information.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Pharma Pcd Franchise in Jharkhand - Yodley Lifesciences
Prof. Serge Jurasunas Biological Aging vs. Chronological Aging Part 1.pdf
1. Biological Aging VS. Chronological Aging - How to Build a Healthy
Longevity - An Important Role for the Mitochondria
Part I
Professor Serge Jurasunas, M.D. (hc) N.D. M.D (Hom)
Figure #1: Older vs. Younger
Introduction
During my professional career, I have concentrated my research on cancer
treatment using a variety of innovative protocols, and dietary
supplementation and published many articles in the Townsend Letter.
However, biological aging and mitochondria are also a subject of great
interest to me, since in my work I am dealing with both cancer patients and
the elderly. It’s been years since I read a book by the famous Swiss doctor,
Bircher Benner about the Hunza land and longevity. This was associated
2. with their food style and it became a way for me to teach people some
rules to facilitate a healthy lifespan. Years later, Dr. Bernard Jensen
personally visited the Hunza land and told me all about his trip which
further convinced me about the value of natural food in the process of
healthy longevity. Over the past 5 decades, I considered myself fortunate
since I had the opportunity with most of my patients to observe year after
year how they aged according to my dietary and lifestyle advice. Others
have not followed my dietary advice and lifestyle, just coming in from
time to time when feeling bad for some help. They kept on eating the
wrong food. One man I saw recently now has a serious cognitive disorder,
having lost his sense of orientation, not to mention a list of other physical
disturbances. This week a regular patient came in for a consultation, a 71-
year-old woman, very good looking, she was 23 years old when she first
came to me, some 48 years ago. I also observed how individuals aged
prematurely and changed their physical morphology, complaining of
cognitive disorders long before their chronological age, including a patient
as young as 26 years old.
Once I had a 55-year-old man with Alzheimer's and dementia, who looked
20 years older. His 14-year-old son already looked like he was much older
and already showed a cognitive disorder. (1) It all started when in 1969
while traveling to Germany I met two research assistants of Otto Warburg,
including Paul Seeger, one of the great innovative scientific thinkers of the
past century. He spent four decades investigating mitochondria,
accumulating profound knowledge about mitochondrial function
associated with cancer. (see reference 3). Thus I discovered something
very new about the nature of mitochondria and the central role they play in
both the theory and treatment of cancer. As result, in 2008 and again in
2012 I published articles about mitochondria and cancer in the Townsend
Letter. (2-3) Today mitochondrial dysfunction and excessive free radical
activity are not only seen as a cause and treatment of cancer (4) but largely
implicated in the origin of early aging and neurodegenerative disease such
as Alzheimer’s. (5-6) For the past 3 decades, both the US and Europe have
seen a dramatic increase in neurodegenerative diseases chiefly Alzheimer's
disease (AD) Parkinson's Disease (PD), and other neurological diseases
and physical debility conditions in seniors from age of 60 years.
3. A Longer Lifespan No Longer Means a Healthier Lifespan
While human life expectancy has greatly increased over the past few
decades in most western countries, today it no longer coincides with a
similar increase in their health. In countries like the US which are
supposed to be at the leading edge of science and medicine, statistics have
shown that 86 percent of Americans suffer from some degenerative disease
that the situation is even deteriorating with poor health conditions in
elderly people. As another example, in France recently it has been shown
that 3 million seniors (over 60 years) are in a situation of extreme
dependence. A high percentage live in their homes, not being able to walk
out and come back. It is not better in retirement homes. Alzheimer’s
disease affects approximately 5.5 million people in the US and is projected
to grow to 11 to 16 million by 2030. 65% of women above the age of 60
years are affected by AD and according to the WHO, the number is
projected to quadruple by 2030. In the US every year more than $100
billion is spent for health care to treat AD in primary care settings alone.
