Distal femur fractures are rare but severe injuries, often requiring surgical treatment. They are classified based on their location and involvement of the knee joint. Surgical techniques include external fixation, intramedullary nailing, plating, and total knee arthroplasty in elderly patients. The goals of treatment are to restore the knee joint, obtain stability in both frontal and sagittal planes, and allow early mobilization. Proper surgical technique and implant choice are important for achieving good clinical and radiological outcomes.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. INTRODUCTION
Fractures of the distal femur are rare and
severe. The estimated frequency is 0.4% of
all fractures and 3% of femoral fractures.
A classic bimodal distribution is found
with a peak in frequency in young men (in
their 30s) and elderly women (in their 70s).
The usual context is a high energy trauma
in a young patient and a domestic accident
in an elderly person.
8. CLINICAL EVALUATION
Plain radiographs should be
obtained for suspected
fracture of the distal femur.
In more complex fractures, CT
is used to delineate intra-
articular extension, degree of
comminution, and fracture
lines in the coronal plane.
Open fracture occurs in 5% to
10% of supracondylar
fractures; thus, the skin
should be meticulously
examined for wounds.
10. INITIAL MANAGEMENT
Besides a clinical examination and a standard radiological
examination, a CT scan is recommended because 55% of these
fractures are intra-articular.
If there is a doubt about the presence of vascular injury, appropriate
tests should be performed. It should be remembered that the
presence of a distal pulse does not exclude vascular injury.
11. THE MAJOR PRINCIPLES OF TREATMENT
The main therapeutic principles are as follows. If the fracture is intra-articular, joint
reconstruction is the first step. The knee must remain free and mobile at the surgical site.
Exposure of epiphyseal fracture lines is obtained with the knee bent, especially with frontal
lines.
Stabilization on the frontal plane is usually not difficult, while saggital plane stability with
rotation of the condyles is much more difficult.
12. THE MAJOR PRINCIPLES OF TREATMENT
The metaphyseal portion,
in particular of the
anterior cortex can serve
as a reference point.
The second step includes
reducing the epiphysis on
the metaphyso-diaphysis:
this is performed with the
leg in extension.
In case of a comminutive
fracture, rotation and
length should be carefully
controlled.
13. SURGICAL
For an extra-articular
fracture, all therapeutic
options are possible and
mini-invasive surgery can be
performed.
In case of an intra-articular
fracture, open reduction and
internal plate fixation should
be performed with the
patient on a standard
operating table.
15. EXTERNAL FIXATION
External fixation is not indicated for definitive treatment of these fractures, in
particular in displaced intra-articular fractures.
It is difficult to control alignment
The stability of this technique is poor (lever arm of the leg)
There is no fixation of the articular component and stabilization of the fracture
requires bridging the knee, which increases the risk of stiffness
16. EXTERNAL FIXATION
The indications are more
often for temporary fixation.
If there is a complex
fracture, the fracture can be
evaluated and a therapeutic
strategy can be
determinedusing this
solution.
A bilateral fracture or a
floating knee are typical
examples of these complex
fractures
17. BILATERAL FLOATING KNEE:
A: CLINICAL APPEARANCE;
B: AP X-RAY;
C AND D: POSTOPERATIVE
X-RAY, LEFT SIDE;
E AND F: POSTOPERATIVE
X-RAY, RIGHT SIDE.
18. EXTERNAL
FIXATION
External fixation provides medical management and a Damage
Orthopedic Control approach which reduces pain and facilitates
treatment.
External fixation should bridge the knee when there is intra-
articular involvement.
The femoral pins should be at a distance from the fracture site
and the joint to prevent infection. Anterior femoral pins can be a
good choice if internal fixation with a lateral plate is used later:
External fixation is maintained during the procedure to facilitate
control of alignment during internal fixation.
19. ANTEROGRADE INTRAMEDULLARY NAILING
The indications for anterograde intramedullary nailing are essentially extra-articular
fractures.
In the rare cases of bi-or-trifocal fractures of the distal femur, nailing is often the
only therapeutic alternative.
This solution is contraindicated in complex intra-articular fractures.
The advantages of this technique are that it is closed with conservation of
heamatoma and that the implant is extra-articular which is relatively easy to remove
20.
