Posology is the science of determining drug doses. The optimal dose varies between individuals due to factors like age, health, weight, drug interactions, and rate of drug elimination from the body. Elderly and children typically require lower doses than adults. Drug effects also depend on route of administration, time of administration, environmental factors, and presence of disease. Drug interactions like additive effects, synergism, antagonism, and tolerance further complicate determining proper dosages.
posology is a branch of medical science which deals with dose or quantity of drugs which can be administered to a patient to get the desired pharmacological actions.
posology is a branch of medical science which deals with dose or quantity of drugs which can be administered to a patient to get the desired pharmacological actions.
Before prescribing any pharmaceutical medicine, the physician should consider certain factors that can modify the effect of the drug. The same dose of a drug can produce different degrees of response in different patients and even in the same patient under different situations. The Important factors modify the effect of a drug are subdivided into two groups: patient related factors and drug related factors.
• Patient related factors: age, gender, body weight, presence of food, drug allergy, genetic variation, environmental state, pathological state, psychological state, etc.
• Drug related factors: physical state of a drug, route of drug administration, time of drug administration, drug cumulation, drug combination, drug tolerance, drug dependence, etc.
This ppt covers definition of Posology, Therapeutic dose, Official doses, factors deciding dose calculation, and formulae used for child dose calculation.
It is useful for medical and pharmacy students
unit 1 Posology and dose calculation for child.pdfAkankshaPatel55
Posology is the science of dosage, which encompasses the study of the amount of a medication that should be given to a patient, the frequency of administration, and the duration of treatment. It is a crucial aspect of pharmacology and therapeutics, as determining the correct dosage is essential for ensuring the safety and efficacy of a medication.
Here are some of the key factors that are considered when determining posology:
The patient's age, weight, and medical condition: These factors can all affect how a medication is metabolized and excreted from the body. For example, children and older adults may require different dosages than adults, and people with certain medical conditions may need to avoid certain medications or take them at lower doses.
The severity of the condition being treated: The severity of the condition will often determine the dosage of medication that is needed. For example, someone with a mild infection may only need a low dose of antibiotics, while someone with a severe infection may need a higher dose.
The form of the medication: Different forms of the same medication (e.g., tablets, capsules, injectables) can be absorbed into the body at different rates. This needs to be taken into account when determining the dosage.
The route of administration: The route of administration (e.g., oral, intravenous, topical) can also affect how a medication is absorbed into the body. This needs to be taken into account when determining the dosage.
Posology is a complex field, and there are many different factors that need to be considered when determining the correct dosage for a particular patient. It is important to consult with a healthcare professional to get advice on the appropriate dosage for any medication you are taking.
Here are some additional details about posology:
Posology is often expressed in terms of the following:
Dose: The amount of medication that is given at one time.
Frequency: How often the medication is given.
Duration: How long the medication is taken for.
There are a number of different ways to express posology, including:
Milligrams (mg): This is a unit of mass that is commonly used to measure the amount of medication in tablets, capsules, and liquids.
Micrograms (mcg): This is a unit of mass that is used to measure very small amounts of medication.
International units (IU): This is a unit of activity that is used to measure some medications, such as insulin.
Units: This is a unit that is used to measure some medications, such as heparin.
The specific way that posology is expressed will vary depending on the medication and the condition being treated.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Before prescribing any pharmaceutical medicine, the physician should consider certain factors that can modify the effect of the drug. The same dose of a drug can produce different degrees of response in different patients and even in the same patient under different situations. The Important factors modify the effect of a drug are subdivided into two groups: patient related factors and drug related factors.
• Patient related factors: age, gender, body weight, presence of food, drug allergy, genetic variation, environmental state, pathological state, psychological state, etc.
• Drug related factors: physical state of a drug, route of drug administration, time of drug administration, drug cumulation, drug combination, drug tolerance, drug dependence, etc.
This ppt covers definition of Posology, Therapeutic dose, Official doses, factors deciding dose calculation, and formulae used for child dose calculation.
It is useful for medical and pharmacy students
unit 1 Posology and dose calculation for child.pdfAkankshaPatel55
Posology is the science of dosage, which encompasses the study of the amount of a medication that should be given to a patient, the frequency of administration, and the duration of treatment. It is a crucial aspect of pharmacology and therapeutics, as determining the correct dosage is essential for ensuring the safety and efficacy of a medication.
