1) PRP and PRF are platelet concentrates that provide growth factors that may enhance tissue regeneration.
2) Studies have shown PRP and PRF can increase the release of growth factors like PDGF, TGF-β1, and VEGF compared to control groups.
3) However, the evidence on whether PRP and PRF improve bone regeneration outcomes is mixed. Some studies found benefits for parameters like new bone formation and defect fill, while other studies found no additional benefits compared to control treatments.
Platelet Rich Plasma ( PRP ) is very popular in the treatment of musculo skeletal pathologies. This ppt gives a brief introduction to platelets and in sights into developing a PRP kit.
Dr. Robert Langer - Simposio Internacional 'Terapias oncológicas avanzadas'Fundación Ramón Areces
Los días 15 y 16 de octubre de 2014, la Fundación Ramón Areces y la Real Academia Nacional de Farmacia, en colaboración con la Fundación de la Innovación Bankinter, reunieron en Madrid a algunos de los mayores expertos mundiales en nuevas terapias contra el cáncer. El Simposio Internacional, coordinado por la profesora y académica María José Alonso, analizó el momento actual de la lucha contra esta enfermedad. También fue un punto de encuentro para científicos de los más innovadores institutos de investigación en oncología, quienes debatieron sobre tres grandes temas: la Medicina Personalizada contra el cáncer, los nanomedicamentos en la terapia del cáncer y las terapias basadas en la inmunomodulación.
Platelet Rich Plasma ( PRP ) is very popular in the treatment of musculo skeletal pathologies. This ppt gives a brief introduction to platelets and in sights into developing a PRP kit.
Dr. Robert Langer - Simposio Internacional 'Terapias oncológicas avanzadas'Fundación Ramón Areces
Los días 15 y 16 de octubre de 2014, la Fundación Ramón Areces y la Real Academia Nacional de Farmacia, en colaboración con la Fundación de la Innovación Bankinter, reunieron en Madrid a algunos de los mayores expertos mundiales en nuevas terapias contra el cáncer. El Simposio Internacional, coordinado por la profesora y académica María José Alonso, analizó el momento actual de la lucha contra esta enfermedad. También fue un punto de encuentro para científicos de los más innovadores institutos de investigación en oncología, quienes debatieron sobre tres grandes temas: la Medicina Personalizada contra el cáncer, los nanomedicamentos en la terapia del cáncer y las terapias basadas en la inmunomodulación.
Jason G. Attaman, DO, FAAPMR Presents: Image Guided Platelet Rich Plasma (PRP...Jason Attaman
Jason G. Attaman, DO, FAAPMR presents the advantages of using image guidance in Platelet Rich Plasma (PRP) Therapy for tendon, bone, joint and pain issues.
Dr. Attaman is a double board certified Pain Management Physician with pain control clinic locations in Bellevue, Seattle, and Auburn, Washington, USA.
It is very difficult choosing which physician to see when you are suffering from chronic pain. Should you see a pain doctor, a surgeon, a neurologist, a chiropractor, a naturopath, an acupuncturist? The choices and options are bewildering! If you choose to see Dr. Attaman, you will find a physician that will thoroughly examine your case, and suggest treatment options for you that will draw from every specialty of medicine. Generally Dr. Attaman likes to try conservative treatment options such as physical therapy before invasive options such as pain reducing injections and surgery. Therefore if massage therapy is best for your condition, that will be offered. Though he does everything to prevent it, if Dr. Attaman thinks you require surgery, you will be referred to the best surgeons in the state. Dr. Attaman offers many dozens of treatment options for every type of pain, and takes pride in being honest with his patients about their choices.
He will not, however, waste your valuable time. If you have already had dozens of sessions of physical therapy and chiropractic, tried dozens of medications over the years, and in general are “fed up” with nothing working for you, Dr. Attaman will promptly and appropriately offer you much more advanced pain management options in which he is extensively trained. Dr. Attaman is always amazed at the treatment options available to patients who have been suffering from pain for even decades.
Dr. Attaman is board certified and Anesthesiology-fellowship trained in the medical subspecialty of Pain Medicine and Interventional Pain Management. He is also residency trained and board certified in the specialty of Physical Medicine and Rehabilitation. He is one of only a few with such extensive qualifications in the state of Washington.
He is expert at diagnosing and treating every form of pain, ranging from common back pain to face pain to cancer pain. He uses pain reducing injections and procedures to combat difficult to treat pain conditions. He will guide his treatments to help reduce or eliminate your need for pain medications. He will advise your primary care physician on the best ways to treat your pain.
