Platelet rich fibrin
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This document discusses platelet rich plasma (PRP), which contains concentrated platelets and growth factors that stimulate bone and soft tissue healing. PRP works by secreting growth factors like PDGF, TGF, VEGF and EGF from platelet alpha granules after injury. These growth factors recruit cells and stimulate regeneration. Clinical studies found PRP increased bone mineral density and accelerated bone maturation compared to autogenous bone grafts. For soft tissue healing, PRP reduced scarring and improved pigmentation compared to thrombin. PRP is used to enhance healing in various surgical specialties, though bovine thrombin used to activate PRP carries risks. Contraindications include coagulation defects or hypersensitivity to bovine proteins.
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Platelet rich plasma
Platelet-rich plasma (PRP) is a concentrated source of autologous platelets that contain at least 7 different growth factors. When platelets are activated after injury, these growth factors are released from the alpha granules and promote processes like bone and soft tissue healing, angiogenesis, and re-epithelization. Studies have shown PRP can stimulate more rapid bone formation and earlier bone maturation compared to autogenous bone grafts. PRP has also been shown to reduce scarring and pigmentation changes at skin graft donor sites compared to the use of thrombin as the clot activator. However, PRP requires the use of bovine thrombin which carries risks like potential transmission of diseases.
platelet rich plasma
Platelet rich plasma (PRP) is an effective concentration of growth factors derived from platelets that are released upon activation. PRP is prepared through a double spin process to separate and concentrate platelets. It has various indications like hair loss and wound healing. For hair loss, a dermaroller causes microinjury followed by PRP application to stimulate hair follicle stem cells and prolong the growth phase through growth factors. Research shows PRP increases proliferation of stem cells in vitro and has an angiogenic effect, making it useful for hair growth. While side effects are minimal as PRP is autologous, more research is needed due variability in PRP content and response between patients.
Platelet rich plasma
This document discusses platelet-rich plasma (PRP), which contains a higher concentration of platelets than normal blood. PRP was first used in the 1950s and releases growth factors that can promote tissue regeneration. There are different types of PRP classified by their leukocyte and fibrin contents. PRP is prepared either through plasma-based or buffy coat-based methods. Current clinical applications of PRP include treatment of osteoarthritis, tendonitis, and plantar fasciitis. A study found PRP more effectively reduced pain and improved foot function over 24 weeks compared to corticosteroid injections, which were most effective at 12 weeks.
Platelet-Rich Plasma
This document provides information about platelet-rich plasma (PRP) and its use in orthopedic applications. It discusses:
1) The basic science behind PRP, including the clotting cascade and platelet function. Platelets release growth factors that promote healing when they aggregate at the site of injury.
2) How PRP is created by concentrating the platelet fraction that is separated after centrifugation of blood. There is no consensus on the optimal platelet concentration.
3) The two main types of PRP systems - buffy coat systems and plasma based systems. Buffy coat systems require more steps but produce a higher platelet concentration, while plasma based systems are simpler.
4) Potential risks of PR
Platelet Rich Plasma (PRP) Hair Loss Treatment
Berkowits Hair & Skin Clinics is a 27 Year Old Establishment specializing in Skin & Hair Care. With a wide array of treatments such Hair Transplant, Hair Loss Solutions, Laser Hair Removal, Permanent Tattoo removal etc, Berkowits has established itself as one of the industry Hair Replacement & Skin Clinic
Prp for malar
This document discusses the use of platelet rich plasma (PRP) in aesthetic surgery. PRP contains growth factors released from platelet alpha granules that accelerate wound healing by stimulating tissue growth. It is isolated from a patient's own blood using a machine that centrifuges the blood to increase the platelet concentration. The PRP growth factors promote angiogenesis, collagen deposition, and cell differentiation to enhance effects of procedures like skin rejuvenation, hair restoration, and fat transfers by improving graft survival and structure.
Prp for hair regrowth
PRP means plasma rich protein which contains the fibrin rich plasma which has the platelets in it which when injected at the site helps in growth.The blood is withdrawn from the individual and then it is centrifuged to form the plasma rich fibrin (PRF).This is great source of protein which can be used for hair regrowth and it has the least side effects as it is autologous in nature.It is mostly done for people with androgenic alopecia.You will be needing 3-4 sittings and the result might take around 6 months to show.
