A D D I C T I O N : A chronic, neurobiologic disease characterized by impaired control over drug use, compulsive use,
continued use despite harm, and cravings.
D E P E N D E N C E : A psychological craving for, habituation to, abuse of, or physiologic reliance on a chemical
substance .
T O L E R A N C E : A need for a markedly increased amounts of substance to achieve intoxication or desired effect. W I T H D R A W : Substance specific syndrome that occur after stopping or reducing the amount of substance over a
prolonged period of time
Drug abuse is a common problem that is ruining not only the individuals but offering a global issue. People experiment with drugs for many different reasons. Many first try drugs out of curiosity, to have a good time, because friends are doing it, or in an effort to improve athletic performance or ease another problem, such as stress, anxiety, or depression. Use doesn't automatically lead to abuse, and there is no specific level at which drug use moves from casual to problematic. It varies by individual. Addiction is less about the amount of substance consumed or the frequency, and more to do with the consequences of drug use. No matter how often or how little you’re consuming, if your drug use is causing problems in your life, at work, school, home, or in your relationship, you likely have a drug abuse or addiction problem. And if you are having this problem you are actually in trouble.
Prescription Drug Misuse: Among Young Adultsamankhosa
A project that explains the prevalence of prescription drug misuse, specifically among the young adult population. Includes information on warning and behavioural signs of prescription drug abuse, commonly abused prescription drugs, cultural awareness, and related policies and prevention strategies.
This presentation was done on the 'First Qilu Doctoral Forum on Health Economy and Policy' Conference on 15th May 2019 at Shandong University, Jinan, China
A D D I C T I O N : A chronic, neurobiologic disease characterized by impaired control over drug use, compulsive use,
continued use despite harm, and cravings.
D E P E N D E N C E : A psychological craving for, habituation to, abuse of, or physiologic reliance on a chemical
substance .
T O L E R A N C E : A need for a markedly increased amounts of substance to achieve intoxication or desired effect. W I T H D R A W : Substance specific syndrome that occur after stopping or reducing the amount of substance over a
prolonged period of time
Drug abuse is a common problem that is ruining not only the individuals but offering a global issue. People experiment with drugs for many different reasons. Many first try drugs out of curiosity, to have a good time, because friends are doing it, or in an effort to improve athletic performance or ease another problem, such as stress, anxiety, or depression. Use doesn't automatically lead to abuse, and there is no specific level at which drug use moves from casual to problematic. It varies by individual. Addiction is less about the amount of substance consumed or the frequency, and more to do with the consequences of drug use. No matter how often or how little you’re consuming, if your drug use is causing problems in your life, at work, school, home, or in your relationship, you likely have a drug abuse or addiction problem. And if you are having this problem you are actually in trouble.
Prescription Drug Misuse: Among Young Adultsamankhosa
A project that explains the prevalence of prescription drug misuse, specifically among the young adult population. Includes information on warning and behavioural signs of prescription drug abuse, commonly abused prescription drugs, cultural awareness, and related policies and prevention strategies.
This presentation was done on the 'First Qilu Doctoral Forum on Health Economy and Policy' Conference on 15th May 2019 at Shandong University, Jinan, China
Drug abuse represents a complex and multifaceted issue prevalent across societies globally. It involves the misuse of legal or illegal substances that alter the functioning of the brain, leading to detrimental effects on an individual's physical health, mental well-being, and social relationships. From the casual misuse of substances to the severe grip of addiction, drug abuse encompasses a wide spectrum of behaviors and consequences that profoundly impact individuals and communities.
Types and Categories of Drugs:
Drug abuse spans a broad array of substances, including but not limited to alcohol, cannabis, opioids, stimulants, hallucinogens, and prescription medications. Each category of drugs affects the brain and body in distinct ways, contributing to varying levels of dependence and health risks. Alcohol, for instance, is legal in many societies but is also one of the most commonly abused substances, leading to addiction and a myriad of health problems when consumed excessively. On the other hand, opioids like heroin or prescription painkillers can quickly lead to physical dependence and overdose fatalities.
Causes and Risk Factors:
The reasons behind drug abuse are multifaceted and can involve a combination of genetic, environmental, and psychological factors. Genetic predispositions, family history of substance abuse, trauma, stress, peer pressure, mental health disorders, and socioeconomic factors can all contribute to an individual's susceptibility to drug abuse. Additionally, availability and societal attitudes toward drugs play a significant role in influencing patterns of abuse.
Effects of Drug Abuse:
The effects of drug abuse extend far beyond the individual consuming the substance. Physically, drug abuse can lead to a range of health issues, including cardiovascular problems, liver damage, respiratory complications, infectious diseases from needle sharing, and neurological impairments. Mentally, drug abuse can exacerbate or trigger mental health disorders such as depression, anxiety, psychosis, and cognitive impairments. Socially and behaviorally, it can strain relationships, cause legal issues, financial strain, and impair an individual's ability to function at work or in academic settings.
