This document provides information about postpartum hemorrhage (PPH), including its definition, causes, risk factors, prevention, assessment, management, and treatment. Some key points:
- PPH is a leading cause of maternal mortality worldwide, responsible for 1/3 of maternal deaths. The majority occur within 4 hours of delivery.
- Causes (4 Ts) include uterine atony (80% of cases), retained placenta or clots, genital tract trauma, and coagulation disorders.
- Risk factors include overdistended uterus, rapid/prolonged labor, uterine anomalies, and coagulation disorders.
- Prevention is through active management of the third stage of labor
PPH Postpartum hemorrhage, affecter the delivery of fetus vaginal bleeding you can see with in 24 hours this primary PPH, secondary PPH will be up 28 of delivery.
Prelabour Rupture of Membrane (PROM) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Prelabour Rupture of Membrane (PROM). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
PPH Postpartum hemorrhage, affecter the delivery of fetus vaginal bleeding you can see with in 24 hours this primary PPH, secondary PPH will be up 28 of delivery.
Prelabour Rupture of Membrane (PROM) by Sunil Kumar Dahasunil kumar daha
Please find the power point on Prelabour Rupture of Membrane (PROM). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Maternal collapse by dr alka mukherjee &; dr apurva mukherjeealka mukherjee
Not all maternal deaths are preceded by an identifiable collapse, and not all maternal collapses result in death. Maternal collapse occurs any time during pregnancy, up to 42 days following delivery and is an acute event involving cardiorespiratory systems and/or brain, resulting in impaired consciousness or death.1
Maternal deaths are generally quantified as a maternal mortality ratio (MMR), expressed as the number of maternal deaths per 100,000 women giving birth. It includes deaths that occur due to complications of the pregnancy (direct deaths), and those resulting from worsening of other disease processes due to the pregnancy (indirect deaths). Deaths that occur from causes completely unrelated to pregnancy or birth are termed When faced with an acute maternal collapse, it is helpful to think of potential causes as falling into five categories, or the 5 Hs for simplicity:4
Head including eclampsia, stroke, epilepsy, vasovagal
Heart including myocardial infarction, arrhythmia, cardiomyopathy, thoracic aortic dissection
Hypoxia including pulmonary embolus, pulmonary oedema, anaphylaxis, asthma
Haemorrhage including abruption, uterine atony, genital tract trauma, uterine rupture, uterine inversion, ruptured aortic aneurysm
wHole body and Hazards amniotic fluid embolus, hypoglycaemia, trauma, anaesthetic complications, drug reactions (illicit or prescribed), sepsis
The likelihood of any one of these being causative will obviously depend somewhat on the timing of the collapse – early or late pregnancy, intrapartum, immediately postpartum, remotely postpartum.
Maternal cardiac arrest represents a small subset of women affected by maternal collapse. The incidence is approximately 1 in 30,000 ongoing pregnancies, with a high likelihood of death for both the mother and the fetus. The vast majority of us will never need to attend a maternal cardiac arrest, and doing so is uniquely stressful. For these reasons, it is important to have a framework in mind of how to deal with a maternal cardiac arrest, and to have practised the response to this situation.
incidental deaths, and are not included in calculation of the MMR.
• Several other risk factors for maternal death are recognised. These include:
• Maternal age 35 and older
• Obesity
• Lower socioeconomic status
• Pre-existing mental health issues, substance use and domestic violence, all of which may be exacerbated by pregnancy and the puerperium
• Medical co-morbidities, particularly asthma, autoimmune diseases, inflammatory and atopic disorders, haematological disorders, essential hypertension, infections and musculoskeletal disorders
One of the important developments in improving identification of a pregnant or postnatal patient at risk of collapse during hospital admission has been the development of maternity-specific Early Warning Charts.
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Presented by
Ahmed Mukhtar
M.B.B.Ch., M.Sc Obstetrics and GynecologyAssistante lecturer of Obstetrics and Gynecology
Faculty of Medicine, Zagazig University
Placental abruption is premature separation of placenta from the uterus/ in other words separates before childbirth.
