Speech sound disorders is an umbrella term referring to any combination of difficulties with perception, motor production, and/or the phonological representation of speech sounds and speech segments that impact speech intelligibility.
Known causes of speech sound disorders include motor-based disorders (apraxia and dysarthria), structurally based disorders and conditions (e.g., cleft palate and other craniofacial anomalies), syndrome/condition-related disorders (e.g., Down syndrome) and sensory-based conditions (e.g., hearing impairment.
Speech sound disorders include Articulation disorder & Phonological disorder.
Assessments include screening and detailed comprehensive assessment.
Effective treatment of speech sound disorder include Contrast therapy, Core vocabulary approach ,Cycles Approach, Distinctive feature therapy, Naturalistic speech intelligibility intervention,Non speech oral motor therapy,Speech sound perception training.
The use of voice is an integral part of communication; our voice is one of the defining features of our individuality, and it shares a lot of information about you, your voice tells others if you are happy or sad, healthy or unwell, young or old. Our voice can also reveal to others our background, such as the region of the world where we live, and even our social economic status, when a voice produced that perceived by others as unusual or strange and draws attention to the person who is speaking, it is quite likely the person is demonstrating a voice disorder.
So, I am happy to introduce this presentation about Pubertal voice disorders & Puberphonia, I would like this presentation to be useful and add a lot of information on this topic.
Pubrica's scientific editing services use a "three-tier" editor procedure. First, a SME reviews the document for consistency, coherency, and intelligibility; second, another SME goes through the material again to recast ambiguous writing. Finally, the document was approved by the quality assurance team.
Speech sound disorders is an umbrella term referring to any combination of difficulties with perception, motor production, and/or the phonological representation of speech sounds and speech segments that impact speech intelligibility.
Known causes of speech sound disorders include motor-based disorders (apraxia and dysarthria), structurally based disorders and conditions (e.g., cleft palate and other craniofacial anomalies), syndrome/condition-related disorders (e.g., Down syndrome) and sensory-based conditions (e.g., hearing impairment.
Speech sound disorders include Articulation disorder & Phonological disorder.
Assessments include screening and detailed comprehensive assessment.
Effective treatment of speech sound disorder include Contrast therapy, Core vocabulary approach ,Cycles Approach, Distinctive feature therapy, Naturalistic speech intelligibility intervention,Non speech oral motor therapy,Speech sound perception training.
The use of voice is an integral part of communication; our voice is one of the defining features of our individuality, and it shares a lot of information about you, your voice tells others if you are happy or sad, healthy or unwell, young or old. Our voice can also reveal to others our background, such as the region of the world where we live, and even our social economic status, when a voice produced that perceived by others as unusual or strange and draws attention to the person who is speaking, it is quite likely the person is demonstrating a voice disorder.
So, I am happy to introduce this presentation about Pubertal voice disorders & Puberphonia, I would like this presentation to be useful and add a lot of information on this topic.
Pubrica's scientific editing services use a "three-tier" editor procedure. First, a SME reviews the document for consistency, coherency, and intelligibility; second, another SME goes through the material again to recast ambiguous writing. Finally, the document was approved by the quality assurance team.
The DSM-5: Overview of Main Themes and Diagnostic RevisionsJames Tobin, Ph.D.
DSM-5 represents the field’s most recent attempt at revising the DSM-IV-TR diagnostic nomenclature. In this presentation, I will outline the primary efforts of the DSM-5 Task Force and the major diagnostic changes that were incorporated in the new manual, with an emphasis on the disorders of adulthood. The most promising changes are the organization of mental illness as a spectrum, the addition of dimensionality to specifier descriptions, lifespan/development and cultural refinements, and the articulation of a new hybrid model of mental illness. In the context of these gains, I also will provide a summary of the major controversies surrounding the DSM-5, including misgivings about lower thresholds to qualify for numerous diagnoses and the related concern that we may now run the risk of pathologizing “normal” human functioning.
More than 550 million people worldwide suffer from hearing loss. Around 60 million people have acute hearing loss or worse (Smulders et al., 2016; Stevens et al., 2013). Cochlear implants are one of the most significant advances in contemporary medicine (CI) (Farinetti et al., 2014). Many infants with a CI before age 12 experience typical language development due to the procedure (Birman et al., 2016).
Know More - https://pubrica.com/wp-content/uploads/2022/10/Clinical-efficacy-of-cochlear-implant-surgery-in-pediatric-and-adult-patients.pdf
Running Head Evidence based Practice, Step by Step Asking the Cl.docxtodd271
Running Head: Evidence based Practice, Step by Step: Asking the Clinical Question: A Key Step in Evidence based Practice 1
Evidence based Practice, Step by Step: Asking the Clinical Question: A Key Step in Evidence based Practice 9
Please review APA for header sections for the title page and subsequent pages. Thanks.