Impact on Society:
Drug abuse poses significant challenges at a societal level. It contributes to crime rates, strains healthcare systems, leads to lost productivity, and imposes substantial economic burdens. Moreover, the societal stigma associated with drug abuse often hinders individuals from seeking help, exacerbating the problem further.
Prevention and Treatment:
Preventing drug abuse involves a multifaceted approach, including education, early intervention, addressing risk factors, and promoting healthy coping mechanisms. Treatment strategies vary and often include behavioral therapies, counseling, support groups, and, in some cases, medication-assisted therapies. The goal of treatment is not only to help individuals overcome their dep
Drug Dependence & Abuse - Presentation by Akshay AnandAkshay Anand
A presentation on Drug Dependence and Drug Abuse that explains in brief about the various practices of substance abuse and dependence and the medicinal agents and drugs that can be used to overcome or treat such abuses. This was presented as a part of curriculum by Akshay Anand in Sree Siddaganga College of Pharmacy during May 2013.
This presentation covers the nature and features of drug dependence. It also gives coverage to different psychological or biological models of drug addiction.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Pratyush kashyap #dibrugarh university
1. Seminar on Pharmacology
DRUG ADDICTION AND DRUG ABUS
Presented By-
Pratyushpal Kashyap
B.Pharm 5th semester
Roll No-08
Department of pharmaceutical Scienc
2. CONTENTS
Introduction
Drug dependence
Types of Drug dependence
Drug abuse
Types of drug abuse
Factors contribute to drug abuse
Categories of Drugs
Reference
3. INTRODUCTION
Drug addiction:- Drug addiction is a chronic or brain disease
that causes compulsive drug seeking and use , deposit harmful
consequence to the drug addict and those around them .
A person is said to have developed “Drug addiction” when he/she
believes that optimal state of well being is achieved only through the
actions of the drug .
Addiction also involves other behaviors :-
Finding it difficult to control the need to use the drug
The subjects feels emotionally distressed
Feeling the use of drug to be more important than normal
things like family or work .
4. DRUG DEPENDENCE
It is a state in which use of drugs for personal satisfaction is accorded a
higher priority than other basic needs , often in the face of known risk to
health
Important Drugs known to cause dependence
Drugs that cause severe psychic as well as physical dependence:
Opiate or morphine type: Codeine, heroin
Alcohol –Barbituric type: Ethyl alcohol, barbiturates, meprobamate,
benzodiazepines
Nicotine
Drugs that cause definite psychic but mild physical dependence:
Opiate antagonist type: nalorphine
Amphetamine type: Amphetamine ,methamphetamine
5. TYPE OF DEPENDENCE
There are 2 main type of dependence –
1) Psychological dependence :
It is developed when individual believes that optimal state of well-being is achieved
only through drug action.
Subject feels emotionally distressed if the drug is not taken.
eg : Cocaine
(2) Physical dependence:-
It is characterized by tolerance and withdrawal symptoms when the user is abstinent
Discontinuation of drug results in characteristic withdrawal (abstinent) syndrome .
It necessary the continued presence of drugs to maintain physiological equillibrium.
6. DRUG ABUSE
Drug abuse means unnecessary use of too many drug or inappropriate use
of drug.It refers to use of drug by self medication in a manner and amount
that deviates from the approved medical and social patterns in a given
culture at a given time.
The 2 major patterns of Drug abuse
Continuous use Occasional use
Drug is taken regularly Drug is taken off & on to obtain
pleasure or high ,recreation
The subject wishes to continuously
remain under the influence of drug
For enhancement of sexual experience
e.g. Opioids, alcohol ,sedatives e.g. Amphetamines,cocaine,cannabis
7. Factors contribute to drug abuse
Pursuit to health
Pressure seeking
Curiosity and emptiness
Influence of the peer groups
depression
Categories of drugs
1. Soft drug- Do not cause physical addiction, but some of them are
cause psychological dependency, which means that people feel
better when they have the drug. Eg-cannabis ,LSD
2. Hard drug- They cause physical addiction. This drug is more
dangerous than soft drug. Eg- heroin , cocaine.
8. REFERENCE
Tripathi K.D;”Essentials of MEDICINAL PHARMACOLOGY”
seventh edition ,published by Jaypee Brothers Medical Publishers(P) Ltd.
( Pg.No.-87-91)
Satoskar R .S,Nirmala N.Rege , Bhandarkar
“S.D;PHARMACOLOGYAND PHARMACOTHERAPEUTICs”
published by Popular Prakashan Pvt Ltd.(Pg.no.:3-65)