Today it is estimated that there are about 50 million cases of AD in the
world. We are not talking anymore about only physical diseases but
neurodegenerative diseases and processes that over a lifetime deteriorate
the brain and physical body in a way that humans are now getting old
before their chronological age. Aging and change in our bodies appear
long before the age of 62 years and even many degenerative processes
begin in a person in their 20s. (7) While some people according to their
lifestyle and food style appear younger than their real chronological age,
others look much older with physical deterioration and cognitive disorders
associated with lifestyle and dietary style. In comparison, Centenarian
societies of various countries such as Okinawa are still physically active,
healthy, and happy long into their 80s and 90s even being very active
working in the field for up to 100 years. They have shown little if any
western degenerative disease even at these advanced ages. It seems that
other factors independent of food style and lifestyle may drive aging.
What are the Causes of Normal Aging or Premature Aging?
First aging is a normal process that occurs over the years in our lifetime
resulting in a decline in physical activity, accumulation and degradation of
oxidized proteins, a breakdown in muscle mass, skeleton, and blood
4. vessels, excessive free radicals activity that damages brain neurons, the
gradual decline of the senses, hearing, vision, wrinkle accumulating in the
skin, deterioration of our brain function and age-related diseases including
neurodegenerative disease, cardiovascular disease, etc. Aging may also
affect the function of the bowel, bladder, kidney, etc. From a naturopathic
standpoint, some theories stipulate that we may age from the colon, from
bad bowel function, and autointoxication. Thirty years ago, the Soviet
scientist Dr. Popov suggested that constipation and poor elimination of
toxic waste may lead to the aging process and I agree. This theory was
followed by several pioneers including Dr. W. Walker Dr. Sc., a well-
known nutritional researcher of aging in the US, and the author of the book
“Become Younger” In fact, it matches my theory of auto-intoxication that
I explain in my book, “Health and Disease Begin in the Colon” together
with my decades of clinical experience and iridology examination which
can easily focus on the condition of the colon. So the colon is important,
auto-intoxication is probably causing a disturbance in our cells but I
always give great importance to mitochondria function related to disease,
fatigue, heart failure cancer, and premature aging, Now Scientists noted
that mitochondria dysfunction is one of the major cause of aging but not,
of course, the only one. Shortening of telomeres from chronic oxidative
stress is also a well-known factor associated with aging A new study
published by the team of Elissa. S. Epel of the University of California
where the researcher measured the length of telomeres with healthy
females aged between 20 and 50 years under strong psychological stress.
Women with the highest levels of oxidative stress have their telomere
shorter and show at least 9 to 17 years of additional aging compared to
low-stressed women. (8)
Mitochondria, Oxidative Stress, and Premature Aging
Mitochondrial function is very much affected by three major factors
which are:
1- The aging process and the production of excessive free radicals.
2- By environmental factors such as insecticides, and herbicides.
Radiation etc... Pesticides are one main damaging factor to
mitochondria. Paraquat is one example since it has been shown to
5. inhibit the ETC enzyme complex and produce reactive oxygen
species. Organochlorine pesticides can reduce mitochondria counts,
membrane potential, and ATP production. Organophosphorus
insecticides have been shown to reduce the number of mitochondria
and can seriously damage the mitochondria. Several antibiotics like
fluoroquinolones, Statins, anti-depressants, NSAIDs (former
Ibuprofen), birth control pills, Viagra and even some vaccines, etc.,
are all factors that may affect the mitochondria respiratory chain and
ATP production. Some antineoplastic treatments, doxorubicin, and
tamoxifen also may impair the respiratory chain of the mitochondria.
It is important to mention that 70% of the antibiotics in the US go to
farm animals and agriculture thus in food.
3- By genetic dysfunction. mutation of mitochondrial DNA inherited
from the mother can hasten the offspring’s aging process. A team
from the Max Planck Institute for The Biology of Aging in Cologne
Germany has shown that aging is determined not only by the
accumulation of mtDNA damage that occurs during our lifetime
but also by damage (mutation) that we acquired from our
mother. (9) We inherit our mitochondrial DNA only from our
mother from the oocytes and anything that may have affected our
mother or grandmother, good or bad passes on to us. Mutation of
maternally inherited mtDNA influences the offspring so the aging
process may start from birth. Pregnant women have the greatest
responsibility to improve their diet and lifestyle, defend themselves
from pollution and avoid drugs including vaccines.
