The document discusses solvents used in pharmaceutical manufacturing and green chemistry principles to reduce their environmental impact. It provides a classification of solvents, listing class II and III solvents and acceptable limits for residual levels. Green chemistry aims to design chemical syntheses to be more sustainable by promoting solvent-free reactions, ionic liquids, and microwave synthesis to reduce solvent usage and waste. The document concludes that green chemistry is a fundamental approach for preventing pollution, though not a solution to all environmental problems.

1. Solvents in the pharmaceutical use & The Green chemistry

2. Solvents Solvent chemistry Terms used in the solvent discussion Classification of the solvents Practical difficulties in meeting the residual solvents level Green chemistry Principles Atom Economy Greener ways of the preparation of some common chemicals Solvent free reactions Ionic liquids Microwave synthesis PMI ( Process mass Intensity ) conclusion Contents

3. List of class II solvents The Solvent levels should to be screened through the chromatographic method & Quantified in the Final API

4. Genotoxic carcinogens Carcinogens which are produces cancer by the affecting the genes are or chromosomes Nurotoxicity The ability of a substance to cause adverse effect on the nervous system PDE: Abbreviation for permitted daily exposure

5. LIST OF CLASS III SOLVENTS Since the solvents are class-III the accepted limit is LOD NMT 0.5% in Final API .No need of the chromatographic method or Quantification.

6. Class II solvent for which no toxicological data available . Due to the non availability of the toxicological data the manufacturer should give the Justification for the usage & the residual solvent levels of the above solvents in the final API.

8. Preferably all the reactants & reagents used should be the RSMS

22. GREEN ROUTES FOR THE SYNTHESIS OF THE COMMON CHEMICALS

26. IONIC LIQUIDES

27. Enantioseletive robinson annulation Solvent free Reaction

28. Neat reactant Witting olifination

29. Pyridenes synthesis

30. Synthesis of the 3-coumarins

31. Chemoseletive aldol condensation

51. Conclusion Green chemistry Not a solution to all environmental problems But the most fundamental approach to preventing pollution.

52. Thank you