Dr Sachdeva's Dental clinic and Facial aesthetic center is one of the leading clinics performing PRP for hair regrowth in Delhi. So hurry up and come book an appointment with us at Dr.Sachdeva’s Dental Institute, Ashok Vihar, Delhi which has state of the art clinic and all the latest and advanced equipments.
To book an appointment contact:
Dr. Rajat Sachdeva
Director & Mentor
Dr Sachdeva’s Dental Aesthetic And Implant Institute
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
Phone : +919818894041,01142464041
Our Websites:
www.sachdevadentalcare.com
www.dentalimplantindia.co.in
www.dentalclinicindelhi.com
www.dentalcoursesdelhi.com
Facebook- dentalcoursesdelhi
Youtube- drrajatsachdeva
Linkedin- drrajatsachdeva
Slideshare- Dr Rajat Sachdeva
Twitter Page- drrajatsachdeva
Instagram page- surgicalmasterrajat
PRP in Orthodontics
1) Platelet rich plasma (PRP) is an autologous concentration of human platelets that contains growth factors which stimulate wound healing. PRP and leukocyte platelet-rich fibrin can be prepared from a patient's own blood and injected to accelerate orthodontic tooth movement.
2) PRP is prepared by centrifuging a patient's blood to separate the platelets from other blood components. The concentrated platelets contain growth factors that regulate cellular processes and stimulate bone formation.
3) Submucosal injection of PRP near the teeth can accelerate orthodontic tooth alignment, space closure, and protraction by stimulating local bone remodeling through growth factor release. A single injection lasts 5-6 months and multiple
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Platelet rich plasma
Platelet-rich plasma (PRP) is a concentrated source of autologous platelets that contain at least 7 different growth factors. When platelets are activated after injury, these growth factors are released from the alpha granules and promote processes like bone and soft tissue healing, angiogenesis, and re-epithelization. Studies have shown PRP can stimulate more rapid bone formation and earlier bone maturation compared to autogenous bone grafts. PRP has also been shown to reduce scarring and pigmentation changes at skin graft donor sites compared to the use of thrombin as the clot activator. However, PRP requires the use of bovine thrombin which carries risks like potential transmission of diseases.
platelet rich plasma
Platelet rich plasma (PRP) is an effective concentration of growth factors derived from platelets that are released upon activation. PRP is prepared through a double spin process to separate and concentrate platelets. It has various indications like hair loss and wound healing. For hair loss, a dermaroller causes microinjury followed by PRP application to stimulate hair follicle stem cells and prolong the growth phase through growth factors. Research shows PRP increases proliferation of stem cells in vitro and has an angiogenic effect, making it useful for hair growth. While side effects are minimal as PRP is autologous, more research is needed due variability in PRP content and response between patients.
Platelet rich plasma
This document discusses platelet-rich plasma (PRP), which contains a higher concentration of platelets than normal blood. PRP was first used in the 1950s and releases growth factors that can promote tissue regeneration. There are different types of PRP classified by their leukocyte and fibrin contents. PRP is prepared either through plasma-based or buffy coat-based methods. Current clinical applications of PRP include treatment of osteoarthritis, tendonitis, and plantar fasciitis. A study found PRP more effectively reduced pain and improved foot function over 24 weeks compared to corticosteroid injections, which were most effective at 12 weeks.
Platelet-Rich Plasma
This document provides information about platelet-rich plasma (PRP) and its use in orthopedic applications. It discusses:
1) The basic science behind PRP, including the clotting cascade and platelet function. Platelets release growth factors that promote healing when they aggregate at the site of injury.
2) How PRP is created by concentrating the platelet fraction that is separated after centrifugation of blood. There is no consensus on the optimal platelet concentration.
3) The two main types of PRP systems - buffy coat systems and plasma based systems. Buffy coat systems require more steps but produce a higher platelet concentration, while plasma based systems are simpler.
4) Potential risks of PR
Platelet Rich Plasma (PRP) Hair Loss Treatment
Berkowits Hair & Skin Clinics is a 27 Year Old Establishment specializing in Skin & Hair Care. With a wide array of treatments such Hair Transplant, Hair Loss Solutions, Laser Hair Removal, Permanent Tattoo removal etc, Berkowits has established itself as one of the industry Hair Replacement & Skin Clinic
Prp for malar
This document discusses the use of platelet rich plasma (PRP) in aesthetic surgery. PRP contains growth factors released from platelet alpha granules that accelerate wound healing by stimulating tissue growth. It is isolated from a patient's own blood using a machine that centrifuges the blood to increase the platelet concentration. The PRP growth factors promote angiogenesis, collagen deposition, and cell differentiation to enhance effects of procedures like skin rejuvenation, hair restoration, and fat transfers by improving graft survival and structure.