It occurs most commonly around 25 weeks of pregnancy characterized by vaginal bleeding, lower abdominal pain, and dangerously low blood pressure
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Pph
1. Post Partum
Haemorrhage
Dr. Uma Gupta *Head & Prof. Obstetrics &
Gynecology
*M.D, MARD, FAIMER (CMCL 2012), PGDHHM,MHPE.
umankgupta@gmail.com
5/10/2021 Uma Gupta 1
2. 5/10/2021 Uma Gupta 2
Mumtaz Mahal
died
from postpartum
hemorrhage in
Burhanpur on 17
June 1631 while
giving birth to
her fourteenth
child, after a
prolonged labor
of approximately
30 hours.
3. Learning Objectives
1. Define postpartum hemorrhage
2. Differentiate between primary and secondary postpartum
hemorrhage.
2. Describe prevention (active management of the third stage
of labour) and treatment of postpartum hemorrhage.
3. Recall the four Ts as causes of postpartum hemorrhage.
4. Identify risk factors for PPH.
5. Describe the implications of postpartum hemorrhage on
the health of the mother and baby.
6. Prevention and management of PPH
5/10/2021 Uma Gupta 3
4. Postpartum hemorrhage (PPH) is leading
cause of maternal mortality, accounting for
one-third of all maternal deaths worldwide
PPH causes up to 60% of all maternal deaths
in developing countries.
The majority of these deaths - within 4
hours of delivery, indicating they are a
consequence of third stage of labour.
5/10/2021 Uma Gupta 4
5. • Primary (immediate) postpartum hemorrhage is
defined as excessive bleeding that occurs within the
first 24 hours after delivery.
• About 70% of immediate PPH cases are due to uterine
atony.
• Atony of the uterus is defined as the failure of the
uterus to contract adequately after the child is born.
5/10/2021 Uma Gupta 5
6. • Secondary (late) postpartum hemorrhage is
defined as excessive bleeding occurring between 24
hours after delivery of the baby and 6 weeks
postpartum. Most late PPH is due to retained
products of conception, or infection, or both
combined.
5/10/2021 Uma Gupta 6
7. Quantified
PPH has been defined as blood loss in excess of 500
cc in vaginal deliveries and in excess of 1,000 cc in
cesarean section deliveries. For clinical purposes,
any blood loss that has the potential to produce
hemodynamic compromise should be considered a
PPH.
5/10/2021 Uma Gupta 7
8. The amount of blood loss required to cause
hemodynamic compromise will depend on the pre-
existing condition of the woman.
Hemodynamic compromise is more likely to occur in
conditions such as anemia (e.g. iron deficiency, sickle
cell, and thalassemia) or volume contracted states
(e.g. dehydration, gestational hypertension with
proteinuria).
5/10/2021 Uma Gupta 8
9. Classification
• Primary : Loss within 1st 24 hours after delivery
• Secondary : 24 hours till 12 weeks postnatally
• Minor : 500-1000 ml
• Moderate : 1000-2000 ml
• Severe : > 2000 ml
5/10/2021 Uma Gupta 9
10. Clinical Findings With Varying
Amounts of Blood Loss
Blood loss will result in changes to the state of
consciousness, the pulse rate, the respiratory rate,
the temperature, the blood pressure, the status of
the skin and mucous membranes, capillary refilling,
and urine output.
5/10/2021 Uma Gupta 10
11. Estimating Blood Loss
• Accurate estimation of blood loss is essential in the
recognition and management of obstetric
hemorrhage. Underestimation of blood loss may
result in lack of recognition of PPH, and inadequate
or inappropriate management
5/10/2021 Uma Gupta 11
12. Direct Measurement
PAD 120 CC
TAMOPNE 50 CC
GUAZE 30 CC
SMALL ABDOMINAL PACK 250 CC
LARGE ABDOMINAL PACK 450 CC
5/10/2021 Uma Gupta 12
13. • Mild hypovolemia, loss of <20% of the blood
volume,
• mild tachycardia,
• mottled skin,
• cool extremities due to increased systemic vascular
resistance and prolonged capillary refilling,
• urinary output may be decreased.
• The woman may report dizziness, although her
neurologic status usually remains normal.
5/10/2021 Uma Gupta 13
14. • With moderate hypovolemia, i.e. loss of 20% to 40%
of the blood volume,
• woman will become increasingly anxious.
