Prevention of Thoracic Aortic Aneurysm Formation. The THORA - study

1. Prevention of Thoracic Aortic Aneurysm Formation the THORA - study Prof.dr. BJM Mulder Prof.dr. MC DeRuiter Cardiology A natomy and Embryology AMC LUMC THORA

2. Principal investigators Dr. MJ Goumans, Molecular Cellbiology, LUMC Prof. dr. B Loeys, Clinical Genetics, RUNMC Prof. dr. CVC Bouten, Biomedical Engineering, TU/e Prof. dr. AH Zwinderman, Clinical Epidemiology, Biostatistics & Bioinformatics, AMC Disciplines: basic science- clinical practice Cardiology, Pathomorphology, Developmental Biology, Genetics, Thoracic Surgery, Biostatistics, Bioengineering, Computational Modelling Participating centers nationwide AMC, LUMC, UMCG, RUNMC, EMC, UMCU, TUE Consortium THORA

4. Research plan THORA

9. WP 1a: MRM Jongbloed (LUMC), J Lindeman (LUMC), J Essers (EMC) WP 1b: MM Bartelings (LUMC), RJM Klautz (LUMC), BJ Bouma (AMC), AJJC Bogers (EMC) WP 2a: RMW Hofstra (UMCG), AV Postma (AMC) WP 2b: CMA van Ravenswaay (UMCG), WS Kerstjens (UMCG) WP 3a: FPT Baayens (TUE), BP Hierck (LUMC), J Essers (EMC) WP 3b: FN van de Vosse (TUE), PH Schoof (UMCU), J Kluin (UMCU), M Groenink (AMC), AP van Dijk (RUNMC) WP 4a: MJ Goumans (LUMC), AH Zwinderman (AMC) WP 4b: PG Pieper (UMCG), JJM Takkenberg (EMC), MG Hazekamp (LUMC/AMC), J Timmermans (RUNMC), BJ Bouma (AMC), DR Koolbergen (LUMC/AMC) THORA Participants