Prp for hair regrowth
PRP means plasma rich protein which contains the fibrin rich plasma which has the platelets in it which when injected at the site helps in growth.The blood is withdrawn from the individual and then it is centrifuged to form the plasma rich fibrin (PRF).This is great source of protein which can be used for hair regrowth and it has the least side effects as it is autologous in nature.It is mostly done for people with androgenic alopecia.You will be needing 3-4 sittings and the result might take around 6 months to show.
Dr Sachdeva's Dental clinic and Facial aesthetic center is one of the leading clinics performing PRP for hair regrowth in Delhi. So hurry up and come book an appointment with us at Dr.Sachdeva’s Dental Institute, Ashok Vihar, Delhi which has state of the art clinic and all the latest and advanced equipments.
To book an appointment contact:
Dr. Rajat Sachdeva
Director & Mentor
Dr Sachdeva’s Dental Aesthetic And Implant Institute
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
Phone : +919818894041,01142464041
Our Websites:
www.sachdevadentalcare.com
www.dentalimplantindia.co.in
www.dentalclinicindelhi.com
www.dentalcoursesdelhi.com
Facebook- dentalcoursesdelhi
Youtube- drrajatsachdeva
Linkedin- drrajatsachdeva
Slideshare- Dr Rajat Sachdeva
Twitter Page- drrajatsachdeva
Instagram page- surgicalmasterrajat
PRP in Orthodontics
1) Platelet rich plasma (PRP) is an autologous concentration of human platelets that contains growth factors which stimulate wound healing. PRP and leukocyte platelet-rich fibrin can be prepared from a patient's own blood and injected to accelerate orthodontic tooth movement.
2) PRP is prepared by centrifuging a patient's blood to separate the platelets from other blood components. The concentrated platelets contain growth factors that regulate cellular processes and stimulate bone formation.
3) Submucosal injection of PRP near the teeth can accelerate orthodontic tooth alignment, space closure, and protraction by stimulating local bone remodeling through growth factor release. A single injection lasts 5-6 months and multiple
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This document summarizes hemostasis and the coagulation process. It discusses that hemostasis involves platelets, blood vessels, and plasma proteins interacting to maintain blood fluidity and prevent hemorrhage. The three main steps of hemostasis are primary hemostasis involving platelet plug formation, the coagulation cascade, and fibrinolysis. Disorders can occur from abnormalities in blood vessels, platelets, or coagulation factors, causing excessive bleeding. Several laboratory tests are used to monitor coagulation factors and platelet function, including prothrombin time, activated partial thromboplastin time, and thromboelastography.
Prp presentation
PRP (platelet-rich plasma) is a concentration of a patient's own blood plasma and platelets that contains growth factors. It is obtained through centrifugation of blood and used to speed healing in wound care, orthopedics, sports medicine, and cosmetic procedures. The PRP is injected into the injured area where it clots and releases growth factors to stimulate cells to repair and multiply, improving healing. CLINICell-PRP uses a proprietary technique to obtain a pure concentration of platelets low in red blood cells for various medical applications.
Basciano platelets fellows 2013
This document discusses platelet function and disorders. It begins by describing platelet production, structure, and the key roles of platelets in hemostasis and thrombosis. It then examines the processes of platelet activation and aggregation. The document reviews methods to assess platelet function including bleeding time, aggregometry, and thromboelastography. It details several inherited disorders of platelet function like Bernard-Soulier syndrome and Glanzmann thrombasthenia. Finally, it covers acquired platelet dysfunctions from medications and treatments for platelet disorders.
PT APTT Technical Information
The document discusses hemostasis, which involves a balance between clot formation and clot dissolution. It describes the intrinsic and extrinsic coagulation pathways, factors involved, and PT and aPTT tests used to evaluate these pathways. Fibrinolysis and markers like D-dimer are also summarized. Clinical conditions related to deficiencies in the coagulation or fibrinolytic systems are briefly mentioned.