21. ANTEROGRADE INTRAMEDULLARY NAILING
• The patient should be installed on a traction table. If condylar traction is
being performed (extra-articular fracture), this should be as anterior as
possible. If there is intra-articular involvement, a traction boot is
indicated.
• Recurvatum deformity of the distal fragment is controlled by providing
distal support attached to the traction table.
• Internal fixation of an epiphyseal fragment should take into account the
position of the future nail. The nail should descend as deeply as possible
into the condyle for maximum stability.
22. ANTEROGRAD
E
INTRAMEDULL
ARY NAILING
• Anterograde intramedullary nailing
is possible when the fracture is
located more than 3 cm from the
proximal screw, which can resist
one million cycles of loading. The
diameter of the nail is also
important.
• Distal cortical contact increases
stability of the system while
reducing strains which are absorbed
by the nail and the locking screws.
23. RETROGRADE NAILING
The indications for retrograde nailing are classic:
1. Extraarticular fracture
2. Simple intra-articular fractures with little or no
displacement.
3. Floating knee with a single surgical approach for
stabilization of both fracture sites.
24. RETROGRADE NAILING
Passing a nail near the fractured trochlea can worsen the situation by opening the fracture site, thus if there is
an intra-articular fracture line, initial screw fixation is indicated.
Retrograde nailing has the advantages of being a closed technique, but because it is intra-articular, there is a
risk of septic arthritis in case of infection.
Removal is also more difficult. The patient can be installed on a standard or a fracture table. On a standard
table, the knee is in 30◦ flexion and the distal femur is supported.
On a fracture table, reduction is obtained by skeletal traction at the proximal tibia with the leg hanging slightly.
The nail should be inserted deep enough to avoid any impingement with the patella and should not be used as a
lever to prevent creating an intercondylar fracture line.
25. AP (A) and lateral (B) radiographs demonstrating supracondylar femoral fracture with metaphyseal comminution. AP
(C) and lateral (D) radiographs demonstrating the use of retrograde intramedullary nailing to manage this AO type A3
injury.
26. SIMPLE SCREW
FIXATION
It is proposed in the presence of a frontal or sagittal
unicondylar fracture.
A medial or lateral parapatellar approach is often necessary,
In case of a fracture with no or little displacement, a
percutaneous procedure is possible and reduction is
controlled by ligamentotaxis
Osteosynthesis using two 6.5 mm screws were more effective
than osteosynthesis using two or four 3.5 mm screws. A load
of 40—56% more was required with 6.5 mm screws to cause
system failure.
27. SIMPLE SCREW
FIXATION
In frontal fractures, the direction of
the screws changes the mechanical
stability.
Double screws using cancellous lag
screws in a posterior to anterior
direction provide better mechanical
strength during loading than those
in an anterior to posterior direction
28. BLADE
PLATE
Classic indications are extra-articular fractures, sagittal
unicondylar fractures or supracondylar and intercondylar fractures.
The system is very stable allowing compression of the epiphyseal-
metaphyseal fracture site.
In osteoporotic bone, placement of the blade can be traumatic and
have little resistance to breakage. Mechanically, the plate functions
like a dynamic tension band and creates medial compression.
For an optimal effect, the medial pillar must be perfectly
reconstructed. The diaphyseal position of the plate is determined
by the position of the blade which must be precisely defined
29. BLADE
PLATE
It should be located 2 cm from the joint line (AP and
lateral view), along the axis of the femoral diaphysis
and in the middle of the anterior half of the largest
diameter of the condyle in profile.
The blade is inserted in front of the Blumensatt line
(avoiding the cruciate ligaments) and behind the
groove of the trochlea (avoiding the patellofemoral
joint line).
30. (A) The 95° angled blade plate
consists of a rigid condylar blade
fixed to a precontoured lateral
side plate. Postoperative lateral
(B) and AP (C) radiographs
demonstrating management of a
comminuted extra-articular
distal femoral fracture (AO type
A3) with a blade plate
supplemented with bone graft.
31. DYNAMIC COMPRESSION PLATE
• The indications are classic:
• Extra-articular fractures
• Sagittal unicondylar fractures or supra- and intercondylar
fractures.
