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Platelet rich plasma
Platelet-rich plasma (PRP) is a concentrated source of autologous platelets that contain at least 7 different growth factors. When platelets are activated after injury, these growth factors are released from the alpha granules and promote processes like bone and soft tissue healing, angiogenesis, and re-epithelization. Studies have shown PRP can stimulate more rapid bone formation and earlier bone maturation compared to autogenous bone grafts. PRP has also been shown to reduce scarring and pigmentation changes at skin graft donor sites compared to the use of thrombin as the clot activator. However, PRP requires the use of bovine thrombin which carries risks like potential transmission of diseases.
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Platelet rich plasma
- 1. Rani Somani,Iram Zaidi, Shipra Jaidka International Journal Of Clinical Pediatric Dentistry, January-April 2011;4(1):69-75 Presented By: Roshni Maurya
- 2. PRP (Plateletrich plasma) :concentrated source of autologous PLTs. Platelet concentrate APG(Autologous platelet gel) Buffy coat GDC
- 3. Anuclear pieceof cytoplasm Include hemostasis, α-granule,lysosomal granule, dense granules GDC
- 4. At least7 different growth factors that stimulate bone & soft tissue healing PDGF aa,bb,ab TGF b1,b2 VEGF EGF GDC
- 5. Do notcontain insulin-like growth factors nor BMP Adhesion molecule fibronectin vitronectin fibrin GDC
- 6. Injury PLTactivation Within 10 min,α-granule migrate to the cell membrane surface and secrete growth factors ( inactive →active form) GDC
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- 8. PLT exhaustedafter 7 days Macrophage by low oxygen tension, acidity, lactate concentration Secrete same growth factors Activated until it is down regulated by the restoration of normal oxygen tension GDC
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- 10. Graft iscompletely permeated by new capillaries Initial osteoid formation Osteoclast resorb osteoid and BMP released New bone formation and maturation GDC
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- 12. Platelet 는cell replicaion, vascular ingrowth,bone cell differentiation, early osteoid formation .. 등의 acativit 가 일어나도록 initiator 역할 담 당함 . GDC
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- 14. PDGF aa,bb,ab Promoting angiogenesis, re- epithelization,formation of granulation tissue Chemotaxis for mesenchymal cell(OB< FB,Macrophage…),monocyte,ne utrophiles GDC
- 15. TGF β1,β2 Stimulate cell replication similar to PDGF Stimulate matrix production and guide differentiation towards cartilage or bone GDC
- 16. Most potentmultifuctional regulator of bone cell metabolism(OB 에 TGF receptor 많다 .) GDC
- 17. Effects onendothelial cells GDC
- 18. Effect limitedon the basal cells of skin and mucus membrane GDC
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- 22. 4~7 timesabove a concentration of platelets than peripheral blood plates level Bone mineral density 1.6~2,2 times increased Rapid bone formation & earlier maturation. GDC
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- 24. Split thicknessskin graft 후 donor site 의 healing 양상을 비교함 GDC
- 25. GDC Thrombin side : 5%epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue
- 26. GDC Thrombin side : scarring hypoand hyper- pigmentation area 가 두드러 짐 PRP side ;less scarring Much less pigmentation change
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- 31. Growth factorscontained PRP stimulated complete revascularization earlier and more complete Early epithelial covering of exposed granulation tissue and C.T, the development of dermis is the mechanism that reduced scarring and a maximum regeneration of normal skin pigmentation GDC
- 32. Bovine thrombin+ CaCl2 :clot initiator to activate PRP CJD(Creutzfeldt-jakob disease) : mad cow disease Postop bleeding : 100mg/ml of bovine factor aⅤ GDC
- 33. Pre-existing coagulationdefect : thrombocytopenia, hypofibrinogenia… Hypersensitivity to bovine thrombin GDC
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