This document discusses commonly abused prescription drugs and signs of abuse. It describes several classes of prescription drugs like opioids, CNS depressants, and stimulants that are often abused. It also focuses on dextromethorphan (DXM), an active ingredient in many cough medicines, explaining its approved uses but risks of abuse. The document outlines signs that could indicate prescription drug abuse and provides strategies to address the problem through education, monitoring, safe disposal, and enforcement.