Evidence based Practice, Step by Step: Asking the Clinical Question: A Key Step in Evidence based Practice Comment by Doreen Farley: Please shorten your title here and in your header section. Thank. In the header section the title cannot be greater than 50 characters including spaces in APA.
Student’s Name:
Institution:
Abstract
The ability to evaluate the advantages of a quantitative setup research article is an essential mastery for authorities and investigators of all controls, including nursing, to judge the uprightness and estimation of the evidence and conclusions made in an article. At the point when all is said in done, this aptitude is customized for a few experts and masters who starting at now have a tolerable working data of investigation logic, including hypothesis headway, assessing frameworks, ponder layout, testing procedures and instrumentation, data social occasion and data organization, estimations, and clarification of revelations. For graduate understudies and junior workforce who still can't seem to confront these capacities, completing a formally made article assess can be a significant methodology to hone such states of mind. Nevertheless, focal data investigation techniques are as yet required remembering the true objective to be viable. Since there are few dispersed instances of assessing outlines, this article gives the sound judgment reasons for coordinating a formally created quantitative investigation article examine while giving a handbag to show the measures and structure. Exactly when passed on in a setting of minding and an unfaltering authoritative culture, the most surprising nature of thought and best patient outcomes can be accomplished. The inspiration driving this plan is given to sustain the data and states of mind they need to execute EBP dependably, with additional consideration. Articles will appear predictably to allow you a chance to intertwine information as you move in the direction of executing EBP at your establishment. Moreover, we've booked "Ask the Authors" call-ins predictably to give a quick line to the pros to enable you to determine questions. Comment by Doreen Farley: This assignment did not call for an abstract. Just your title page, PICOT question and your six articles with abstracts and no reference section.
Type of Clinical Question Comment by Doreen Farley: I am not sure what all of this is. Also, just taking a quick look there is a lot of information in this text that does not have in-text citation. Please take this into account and ensure that when you write your next assignments that all information is correctly cited.
It is important to put .
Reproducibility, preregistration, etc.: Making good science even betterAlex Holcombe
Reproducibility problems afflict many sciences, including psychology. The problems are, to some extent, rooted in the criteria for and process of scientific publication. In response, many journals, funders and professional societies have begun incentivising change. For example, study preregistration, although traditionally used only by clinical trials researchers, is becoming more common. In this seminar, you will learn how it is now used even in basic experimental psychology, and how you can take advantage of preregistration and other new practices to smooth your path to publication and dissemination of your work. Bring your laptop (optional), walk with me through preregistering a study, and also learn how sites such as Open Science Framework facilitate project management and collaboration. One object of this seminar is to spark discussion of how we can all make our already wonderful system of science even better.
FREQUENT ARTICULATION DISORDERS IN CHILDRENIJCSEA Journal
Millions of children worldwide suffer from articulation disorders. An essential part of their treatment
requires performing home exercises prescribed by their Speech Language Pathologist.Hence, academic
institutions and companies are developing algorithms to address the correct classification of good versus
poor phoneme articulation. As of today, the efforts to cover all the phonemes in the English language
provide less than 90% accuracy.
FREQUENT ARTICULATION DISORDERS IN CHILDRENIJCSEA Journal
Millions of children worldwide suffer from articulation disorders. An essential part of their treatment
requires performing home exercises prescribed by their Speech Language Pathologist.Hence, academic
institutions and companies are developing algorithms to address the correct classification of good versus
poor phoneme articulation. As of today, the efforts to cover all the phonemes in the English language
provide less than 90% accuracy.
FREQUENT ARTICULATION DISORDERS IN CHILDRENIJCSEA Journal
Millions of children worldwide suffer from articulation disorders. An essential part of their treatment
requires performing home exercises prescribed by their Speech Language Pathologist.Hence, academic
institutions and companies are developing algorithms to address the correct classification of good versus
poor phoneme articulation. As of today, the efforts to cover all the phonemes in the English language
provide less than 90% accuracy.
TIK TALK to Me Ltd., an Israeli company that develops methods and devices for treating speech disorders,
conducted a large-scale study on children's most frequent articulation disorders.
Over more than 24 months, the company accumulated records from some 250 children, ages 3 to 12,
treated by 45 Speech Language Pathologists (SLPs) in the US. The metadata analysis obtained from the
above records shows that 80% of the children required treatment on one or more of just 6 out of the 44
phonemes in the English language. The significance of the above findings is not just of academic interest to
the community of speech-language pathologists. Companies and researchers should prioritize reaching top
performance in the six most frequent articulation problems.
