Powders are mixtures of finely divided drugs or chemicals meant for internal or external use. They have advantages like good chemical stability and ease of swallowing large doses. However, powders can have disadvantages like misunderstanding the correct method of use and difficulty protecting hygroscopic materials from decomposition. Powders are prepared as divided doses or bulk mixtures and come in various forms like dusting powders, dentifrices, and insufflations. Proper particle size, mixing, and packaging are important to ensure uniform doses and stability. Hygroscopic powders require special techniques to prevent moisture absorption.
Pharmaceutical powders are mixtures of finely divided drugs or chemicals meant for internal or external use. Powders have advantages like good chemical stability and ease of swallowing large doses. However, powders also have disadvantages such as the potential for misunderstanding correct usage and difficulty making uniform individually wrapped doses. Proper mixing and particle size reduction are important to ensure homogeneity and the desired properties of pharmaceutical powders.
This document discusses pharmaceutical powders, including their advantages and disadvantages. Powders have good chemical stability and are useful for bulky or bitter drugs, but require careful instructions and packaging. Particle size affects properties like dissolution rate and uniformity. Powders are prepared by reducing particle size, mixing, and dividing into individual doses packaged in powder papers or other containers. Factors like hygroscopicity and potency influence preparation techniques.
This document discusses powders and granules used in pharmaceutical preparations. It defines powders as finely divided solids and describes their advantages as flexibility, good chemical stability, and rapid dispersion due to small particle size. Granules are agglomerates of powder particles that have better flow properties than powders. The document discusses methods for preparing powders and granules, including wet and dry granulation techniques. It also covers topics like particle size analysis, blending powders, and special powder formulations like effervescent granules.
This document discusses powder dosage forms, including their definition, advantages, disadvantages, classification, formulation, and characterization. Powders are intimate mixtures of dry, finely divided drugs and/or chemicals that can be used internally or externally. They have advantages like good stability, rapid onset of action, and ease of administration. However, they are not suitable for unstable, bitter, or hygroscopic drugs. The document outlines methods for obtaining powders, mixing them, and packaging different types including bulk powders, snuffs, dental powders, and insufflations. Characterization parameters like particle size and flow properties that influence formulation are also described.
Powders are a pharmaceutical dosage form consisting of finely divided drugs or chemicals meant for internal or external use. They provide flexibility in compounding but require accurate dosing. Powders can be bulk or divided. Bulk powders include oral powders for suspension, effervescent granules, dentifrice powders, douche powders, dusting powders, and insufflations. Divided powders are dispensed in individual doses in packets or foil. Proper mixing and accurate division of doses is important for powders.
Powders are mixtures of finely divided drugs and chemicals that may be intended for internal or external use. They offer advantages like rapid onset of action and ease of administration to infants. However, they can be difficult to formulate when drugs are hygroscopic, deliquescent, or efflorescent. Powder production involves size reduction, mixing, and packaging. Size reduction methods include cutting, compression, impact, and attrition. Mixing ensures uniform drug distribution and appearance. Hygroscopic powders require formulations like granules or packets to reduce moisture absorption.
This document discusses powders used in pharmaceutical preparations. Powders are mixtures of finely divided drugs and chemicals that can be used internally or externally. Powders are characterized based on properties like particle size, morphology, purity, solubility, and stability. Powder particle size ranges from 10 mm to 1 μm. Powders are analyzed using sieving, sedimentation rate, microscopy, and other methods. Proper particle size influences dissolution, suspension, distribution in mixtures, and other factors. Segregation during blending can be an issue and is influenced by particle size, shape, density, and other properties. Powders are used to prepare various dosage forms like tablets, capsules, liquids, and semisolids through processes like blending,
Pharmaceutical powders are mixtures of finely divided drugs or chemicals meant for internal or external use. Powders have advantages like good chemical stability and ease of swallowing large doses. However, powders also have disadvantages such as the potential for misunderstanding correct usage and difficulty making uniform individually wrapped doses. Proper mixing and particle size reduction are important to ensure homogeneity and the desired properties of pharmaceutical powders.
This document discusses pharmaceutical powders, including their advantages and disadvantages. Powders have good chemical stability and are useful for bulky or bitter drugs, but require careful instructions and packaging. Particle size affects properties like dissolution rate and uniformity. Powders are prepared by reducing particle size, mixing, and dividing into individual doses packaged in powder papers or other containers. Factors like hygroscopicity and potency influence preparation techniques.
This document discusses powders and granules used in pharmaceutical preparations. It defines powders as finely divided solids and describes their advantages as flexibility, good chemical stability, and rapid dispersion due to small particle size. Granules are agglomerates of powder particles that have better flow properties than powders. The document discusses methods for preparing powders and granules, including wet and dry granulation techniques. It also covers topics like particle size analysis, blending powders, and special powder formulations like effervescent granules.
This document discusses powder dosage forms, including their definition, advantages, disadvantages, classification, formulation, and characterization. Powders are intimate mixtures of dry, finely divided drugs and/or chemicals that can be used internally or externally. They have advantages like good stability, rapid onset of action, and ease of administration. However, they are not suitable for unstable, bitter, or hygroscopic drugs. The document outlines methods for obtaining powders, mixing them, and packaging different types including bulk powders, snuffs, dental powders, and insufflations. Characterization parameters like particle size and flow properties that influence formulation are also described.
Powders are a pharmaceutical dosage form consisting of finely divided drugs or chemicals meant for internal or external use. They provide flexibility in compounding but require accurate dosing. Powders can be bulk or divided. Bulk powders include oral powders for suspension, effervescent granules, dentifrice powders, douche powders, dusting powders, and insufflations. Divided powders are dispensed in individual doses in packets or foil. Proper mixing and accurate division of doses is important for powders.
