This document discusses the field of immunotoxicology and the immunosuppressive effects that various drugs and heavy metals can have on the immune system. Immunotoxicology is the study of how chemicals like pharmaceuticals can impair immune function by causing immunosuppression, immunostimulation, hypersensitivity, and autoimmunity. Common drugs like alcohol, benzodiazepines, NSAIDs, and opioids have been shown to negatively impact immune cells and responses. Heavy metals such as cadmium and lead can also influence the immune system by reducing antibody production and affecting lymphoid organs. Understanding these immunomodulatory effects is important for evaluating vaccine effectiveness and managing infection risk.