FREQUENT ARTICULATION DISORDERS IN CHILDRENIJCSEA Journal
Millions of children worldwide suffer from articulation disorders. An essential part of their treatment
requires performing home exercises prescribed by their Speech Language Pathologist.Hence, academic
institutions and companies are developing algorithms to address the correct classification of good versus
poor phoneme articulation. As of today, the efforts to cover all the phonemes in the English language
provide less than 90% accuracy.
TIK TALK to Me Ltd., an Israeli company that develops methods and devices for treating speech disorders,
conducted a large-scale study on children's most frequent articulation disorders.
Over more than 24 months, the company accumulated records from some 250 children, ages 3 to 12,
treated by 45 Speech Language Pathologists (SLPs) in the US. The metadata analysis obtained from the
above records shows that 80% of the children required treatment on one or more of just 6 out of the 44
phonemes in the English language. The significance of the above findings is not just of academic interest to
the community of speech-language pathologists. Companies and researchers should prioritize reaching top
performance in the six most frequent articulation problems.
FREQUENT ARTICULATION DISORDERS IN CHILDRENIJCSEA Journal
Millions of children worldwide suffer from articulation disorders. An essential part of their treatment requires performing home exercises prescribed by their Speech Language Pathologist.Hence, academic institutions and companies are developing algorithms to address the correct classification of good versus poor phoneme articulation. As of today, the efforts to cover all the phonemes in the English language provide less than 90% accuracy.
TIK TALK to Me Ltd., an Israeli company that develops methods and devices for treating speech disorders, conducted a large-scale study on children's most frequent articulation disorders.
Over more than 24 months, the company accumulated records from some 250 children, ages 3 to 12, treated by 45 Speech Language Pathologists (SLPs) in the US. The metadata analysis obtained from the above records shows that 80% of the children required treatment on one or more of just 6 out of the 44 phonemes in the English language. The significance of the above findings is not just of academic interest to the community of speech-language pathologists. Companies and researchers should prioritize reaching top performance in the six most frequent articulation problems.
FREQUENT ARTICULATION DISORDERS IN CHILDRENIJCSEA Journal
Millions of children worldwide suffer from articulation disorders. An essential part of their treatment
requires performing home exercises prescribed by their Speech Language Pathologist.Hence, academic
institutions and companies are developing algorithms to address the correct classification of good versus
poor phoneme articulation. As of today, the efforts to cover all the phonemes in the English language
provide less than 90% accuracy.
TIK TALK to Me Ltd., an Israeli company that develops methods and devices for treating speech disorders,
conducted a large-scale study on children's most frequent articulation disorders.
Over more than 24 months, the company accumulated records from some 250 children, ages 3 to 12,
treated by 45 Speech Language Pathologists (SLPs) in the US. The metadata analysis obtained from the
above records shows that 80% of the children required treatment on one or more of just 6 out of the 44
phonemes in the English language. The significance of the above findings is not just of academic interest to
the community of speech-language pathologists. Companies and researchers should prioritize reaching top
performance in the six most frequent articulation problems.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
3. researchers and clinicians in
cluttering worldwide
Daly and Cantrell (2006) called
To frame questionnaire containing a number of
statements about disorder
4. They completed 50-item questionnaire.
First, they RATED the factors they felt most
important for identifying cluttering
Second, they RANK ORDERED the top ten
statements which they felt most accurately
described cluttering.
Third, they listed other features they thought
the inventory omitted.
After analysing the data, the checklist contained 33 symptoms associated with cluttering, in four
domains (pragmatics, speech motor, language -cognition & motor coordination -writing
problems).
5. AIM
The PCI was developed to detect cluttering symptoms in running
speech. And to differential diagnose between stuttering and cluttering
7. SCORING
• The total maximum score would be 198.
• Preliminary data suggest that a Score of 120+ indicates a diagnosis of
cluttering.
• Scores between 80 and 120 indicate a diagnosis of cluttering-
stuttering.
8. CONCLUSION
• In conclusion, the PCI in its current state does not serve as a valid
diagnostic instrument for cluttering, but it serves as a valid screening
instrument for possible cluttering symptoms.
• Although the revised PCI subtotal score did not differentiate between
cluttering and stuttering, the revised PCI could be of value in the
prediction of cluttering components in speech.
• Further research on defining items is required in order to make this
screening instrument a valid diagnostic tool that can be used by SLPs.
9. BIBLIOGRAPHY
• Cluttering identified Differential diagnostics between cluttering,
stuttering and speech impairment related to learning disability
Yvonne van Zaalen – op ’t Hof
• Cluttering: Characteristics Identified as Diagnostically Significant by 60
Fluency Experts
• by David Daly
• David. A. Daley, Ed. D. titled, Identifying and Treating Cluttering:
Effective Strategies Clinicians Need to Know
• https://www.mnsu.edu/comdis/isad10/papers/daly10/dalycluttering
2006R.pdf
