The document discusses startling statistics about chronic disease in America, despite advances in medicine and healthcare spending. While the U.S. has the most advanced healthcare system, the WHO and AMA said in 1985 that America is experiencing the worst epidemic of chronic disease ever. Two out of three Americans will die from heart disease, cancer, stroke, lung disease or diabetes. Since then, rates of obesity and diabetes have doubled or tripled. Nitric oxide was discovered to play a key role in cardiovascular health, and Dr. Prendergast found that supplementing with L-arginine successfully reduced plaque and reversed disease in his patients.