What are Mitochondria?
The name mitochondrion comes from the Greek ‘mitos’ (filaments) and
‘hondros’ grains. Mitochondria are subcellular organelles of 0.5-20u in
length, either filamentous or oval, and are bounded by a double membrane
and found in all aerobic (eukaryotic) mammalian cells both animal and
plant cells and vary considerably in size, structure, and number which can
be from several hundred up to several thousand. They are the descendants
of an ancestral anaerobic bacteria incorporated about 2-3 billion years ago
into the eukaryotic cell after the release of billions of tons of oxygen on the
planet becoming poisonous to anaerobic life. Some species die, while
6. others penetrate the host cell and became symbiotic, intracellular parasites,
that evolved, adapted, and developed some systems to use oxygen as fuel
to burn foodstuff to generate high-energy molecules of adenosine
triphosphate (ATP) critically important for all the cell’s function including
cellular differentiation, regulating the cell cycle and cell death. When
released ATP energy is transferred to cytosols and this is why we call
mitochondria the powerhouses of the cells. This is the basis of aerobic life
on this planet. We are all aware of how dependent we are on oxygen
however at the same time mitochondria have developed effective
antioxidant enzyme systems against the corrosive effect of oxygen itself a
deadly gas and the production of ROS. The mitochondrial antioxidant
enzyme, manganese superoxide dismutase (MnSOD acts as the chief ROS
scavenger enzyme), sometimes known as the Guardian of the
Powerhouses.
Animals with the longest life spans, such as man have the highest levels of
SOD when it is expressed as a function of the oxidative metabolic rate.
Lifespan is directly proportional to the level of SOD produced in a
mammalian species or man. Thus SOD is associated with aging since it is
the only antioxidant enzyme synthesized in the mitochondria, to detoxify
the first free radicals generated the superoxide radical damaging by
themselves, that if not scavenged contribute to produce other free radicals
such as the destructive hydroxyl radical associated with degenerative
disease. (10-11)
7. Figure 2: Electron Micrograph of Human Liver Cell. Mitochondria (M)
on Left Nucleus (N)
Mitochondria are the major source of superoxide radicals mainly in
complexes I, and II followed by complex III, and responsible for oxidative
damage and mitochondrial dysfunction if not scavenged by MnSOD. Due
to its strategic location in the mitochondria, MnSOD is essential for the
survival of aerobic life (12) and to increase the life span of species. (13)
Mice lacking MnSOD die shortly after birth indicating its crucial role to
maintain lifespan in humans and animals. Normally about 90-95% of the
oxygen we breathe is utilized in the process of oxidative phosphorylation
to produce ATP energy and for this reason, are more susceptible than any
other organ to produce oxygen free radicals. As explained, a decline in
MnSOD is associated with aging since logically it increases the production
8. Figure 3: Mitochondria - Hallmark of Aging
of reactive oxygen species and correlates with mitochondria oxidative
damage and mtDNA mutation (14) One other example is the study done
by Gregory, EM, and Fridovitch, I, who have provided substantial
evidence that MnSOD is necessary for survival in all oxygen metabolizing
cells. Knockout of MnSOD activity by creating inactive mutants or the
complete elimination of MnSOD led to early death in mice. (15) One other
characteristic; mitochondria have their own DNA and ribosomes. They can
make their own proteins, exactly 13 proteins encoded in the mitochondrial
genomes localized within the matrix out of 1500 different types imported
from the cell nucleus which are essential for the electron transport and
oxidative phosphorylation, which occur in cellular respiration. They
replicate differently and at a different time than molecular DNA showing
their independent biological origin. While nuclear DNA is well protected
by histone proteins that act like a shield to protect DNA from high energy
radiation and reactive oxygen species mtDNA does not have such
protection and is thus more subject to damaging effects. For instance, the