In addition, he has had extensive training in integrative and “alternative” medicine. He has trained extensively with some of the most prominent alternative medicine physicians.
Platelet Rich Fibrin (PRF) in Dentistry, What is PRF ? , What are the difference between PRP,PRGF and PRF ?, Preparation of PRF , shapes of PRF, Role of PRF in wound healing, APPLICATIONS OF PRF, Applications of PRF In Oral and Maxillofacial Surgery, Applications of PRF In Periodontics, Applications of PRF In Endodontics, Applications of PRF In Tissue Engineering
Jason G. Attaman, DO, FAAPMR Presents: Image Guided Platelet Rich Plasma (PRP...Jason Attaman
Jason G. Attaman, DO, FAAPMR presents the advantages of using image guidance in Platelet Rich Plasma (PRP) Therapy for tendon, bone, joint and pain issues.
Dr. Attaman is a double board certified Pain Management Physician with pain control clinic locations in Bellevue, Seattle, and Auburn, Washington, USA.
It is very difficult choosing which physician to see when you are suffering from chronic pain. Should you see a pain doctor, a surgeon, a neurologist, a chiropractor, a naturopath, an acupuncturist? The choices and options are bewildering! If you choose to see Dr. Attaman, you will find a physician that will thoroughly examine your case, and suggest treatment options for you that will draw from every specialty of medicine. Generally Dr. Attaman likes to try conservative treatment options such as physical therapy before invasive options such as pain reducing injections and surgery. Therefore if massage therapy is best for your condition, that will be offered. Though he does everything to prevent it, if Dr. Attaman thinks you require surgery, you will be referred to the best surgeons in the state. Dr. Attaman offers many dozens of treatment options for every type of pain, and takes pride in being honest with his patients about their choices.
He will not, however, waste your valuable time. If you have already had dozens of sessions of physical therapy and chiropractic, tried dozens of medications over the years, and in general are “fed up” with nothing working for you, Dr. Attaman will promptly and appropriately offer you much more advanced pain management options in which he is extensively trained. Dr. Attaman is always amazed at the treatment options available to patients who have been suffering from pain for even decades.
Dr. Attaman is board certified and Anesthesiology-fellowship trained in the medical subspecialty of Pain Medicine and Interventional Pain Management. He is also residency trained and board certified in the specialty of Physical Medicine and Rehabilitation. He is one of only a few with such extensive qualifications in the state of Washington.
He is expert at diagnosing and treating every form of pain, ranging from common back pain to face pain to cancer pain. He uses pain reducing injections and procedures to combat difficult to treat pain conditions. He will guide his treatments to help reduce or eliminate your need for pain medications. He will advise your primary care physician on the best ways to treat your pain.
In addition, he has had extensive training in integrative and “alternative” medicine. He has trained extensively with some of the most prominent alternative medicine physicians.
Platelet Rich Fibrin (PRF) in Dentistry, What is PRF ? , What are the difference between PRP,PRGF and PRF ?, Preparation of PRF , shapes of PRF, Role of PRF in wound healing, APPLICATIONS OF PRF, Applications of PRF In Oral and Maxillofacial Surgery, Applications of PRF In Periodontics, Applications of PRF In Endodontics, Applications of PRF In Tissue Engineering
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
2. Contains resting platelets at a
concentration of at least 106/ul.
The PRP may or may not be activated
prior to use; the term “PRP” does not
indicate that activation has occurred.
Petrungaro P S 2001
PRP is a fraction of plasma that
provides a rich source of growth factors
and may enhance the initial stabilization
and revascularization of the flaps and
grafts. Petrungaro 2001
3. • the nature of a matrix itself, in theory providing a
construct for tissue regeneration as well as
degradable (autologous), biologic, from which
growth factors are slowly released.
• Non-thrombinized autologous graft material
4.
5. 8 ml autologous whole
blood
Platelet-poor plasma and
buffy coat
Platelet-
poor plasma
Platelet-rich
plasma
Erythrocytes
2400 rpm for 10 minutes
3600 rpm for 15 minutes
Weibrich 2003
10% CaCl2+bovine
thrombin
6. blood is collected without
anticoagulant
Centrifuged (3000 rpm
10mins)
three parts quickly appear
in the tube
clot can be transformed
into a membrane by
compression between two
sterile gauzes
using a specific tool for
clot collection and
membrane standardization
Coagulation
starts during the
centrifugation
Choukroun et al
2000
7. 1. PRF preparation process creates a gel-like matrix,
that contains high concentration of non-activated
functional intact platelets contained within a fibrin
matrix that release a relatively constant
concentration of growth factors over a period of 7
days. Carroll 2005
2. It can be squeezed to form a membrane and can
be used as fibrin bandage serving as a matrix to
accelerate the healing of wound edges. Gabling
2009, Vence 2009
3. Chair-side preparation of PRF is quite easy, fast
and simplified process minus artificial biochemical
modification than PRP, which takes more time.