Here are some of the key factors that are considered when determining posology:
The patient's age, weight, and medical condition: These factors can all affect how a medication is metabolized and excreted from the body. For example, children and older adults may require different dosages than adults, and people with certain medical conditions may need to avoid certain medications or take them at lower doses.
The severity of the condition being treated: The severity of the condition will often determine the dosage of medication that is needed. For example, someone with a mild infection may only need a low dose of antibiotics, while someone with a severe infection may need a higher dose.
The form of the medication: Different forms of the same medication (e.g., tablets, capsules, injectables) can be absorbed into the body at different rates. This needs to be taken into account when determining the dosage.
The route of administration: The route of administration (e.g., oral, intravenous, topical) can also affect how a medication is absorbed into the body. This needs to be taken into account when determining the dosage.
Posology is a complex field, and there are many different factors that need to be considered when determining the correct dosage for a particular patient. It is important to consult with a healthcare professional to get advice on the appropriate dosage for any medication you are taking.
Here are some additional details about posology:
Posology is often expressed in terms of the following:
Dose: The amount of medication that is given at one time.
Frequency: How often the medication is given.
Duration: How long the medication is taken for.
There are a number of different ways to express posology, including:
Milligrams (mg): This is a unit of mass that is commonly used to measure the amount of medication in tablets, capsules, and liquids.
Micrograms (mcg): This is a unit of mass that is used to measure very small amounts of medication.
International units (IU): This is a unit of activity that is used to measure some medications, such as insulin.
Units: This is a unit that is used to measure some medications, such as heparin.
The specific way that posology is expressed will vary depending on the medication and the condition being treated.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
2. Introduction
The word posology is derived from the Greek words ‘posos’ meaning how
much and ‘logos’ meaning science.
So posology is a branch of medical science which deals with dose or
quantity of drugs which can be administered to a patient to get the desired
pharmacological actions.
The dose of a drug cannot be fixed rigidly because there are so many factors
which influences the doses.
These factors are age, condition of the patient, severity of the disease,
tolerances both natural and acquired, idiosyncrasy, route of administration,
formulation used, drug interactions and rate of elimination.
3. Factors influencing dose
The optimum dose of a drug which produces the desired therapeutic effect
varies from person to person, because every individual varies both in the
degree and character of the response produced by the drug.
Due to this reason the doses of official preparations of drugs are expressed in
the form of a range which gives the therapeutic effect.
The dose range is usually based on the average requirements of an adult
patient.
4. Age:
The pharmacokinetics of many drugs changes with age. So while
determining the dose of a drug of an individual is of great significance.
Children and old people need lesser amount of drug than the normal adult
dose, because they are unable to excrete drugs to the extent as adults.
Children’s can tolerate relatively larger amounts of belladona, digitalis and
ethanol, whereas, elderly patients are more sensitive to some drug effects
Eg:hypnotics and tranquilizers which may produce confusion states in them.
Sex:
Women do not always respond to the action of drugs in the same mannr as it
is done in men.
Morhine and barbiturates may produce more excitement before sedation in
women.
5. Special care should be taken when drugs are administered during
menstruation, pregnancy and lactation.
The strong purgatives such as aloes should be avoided during menstruation.
Similarly the drugs which may stimulate the uterine smooth muscle eg.drastic
purgatives, antimalarial drugs and ergot alkaloids are contra indicated during
pregnancy.
There are certain drugs which on administration to the mother are capable of
crossing the placenta and affecting the foetus e.g.alcohol, barbiturates,
narcotic and non narcotic analgesics etc.
During lactation, the drugs like antihistamines, morphine and tetracycline
which are excreted in milk should be avoided or given very cautiously to the
mothers who are breast feeding the babies.
6. Body weight:
The average dose is mentioned either in terms of mg per kg body weight or
as a total single dose for an adult weighing between 50-100kg.
However, the dose expressed in this fashion may not apply in cases of
obese patients, children and malnourished patients.
It should be calculated according to body weight.
Route of administration:
o Intravenous doses of drugs are usually smaller than the oral doses, because
the drugs administered intravenously enter the blood stream directly.
o Due to this reason the onset of drug action is quick with intravenous route
and this might enhance the chances of drug toxicity.
o The effectiveness of drug formulation is generally controlled by the route
of administration.