9. mutation rate of mtDNA is up to 15-fold higher as compared to the DNA in
the cell nucleus itself. MtDNA is much more sensitive than nuclear DNA
to oxidative attack and damage. mtDNA has only rudimentary DNA repair
capability, contrary to nuclear DNA since none of the proteins made in
mitochondria are designed for DNA repair. This is why mitochondria are
very sensitive to oxidation and damage since the repair mechanism is
limited while mitochondria turnover is rapid (about 30 days). Impairment
of mitochondrial function and ETC due to overproduction of ROS,
decreasing antioxidant enzyme levels of ATP production that affect organs
such as the brain, the heart, and the skeletal muscles was reported (16-17)
causing accelerated aging. However, it may also be responsible for several
disorders or serious clinical features such as dementia, myopathy,
cardiomyopathy, liver failure, and kidney pathologies. In addition, the link
between mitochondrial DNA mutation dysfunction and age-related
diseases as well as Alzheimer's disease is well established, (18) Now
damaged mitochondria produce more ROS and thus accelerate more toxic
ROS generation and more damage. But of course, the normal lifespan of
both mice and humans is also associated with a decrease in the number of
mitochondria and changes in mitochondrial morphology. (19) Species with
high metabolic rates have shorter lifespans. (20) Rats, for instance, live
only about 40 months because of the high rate of free radicals such as
10,000 attacks per day, per cell while in humans only 1000 attacks per day,
per cell.
Brain Neurons
The brain is rich in unsaturated fatty acids, and approximately 60 percent
consists of lipids. This is why brain neuron membranes are more
susceptible to oxidative stress, these membranes being sensitive to oxygen
radicals. Neurons contain a high concentration of mitochondria and require
a large flux of oxygen because the central nervous system (CNS) has an
extraordinarily high metabolic rate as it consumes about 20% of oxygen
inspired at rest, and account for only 2% of body weight. Inevitably they
are the main source of free radicals and more vulnerable to the damaging
effects on mtDNA which oxidizes much faster than other cells, inducing
mutations associated with aging (21-22). For instance, damaged mtDNA
10. Figure #4: A - As normal neurons begin to age they accumulate
a dense granular material, the lipofuscin. B-C: The dendrites
begin to degenerate disrupting connections with other neurons.
C- The neuron is practically near death (Alzheimer’s).
appears up to three-fold higher in brain samples from Alzheimer’s patients
and is substantially increased in very old patients without any clinically
detectable disease. The number of mitochondria reflects the energy
demand of the cell type, such as in the liver containing about 2000-4000
mitochondria, since higher ATP energy is necessary. Did you know that a
healthy person produces from 40kg to 65 kg ATP per day on average?
Therefore mitochondria have a Herculean task to fulfill as the most
efficient production sites for the cell’s current ATP. The reason is that ATP
energy is not stored, but only approximately 85 gr. accumulates
permanently in the form of ATP molecules, offering the organism a quick 5
to 8-second release in the caloric form. One example is seen in cardiac
tissue. Mitochondria turnover produces each time, 700mg of ATP that lasts
11. for 10 seconds or about 10 heartbeats. 86,000 beats/day = 6 million mg.
ATP is utilized daily. Now myocardial ATP turns over 10,000 times/day so
imagine how the mitochondria need to constantly produce energy. Heart
muscle cells contain from 5000 to 8000 mitochondria to power heart
pumping while the kidney has the second highest mitochondrial content
after the heart and also requires high levels of SOD due to a higher
superoxide radical production. Do we think about it?! Thus the importance
of Coenzyme Q10, an electron carrier, is necessary to stimulate the
respiratory chain. We will discuss the process further in part II. The
increasing number of deaths from heart failure in middle age and younger
could be very well associated with mitochondria ATP collapse (23). Now
as explained before a person can inherit a mutation with no disease and
accumulate a somatic mutation that in such person will accelerate aging.