Dohan 2006
4. This procedure produces an inexpensive
autologous fibrin membrane in approximately 1
min and hence no cost for membrane and bone
graft to the patients.
8. Leukocyte poor or pure platelet-rich
plasma (P-PRP)
Leukocyte & platelet-rich plasma (L-PRP)
Leukocyte poor or pure platelet rich
fibrin(P-PRF)
Leukocyte and platelet-rich fibrin (L-PRF)-
Choukroun’s PRF
Dohan Ehrenfest 2009
9. 1. Effect – Something that is produced by an agency
or cause
2. Efficacy -It is the extent to which an intervention
does more good than harm when delivered under
optimal conditions
3. Effectiveness -It is the extent to which planned
outcomes are achieved as a result of an
intervention intended to achieve the desired effect,
under ordinary circumstances (not controlled
circumstances such as in laboratory).
4. Efficiency - It is the ratio of the output to the
inputs of any system.
Flay 1986; Last 1988
12. Do PRP & PRF release growth factors?
Do these growth factors affect regeneration?
13. PDGF-AB PDGF-AB
ng/109 ml
TGF-β TGF-β1
ng/109 ml
PRP vs
Unconcentrate
d plasma PRP vs
Unconcentr
ated
plasma
KAWASE ET
AL 2003
440.6±211.8% 256.7 346.6±111.
3%
198.7
27. STUDIES MATERIALS
&
METHODS
BMP-2 COLLAGEN-
1
OSTEOCALC
IN
WILTFANG J
2004
Autograft+P
RP (+1, +2
conc)
+collagen
lyophilisat in
various
combin in 6
groups
Inc in 2 wks
–collagen &
(+1)PRP
group
Inc at2 wks
in all
collagen
groups
Inc at 2 wks
in collagen
groups &
autogenous
bone + PRP
Inc in 4 wks
– collagen
&(+2) PRP
group
Pigs- critical
size defects
IHC at
2,4,12&26
wk
28. STUDIES MATERIALS
& METHODS
CP
RESORPTION
New bone formation
SOFFER E
2006 - Rabbits
Ceramic
particles (CP)
vs
Autogenous
platelet
lysates(APL) +
CP vs
CP+APL±Thro
mbin(THR)
+APL grps-
increased
APL+CP in calvaria-
decreased
APL+CP in femur -
increased
+THR grps -
decreased
Duration of
study -2
months
Critical size
defects in
calvaria &
femur
+THR in femur –
decreased
29. STUDIES MATERIALS &
METHODS
DEFECT CLOSURE
Pryor et al 2005 Sprague-Dawley rats
Contralateral critical-
size defects
No significant
difference between
test and control
PRP+ACS vs ACS
4th ,8th week
Torres et al 2010 Rabbits –calvarial
defects
Test group produced
twice the
vertical bone volume
PRP+ABB vs ABB
6 weeks
30. STUDIES MATERIA
LS &
METHODS
BiIT BIC BoIT OUTCOME
ASSESSM
ENT
Sánchez
2005
Mesial and
distal 3-
wall peri-
implant
defects
Significant difference between
treatment groups
Low
regenerative
potential
Dogs
DFDB+PRP
vs DFDB
vs NT
1 ,2 and 3
months
31. STUDIES MATERIA
LS &
METHODS
TOTAL
AREA OF
BONE
FILL
% OF
BONE
FILL
DURATIO
N OF
STUDY
OUTCOME
ASSESSM
ENT
Grageda E
2005
sheep Significant
increase in
test
No
significant
difference
6 months No significant
effect of PRP
in
combination
with allograft
in max sinus
augmentation
DFDBA +
CCFDBA +
PRP vs
DFDBA +
CCFDBA
32. STUDIES MATERIALS
& METHODS
DURATION
OF STUDY
OUTCOME
ASSESSMEN
T
de
Vasconcelos
Gurgel BC
2007
Mongrel dogs no
differences
were
observed for
all
parameters
3 months PRP does
not exert
additional
effects
PRP vs GBR
vs
PRP+GBR vs
control
Kazakos K
2011
Rabbits + critical
size defects
3 months does not
enhance
bone healing
process
Membrane vs
Membrane +
PRP
33. STUDIES MATERIALS &
METHODS
OSSEOUS FILL Outcome
assessment
Simon BI 2009 Dogs By 3 weeks in
PRFM containing
sites
PRFM alone may
be the best graft
for ridge
preservation
procedures
PRFM ,
Membrane
DFDBA &
untreated
control
Clinical &
histological
evaluation at
10days,2,3,6
and 12 weeks
34. Increase in bone related proteins in sites
treated with PRP ?