Powders are mixtures of finely divided drugs and chemicals that may be intended for internal or external use. They offer advantages like rapid onset of action and ease of administration to infants. However, they can be difficult to formulate when drugs are hygroscopic, deliquescent, or efflorescent. Powder production involves size reduction, mixing, and packaging. Size reduction methods include cutting, compression, impact, and attrition. Mixing ensures uniform drug distribution and appearance. Hygroscopic powders require formulations like granules or packets to reduce moisture absorption.
This document discusses powders used in pharmaceutical preparations. Powders are mixtures of finely divided drugs and chemicals that can be used internally or externally. Powders are characterized based on properties like particle size, morphology, purity, solubility, and stability. Powder particle size ranges from 10 mm to 1 μm. Powders are analyzed using sieving, sedimentation rate, microscopy, and other methods. Proper particle size influences dissolution, suspension, distribution in mixtures, and other factors. Segregation during blending can be an issue and is influenced by particle size, shape, density, and other properties. Powders are used to prepare various dosage forms like tablets, capsules, liquids, and semisolids through processes like blending,
The document discusses pharmaceutical powders, including their advantages and disadvantages as a dosage form. It defines powders as intimate mixtures of dry, finely divided drugs and chemicals that can be used internally or externally. The document outlines different types of powders like bulk powders, simple powders, compound powders, and effervescent granules. It also describes methods of preparing powders, including particle size reduction, homogeneous mixing, packaging, and addressing special issues like volatile, hygroscopic, or efflorescent ingredients. Quality control testing of powders is also summarized.
Powders are solid dosage forms where drugs are dispensed in a finely divided state, with or without excipients. They have advantages like faster onset of action compared to other forms but also disadvantages like bitter drugs not being suitable. Powders are prepared through processes like size reduction, weighing ingredients, mixing through methods like spatulation or geometric dilution, and packaging. They are classified based on use and include bulk powders, simple/compound powders, and compressed powders.
Powders are mixtures of finely divided drugs and chemicals that can be used internally or externally. Powders consist of particles that can range in size from 10 mm to 1 μm. The particle size distribution and properties influence how powders can be used. Before using powders to make pharmaceutical products, their chemical and physical characteristics like morphology, purity, solubility, and stability are analyzed. Proper blending and avoiding segregation of powder mixtures is important for ensuring uniform and consistent dosing.
Powders are mixtures of finely divided drugs and chemicals that can be used internally or externally. Powders consist of particles that can range in size from 10 mm to 1 μm. The particle size distribution and other properties of powders are important and must be characterized. Powders are commonly used to make other dosage forms or are administered directly after mixing with water or other liquids. Some powders are intended for inhalation while others are reconstituted before oral or injectable use.
PowerPoint presentation on Powders: pharmaMyronFerrao1
Powders are mixtures of finely divided drugs or chemicals that can be used internally or externally. Powder particle sizes typically range from 0.1 to 10 microns. Smaller particle sizes dissolve faster and improve properties like suspendability and uniform distribution. Particle size affects dissolution rate, suspendability, distribution, penetrability, and grittiness. Powders are classified as divided or bulk and have advantages like stability and ease of swallowing but also disadvantages like misunderstanding instructions and protecting hygroscopic materials.
This document discusses powder dosage forms in pharmaceuticals. It defines powders and describes their advantages and disadvantages. The main types of powders are bulk powders for internal or external use, and divided powders packaged in packets, cachets, or capsules. Bulk powders require mixing before use while divided powders are pre-measured. Important considerations for powder formulation include particle size and flow properties. Common issues like hygroscopicity are also addressed.
This document provides information about tablet formulation and manufacturing. It discusses the different types of tablets, advantages and disadvantages of tablets, granulation process, tablet excipients including diluents, binders, disintegrants, lubricants and glidants. The key points covered are:
1) Tablets are solid oral dosage forms made by compressing powder mixtures into various shapes and sizes. They have advantages like precise dosing, stability and low cost of production.
2) Granulation is used to improve powder flow and compressibility. It can be done by wet or dry methods. Common excipients added to tablets include diluents, binders, disintegrants and lubricants which aid in tablet
This document discusses powders and granules used in pharmaceutical preparations. It begins by defining powders as mixtures of finely divided drugs or chemicals for internal or external use. The advantages of powders include stability, flexibility in dosing, and low cost of preparation. Challenges include unpleasant taste, instability of hygroscopic drugs, and difficulty dispensing small doses. Powders are generally prepared through comminution to reduce particle size and blending. The document then classifies and describes methods for different types of powders including bulk powders, simple/compound powders, powders in capsules/cachets, and those addressing special stability issues.
The document discusses powders as a dosage form of drugs for internal and external use. It defines powders as finely divided solid substances that can be used orally or topically. The advantages of powders include a wide range of ingredients, greater stability compared to liquids, and ease of large doses. Disadvantages include messiness, unpleasant taste, and issues with hygroscopic or volatile substances. Powders are classified as bulk, simple/compound, enclosed in cachets, or compressed into tablets. Bulk powders are used internally or externally, while simple powders contain one ingredient and compound powders contain multiple ingredients. Cachets enclose unpleasant powders, and tablets are compressed powders. Mixing methods include spatulation
This document provides information about tablets, including their formulation, design, manufacturing, types, advantages, and excipients. Tablets are solid oral dosage forms made by compressing powder mixtures into various shapes. They have advantages like precise dosing and ease of production. The document discusses different granulation and compression methods used in tablet manufacturing. It also describes common excipients like diluents, binders, disintegrants, lubricants and their functions in tablets.