For instance in Alzheimer's disease somatic mutation and inherited
mutation when compared to healthy tissue accumulated long before the
disease is diagnosed. About one out of 200 women carry a mitochondrial
mutation which can drive the child to earlier degenerative disease and
heart failure as we assist now with juveniles in various countries including
Portugal and the US. In our Society, about 35% to 50% of people over 35
years show early dysfunction in ATP production. They already start to age
with no disease yet. At age 67 you have twice as less mitochondria than at
40 years of age. Much less ATP energy is produced. During our lifetime,
our normal capacity to synthesize ATP energy decreases by about 8% per
decade. (24) Our body produces more free radicals from stress or oxygen
itself than oxidized lipids and proteins found in cells. With age, the body
produces more free radicals from oxygen alone. For instance, in a healthy
individual, 20% of oxygen inhaled produces free radicals, while in an
elderly unhealthy person, 80% of oxygen inspiration forms free radicals.
Definitively the link between mitochondrial dysfunction and age-related
diseases is well-established with Alzheimer's disease. (25)
Aging and Alzheimer's is also Determined by the Damage We Acquire
from our Mother
It is interesting to point out what I have been documenting for many years
in my practice, noting that in the same family several members may suffer
from the same pathology such as diabetes and obesity, including the
mother and grandmother. The 40-year-old female patient I saw looked
12. already like a 55-year-old woman, especially from the skeleton. Now her
daughters, respectively 19 years and 15 years follow the same path with
diabetes and obesity. According to Roy Wolford a well know biologist,
diabetic patients reflect an aging pattern that is 15 to 20 years ahead of
their chronological age, which here is the case for the mother and the two
daughters. Remember mitochondria pass only from the mother to her child
and if her girl will be the same in the future for her children. Another
interesting fact is the excessive oxidative stress condition of the mother
and the two daughters from the results I obtained with the observation of
the Oxidative Dried Blood Test. (26) It confirmed the decreasing
antioxidant enzymatic defense in diabetic patients or other patients such as
ones with Alzheimer's disease since the test usually shows with this
particular patients at stage 3 (See my book, “Cancer Treatment
Breakthrough”, pages 34-35) but I do manage to decrease it with dietary
supplementation and some molecular antioxidant compound having a
SOD-like activity, quickly absorbed by the body for immediate healing.
Therefore, aging can start already in the embryo. In fact, the number of
mitochondria we have in cells is highly associated as explained, with
inherited mitochondria from our mother including mtDNA mutation.
Oocytes contain from 100,000 to 600,000 mitochondria while only 10 in a
germinal cell and 1000 in the blastocysts. The embryo requires an
enormous supply of energy to develop an abnormal functioning of oocyte
mitochondria leading to a decrease in oxphos can cause abnormal embryo
development in humans.
The Brain and Alzheimer’s
I mentioned that aging can start in the embryo and why not Alzheimer's
disease as well? Speaking again about oxidative stress and free radicals we
need a stable balance between the pro-oxidant and the antioxidant to
prevent excessive free radical activity and damage done to our
mitochondria. Oxidative damage contributes to the degradation of neurons
as it has been supported by numerous studies in experimental animals, For
instance, as they age, cells tend to accumulate material not found in
younger cells. As an example, excessive ROS activity in the brain neurons
contributes to the formation of an abnormal material or toxic waste known
as lipofuscin-meaning dark fat in Greek and Latin that appears to be the
by-product from the oxidation of unsaturated fatty acid from damaged
13. neuron membranes or damage to the mitochondria. Lipofuscin is made of
cross-bound oxidized proteins (30%) and oxidized lipid degradation
products (50%) formed from lipid peroxidation and other oxidative