• Yes
Quantity n quality of new bone form??
Quantity
Significant new bone formation
Quality
Remaining graft particle
35. SUAID ET AL 2008
Mongrel dogs
Histomorphometric analysis after 1month
Results
Parameters Difference between test and
control (mm)
Length of new cementum 0.99±0.16
Sulcular+ junctional epithelium -0.45±0.25
New C/T attachment adjacent
to root without cementum
formation
0.06±0.1
Bone position -0.11±0.39
40. STUDIE
S
MATERI
ALS &
METHO
DS
PD
REDUCT
ION
CAL
REDUCT
ION
DEFECT
FILL
OUTCO
ME
ASSESS
MENT
DURATION
OF STUDY
Lekovic
et al
2003
PRP+
ABB+GT
R vs
OFD
1.58±0.
05
1.61±0.
11
ver
tica
l
hor
izo
ntal
Significa
ntly
Positive
6 months
2.7
5±
0.3
8
2.2
0±
0.3
5
Camargo
PM et al
2002
PRP+AB
B+GTR
vs GTR
buc
cal
ling
ual
buc
cal
ling
ual
buc
cal
ling
ual
Not
determin
ed
6 months
2.4
7±
0.5
2.4
±0.
51
1.3
6±
0.1
5
1.3
9±
0.0
4
1.7
5±
0.0
8
1.8
4±
0.1
1
Camargo
PM et al
2005
PRP+AB
B+GTR
vs OFD
2.2
2±
0.3
2.1
2±
0.3
3.0
5±
0.5
2.8
8±
0.4
3.4
6±
0.9
3.4
2±
0.0
Not
determin
ed
6 months
41. STUDIES MATERIALS &
METHODS
OUTCOME
ASSESSMENT
DURATION OF STUDY
Mauro et al
2003
GTR + PRP No additional
benefits
1 year
Yassibag-
Berkman 2007
β-TCP vs β-TCP
+ PRP /β-TCP +
PRP +
membrane
No additional
benefits
1 year
Dori et al 2008 ABB+ EMD
+PRP vs ABB+
EMD
No additional
benefits
1 year
Dori et al 2008 β-TCP +GTR+
PRP vs β-
TCP+GTR
No additional
benefits
1 year
42. STUDIES MATERIALS &
METHODS
OUTCOME
ASSESSMENT
DURATION OF
STUDY
Christgau et al
2006
PRP+ β-TCP+
GTR vs β-TCP+
GTR
No additional
benefits
12 months
Dori et al 2007 PRP+ABB+GTR vs
ABB+GTR
No additional
benefits
12 months
Dori et al 2007 ABB+PRP+GTR vs
ABB+GTR
No additional
benefits
12 months
Keles et al 2006 GTR+PRP vs
BG+GTR
No additional
benefits
12 months
Camargo et al
2009
ABB+GTR+PRP vs
ABB+GTR
No additional
benefits
12 months
43. STUDIES MATERIALS
& METHODS
CT
ANALYS
IS
OPG
ANALYSIS
DURATIO
N OF
STUDY
OUTCOM
E
ASSESS
MENT
NEW
BONE
FORMATIO
N
Graziani
et al
2005
PRP +
autologous
BG+
fibrinogen
cryo
precipitate
6.27
mm
mineralizatio
n as early as
3 months
postoperativ
ely
6
MONTHS
POSITIVE
44. STUDIES MATERIAL
S &
METHODS
HISTOMO
RPHOMET
RIC
ANALYSIS
IMPLANT
S
DURATIO
N OF
STUDY
OUTCOME
ASSESSM
ENT
Rodriguez
A 2003
PRP+anorg
anic
deproteiniz
ed bovine
BG+
immediate
implant
placement
viable new
bone
formation
in close
approximat
ion to the
xenograft
Lost= 5/70
in 15
patients
36 months Significantly
positive
Mazor Z
2004
PRP+autolo
gous
BG+immed
iate
implant
placement
no clinical
evidence of
crestal
bone loss
around the
implants
both
clinically
and
radiographi
6 months Significantly
positive
45. STUDIES MATERIAL
S &
METHODS
CT
ANALYSIS
HISTOMO
RPHMETR
IC
ANALYSIS
DURATIO
N OF
STUDY
OUTCOME
ASSESSM
ENT
NEW BONE
FORMATIO
N NEW
BON
E
RES
ORP
TIO
N
RAT
E
Philippart P
2003
PRP+rhTF+
autologous
BG
success
rate of
grafting
90.3%
6 months Positive
Philippart P
2005
PRP+rhTF+
autologous
BG+
inorganic
xenograft
6mt
hs-
0.5
6& 10
months
Positive
10m