Powders, granules, tablets and capsules are common solid oral dosage forms. Powders are mixtures of finely divided drugs or chemicals that can be used internally or externally. Particle size influences properties like dissolution rate and suspendability. Powders are classified based on number of active ingredients and mode of dispensing. Granules are agglomerates of powder particles made using a solvent or binder. They have better flow properties than powders. Granules can be coated to modify drug release. Effervescent granules contain acid and carbonate ingredients that react to produce carbon dioxide when mixed with water, masking unpleasant tastes.
Powders can be prepared on a small scale using mortars and pestles or spatulas for mixing. Larger scale mixing uses specialized equipment to rapidly and uniformly blend ingredients. Divided powders contain individually weighed doses packaged in paper or foil for administration. Bulk powders include oral powders mixed with water, dentifrices, dusting powders, and insufflations introduced into body cavities. Special techniques are needed for volatile, hygroscopic, or deliquescent substances to avoid degradation or inaccuracies in dosing.
This document defines powders and describes their uses in pharmaceutical preparations. Powders can be mixtures of dry particles intended for internal or external use. Particle size analysis is important for powders to characterize properties like dissolution and flow. Various methods are used to measure particle size, including sieving and sedimentation. Proper blending and comminution (size reduction) of powders is necessary for preparing uniform mixtures and formulations.
This document provides information about powders as a pharmaceutical dosage form. It begins with learning objectives about powders and then covers content such as the definition of powders, advantages and disadvantages, preparation methods, mixing techniques, classifications, weighing, and special considerations for dispensing powders. Methods for preparing powders include spatulation, trituration, geometric dilution, sifting, and tumbling. Powders are classified based on their intended use and form, such as bulk powders, simple/compound powders, powders in capsules, and compressed powders. Weighing techniques and issues related to accuracy are also discussed.
Pharmaceutical powders are solid dosage forms containing one or more drugs in finely divided form, with or without excipients. They have advantages like faster onset of action compared to other oral solid dosage forms. Powders are classified based on their intended use and formulation. They include bulk powders, simple/compound powders enclosed in papers or capsules, and compressed powders made into tablets. Proper mixing and packaging is important for powder formulations to ensure uniform drug content and stability.
This document discusses solid dosage forms, specifically powders. It defines powder as a solid dosage form containing finely divided drugs or chemicals that can be administered internally or externally. Powders are classified based on their intended use and form, such as bulk powders, simple/compound powders, powders in capsules/cachets, and compressed powders (tablets). Preparation methods like mixing, packing, and labeling are also outlined. Common bulk powders for external use include dusting powders, snuffs, and dentifrices. Powders provide advantages like stability and ease of administration but also have disadvantages like unpleasant taste and instability of some drugs.
Granules are aggregations of fine powder particles that are roughly spherical in shape. They are produced to improve powder flowability, enhance compressibility, reduce toxicity, and prevent caking. There are three main granulation methods: wet granulation, dry granulation, and granulation by crystallization. Wet granulation is most common and involves mixing powder with a liquid to form a paste, then granulating and drying the paste. Granules are sieved after drying to achieve a uniform size distribution suitable for their intended use as a final or intermediate pharmaceutical product. Quality tests such as dissolution and friability are performed to ensure granule properties are suitable.
Powders are solid dosage forms consisting of finely divided drugs and chemicals meant for both internal and external use. They are classified as bulk powders, divided powders, granules, and those contained in capsules. Bulk powders are less accurate but more stable than other forms. Divided powders allow accurate dosing. Granules can mask unpleasant tastes and are easier to swallow than powders. Other solid dosage forms discussed include tablets, capsules, lozenges, pills, and pastilles, each having advantages and disadvantages for drug delivery and patient acceptance.
The document discusses pharmaceutical powders, including their advantages and disadvantages as a dosage form. It defines powders as intimate mixtures of dry, finely divided drugs and chemicals that can be used internally or externally. The document outlines different types of powders like bulk powders, simple powders, compound powders, and effervescent granules. It also describes methods of preparing powders, including particle size reduction, homogeneous mixing, packaging, and addressing special issues like volatile, hygroscopic, or efflorescent ingredients. Quality control testing of powders is also summarized.
Powders are solid dosage forms where drugs are dispensed in a finely divided state, with or without excipients. They have advantages like faster onset of action compared to other forms but also disadvantages like bitter drugs not being suitable. Powders are prepared through processes like size reduction, weighing ingredients, mixing through methods like spatulation or geometric dilution, and packaging. They are classified based on use and include bulk powders, simple/compound powders, and compressed powders.
Powders are mixtures of finely divided drugs and chemicals that can be used internally or externally. Powders consist of particles that can range in size from 10 mm to 1 μm. The particle size distribution and properties influence how powders can be used. Before using powders to make pharmaceutical products, their chemical and physical characteristics like morphology, purity, solubility, and stability are analyzed. Proper blending and avoiding segregation of powder mixtures is important for ensuring uniform and consistent dosing.
Powders are mixtures of finely divided drugs and chemicals that can be used internally or externally. Powders consist of particles that can range in size from 10 mm to 1 μm. The particle size distribution and other properties of powders are important and must be characterized. Powders are commonly used to make other dosage forms or are administered directly after mixing with water or other liquids. Some powders are intended for inhalation while others are reconstituted before oral or injectable use.