• pulse will become very fast and weak, >110/bpm
(tachycardia).
• Her respiratory rate will increase to a rate of
>30/bpm.
• will exhibit marked pallor; her eyelids, palms, and
mucous membranes will be very pale.
• Her blood pressure may be normal when she is in the
supine position. However, there may be significant
postural hypotension
5/10/2021 Uma Gupta 14
15. • When blood loss is severe, i.e. >40% of the blood
volume,
• the classic signs of shock will appear.
• The blood pressure declines and becomes unstable
even in the supine position.
• The woman will develop marked tachycardia,
oliguria or anuria, and agitation or confusion.
• Loss of consciousness is an ominous sign.
5/10/2021 Uma Gupta 15
16. Rule of 30
This rule is used to measure severity of shock
resulting from at least 30% of blood loss –
• Increase in HR by >30 beats/min
• Fall in Systolic BP >30 mmHg
• RR >30/min
• Hematocrit drops by >30%
• Urine output <30ml/min
5/10/2021 Uma Gupta 16
18. • Frequent measuring of birth fluids may help health
care providers become more skilled in assessing
blood loss. Health care providers should become
familiar with the absorbency of maternity pads,
under pads, and other surfaces on which maternal
blood may accumulate during delivery in their
practice location
5/10/2021 Uma Gupta 18
19. ➢REMEMBER
➢ Blood loss is consistently underestimated.
➢ Underestimation may result in inadequate treatment
resulting in complications or death.
➢ Ongoing trickling can lead to significant blood loss.
➢ Blood loss is generally well tolerated by healthy
women, to a point.
➢ Anemia and other underlying health conditions may
profoundly affect a woman‘s ability to tolerate any
amount of blood loss.
5/10/2021 Uma Gupta 19
20. • Complications Associated With Postpartum
Hemorrhage
• Significant blood loss can occur very quickly. Women
can lose up to 500 ml of blood in 1 minute during a
PPH.
• The average woman has approximately 5 litres of
blood in her circulation. At this rate, it is possible for a
woman to become exsanguinated (lose all of her
blood) within 10 minutes. Rapid, efficient action must
be taken to save the woman‘s life and to prevent
complications related to significant blood loss
5/10/2021 Uma Gupta 20
21. Effects of PPH
• PPH is associated with orthostatic hypotension,
anemia, and fatigue.
• Postpartum anemia is associated with lactation failure
placing the health of the newly born infant at risk.
• It is also associated with postpartum depression that
may in turn affect maternal bonding with the
newborn. Maternal attachment to the newborn is
essential for the long-term well-being of the infant.
• Extreme fatigue resulting from anemia may make
maternal care of the newborn and other siblings more
difficult
5/10/2021 Uma Gupta 21
22. Etiology
• Causes of PPH in terms of the Four T‘s:
• Tone - uterine atony
• Tissue - retained placenta or clots
• Trauma - uterine, cervical, or vaginal injury
• Thrombin - pre-existing or acquired coagulopathy
5/10/2021 Uma Gupta 22
23. CAUSES - THE ‘FOUR Ts’ OF PPH
5/10/2021 Uma Gupta 23
CAUSE INCIDENCE (% )
TONE – atonic uterus 80
TRAUMA -
lacerations, rupture
10 – 15
TISSUE – retained
tissue
3 – 5
THROMBIN 1-2
24. Risk factors for postpartum hemorrhage
Etiologic Process (Cause) Clinical Risk Factors
Abnormalities
of Uterine
Contraction
(Tone)
Over-distended uterus
•Polyhydramnios
• Multiple gestation
• Macrosomia
Uterine muscle exhaustion
• Rapid labour
• Prolonged labour
• High parity
Intraamniotic infection • Fever
• Prolonged rupture of membranes
(ROM)
Functional or anatomic
distortion of the uterus, i.e.
distended bladder may
prevent contraction of the
uterus
• Fibroid uterus
• Placenta previa or abruptio
• Uterine anomalies
Uterine-relaxing
medications
• Halogenated anesthetics,
nitroglycerin, magnesium sulphate
5/10/2021 Uma Gupta 24
25. Living ligature
• Failure of this living ligature leads to atonicity of
uterus leading to PPH .