32. DYNAMIC COMPRESSION PLATE
This solution includes dynamic epiphyseal screw fixation (lag
screw) for compression of the fracture site.
Epiphyseal fixation is obtained by a single screw which the plate
pivots upon for sagittal adjustment.
The 95◦ angle between the plate and the screw facilitates frontal
placement and positions the ephiphyseal screw parallel to the joint.
33. DYNAMIC
COMPRESSIO
N PLATE
The advantage of being fairly easy to position, because the
screw is cannulated, to limit bone trauma and to have good
resistance to screw failure
However the screw hole is large, there may be rotational
instability in the distal screw before diaphyseal fixation and
the insertion site of the screw may be located near a frontal
fracture.
The insertion guide is positioned according to the same
criteria as the blade plate, and its direction on the axial plane
is parallel to the anterior trochlear rims, or 10◦ downwards
and inwards
35. LOCKING COMPRESSION PLATE
The goal of locking plate is Provide better stability in fragile bone.
Primary stability of the plate is independent of the friction effect as the screw
presses the plate, and is obtained by locking the screw into the plate.
Plate design is usually anatomical which allows it to be used as a ‘‘reduction
mold’’, molding the bone to the plate.
36. LOCKING COMPRESSION PLATE
Dougherty et al. [16] suggest that bicortical screws should be systematically used to
provide three points of fixation (2 cortical + the plate) to limit breakage.
If the fracture is unstable (long fracture line, comminutive fracture) locking screws are
placed near the fracture line to stabilize the fracture site.
If it is a simple fracture, locking screws are placed further away with an open hole on
each side of the fracture to create elasticity in the system, which will promote union.
Dougherty PJ, Kim DG, Meisterling S, Wybo C, Yeni Y. Biomechanical comparison of bicortical versus unicortical screw placement of proximal tibia locking plates: a cadaveric
model.
J Orthop Trauma 2008;22:399—403.
37. LOCKING COMPRESSION PLATE
For Ahmad et al. [18], the internal fixation system should be close to the fracture.
A distance of less than 2 mm provides better resistance to compression and torsion,
while there is significant plastic deformity with more than 5 mm.
Bottlang et al. [20] propose the use of a standard screw at the end of the plate in case
of a fracture in osteoporotic bone to limit strains and prevent a stress fracture.
Ahmad M, Nanda R, Bajwa AS, et al. Biomechanical testing of the locking compression plate: when does the distance between bon and implant significantly
reduce construct stability? Injury 2007;38:358—64.
Bottlang M, Doornink J, Byrd GD, Fitzpatrick DC, Madey SM. A nonlocking end screw can decrease fracture risk caused by locked plating in the osteoporotic
diaphysis. J Bone Joint Surg Am 2009;91:620—7.
38. TOTAL KNEE ARTHROPLASTY
Total knee arthroplasties
can be included as a
therapeutic option in
elderly patients.
This is a difficult
procedure in a fragile
population requiring
extensive expertise in
arthroplasty.
The main technical point
is to restore the height of
the joint line when there
is no longer any
possibility of reduction
39. TOTAL KNEE ARTHROPLASTY
An intact lateral or medial pillar facilitates adjustment of the
replacements.
A constrained knee replacement is usually chosen and even in certain
cases a megaprosthesis such as that used after tumor resection.
Postoperative morbidity-mortality is high
40. AP (A) and lateral (B) radiographs demonstrating periprosthetic fracture of the distal femur proximal to a total
knee arthroplasty. The femoral component appears to be well-fixed; however, definitive determination of the
integrity of the implant must be made intraoperatively. Postoperative AP (C) and lateral (D) radiographs
demonstrating management of the periprosthetic fracture with a periarticular locking plate.
41. CONCLUSION
The quality of the surgical technique is the primary factor, and the only guarantee of
obtaining good radiological and clinical results in distal femoral fractures.
Mini-invasive treatment (nailing or plates) seems to provide better results.
All types of fractures can be treated with locking plates and a classic or mini-invasive
surgical approach is possible.
Recent biomechanical studies have shown that results are better with locking plates.
The surgical technique must be rigorous and the biomechanical qualities of these
implants must be understood to prevent the development of major complications.