PowerPoint presentation on Powders: pharmaMyronFerrao1
Powders are mixtures of finely divided drugs or chemicals that can be used internally or externally. Powder particle sizes typically range from 0.1 to 10 microns. Smaller particle sizes dissolve faster and improve properties like suspendability and uniform distribution. Particle size affects dissolution rate, suspendability, distribution, penetrability, and grittiness. Powders are classified as divided or bulk and have advantages like stability and ease of swallowing but also disadvantages like misunderstanding instructions and protecting hygroscopic materials.
This document discusses powder dosage forms in pharmaceuticals. It defines powders and describes their advantages and disadvantages. The main types of powders are bulk powders for internal or external use, and divided powders packaged in packets, cachets, or capsules. Bulk powders require mixing before use while divided powders are pre-measured. Important considerations for powder formulation include particle size and flow properties. Common issues like hygroscopicity are also addressed.
This document provides information about tablet formulation and manufacturing. It discusses the different types of tablets, advantages and disadvantages of tablets, granulation process, tablet excipients including diluents, binders, disintegrants, lubricants and glidants. The key points covered are:
1) Tablets are solid oral dosage forms made by compressing powder mixtures into various shapes and sizes. They have advantages like precise dosing, stability and low cost of production.
2) Granulation is used to improve powder flow and compressibility. It can be done by wet or dry methods. Common excipients added to tablets include diluents, binders, disintegrants and lubricants which aid in tablet
This document discusses powders and granules used in pharmaceutical preparations. It begins by defining powders as mixtures of finely divided drugs or chemicals for internal or external use. The advantages of powders include stability, flexibility in dosing, and low cost of preparation. Challenges include unpleasant taste, instability of hygroscopic drugs, and difficulty dispensing small doses. Powders are generally prepared through comminution to reduce particle size and blending. The document then classifies and describes methods for different types of powders including bulk powders, simple/compound powders, powders in capsules/cachets, and those addressing special stability issues.
The document discusses powders as a dosage form of drugs for internal and external use. It defines powders as finely divided solid substances that can be used orally or topically. The advantages of powders include a wide range of ingredients, greater stability compared to liquids, and ease of large doses. Disadvantages include messiness, unpleasant taste, and issues with hygroscopic or volatile substances. Powders are classified as bulk, simple/compound, enclosed in cachets, or compressed into tablets. Bulk powders are used internally or externally, while simple powders contain one ingredient and compound powders contain multiple ingredients. Cachets enclose unpleasant powders, and tablets are compressed powders. Mixing methods include spatulation
This document provides information about tablets, including their formulation, design, manufacturing, types, advantages, and excipients. Tablets are solid oral dosage forms made by compressing powder mixtures into various shapes. They have advantages like precise dosing and ease of production. The document discusses different granulation and compression methods used in tablet manufacturing. It also describes common excipients like diluents, binders, disintegrants, lubricants and their functions in tablets.
Powders, granules, tablets and capsules are common solid oral dosage forms. Powders are mixtures of finely divided drugs or chemicals that can be used internally or externally. Particle size influences properties like dissolution rate and suspendability. Powders are classified based on number of active ingredients and mode of dispensing. Granules are agglomerates of powder particles made using a solvent or binder. They have better flow properties than powders. Granules can be coated to modify drug release. Effervescent granules contain acid and carbonate ingredients that react to produce carbon dioxide when mixed with water, masking unpleasant tastes.
Powders can be prepared on a small scale using mortars and pestles or spatulas for mixing. Larger scale mixing uses specialized equipment to rapidly and uniformly blend ingredients. Divided powders contain individually weighed doses packaged in paper or foil for administration. Bulk powders include oral powders mixed with water, dentifrices, dusting powders, and insufflations introduced into body cavities. Special techniques are needed for volatile, hygroscopic, or deliquescent substances to avoid degradation or inaccuracies in dosing.
This document defines powders and describes their uses in pharmaceutical preparations. Powders can be mixtures of dry particles intended for internal or external use. Particle size analysis is important for powders to characterize properties like dissolution and flow. Various methods are used to measure particle size, including sieving and sedimentation. Proper blending and comminution (size reduction) of powders is necessary for preparing uniform mixtures and formulations.
This document provides information about powders as a pharmaceutical dosage form. It begins with learning objectives about powders and then covers content such as the definition of powders, advantages and disadvantages, preparation methods, mixing techniques, classifications, weighing, and special considerations for dispensing powders. Methods for preparing powders include spatulation, trituration, geometric dilution, sifting, and tumbling. Powders are classified based on their intended use and form, such as bulk powders, simple/compound powders, powders in capsules, and compressed powders. Weighing techniques and issues related to accuracy are also discussed.
Pharmaceutical powders are solid dosage forms containing one or more drugs in finely divided form, with or without excipients. They have advantages like faster onset of action compared to other oral solid dosage forms. Powders are classified based on their intended use and formulation. They include bulk powders, simple/compound powders enclosed in papers or capsules, and compressed powders made into tablets. Proper mixing and packaging is important for powder formulations to ensure uniform drug content and stability.
This document discusses solid dosage forms, specifically powders. It defines powder as a solid dosage form containing finely divided drugs or chemicals that can be administered internally or externally. Powders are classified based on their intended use and form, such as bulk powders, simple/compound powders, powders in capsules/cachets, and compressed powders (tablets). Preparation methods like mixing, packing, and labeling are also outlined. Common bulk powders for external use include dusting powders, snuffs, and dentifrices. Powders provide advantages like stability and ease of administration but also have disadvantages like unpleasant taste and instability of some drugs.
