I gave this presentation during my iii semester M.Sc program.This is about experiment technique to measure magnetization.Here we discuss induction method magnetometry.
Mass Analyzers for example Magnetic Sector Mass Analyzer, Double Focusing Mass Analyzer, Quadroupole Mass Analyzer, Time of Flight Mass Analyzer and Applications of Mass Analyzer were explained
This slide contains information about two type of accelerometer :- 1. Seismic Accelerometer 2 :- Displacement type accelerometer.
it contains working and construction.
Mass Analyzers for example Magnetic Sector Mass Analyzer, Double Focusing Mass Analyzer, Quadroupole Mass Analyzer, Time of Flight Mass Analyzer and Applications of Mass Analyzer were explained
This slide contains information about two type of accelerometer :- 1. Seismic Accelerometer 2 :- Displacement type accelerometer.
it contains working and construction.
Accelerometers
Accelerometers are devices that produce voltage signals proportional to the acceleration experienced. There are several techniques for converting acceleration to an electrical signal. The most general technique is described first and more recent techniques will be considered later.
In this presentation, i have explain the role of instruments, its working principle with suitable examples.
its application and how a student can learn more about instruments.
Accelerometers
Accelerometers are devices that produce voltage signals proportional to the acceleration experienced. There are several techniques for converting acceleration to an electrical signal. The most general technique is described first and more recent techniques will be considered later.
In this presentation, i have explain the role of instruments, its working principle with suitable examples.
its application and how a student can learn more about instruments.
Microwave Planar Sensor for Determination of the Permittivity of Dielectric M...journalBEEI
This paper proposed a single port rectangular microwave resonator sensor. This sensor operates at the resonance frequency of 4GHz. The sensor consists of micro-strip transmission line and applied the enhancement method. The enhancement method is able to improve the return loss of the sensor, respectively. Plus, the proposed sensor is designed and fabricated on Roger 5880 substrate. Based on the results, the percentage of error for the proposed rectangular sensor is 0.2% to 8%. The Q-factor of the sensor is 174.
This article describes the operational principles, construction and other features of the four most basic transducers viz. Strain Gauge, Potentiometer, Load Cell and LVDT. Also this article describes the characteristic features of different material transduction properties.
Nonequilibrium Thermodynamics of Turing-Hopf Interplay in Presence of Cross D...Premashis Kumar
A systematic introduction to nonequilibrium thermodynamics of dynamical instabilities are considered for an open nonlinear system beyond conventional Turing pattern in presence of cross diffusion. An altered condition of Turing instability in presence of cross diffusion is best reflected through a critical control parameter and wave number containing both the self- and cross-diffusion coefficients. Our main focus is on entropic and energetic cost of Turing-Hopf interplay in stationary pattern formation. Depending on the relative dispositions of Turing-Hopf codimensional instabilities from the reaction-diffusion equation it clarifies two aspects: energy cost of pattern formation, especially how Hopf instability can be utilized to dictate a stationary concentration profile, and the possibility of revealing nonequilibrium phase transition. In the Brusselator model, to understand these phenomena, we have analyzed through the relevant complex Ginzberg-Landau equation using multiscale Krylov-Bogolyubov averaging method. Due to Hopf instability it is observed that the cross-diffusion parameters can be a source of huge change in free-energy and concentration profiles.
This is a research paper presentation.Name of the paper is '-Information thermodynamics of turing pattern.It has been published by Espasito group in september 2018 edition of Physics review letter.I presented this slides as a part of evaluation of my PhD coursework..
SQUID METAMATERIALS IN THE LIGHT OF KURAMOTO MODELPremashis Kumar
SQUID metamaterials exhibit extraordinary properties like tunability, multistability,
negative magnetic permeability. We have tried to figure out a model suitable for describing
the collective behavior of globally coupled SQUID metamaterials. Mean field Kuramoto
model is a simple but successful model for explaining synchronization in many composite
systems. Kuramoto model’s success in explaining the synchronization in Josephson
junction arrays indicates that one can also transform model of SQUID metamaterials into
Kuramoto model under proper assumptions. So, we have investigated the main features
of mean-field Kuramoto model and possible variants of Kuramoto model numerically to
find out a more relevant model and corresponding modified order parameter to describe
the coherence of SQUID metamaterials that significantly affects the performance of SQUID
metamaterials.
Chimera is a counter-intuitive spatiotemporal state where two completely different states can coexist in the collective behavior of identical oscillators.SQUID metamaterials are a kind of Superconducting metamaterials.Chimeras can appear in SQUID metamaterials in the case of both local and nonlocal interactions between SQUIDs.This slide also includes an introduction to The Kuramoto model which is the most accepted model of synchronization.
One dimensional flow,Bifurcation and Metamaterial in nonlinear dynamicsPremashis Kumar
When dealing with real life systems, we try to interpret the systems qualitatively rather than
quantitatively as most of them is nonlinear in behaviour and have extremely complex dynamics.
Most fundamental approach is interpreting the differential equation vector field, and then
drawing vector fields analogous to flows of the fluid in line. By this phase portrait analysis we
can easily say how the system evolves with time. Whereas by exploiting bifurcation diagram we
can visualise the transitions due changes in parameters of dynamical system. Metamaterial is
man-made material that can be made of nonlinear materials and hence had a nonlinear response
to the electromagnetic wave. In addition, exotic properties such as a negative refractive index,
metamaterials create opportunities to tailor the phase matching conditions that must be satisfied
in any nonlinear optical structure. Here we don’t want to look at the metamaterials as a material
scientist rather our main concern is the dynamics of the metamaterial and prediction of different
phases that it is passing through.
