This document discusses prevention of mother-to-child transmission (PMTCT) of HIV. PMTCT aims to reduce the risk of HIV transmission from an HIV-positive mother to her child through antenatal care, HIV testing, antiretroviral therapy, safe delivery practices, postnatal care, and informed breastfeeding guidelines. Barriers to effective PMTCT include HIV stigma, limited healthcare access, lack of awareness, and weak healthcare systems. Strategies to overcome these barriers include public education, expanding healthcare services, mobile clinics, and investments in healthcare infrastructure. With comprehensive PMTCT strategies, the risk of mother-to-child HIV transmission can be significantly reduced.