Granules are aggregations of fine powder particles that are roughly spherical in shape. They are produced to improve powder flowability, enhance compressibility, reduce toxicity, and prevent caking. There are three main granulation methods: wet granulation, dry granulation, and granulation by crystallization. Wet granulation is most common and involves mixing powder with a liquid to form a paste, then granulating and drying the paste. Granules are sieved after drying to achieve a uniform size distribution suitable for their intended use as a final or intermediate pharmaceutical product. Quality tests such as dissolution and friability are performed to ensure granule properties are suitable.
Powders are solid dosage forms consisting of finely divided drugs and chemicals meant for both internal and external use. They are classified as bulk powders, divided powders, granules, and those contained in capsules. Bulk powders are less accurate but more stable than other forms. Divided powders allow accurate dosing. Granules can mask unpleasant tastes and are easier to swallow than powders. Other solid dosage forms discussed include tablets, capsules, lozenges, pills, and pastilles, each having advantages and disadvantages for drug delivery and patient acceptance.
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The document summarizes the One-Minute Preceptor (OMP) teaching model. The OMP is a brief clinical teaching tool that uses 5 microskills to organize learning experiences for students. The goal of the OMP model is to provide clinical preceptors with the tools to teach a general principle to students in 5 minutes or less, with the aims of increasing student involvement with patients, clinical reasoning skills, and providing concise feedback. The 5 microskills of the OMP method are: 1) get a commitment from the student about their findings or plan, 2) probe the student to provide supporting evidence, 3) reinforce what the student did well, 4) provide guidance about errors or omissions, and 5) teach
Bronchitis is an infection and inflammation of the bronchial tubes that make up the airways of the lungs. It is usually caused by viruses or bacteria. There are two main types: acute bronchitis, which is a short illness following a cold or flu, and chronic bronchitis, a long-term irreversible illness where patients have a daily cough producing mucus for at least 3 months per year. Symptoms include cough, sputum production, shortness of breath, wheezing, and fatigue. Diagnosis involves taking a medical history, physical examination, sputum culture, chest x-ray, and pulmonary function tests. Treatment focuses on antibiotics, cough medicines, bronchodilators, anti-inflammatory drugs,
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STADA Arzneimittel AG is a German pharmaceutical company headquartered in Bad Vilbel, Germany that was founded in 1895 when pharmacists teamed up to jointly produce medicines. In 1960, Hemofarm AD was founded in Vršac, Serbia and is now a leading generic pharmaceutical producer in the region. Hemofarm joined STADA group in 2006 and STADA is now one of the largest generic pharmaceutical companies worldwide.
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This document provides an overview of suppositories, including:
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Rate Controlled Drug Delivery Systems, Activation Modulated Drug Delivery Systems, Mechanically activated, pH activated, Enzyme activated, Osmotic activated Drug Delivery Systems, Feedback regulated Drug Delivery Systems systems are discussed here.
TEST BANK For Accounting Information Systems, 3rd Edition by Vernon Richardso...rightmanforbloodline
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The best massage spa Ajman is Chandrima Spa Ajman, which was founded in 2023 and is exclusively for men 24 hours a day. As of right now, our parent firm has been providing massage services to over 50,000+ clients in Ajman for the past 10 years. It has about 8+ branches. This demonstrates that Chandrima Spa Ajman is among the most reasonably priced spas in Ajman and the ideal place to unwind and rejuvenate. We provide a wide range of Spa massage treatments, including Indian, Pakistani, Kerala, Malayali, and body-to-body massages. Numerous massage techniques are available, including deep tissue, Swedish, Thai, Russian, and hot stone massages. Our massage therapists produce genuinely unique treatments that generate a revitalized sense of inner serenely by fusing modern techniques, the cleanest natural substances, and traditional holistic therapists.
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Map: https://cutt.ly/BwCeflYo
Name: Apollo Hospital
Address: Singar Nagar, LDA Colony, Lucknow, Uttar Pradesh 226012
Phone: 08429021957
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A feeding plate is a prosthetic device used for newborns with a cleft palate to assist in feeding and improve nutrition intake. From a prosthodontic perspective, this plate acts as a barrier between the oral and nasal cavities, facilitating effective sucking and swallowing by providing a more normal anatomical structure. It helps to prevent milk from entering the nasal passage, thereby reducing the risk of aspiration and enhancing the infant's ability to feed efficiently. The feeding plate also aids in the development of the oral muscles and can contribute to better growth and weight gain. Its custom fabrication and proper fitting by a prosthodontist are crucial for ensuring comfort and functionality, as well as for minimizing potential complications. Early intervention with a feeding plate can significantly improve the quality of life for both the infant and the parents.
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The South Beach Coffee Java Diet is a variation of the popular South Beach Diet, which was developed by cardiologist Dr. Arthur Agatston. The original South Beach Diet focuses on consuming lean proteins, healthy fats, and low-glycemic index carbohydrates. The South Beach Coffee Java Diet adds the element of coffee, specifically caffeine, to enhance weight loss and improve energy levels.
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In order to protect visitors' safety and wellbeing, Travel Clinic Leicester offers a wide range of travel-related health treatments, including individualized counseling and vaccines. Our team of medical experts specializes in getting people ready for international travel, with a particular emphasis on vaccines and health consultations to prevent travel-related illnesses. We provide a range of travel-related services, such as health concerns unique to a trip, prevention of malaria, and travel-related medical supplies. Our clinic is dedicated to providing top-notch care, keeping abreast of the most recent recommendations for vaccinations and travel health precautions. The goal of Travel Clinic Leicester is to keep you safe and well-rested no matter what kind of travel you choose—business, pleasure, or adventure.
2. Powders
2
A Pharmaceutical powder is a mixture of finely
divided drugs or chemicals in a dry form meant
for internal or external use.