5/10/2021 Uma Gupta 25
26. Etiologic Process (Cause) Clinical Risk Factors
Retained
Products of
Conception
(Tissue)
Retained products
abnormal placentation
retained cotyledon or
succinturiate lobe
• Incomplete placenta at
delivery
• previous uterine surgery
• High parity
• Abnormal placenta on
ultrasound
• Retained blood clots •Atonic uterus
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27. Etiologic Process (Cause) Clinical Risk Factors
Genital Tract
Trauma
(Trauma)
• Tears (lacerations) of the cervix,
vagina, or perineum
• Ruptured vulval varicosities
• Precipitous delivery
• Operative delivery
• Mistimed or inappropriate
use of episiotomy
• Extensions, lacerations at cesarean
section • Malposition
• Deep engagement
Uterine rupture Previous uterine surgery
• Uterine inversion • High parity
• Fundal placenta
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28. Etiologic Process (Cause) Clinical Risk Factors
Abnormalities
of
Coagulation
(Thrombin)
• Pre-existing states
- hemophilia A
-von Willebrand‘s disease1
History of hereditary
coagulopathies
• History of liver disease
• Acquired in pregnancy
- idiopathic thrombocytopenic purpura2
- thrombocytopenia with preeclampsia
- disseminated intravascular coagulation
- preeclampsia
- dead fetus in utero
- severe infection/sepsis
- placental abruption
- amniotic fluid embolus
• bruising
• elevated BP
• elevated BP
• fetal demise
• fever
• elevated white blood
cells
• antepartum hemorrhage
• sudden collapse
Therapeutic anticoagulation history of thrombotic
disease
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29. Prevention
• Compared to expectant management, active
management of the third stage of labour (AMTSL) is
associated with
• ↓ maternal blood loss,
• ↓ postpartum hemorrhage,
• ↓ postpartum anemia,
• ↓ need for blood transfusions
• and a ↓ e in the incidence of prolonged third stage
of labour.
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30. What is active management of 3rd stage of labour?
Active management of 3rd stage of labour (AMTSL)
involves 3 steps after delivery of baby:
1. Uterotonic drug given immediately after birth of baby
2. Placenta delivered by controlled cord traction with
counter-traction on the fundus during contraction
3. Fundal massage after delivery of the placenta
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32. What are the oxytocic drugs used in AMTSL?
There are 4 kinds of drugs used in third stage of labor
• Oxytocin- posterior pituitary extract
• Ergometrine- preparation of ergot
• Syntometrine- combination of oxytocin and
ergometrine
• Misoprostol- prostaglandin E1 analogue
5/10/2021 Uma Gupta 32
33. Drugs Advantage Disadvantage
Oxytocin Causes uterus to contract
• Acts within 2.5 minutes when
given IM
• Generally does not cause side
effects
• Safe in hypertension
• IM or IV preparations only
• Not heat stable
Ergometrine Low price
• Effect lasts 2–4 hours
• Takes 6–7 minutes to
become effective when
given IM; oral form
insufficiently effective
• Causes tonic uterine
contraction
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34. Drugs Advantage Disadvantage
Syntometrine Combined effect of
rapid action of oxytocin
and sustained action of
ergometrine
Increased risk of
hypertension, nausea
and vomiting
• Not heat stable
Misoprostol
• Effective orally,
buccally, vaginally and
rectally
• Rapid absorption after
oral 3 minutes
T1/2 life = 20-40
minutes
• Predictable side
effects: shivering,
pyrexia, nausea,
vomiting and diarrhea
• Rate of PPH is higher
with misoprostol
compared to oxytocin.