damage, being considered a Hallmark of Aging. (27) By middle age the
brain is already overloaded with a large amount of this insoluble material
Figure 5: Mean Lipofuscin Content in Nerve Cells
or toxic waste that seems to be the end result of the cell’s capacity to
eliminate this waste. A major constituent of lipofuscin is malondiadehyde
(MDA) which is often used as a marker of lipid peroxidation. As we age
mitochondria progressively lose the capacity to eliminate MDA. In
experiments done with rats, at 24 months of age, their capacity was
reduced by 40 % to eliminate MDA compared to the level of 6-month-old
rat Lipofuscin that accumulates in neurodegenerative diseases including
Alzheimer’s disease, dementia, and Parkinson's disease. (28) However,
lipofuscin may also contain other materials such as heavy metals including
mercury, aluminum, iron, copper, zinc, etc... Several studies have related
elevated aluminum concentration in drinking water as well as
environmental aluminum increasing the incidence of AD in rats
14. and human. (29) With no surprise Alzheimer’s patients exhibit four to six
times more aluminum deposits in the brain tissue than a normal person. In
humans, lipofuscin may accumulate in neurons up to 80 percent of the
cellular volume before killing it. The bad news is when the pigment of
lipofuscin accumulates in the apex of the nerve cell communication, a
process leading to a gradual deterioration of brain function, blocking the
flow of vital nutrients, and may eventually destroy all. As consequence, the
dendrites begin to degenerate disrupting connections with other neurons
and mental function starts to deteriorate. This is what happens with
Alzheimer's disease. (see the figure) What is more tragic is the fact that
today lipofuscin pigment may appear very early in life, even in even in
children. Some research has observed lipofuscin in fetal nerve cells and as
bad new offspring’s aging process can start already in the embryo and
immediately at birth. Consequently, our interest is to focus on the various
factors associated with the physical and neurological degradation leading
to premature aging and age-related disease as Alzheimer's. It includes
environmental pollution, electromagnetic pollution, lifestyle, exercise,
meditation, and especially dietary style. Thus several potential targets that
have effects on mitochondria and brain mitochondria, eliminate toxins,
reducing MDA levels for prolonging health and lifespan will be discussed
in part 2 of the article.
References
1- Serge Jurasunas. Biological Aging-Signs in the Iris. Explore. Volume
13, Nov 6.2004.
2- Serge Jurasunas. Mitochondria and Cancer. Townsend Letter.
August/Sept 2007.
3- Serge Jurasunas. The Clinical Evidence of Cellular Respiration to Target
Cancer. Townsend Letter. AugSept 2012.
4- J.S Modica-Napolitno and KK Singh. Mitochondrial dysfunction in
cancer. Mitochondrion. Vol4. N.56 pp 755-762. 2004.
5- Hirai K, Aliev G, Nunomura A, et al. Mitochondrial Abnormalities in
Alzheimer’s disease. Journal of NeuroScience. 2001-21 (4) 3017-3023.
6- Lunnon K, Keohane A, et al. Mitochondrial genes are altered in blood
early in Alzheimer’s disease. Neurobiol Aging. 2017.53, 36-47.
15. 7- Cheryl Buxberry. Aging and the Threshold of disease. University of
Waterloo. CA. Course Notes Biology and Human Aging.
8- Ehssa S. Epel, Elizabeth H, Blackburn Jue Lin. Accelerated Telomere
shortening in response to life stress. Biological Sciences. Dec 1. 2004 1001
(49) 17312-17315.
9- Prof Dr Nils, Goran Larsson. A mother’s genes influence her child’s
aging. Max Plank Institute for Biology of Aging (Germany) August 21-
2013.
10- Li Y, Huang TT, Carlson EJ, Wallace DC, Epstein CJ. Dilated
cardiomyopathy and neonatal lethality in mutant mice lacking manganese
superoxide dismutase. Nat Genet.1995. (11)376-381.
11-Fridovitch I. Superoxide radical and superoxide dismutase. Ann Rev
Biochem. 1995-64-97-118.
12- Carlioz A, Touati D. Isolation of superoxide dismutase mutants in
Escherichia Coli is superoxide dismutase necessary for aerobic life?
EMBO journal. 1986.5. 623-630.
13- J Sun. D Folk. TS Bradley and J Tower. Induced overexpression of
mitochondrial Mn superoxide dismutase extends the life span of adult
drosophila melanogaster. Genetics. Vol 161. N2. Pp 661-672.