3. Advantages of Powders:
3
Good chemical stability compared with fluids
useful for bulky drugs with large dose, e.g.
indigestion powder.
Easy to swallow even in large bulk, especially if
mixed with drink food (useful for stomach- tube
feeding)
The smaller particle size of powders causes more
rapid dissolution in body fluids, increases drug
bioavailability, and decreases gastric irritation
compared with tablets
4. Disadvantages of Powders
4
1. Patient
method of
may misunderstand
use. Without clear
the correct
instruction,
patients may inhale through the nose a drug
intended for oral administration. In oral
administration, it may have to be clear whether
the drug has to be dissolved first in water or
taken as it is.
5. Disadvantages of Powders
5
2. It is undesirable to take bitter or unpleasant
tasting drugs by oral administration. Many
herbal drugs (mainly infusions in boiling water)
have very bitter tastes. To overcome the
unpleasant taste of the extracts, it was often told
that “bitter medicine is better medicine.” This
may not necessarily be true.
6. Disadvantages of Powders
6
3. It is difficult to protect powders
containing hygroscopic, deliquescent
(tending to melt or dissolve in humid
environment), or aromatic materials from
decomposition.
7. Disadvantages of Powders
7
4. Uniform, individually wrapped doses of
powders (sachets) are required and this
may increase the manufacturing expense.
(It is possible to include a spoon in a packet
of powder drug. This may result in
inaccurate amount of drug delivered).
8. Disadvantages of Powders
8
5. Powder must be a homogeneous blend of all
of the components and must be of the most
advantageous particle size. The particle size of
a drug influences the rate of solubility in water.
It may also influence the biological activity of
a drug
10. Oral divided powder may contain one
or more active ingredients together
with an inert diluent to produce a
minimum quantity of 120 mg.
Oral undivided powder are usually a
simple mixture of the prescribed
medication without additional
ingredients.
10
11. Particle Size of Powders
11
United States Pharmacopeia (USP) classify
powders as: very coarse, coarse, moderately
coarse, fine, and very fine.
These are related to the proportion of powder that
is capable of passing through the openings of
standard sieves of varying fineness in a specified
period while being shaken, generally in a
mechanical sieve shaker.
12. Very coarse (No. 8): All particles pass through a No. 8
sieve and not more than 20% pass through a No. 60
sieve.
Coarse (No. 20): All particles pass through a No. 20
sieve and not more than 40% pass through a No. 60
sieve.
Moderately coarse (No. 40): All particles pass through
a No. 40 sieve and not more than 40% pass through a
No. 80 sieve.
12
13. Fine (No. 60): All particles pass through a No. 60
sieve and not more than 40% pass through a No.
100 sieve.
Very fine (No. 80): All particles pass through a
No. 80 sieve. There is no limit to greater fineness.
Granules fall within the range of 4- to 12-sieve size,
although granulations of powders prepared in the 12- to 20
sieve range are sometimes used in tablet making.
13
14. Effects of Particle Size
14
Dissolution rate of particles intended to dissolve;
drug micronization can increase the rate of drug
dissolution and its bioavailability
Suspendability of particles intended to remain
undissolved but uniformly dispersed in a liquid
vehicle (e.g., fine dispersions have particle
approximately 0.5 to 10 μm)
15. Effects of Particle Size
15
Uniform distribution of a drug substance in a powder
mixture or solid dosage form to ensure dose-to-dose
content uniformity.
Penetrability of particles intended to be inhaled for
deposition deep in the respiratory tract (e.g., 1 to
5μm).
Lack of grittiness of solid particles in dermal
ointments, creams, and ophthalmic preparations
(e.g., fine powders may be 50 to 100 μm in size).
16. Particle Size Determination
Sieving
Particles are passed by mechanical shaking through a
series of sieves of known and successively smaller
size and the proportion of powder passing through or
being withheld on each sieve is determined (range
about 40 to 9,500 μm, depending upon sieve sizes).
16
17. Coulter Counter
17
Coulter counter determines the
volume distribution of particles
suspended in an electrolyte-
containing solution. When a particle
passes through a small orifice, it
blocks the electric current. The
information on particle volume is used
for calculating particle size assuming
a spherical shape.
18. Other methods
Microscopic analysis (0.2 to 100m)
Sedimentation Rate (0.8 to 300 m)
Light Scattering (0.2 to 500m)
Permeability methods (>1 m)
Laser diffraction analysers(0.02 to
2000m)
Laser holography (1.4 to 100m)
Electronic particle counters
19. Preparation of Powders
19
1 Reduction of particle size of all
ingredients to the same range to
prevent stratification.
2 Sieving.
3Weighing of each ingredient.
4- Mixing.
5- Packaging.
20. Reduction of Particle Size
20
The manually operated procedures are trituration,
pulverization and levigation.
1- Trituration: is used to comminute( reduce particle
size) & to mix powders.
1-A porcelin preferred than glass morter.
2- A glass morter is preferrable for chemicals that stain a
porcelin. When granular or crystalline materials are to
be incorporated in to powdered product ,these
materials are comminuted individually and then blended
together in the morter.
21. 2- Pulverization
21
Substance are reduced& subdivided with an additional
material ( i.e solvent) that can be removed easily
after pulverization is complete.
* This technique is applied to
Substances which are gummy and tend to
reagglomerate or which resist grinding. As camphor
which is gummy, so addition of alcohol or other
volatile solvent can be reduced readily to a fine
powder.
Similarly, iodine crystals may be comminuted with the
aid of ether.
In both instances the solvent is permitted to evaporate
and the powdered material is recovered
22. 3- Levigation
22
In this process
A- paste is first formed by the
addition of a suitable non solvent to
the solid material.