An optical time-domain reflectometer (OTDR) is an optoelectronic instrument used to characterize an optical fiber. An OTDR is the optical equivalent of an electronic time domain reflectometer. It injects a series of optical pulses into the fiber under test and extracts, from the same end of the fiber, light that is scattered (Rayleigh backscatter) or reflected back from points along the fiber. The scattered or reflected light that is gathered back is used to characterize the optical fiber. This is equivalent to the way that an electronic time-domain meter measures reflections caused by changes in the impedance of the cable under test. The strength of the return pulses is measured and integrated as a function of time, and plotted as a function of fiber length.
Giant magnetoresistance and their applicationsPremashis Kumar
Giant magnetoresistance (GMR) is a quantum mechanical magnetoresistance effect observed in multilayers composed of alternating ferromagnetic and non-magnetic conductive layers. The 2007 Nobel Prize in Physics was awarded to Albert Fert and Peter Grünberg for the discovery of GMR.
The effect is observed as a significant change in the electrical resistance depending on whether the magnetization of adjacent ferromagnetic layers are in a parallel or an antiparallel alignment. The overall resistance is relatively low for parallel alignment and relatively high for antiparallel alignment. The magnetization direction can be controlled, for example, by applying an external magnetic field. The effect is based on the dependence of electron scattering on the spin orientation.
An Optical Time Domain Reflectometer (OTDR) is an important instrument used by organizations to certify the performance of new fiber optics links and detect problems with existing fiber links.
The term phase transition (or phase change) is most commonly used to describe transitions between solid, liquid and gaseous states of matter, and, in rare cases, plasma (physics). A phase of a thermodynamic system and the states of matter have uniform physical properties. During a phase transition of a given medium certain properties of the medium change, often discontinuously, as a result of the change of some external condition, such as temperature, pressure, or others. For example, a liquid may become gas upon heating to the boiling point, resulting in an abrupt change in volume. The measurement of the external conditions at which the transformation occurs is termed the phase transition. Phase transitions are common in nature and used today in many technologies.
In computational physics and Quantum chemistry, the Hartree–Fock (HF) method also known as self consistent method is a method of approximation for the determination of the wave function and the energy of a quantum many-body system or many electron system in a stationary state
In this slide you can find a brief history,progress and futuristic model of space research.It was used as presentation in central university of Rajasthan in M.Sc B.Ed course.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
2. Frequently used unit of magnetic dipole moment in magnetism: emu/g
g
Magnetization M is defined as magnetic moment/ volume
Classification of magnetic behavior of material done on the basis of
bulk magnetic susceptibility×.
13%
3. WHAT IS MAGNETOMETER
A magnetometer is an instrument that measures magnetism—
either magnetization of magnetic material like a ferromagnet, or
the direction, strength, or the relative change of a magnetic field at
a particular location.
COMPASS.
In recent days, the magnetometers are used as compasses in tablet computers and mobile
phones.
20%
5. Total field magnetometers or scalar magnetometers measure
the magnitude of the vector magnetic field.
Vector magnetometers measure the vector components of
the magnetic field.
Humans do not seem to have the ability to
sense either direction or the intensity of
magnetic field.
40%
6. SENSITIVITY RANGE OF THE
PROBE SHOULD COVER
WHOLE RANGE OF FIELDS
IN WHICH MAGNETIC
CONFIGURATION
SIGNIFICANTLY CHANGES
METHOD MOST RELEVANT
IN SPINTRONIC
MEASUREMENTS: AC AND
DC HALL PROBES
33%
7. Stationary magnetometers
Portable or mobile magnetometers:
.
Survey magnetometers
May be stationary as in INTERMAGNET network.
May be mobile magnetometers scan a geographic region.
Laboratory magnetometers
Typically Stationary.
Unlike survey magnetometers , sample to be placed inside the magnetometer.
The temperature, magnetic field etc. the sample can be controlled.
47%
8. This method depends on the Faraday's law of electromagnetic induction.
The electro motive force (e.m.f) induced in a circuit is equal to the rate of change of flux linking the
circuit.
Φ:magnetic flux passing through the coil
N :the number of turns in coil
Principle
53%
10. PICK UP COIL
• Analog
• A/C
Frequency(Hz)
Amplitude(Volts)
67%
11. 1.The sample should be an ellipsoid of revolution or be in the
form of thin film
2.the sample can vibrate along any direction
3.In principle it is enough to have one sensing coil
i. The second coil increases sensitivity.
ii. Reduces the noise due to external field.
73%
12. The sample moving to the right induces some voltage in
the right pick-up coil.
The voltage induced in the left coil has an opposite sign.
The coils are connected in reverse- so both
voltages add-sensitivity increases
80%
13. 1.The electromotive force generated in the pick-up coils is proportional to the
magnetization of the sample.
2.It depends too on the orientation of the magnetic moment relative to the coils.
87%
Magnetization, linked to the magnetic field as:
14. the voltage depends on the
rate of change of induction B
Depending on position of the coils the integral of the induction through the surface
bounded by the coils changes.
Digital
Voltmeter
Digital Integrator: Directly
gives change in flux.
Digital voltmeter Gives
rate of change of flux-but
Numerical Integration is
needed.
15. In measurement one usually
uses
static pick-up coils while the
sample
(and its magnetic field)
vibrates
93%
PRECAUTION
Measure flux, not field. ⇒Calibration of geometry very important ; it
limits accuracy.
Induction sensors can be sensitive both to magnetic field and electric field. An
electrostatic shielding should surround the sensor .
16. ADVANTAGES
Even if new technologies have excellent performances ,Induction sensors (also known
as search coils) still the best way to achieve AC magnetic field measurements.
Despite the disadvantage of their size , indispensable in numerous fields due to sensitivity
and robustness.
Low costs and independent of temperature variations are two other advantages of the air
coil induction sensor.
100%