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35. Management
of third stage
of labor
Blood Loss (>
1000 ml)
Physiologic 13-18%
Active
(oxytocin)
2.9%
Misoprostol 4%
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36. Management of PPH
Principles of management -
To replace the blood
To empty the uterus
To ensure effective hemostasis
For systematic management of PPH there is algorithm
known as
‘ HEMOSTASIS ’
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37. HEMOSTASIS
H: Ask for help
A: Assess (vitals, blood loss) & resuscitate
E: Establish etiology & check Ecbolics
(syntometrine, ergometrine)Ensure availability
of blood
M: Massage uterus
O: Oxytocin infusion, prostaglandins
S: Shift to operating room, exclude retained
products & trauma
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38. CONT…
T: Tissue & Trauma to be excluded , proceed for
Tamponade , bakri balloon, uterine packing
A : Apply compression sutures
S : Systematic pelvic devascularization (uterine,
ovarian, internal iliac artery ligation)
I : Intervention radiologist, uterine artery
embolization
S : Subtotal or total abdominal hysterectomy
5/10/2021 Uma Gupta 38
40. Volume Replacement
5. Fluid of Choice – Crystalloid over colloids
6. Crystalloid of choice – Ringer Lactate
7. Loss of 1 Lit of blood requires replacement
with 4-5 Lit of crystalloids (NS or RL) or
colloids until cross matched blood Is available
(1 ml of blood loss= 3 ml of crystalloids)
8. The recommended transfusion ratio for
PRBC:FFP:RDP IS 1:1:1
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41. Medical management
1 . FIRST LINE DRUG
Oxytocin:
• Start with 10 units im and Infusion of 20 units in 1L
@ 60 drops /min.
• Continue same dose @ 40 drops/min until bleeding
stops.
• Maximum dose of 3 liters of oxytocin infusion
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42. SECOND LINE DRUG
Ergometrine/ methyl ergometrine:
• Dose: 0.2 mg im or slow iv Repeat 0.2mg after 15
min.
• Maximum 5 doses (1 mg) can be given
• Syntometrine im
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43. Third line
Carboprost / (PGF2alpha)
Dose: 0.25mg (250µgm) mg im.
Can be repeated every 15 min. Maximum
upto 2 mg or8 doses can be given .
Misoprostol
• 200-800 µg sublingually. Do not exceed 800 µg
5/10/2021 Uma Gupta 43
44. 3. Bimanual
Compression
5/10/2021 Uma Gupta 44
•
•
•
•
Form a fist.
Place the fist in anterior
fornix & apply pressure
against the anterior wall of
uterus.
With the other hand press
deeply into the abdomen
behind the uterus to make it
anteverted.
Pressure against the posterior
wall of uterus Maintain
pressure until bleeding is
controlled & uterus contracts.
45. 4. Shift to OT
• Patient is to be shifted to O.T
• By P/S examination rule out trauma to perineum ,
vagina, and cervix .
• If required then hemostasis sutures are to be taken by
catgut suture.
• Also examine the placenta for its completeness.
• Exploration of uterus is done .
• Evacuation of any product of conception if retained.
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46. 5. Uterine tamponade
1.Tight uterine packing
2. Balloon tamponade
a. Bakri balloon
b. Sengstaken Blakemore catheter
c. Condom catheter
5/10/2021 Uma Gupta 46
47. Intrauterine packing
• A long gauze of 5 metre soaked in antiseptic cream
is introduced inside the uterus and placed in to the
fundal area.
• Exerts direct haemostatic effect to open uterine
sinuses.
• Obselete now days because of risk of intra uterine
sepsis .
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48. Balloon tamponade
• Balloon Inflate balloon with 200- 500 ml warm 0.9 %
Sodium chloride.
• It adapts to shape of the uterine cavity and occludes
the venous sinus.
• If the bleeding is controlled it known as Positive
Tamponade Test.
• The catheter should not be removed within 12-
24hrs.
• Effectiveness – 88%
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51. 6.Compression sutures
1. B - Lynch suture
2. Hayman suture
3. Cho suture
✓ These suture causes bimanual compression of the
uterus.
✓ Apposes anterior and posterior wall of uterus.
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54. 7. Systematic pelvic devascularization
▪ Ligation of Uterine arteries
▪Ligation of Tubal branch of ovarian artery
▪ Ligation of Internal iliac artery
➢ Ascending branch of uterine artery is ligated at
lateral border b/w upper and lower segment.
➢ And ovarian artery is ligated just below ovarian
ligament.
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55. Ligation of uterine and internal iliac
artery ( ascending branch)
5/10/2021 Uma Gupta 55
56. 8. Interventional radiology
• Angiographic selective arterial embolization
• Possible where facility of interventional radiology
available.