ths-
2
46. STUDIES MATERIALS
& METHODS
HISTOMORP
HOMETRIC
ANALYSIS
DURATION
OF STUDY
OUTCOME
ASSESSMEN
T
NEW
BONE
%
GRAF
T
RESO
RPTIO
N
RATE
(%)
Wiltfang J
2003
beta-TCP +
PRP vs beta-
TCP
about
8-
10%
higher
Not
enhan
ced
6 months Regeneration
small extent
Kassolis JD
2005
FDBA + PRP
vs FDBA +
membrane
Non
signifi
cantly
higher
6.8 ±
4.5
0.84±
0.11
6 months Positive
Torres J 2009 ABB +PRP vs
ABB
Signifi
cantly
increa
6months Positive
47.
48. STUDIES MATERIAL
S &
METHODS
Ti-MESH
EXPOSUR
E
CLINICAL
&
RADIOGR
APHIC
ASSESSM
ENT
DURATIO
N OF
STUDY
OUTCOME
ASSESSM
ENT
Shanaman
R 2001,
PRP+
allograft
gains in
both
vertical
and
horizontal
component
s
Positive
Brugnami F
2011
Autologous
BG+PRP vs
Autologous
BG
enough
bone width
and height
6 months Positive
Torres J
2010
ABB +Ti-
mesh +
PRP vs ABB
+ Ti-mesh
28.5% in
control
,none in
test group
Bone
augmentati
on higher
in test
group
6 months Not
significant
53. Root coverage
• % of root coverage in general –
no significant effect on
improvement of root coverage
• How many studies talk of 100%
coverage and stability of results?
57. STUDIES MATERIAL
S &
METHODS
RADIOGR
APHIC
ANALYSIS
NO. OF
IMPLANT
S LOST
DURATIO
N OF
STUDY
OUTCOME
ASSESSM
ENT
BONE GAIN
Mazor et al
2009
PRF
+immediat
e implant
7mm –10mm None 6 months Positive
Toffler M
2010
Osteotome
sinus
elevation +
PRF
7mm-
13mm
None 6 months Positive
Simonpieri
A 2011
L-PRF+
immediate
implant
placement
8.5 - 12
mm
NONE 72 months Positive
61. Del Fabbro 2011
PRP may exert a positive adjunctive
effect when used in combination with
graft materials, but not with GTR, for
the treatment of intrabony defects.
No significant benefit
of platelet concentrates was found for
the treatment of gingival recession.
J Periodontol 2011 ;82:1100-1111
62. Kotsovilis S 2010
Diverse outcomes (positive and
negative) have been reported for the
efficacy of PRP combined with various
therapeutic bioactive
agents/procedures, reflecting the
limited and heterogeneous data
available and possibly suggesting
that the specific selection of
agents/procedures combined with
PRP could be important.
J Periodontol Res 2010;45:428-443
63. Plachkova AS 2008
They found evidence for beneficial
effects of PRP in the treatment of
periodontal defects.
Evidence for beneficial effects of PRP in
sinus elevation appeared to be weak.
No conclusions could be drawn about
other applications of PRP in dentistry.
Clin Oral Implants Res 2008;19:539-545
64. Arora NS 2010
No obvious positive effects of PRP
on healing of bone graft material in
maxillary sinus augmentation
procedures were noted, the
handling of the particulate bone
grafts was improved.
Implant Dent 2010 Apr 19(2):145-57
65. Martinez-Zapata MJ 2009
PRP improves the gingival
recession but not the clinical
attachment level in chronic
periodontitis.
Transfusion 2009;49:44-56
66.
67. 1. Is significant bone gain clinically
relevant?
2. Evidence of supracrestal bone
formation?
3. Evidence of true regeneration?