B-Particle-size reduction then
accomplished by rubbing the paste
in a mortar with a pestle or on an
ointment’ slab using a spatula.
24. Mixing of powders
24
Large-Scale Mixing Equipment
The ideal mixer should
1 produce a complete blend rapidly to avoid
product damage.
2It should be cleaned and discharged easily
3- be dust-tight
4 require low maintenance and low power
consumption.
25. Small-Scale Mixing Equipment
25
1- Mortar and pestle
* The pharmacist most generally employs the mortar and pestle for
the small-scale mixing
* The mortar and pestle method is a single operation. Thus, it is
particularly useful where some degree of particle-size reduction
as well as mixing is required as in the case of mixtures of
crystalline material.
26. Small-Scale Mixing Equipment
26
2- Spatulation
The blending of powders with a spatula on a tile
or paper used sometimes for small quantities
or when the mortar and pestle technique is
undesirable.
It is not suitable for large quantities of powders
or for powders containing one or more potent
substance because homogenous blending may
not occur.
27. Small-Scale Mixing Equipment
27
3- Sieving
Sieving usually is employed as a pre-or
post-mixing method to reduce loosely held
agglomerates and to increase the overall
effectiveness of blending process.
29. Extemporaneous Techniques
29
1. Use of geometric dilution for the incorporation of small
amounts of potent drugs
Geometric dilution:
Entire quantity of potent drug (x volume) + (x volume)
of the diluents + (2x volume) of the diluents + (4x
volume) of the diluents………repeated until all the
diluents are used.
30. Extemporaneous Techniques
30
2. Reduction of particle size of all ingredients to
the same range.
3. Sieving when necessary to achieve mixing or
reduction of agglomerates, especially in
powders into which liquids have been
incorporated.
4. Heavy trituration, when applicable, to reduce
the bulkiness of a powder.
5. Protection against humidity, air oxidation and
loss of volatile ingredients.
31. Powders are prepared most commonly
either as:
1 Divided powders and bulk powders
which are mixed with water prior to
administration
2 Dusting powders which are applied
locally.
3 Dentifrices
4 Insufflations
31
32. Divided Powders
32
Are dispensed in the form of
individual doses and generally are
dispensed in papers, properly folded
(chartulae). They also may be
dispensed in metal foil, small heat-
sealed plastic bags or other
containers.
33. Divided Powders
33
- After weighing, comminuting and mixing
the ingredients, the powders must be
divided accurately into the prescribed
number of doses. In order to achieve
accuracy consistent with the other steps in
the preparation, each dose should
be weighed individually and transferred to a
powder paper. Following completion of this
step the powder papers are folded.
34. Powder Papers
34
- Four basic types of powder papers are
available.
1. Vegetable parchment, a thin semi-
opaque moisture-resistant paper.
2. White bond, an opaque paper with no
moisture-resistant properties.
3. Glassine, a glazed, transparent moisture-
resistant paper.
4. Waxed,( Parrafin) a transparent
waterproof paper.
35. Powder Papers
35
Hygroscopic and volatile drugs can be
protected best by using a waxed
paper, double-wrapped with a bond
paper to improve the appearance of
the completed powder.
Parchment and glassine papers offer
limited protection for these drugs.
36. Bulk Powders
36
may be classified as oral powders, dentifrices, douche
powders, dusting powders, insuffiations and
triturations.
Oral Powders - These generally are supplied as finely
divided powders or effervescent granules.The finely
divided powders are intended to be suspended or
dissolved in water or mixed with soft foods, prior to
administration.
Antacids and laxative powders frequently are
administered in this form
37. 37
Dusting Powders
These are locally applied nontoxic preparations that are
intended to have no systemic action.
Requirements:
1- Homogenous and very fine
2- Free from irritation.
3 Flow easily.
4 Have good covering capacity.
5Have good adsorptive and absorptive capacity.
6- Spread uniformly over body surface.
7 Cling (adhere) to skin surface after application.
8 Protect the skin from irritation caused by friction, moisture
and chemical irritants.
38. Dusting Powders
38
Application:
1 Medicated dusting powders may be applied either to
intact skin or to open wound and mucous
membranes.
2 powders applied to open wound must be sterilized
3 Particle size should be very small. It is better to be
micronized or those passes through # 100 sieve.
4 Highly sorptive powders should not be used on areas
exude large quantities of fluids to avoid hard crust
formation.
Function:
Lubricants- protective- adsorbents- antiseptic -
astringents- antiperspirants
39. Dusting Powders
39
Packaging:
Dispensed in sifter- top cans or pressurized
packs (aerosols).
Aerosols protect the powder from air, moisture
and contamination and more convenient for
application.
40. Insufflations
40
- These are finely divided powders
introduced into body cavities such
as the ears, nose, throat, tooth
sockets and vagina. An insufflator
(powder blower) usually is
employed to administer these
products.
41. Insufflations
41
However, the difficulty in obtaining
a uniform dose has restricted their
general use.
Specialized equipment has been
developed for the administration of
micronized powders of relatively
potent drugs. The Norisodrine
Sulfate Aerohaler Cartridge (Abbott)
is an example.
42. In the use of this Aerohaler, inhalation by the patient
causes a small ball to strike a cartridge containing the
drug. The force of the ball shakes the proper amount
of the powder free, permitting its inhalation. Another
device, the Spin haler turbo-inhaler (Fisons), is a
propeller-driven device designed to deposit a mixture
of lactose and micronized cromolyn sodium into the
lung as an aid in the management of bronchial
asthma.