• Avoids hysterectomy
• Success rate of about 90 %
5/10/2021 Uma Gupta 56
57. 9. Hysterectomy
• If all procedures failed to control bleeding
Decision for hysterectomy is taken to
save mother life
• It may be subtotal or total hysterectomy.
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58. Transferring to referral centre
5/10/2021 Uma Gupta 58
As PPH precedes Death by 2 hours”
If initial medical therapy fails within Golden Hour, then
shift the patient to higher centre.
Two important life savior methods -;
➢ Aortic compression by Skilled Birth Attendant
➢ Non Pneumatic Anti Shock Garment
60. •
NASG is a simple device -
Neoprene
•Shunts blood to vital organs
(anti-shock)
•It can shunt about 500- 1500
ml into central pool
NON–PNEUMATIC ANTI SHOCK GARMENT
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61. PREVENTION:
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Prevention of PPH is not always possible but however its incidence can be reduced
By substantially assessing the risk factors and following guidelines as mentioned:
•ANTENATAL:
1.Improvement of health status of women and to keep the haemoglobin level
normal(>10g/dl), so that the patient can withstand some amount of blood loss.
2.High risk patients who are likely to develop PPH (such as twins, hydramnios, grand
multipara, history of previous pph, severe anemia) are to be screened.
3.Blood grouping should be done for all womenso that no time is wasted during
emergency.
62. 4. Placental localization should for all women with previous cesarean delivery by USG or
MRI to detect placenta accreta or percreta or to determine morbid adherent placenta.
P.P
5. Women with morbid adherent placenta are at high risk of developing pph. Such a case
should be delivered by senior obstetrician. Availability of blood and blood products must
ensured before hand.
• INTRANATAL:
1. Active management of the third stage, for all women in labor should be a routine as it
reduces PPh by 60%
2. Women delivered by cesarean section, oxytoxin 5 IU slow IV is to be given to reduce
blood loss. Carbetocin 100mcg is very useful to prevent PPH.
3. Exploration of the uterovaginal canal for evidence of trauma following difficult
labor or instrumental delivery.
4. Observation for about two hours after delivery to make sure that the uterus is hard and
well contracted before sending her to ward.
5. During cesarean section spontaneous separation and delivery of the placenta reduces
blood loss by 30%
6. Examination of the placenta and membranes should be a routine to detect at the
earliest any missing part.
5/10/2021 Uma Gupta 62
64. Question 1
• To be considered a PPH, what would the estimated
blood loss have to be for a C-section?
A. < 550 ML
B. > 600 ML
C. > 1000 ML
D. < 900 ML
5/10/2021 Uma Gupta 64
65. Question 1
• To be considered a PPH, what would the estimated
blood loss have to be for a C-section?
A. < 550 ML
B. > 600 ML
C. > 1000 ML
D. < 900 ML
5/10/2021 Uma Gupta 65
66. Question 2
• What types of trauma during labour and birth
would lead to PPH risk?
A. Instrumental assisted birth (vacuum or forceps)
B. C-Section
C. Lacerations of the cervix or vaginal wall
D. All of the above
5/10/2021 Uma Gupta 66
67. Question 2
• What types of trauma during labour and birth
would lead to PPH risk?
A. Instrumental assisted birth (vacuum or forceps)
B. C-Section
C. Lacerations of the cervix or vaginal wall
D. All of the above
5/10/2021 Uma Gupta 67
68. Question 3
• In which of these cases could you diagnose PPH
following vaginal delivery: 1. > 500 blood loss over
24 hrs 2. hypotension 3. tachycardia
A. 1 & 3
B. 2
C. 3
D. 1
5/10/2021 Uma Gupta 68
69. Question 3
• In which of these cases could you diagnose PPH
following vaginal delivery: 1. > 500 blood loss over
24 hrs 2. hypotension 3. tachycardia
A. 1 & 3
B. 2
C. 3
D. 1
5/10/2021 Uma Gupta 69
70. Question 4
• The 4 “T’s” of PPH are: 1. Trauma 2. Toxins 3.
Travel 4. Tissue 5. Threads 6. Thrombin 7.