Determination of fibrinogen
This document discusses methods for determining fibrinogen levels. Fibrinogen is a blood coagulating protein synthesized by the liver and plays a key role in blood clotting. The document outlines several methods for measuring fibrinogen including physical-chemical methods, congealable protein methods, and immunology methods. It focuses on the fibrinogen activity test which works by measuring the clotting time after thrombin is added to a sample, with shorter clotting times indicating higher fibrinogen levels. The test procedure, reagents, calibration curve preparation, and clinical significance of fibrinogen levels are also summarized.
Platelet Rich Plasma (PRP) Therapy
This document discusses the use of platelet rich plasma (PRP) for the treatment of tendon injuries in horses. PRP involves concentrating the platelets found in a horse's own blood, which contain growth factors, and injecting them into an injured tendon to aid the healing process. The document reviews what PRP is, how it is prepared, common indications for its use, and the procedure for administering PRP to a tendon lesion in a horse.
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The document summarizes key components of hemostasis and coagulation. It discusses the protein C pathway which inactivates factors Va and VIIIa to inhibit thrombin formation. It also describes fibrinolysis mediated by plasmin which is activated by tPA, urokinase and streptokinase. Tests for hemostasis include platelet count, prothrombin time, activated partial thromboplastin time and bleeding time. Anticoagulants discussed include heparin, warfarin and antiplatelet drugs like aspirin. Thrombolytic agents covered are streptokinase and recombinant tPA. Evaluation of surgical patients for bleeding risks is also summarized.
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This document provides an overview of blood cells and the mechanism of blood coagulation. It discusses the components of blood including red blood cells, white blood cells, platelets, plasma and serum. It describes the coagulation cascade and factors involved. Key aspects of coagulation such as hemostasis, clot retraction and fibrinolysis are summarized. Common anticoagulants like heparin, coumarin derivatives and EDTA are also outlined along with their mechanisms and uses.
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1. The document discusses physiology and pathways of coagulation, as well as antiplatelet drugs, anticoagulants, and thrombolytics used to treat coagulation.
2. Standard heparin and low molecular weight heparins are compared, noting differences in molecular weight, bioavailability, monitoring needs, and clearance.
3. New oral anticoagulants are discussed as alternatives to warfarin, noting their benefits of fixed dosing, limited drug interactions and food effects, and lack of routine monitoring needs. However, concerns remain regarding a lack of monitoring methods and proven antidotes.
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The document summarizes experiences using the Multiplate device for platelet aggregation testing and compares it to traditional Born aggregometry. The Multiplate allows for quicker testing using whole blood rather than platelet-rich plasma. It has advantages of parallel testing and easier operation but cannot detect luminescence and custom agonists require more complex settings. The document discusses experiences testing patient on antiplatelet drugs and with Glanzmann's thrombasthenia. It raises questions about cutoff platelet counts for the Multiplate whole blood tests and its ability to detect heparin-induced thrombocytopenia.
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This document summarizes the human clotting mechanism. It describes that clotting begins with platelets adhering to collagen at the site of injury. The platelets are then activated and secrete substances that initiate the clotting cascade through both the intrinsic and extrinsic pathways, ultimately leading to the conversion of fibrinogen to fibrin and formation of a blood clot. It also discusses fibrinolysis, where plasmin breaks down the fibrin clot. Laboratory tests described include bleeding time, clotting time, and prothrombin time which can identify disorders of the clotting mechanism.
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This document discusses various laboratory tests used to investigate hemostasis and coagulation disorders. It outlines five primary screening tests, including platelet count, bleeding time, prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen level. More specific coagulation factor assays and tests of fibrinolysis are also mentioned. Details are provided on procedures for common coagulation tests like PT, PTT, thrombin time (TT) and activated coagulation time (ACT). The document discusses the clinical implications of abnormal results and potential interfering factors for interpretation.
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-classification of anti-platelet drugs
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Hemostasis
Hemostasis is the process of preventing blood loss from broken blood vessels. It is achieved through three main mechanisms: vascular constriction, platelet plug formation, and blood coagulation. Vascular constriction occurs when smooth muscle contracts after vessel wall trauma. Platelets aggregate at the injury site to form a plug and provide clotting factors. Blood coagulation activates clotting factors through the extrinsic and intrinsic pathways, ultimately converting prothrombin to thrombin which converts fibrinogen to fibrin forming a clot. Clots are dissolved by plasmin which degrades fibrin, and several factors prevent excessive clotting.