7. Time of administration:
The presence of food in the stomach delays the absorption of drugs.
The drugs are more rapidly absorbed from the empty stomach.
So the amount of drug which is very effective when taken before a meal
may not be that much effective when taken during or after meals.
The irritating drugs are better tolerated if administered after meals eg. Iron,
arsenic and cod-liver oil should always be given after meals.
Environmental factors:
o Daylight is stimulant, enhancing the effect of stimulating drugs and
diminishing the effect of hypnotics.
o Darkness is sedative. Hypnotics are more effective at night.
o The amount of barbiturate required to produce sleep during day time is
much higher than the dose required to produce sleep at night.
o Alcohol is better tolerated in cold environments than in summer.
8. Emotional factors:
The personality and behaviour of a physician may influence the effect of
drug especially the drugs which are intended for use in a psychosomatic
disorder.
The females are more emotional than males and requires less dose of
certain drugs.
Inert dosage forms called placebos which resemble the actual medicament
in the physical properties are known to produce therapeutic benefit in
diseases like angina pectoris and bronchial asthama.
Presence of disease:
Drugs like barbiturates and chlorpromazine may produce unusually
prolonged effect in patients having liver cirrhosis.
Streptomycin is excreted mainly by the kidney may prove toxic if the
kidney of the patient is not working properly.
During fever a patient can tolerate high doses of antipyretics than a normal
person.
9. Accumulation:
The drugs which are slowly excreted may built up a sufficient high
concentration in the body and produce toxic symptoms if it is repeatedly
administered for a long time e.g. digitalis, emetine and heavy metals.
This occurs due to accumulative effect of the drug.
The cumulative effects are usually produced by slow excretion, degradation
and rapid absorption of drugs. Sometimes, a cumulative effect is desired in
drugs like phenobarbitone in the treatment of epilepsy.
Additive effect:
When the total pharmacological action of two or more drugs administered
together is equivalent to sum of their individual pharmacological action, the
phenomena is called as an additive effect. For example, combination of
ephedrine and aminophylline in the treatment of bronchial asthama.
Synergism:
When two or more drugs are used in the combination form, their action is
increased.
The phenomena is called synergism.
Synergism is very useful when desired therapeutic result needed is difficult to
achieve with a single drug. E.g. procaine and adrenaline combination, increases
the duration of action of procaine.
10. Antagonism:
When the action of one drug is opposed by the other drug on the same
physiological system is known as drug antagonism.
The use of antagonistic responses to drugs is valuable in the treatment of
poisoning e.g. milk of magnesia neutralise the effect of acid where alkaline
effect of milk of magnesia is given in acid poisoning .
When adrenaline and acetylcholine are given together, they neutralise the
effect of each other due to antagonism because adrenaline is vasoconstrictor
and acetylcholine is vasodilator.
Idiosyncrasy:
An extraordinary response to a drug which is different from its
characteristic pharmacological action is called idiosyncrasy.
The word idiosyncrasy has now been replaced by the term drug allergy.
For example, small quantity of aspirin may cause gastric haemorrhage and a
small dose of quinine may produce ringing in the ears.
Some persons are sensitive to penicillin and sulphonamide because they
produce severe toxic symptoms.
11. Tolerance:
When an unusually large dose of a drug is required to elicit an affect
ordinarily produced by the normal therapeutic dose of the drug, the
phenomenon is termed as drug tolerance. E.g., smokers can tolerate
nicotine, alcoholic can tolerate large quantity of alcohol. The drug
tolerance is of two types
(i) True tolerance, which is produced by oral and parenteral
administration of the drug.
(ii)Pseudo tolerance, which is produced only to the oral route of
administration.
Tachyphylaxis:
It has been observed that when certain drugs are administered repeatedly
at short intervals, the cell receptors get blocked up and pharmacological
response to that particular drug is decreased.
The decreased response cannot be reversed by increasing the dose.
This phenomenon is known as tachyphylaxis or acute tolerance.
12. Metabolic disturbances:
Changes in water electrolyte balance and acid base balance, body
temperature and other physiological factor may modify the effects of
drugs.
Salicylates reduce body temperature only in case an individual has rise in
body temperature.
They have no antipyretic effect if the body temperature is normal.
The absorption of iron from GIT is maximum if the individual has an iron
deficiency anaemia.