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The document discusses the synthesis of various oxacyclic derivatives such as furan, pyran, coumarins, and dioxanes using ionic liquids as reaction media. Ionic liquids offer advantages over traditional organic solvents as they are non-volatile, thermally stable, and recyclable. The synthesis of oxacyclic derivatives in ionic liquid media results in improved yields and reduced reaction times. Ionic liquids provide a more environmentally friendly approach for synthesizing important compounds like pharmaceuticals, agrochemicals, and fragrances.
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Presentation anam
- 2. INTRODUCTION. IONIC LIQUIDS: PREPARATION AND PROPERTIES. SYNTHESIS AND APPLICATION OF: FURAN AND DERIVATIVES. PYRAN AND DERIVATIVES. COUMARINS AND DIOXANES. APPLICATION OF IONIC LIQUIDS IN SYNTHESIS. CONCLUSION. REFERENCES.
- 3. Oxacycles are part of an extensive group of organic structures which are used as a synthetic intermedia. They are also important because of biological, pharmacological and industrial value of some of the structures in which they are present. Most of the reaction media used in traditional chemistry utilize volatile organic compounds which have several disadvantages. Room temperature ionic liquids were introduced as a novel reaction media in synthesis of oxacyclic derivatives. Utilization of RTILs meant some improvement in relation to reaction yield, reagents selectivity, and diminution in the reaction time, recyclability, as well as improvement in environmental condition.
- 4. Ionic liquid is a salt in the liquid state. Largely made of ions and short-lived ion pairs. They are conductors of electricity, non-ionizing, highly viscous and frequently exhibit low vapor pressure. They show: Low combustibility. Wide liquid range. Excellent thermal stability. Favorable solvating properties. They are used in: Organic Synthesis. Chemical Industry. Food and Bio products. Gas Handling. Waste Recycling. Pharmaceuticals. Dispersant. Batteries
- 5. IONIC LIQUIDS ARE PREPARED BY METATHESIS OF HALIDE SALTS.
- 8. 1. SYNTHESIS OF FURAN IN Mn(oAc)3 AS CATALYST AND [Bmim][BF4] AS REACTION MEDIUM GENERALLY SYNTHESISED BY 1, 4- DICARBONYL COMPOUNDS OR β-KETOESTER UNDER ACID CATALYSIS.
- 10. 2.SYNTHESIS WITH β-KETOESTERS WITH SAME REACTION CONDITION
- 12. 3.SYNTHESIS OF BENZOFURAN IN Ln(OTf)3 AS CATALYST IN IONIC LIQUID. 80-90%
- 14. 1.SYNTHESIS OF PYRAN IN [Bmim][PF6] 70-80%
- 15. 2. MULTICOMPONENT SYNTHESIS IN [Bmim][BF4]
- 16. S NO. SOLVENT TEMPERATURE (0 C) TIME (h) YIELD (%) 1 [Bmim][BF4] 80 0.5 98 2 EtOH Reflux 5 76 3 Toluene 80 5 75 4 THF Reflux 5 71 5 [Bmim][BF6] 80 1 90 6 [Bmim][BF4] 80 1 90 TABLE: SOLVENT AND REACTION CONDITIONS FOR PYRAN DERIVATIVES SYNTHESIS
- 18. 1.PECHMAN CONDENSATION IN [Bmim]Cl.2ALCl3
- 20. 2.SYNTHESIS OF BENZOCOUMARIN IN [Bmim][Al2Cl7]
- 23. SYNTHESIS BY THE REACTION OF FORMALDEHYDE AND STYRENE IN IONIC LIQUID.
- 27. Use of RTILs introduces most significant advances in synthesis of Oxacyclic derivatives. From the simplest monooxacycles to most polyoxacycles both are synthesized using RTILs. The main effects reported by using ionic liquids were the improvement of reaction yields and the reduction of reaction time. Other beneficial effects have been also reported when used as supported for other media or reaction catalyst such as silica gel and in microwave assisted synthesis. RTILs are eco-friendly reaction media and help to reduce pollution.
- 28. CURRENT ORGANIC SYNTHESIS, 2012, 9, 65-73. MARTA TEIJEIRA AND MORALES-HELGUERA. CHEMICAL COMMUNICATION, 2001, 1350-1351. PARSON AND THOMAS. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68,4406-4409. TETRAHEDRON LETT. 2004, 45, 5873-5876. TETRAHEDRON LETT. 2003, 59, 1599-1604. TETRAHEDRON LETT. 2007, 48, 7926-7929. APPL.CATAL.A GEN. 2009, 363, 93-99. CATAL.COMMUNICATION.2005, 6, 57-60. TERAHEDRON LETT. 2005, 46, 3931-3933. BIOORG.MED.CHEM.LETT.2010, 20, 809-813.
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