How can you ensure that your work and use of ML gets the most impact in the domain you apply it to? From collaborating with all stake-holders to simulating how predictions will really be used, evaluating them domain-side and deploying models at scale in production, I’ll share some of the lessons I’ve learnt when it comes to integrate ML in real-world applications. Also, I’ll review some research problems and new open source software aimed at making it easier to create, experiment with, and operationalise predictive models.