42
43. A general-purpose powder blower or insufflator.
The powder is placed in the vessel. When the
rubber bulb is depressed, internal turbulence
disperses the powder and forces it from the orifice.
Powders may be delivered to various body
locations such as the nose, throat, tooth sockets,
or skin.
43
44. Douche Powders
44
These products are completely soluble and are
intended to be dissolved in water prior to use as
antiseptics or cleansing agents for a body cavity.
They most commonly are intended for vaginal use,
although they may be formulated for nasal, otic or
ophthalmic use. Generally, aromatic oils are
included in these powders.
Dispensing in wide-mouth glass jars serves to
protect against loss of volatile materials and
permits easy access by the patient
45. Dentifrices
45
These may be prepared in the form of a
bulk powder, generally containing a soap
or detergent, mild abrasive and an
anticariogenic agent.
46. -
46
These are dilutions of potent powdered drugs,
prepared by intimately mixing them with a suitable
diluent in a definite proportion by weight. They were
at one time official as 1 to 10 dilutions.
The pharmacist sometimes prepares triturations of
poisonous substances, eg, atropine, in a convenient
concentration using lactose as the diluent, for use at
the prescription counter.
Triturations
47. The correct procedure for preparing such triturations or
any similar dilution of a potent powder medicament, to
insure uniform distribution of the latter, is:
1 Reduce the drug to a moderately fine powder in a
mortar.
2 Add about an amount of diluents & mix well by thorough
trituration in the mortar.
3 Successively add portions of diluent ,triturating after
each addition ,until the entire quantity of diluent has
been incorporated. Under no circomostances should
the entire quantity of of diluent be added at once to the
drug that is to be diluted, ununiform dispersion will be
achieved
47
Triturations
48. Problems encountered in powder
formulation
48
1- Hygroscopic and Deliquescent Powder
Problem: Absorption of moisture from air
leading to partial or complete liquefaction.
Solution: A- Applied in a granular form to
decrease the exposed surface to air.
B- Packed in aluminum foil or in plastic film
packets
C- Addition of light magnesium oxide to reduce
the tendency to damp
D- Addition of adsorbent materials such as
starch
Examples: - halide salts (ex. Sod. Iodide)
- Certain alkaloids (physostigmine Hcl)
49. Problems encountered in powder
formulation
2- Efflorescent powders
Problem: Crystalline substances which
during storage loose their water of
crystallization and change to powder
(to be efflorescent). The liberated
water convert the powder to a paste
or to a liquid.
Examples: Alum- atropine sulfate-
citric acid- codeine phosphate…
Solution: Using the anhydrous form,
and treating it in a manner similar to
hygroscopic powders
49
50. Problems encountered in powder
formulation
50
3- Eutectic Mixtures
Problem: mixture of substances that liquefy when
mixed, rubbed or triturated together. The melting
points of many eutectic mixtures are below room
temperature.
Examples: menthol- thymol- phenol-camphor…….
Solution: A- using inert adsorbent such as starch,
talc, lactose to prevent dampness of the powder
B- dispensing the components of the eutectic
mixture separately.
51. Problems encountered in powder
formulation
51
4- Potent Drug
Problem: Limited precision and accuracy of the
used balances to weight small amounts of
potent drugs.
Solution: Drug triturates:
A- Suitable diluents like lactose are mixed with
the potent drug to form 10 - 20%w/w drug
triturates.
B- Very fine powders should be used in the
triturates
C- Geometric dilution to prepare drug triturates
52. Problems encountered in powder
formulation
52
5- Incompatible salts
Problem: Chemically incompatible salts when triturated
together produce discoloration, chemical deterioration or
loss of potency.
Solution:
A- Compounding such substances with minimum
pressure
B- Use a convenient method for mixing the powder like
tumbling in a jar or spatulation on a sheet of paper.
C- Each substance should be powdered separately in a
clean mortar and then combined with other ingredients
gently.
D- Powder and dispense separately.
53. Problems encountered in powder
formulation
53
6- Explosive mixtures
Problem: Oxidizing agents(ex. Pot. Salts of
chlorate, dichromate, permanganate and
nitrate- Sod. Peroxide- silver nitrate and silver
oxide) explore violently when triturated in a
mortar with a reducing agent ( ex. sulfides-
sulfur- tannic acid- charcoal).
Solution:
A- Comminute each salt separately.
B- Subject to a minimum pressure.
54. 54
Effervescent Powders
Definition: Mixture of organic acid and alkali
effervesces when subjected to water due to
reaction between the acid and the base with
evolution of co2
Examples: Citric or tartaric acids with sodium
carbonate or bicarbonate
Uses: The liberated carbon dioxide has the
following advantages:
It masks the bitter and nauseous taste.
It promotes gastric secretions.
It acts as a carminative.
psychological impression at the patient..
55. Effervescent Powders
55
Formulation:
- Bulk powders or divided powders
-Packed in separate packages of
contrasting colors.
-The contents are mixed in a
quantity of water at the time of
dosing.
-The liquid is consumed just after
the reaction begin to subside.
56. Effervescent Granules
56
Definition: Sweetened effervescent
powders formulated as granules.
Granulation:
1Wet method: By the addition of a
binding liquid (Alcohol is frequently
used).
2Dry method: Heating effloresced
powder to liberate the water of
crystallization which then acts as the
binding agent
57. Effervescent Granules
57
Wet Granulation
Procedure:
1The powders are mixed without pressure in
a suitable container.
2Alcohol is added in portions with stirring
until a dough like mass is formed.
3The materials are then passed through sieve
# 6.
4The resulted granules are dried at a
temperature not exceeding 50ºC.
5The granules are packed in air tight
containers