14- Yau-Huel Wel. Hsin Chen Lee. Oxidative stress, Mitochondrial DNA
mutation, and impairment of antioxidant enzymes in Aging. Experimental
Biology and Medicine. Volume 227. issue 9. Oct.2002.
15- Gregory EM, Fridovitch I. Oxygen toxicity and the superoxide
dismutase. Journal Bacterial. (1973) 14. (3). 1193-1197.
16- KR, Short, MI, Bigelow J, Kahl, et al. Decline in skeletal muscle
mitochondrial function with aging in human. Proceedings of the National
Academy of Sciences of the United States of America. Vol 12. n15.pp
5618-5623. 2005.
17- G Barja and A Herrero. Oxidative damage to mitochondrial DNA is
inversely related to the maximum life span in the heart and brain of
mammals. FASEB Journal, Vol 4. N2.pp 312-318. 2000.
18- Linnane AW, Marzikis, Ozawa T, Tonaka M. Mitochondrial DNA
mutations as an important contributor to aging and degenerative disease.
Lancet. 1.642-645.1989.
19- Ian R, lanza and K Sreekumaran Nair. Mitochondrial function as a
determinant of life span. Pfluger Arch. 2010. 459. (2) 277-284.
16. 20- Adelman R, Saul RI and Ames B.N. (1988). Oxidative damage to DNA
relation to species metabolic rate and life span. Pro Natl Acad Sci. USA.
85.2706-2708.
21- Bua E, Johson J. Herlist A, and Aiken JM, (2006) Mitochondrial DNA
deletion, mutations accumulate intra-cellularly to detrimental levels in
aged human skeletal muscle fibers. am. j hum genet. 79-469-480.
22- Alexeyev, MF. (2009) is there more to aging than mitochondria DNA
and reactive oxygen species. FEBS. Journal 276. 5768-5787.
23- Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. (June
2001) Mitochondrial dysfunction in cardiac ischemia, reperfusion, aging,
and heart failure. Journal of Molecular and cellular cardiology. 33 (6)
1065-1089.
24- Short KR, Bigelow ML, Kahl J, Raghavakaimal s, Nair K.S. Decline in
skeletal muscle mitochondrial function with aging, Proc. Natl Acad. Sci.
USA. 2005. 102.5618-5623.
25- LunnanK, Kdohan A et al. Mitochondrial genes are altered in blood
early in Alzheimer’s disease. Neurobiol Aging. 2017.53. 36-47.
26. Serge Jurasunas. The oxidative Dried Blood Test in the Assessment of
Metabolic dysfunction and inflammatory conditions. Townsend Letter.
June 2018. 28-33.
27- Brunk UT, Therman A. Lipofuscin mechanism of age-related
accumulation and influence cell function, Free Radic. Biol Med. 2002. 33
611-619.
28- Lipofuscin hypothesis of Alzheimer’s Disease, Dementia, and Genetic
Disorder. Extra. Sept 2011.
29- Virginie Rondeau, Daniel Commenges, Helene Jacquim, Gadda Jean,
Francois Dartignes. Relation between aluminum concentration in drinking
water and Alzheimer’s Disease-An 8 years follow up study. American
Journal of Epidemiology. Vol 152. issue 1- 1 July 2000. 59-6
17. The Author – Professor Serge Jurasunas
Serge Jurasunas is an internationally well-known practitioner and
researcher in complementary oncology and molecular medicine, besides
being a naturopath and a fervent believer in nutrition and detox since he
met with Dr. Bernard Jensen in 1962. Member of the New York Academy
of Science Serge Jurasunas is a former professor at Capital University of
Integrative Medicine in Washington D.C. and has devoted over five
decades to treating all kinds of diseases and cancers of all types and
grades. He is the author of 8 books including Cancer Treatment
Breakthrough. Immuno-Oncology using Rice Bran Arabinoxylan
compounds. He has a large blog with many stories, articles include in
Slideshare. Serge Jurasunas is a frequent contributor to Townsend Letter
since 1999 and maintains a private part-time practice only for cancer
patients.
Contact information: sergejurasunas@gmail.com