Tears 8. Tone
A. 1, 4, 6 & 8
B. 1, 5 7 & 8
C. 1, 2, 3 & 6
D. 3, 4, 5 & 6
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71. Question 4
• The 4 “T’s” of PPH are: 1. Trauma 2. Toxins 3.
Travel 4. Tissue 5. Threads 6. Thrombin 7.
Tears 8. Tone
A. 1, 4, 6 & 8
B. 1, 5 7 & 8
C. 1, 2, 3 & 6
D. 3, 4, 5 & 6
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72. Question 5
• The normal blood flow through the placental site
each minute is 500-800 mls per minute.
A. True
B. False
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73. Question 5
• The normal blood flow through the placental site
each minute is 500-800 mls per minute.
A. True
B. False
5/10/2021 Uma Gupta 73
74. Question 6
• Which of these implantations would most likely
cause excessive bleeding?
A. Increta & Percreta
B. Normal & Accreta
C. Accreta & Increta
D. None of the above
5/10/2021 Uma Gupta 74
75. Question 6
• Which of these implantations would most likely
cause excessive bleeding?
A. Increta & Percreta
B. Normal & Accreta
C. Accreta & Increta
D. None of the above
5/10/2021 Uma Gupta 75
76. Question 7
• _________________ and ________________ are
the two most common causes of primary PPH.
(Tissue, Tone, Trauma, Thrombin)
5/10/2021 Uma Gupta 76
77. Question 7
• _____Tone__ and _Trauma__________ are the two
most common causes of primary PPH. (Tissue,
Tone, Trauma, Thrombin)
5/10/2021 Uma Gupta 77
78. Question 8
Ergometrine to control post-partum hemorrhage :
A. Is contraindicated in patient with high blood
pressure
B. It will not act on the smooth muscle of the blood
vessels
C. Intravenous root is the only way to be given
D. It can be used for induction of labor
E. Is safe in cardiac patient
5/10/2021 Uma Gupta 78
79. Question 8
Ergometrine to control post-partum hemorrhage :
A. Is contraindicated in patient with high blood
pressure
B. It will not act on the smooth muscle of the blood
vessels
C. Intravenous root is the only way to be given
D. It can be used for induction of labor
E. Is safe in cardiac patient
5/10/2021 Uma Gupta 79
80. Question 9
All of the following are used in treatment of PPH
except:
a.Misoprostol
b.Mifepristone
c.Carbaprost
d.Methyl ergometrine
5/10/2021 Uma Gupta 80
81. Question 9
All of the following are used in treatment of PPH
except:
a.Misoprostol
b.Mifepristone
c.Carbaprost
d.Methyl ergometrine
5/10/2021 Uma Gupta 81
82. Question 10
Carbetocin dose for PPH:
a.100 mcg IV
b.50 mcg IV
c.150 mcg IV
d.250 mcg IV
5/10/2021 Uma Gupta 82
83. Question 10
Carbetocin dose for PPH:
a.100 mcg IV
b.50 mcg IV
c.150 mcg IV
d.250 mcg IV
5/10/2021 Uma Gupta 83
84. Question 11
B Lynch suture is applied on:
a.Cervix
b.Uterus
c.Fallopian tube
d.Ovaries
5/10/2021 Uma Gupta 84
85. Question 11
B Lynch suture is applied on:
a.Cervix
b.Uterus
c.Fallopian tube
d.Ovaries
5/10/2021 Uma Gupta 85
86. Save the life of the one who
gives birth to a new life
THANK YOU
5/10/2021 Uma Gupta 86
87. Reference
1. DC Dutta’s OBSTETRICS Including Perinatology and Contraception. 9th Edition.
Jaypee New Delhi
2. Tect Book of Obstetrics Sheila Balakrishnan. Paras Publishers, Delhi
3. Self Assessment Review Obstetrics Sakshi Arora
4. Extracts from: http://www.commonhealth.in/pdf/8.pdf
5. World Health Organization. Managing complications in pregnancy and
childbirth: A
guide for midwives and doctors. . 2003.
5. Obstetrics by Ten Teachers. 20th Edition.CRC Press, Taylor and Francis group UK.
2017.
5/10/2021 Uma Gupta 87