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2. DEFINITION
1. Fever ≥38.3°C (≥101°F) on at least two occasions
2. Illness duration of ≥3 weeks
3. No known immunocompromised state
4. Diagnosis that remains uncertain after a thorough history-
taking,
physical examination, and the obligatory investigations:
obligatory investigations
CBC ESR ,CRP ,LFT KFT,LDH,CREATININE KINASE, ANA, RA FACTOR,URINE
RE,BLOOD CULTURE,URINE CULTURES CHEST XRAY ,USG OF
ABDOMEN,TUBERCULIN SKIN TEST OR IGRA,PROTEIN ELECTROPHRESIS

3. INFLAMATION OF UNKNOWN ORIGIN(IUO )
presence of elevated inflammatory parameters (CRP or ESR) on
multiple occasions for a period of at least 3 weeks in an
immunocompetent patient with normal body temperature, for
which a final explanation is lacking despite history-taking, physical
examination, and the obligatory tests
THUS IUO which has the same definition as FUO, except for the body temperature
criterion:

4. 40%
20%
20%
10%
10%
CAUSES
INFECTIONS
NEOPLAMS
NIDS
MISCELLANEOUS CAUSES
UNDIAGNOSED
 MCC IN NON WESTERN CONTRIES :- INFECTIONS & AMOUNG which 50 % is TB
 MCC IN WESTERN COUNTRIES :- noninfectious inflammatory diseases (NIIDs), including
autoimmune,autoinflammatory, and granulomatous diseases, as well as vasculitides,