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This document reviews the use of platelet-rich plasma (PRP) as an enhancement factor for guided bone regeneration and dental implants. It summarizes that PRP delivers concentrated growth factors to sites requiring bone grafting in order to increase bone formation. However, few human studies have been conducted to scientifically validate the efficacy of PRP for bone regeneration. Well-designed controlled studies are still needed to provide evidence that PRP is effective at improving bone regeneration outcomes.
Platelet rich fibrin
Platelet rich fibrin (PRF) is an autologous platelet concentrate that can be used to deliver growth factors to bone defects for regeneration. It has advantages over platelet rich plasma as it requires no biochemical handling or additives like bovine thrombin. PRF is prepared by centrifuging blood samples without anticoagulant. This results in a fibrin clot containing platelets and growth factors between the acellular plasma and red blood cell layers. PRF can be used with bone grafts or as a membrane to promote wound healing, bone growth, and graft stabilization. The case report describes using PRF mixed with a bone graft to regenerate an intra-bony defect in a patient, which resulted in reduction of pocket
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PRP (platelet-rich plasma) is a concentration of a patient's own blood plasma and platelets that contains growth factors. It is obtained through centrifugation of blood and used to speed healing in wound care, orthopedics, sports medicine, and cosmetic procedures. The PRP is injected into the injured area where it clots and releases growth factors to stimulate cells to repair and multiply, improving healing. CLINICell-PRP uses a proprietary technique to obtain a pure concentration of platelets low in red blood cells for various medical applications.
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Determination of fibrinogen
This document discusses methods for determining fibrinogen levels. Fibrinogen is a blood coagulating protein synthesized by the liver and plays a key role in blood clotting. The document outlines several methods for measuring fibrinogen including physical-chemical methods, congealable protein methods, and immunology methods. It focuses on the fibrinogen activity test which works by measuring the clotting time after thrombin is added to a sample, with shorter clotting times indicating higher fibrinogen levels. The test procedure, reagents, calibration curve preparation, and clinical significance of fibrinogen levels are also summarized.
Platelet Rich Plasma (PRP) Therapy
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Hemostasis Surgury 2
The document summarizes key components of hemostasis and coagulation. It discusses the protein C pathway which inactivates factors Va and VIIIa to inhibit thrombin formation. It also describes fibrinolysis mediated by plasmin which is activated by tPA, urokinase and streptokinase. Tests for hemostasis include platelet count, prothrombin time, activated partial thromboplastin time and bleeding time. Anticoagulants discussed include heparin, warfarin and antiplatelet drugs like aspirin. Thrombolytic agents covered are streptokinase and recombinant tPA. Evaluation of surgical patients for bleeding risks is also summarized.
Mechanism of clotting
This document provides an overview of blood cells and the mechanism of blood coagulation. It discusses the components of blood including red blood cells, white blood cells, platelets, plasma and serum. It describes the coagulation cascade and factors involved. Key aspects of coagulation such as hemostasis, clot retraction and fibrinolysis are summarized. Common anticoagulants like heparin, coumarin derivatives and EDTA are also outlined along with their mechanisms and uses.
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2. Standard heparin and low molecular weight heparins are compared, noting differences in molecular weight, bioavailability, monitoring needs, and clearance.
3. New oral anticoagulants are discussed as alternatives to warfarin, noting their benefits of fixed dosing, limited drug interactions and food effects, and lack of routine monitoring needs. However, concerns remain regarding a lack of monitoring methods and proven antidotes.
Experiences With The Multiplate
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Clotting mechanism
This document summarizes the human clotting mechanism. It describes that clotting begins with platelets adhering to collagen at the site of injury. The platelets are then activated and secrete substances that initiate the clotting cascade through both the intrinsic and extrinsic pathways, ultimately leading to the conversion of fibrinogen to fibrin and formation of a blood clot. It also discusses fibrinolysis, where plasmin breaks down the fibrin clot. Laboratory tests described include bleeding time, clotting time, and prothrombin time which can identify disorders of the clotting mechanism.
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Platelet function and dysfunction
This document provides an overview of platelet function and dysfunction. It discusses platelet production, structure, activation pathways, assessment of function, and inherited and acquired disorders. Key points include: platelets are produced from megakaryocytes at a rate of 1 trillion per day; contain granules storing factors like ADP and serotonin; activate via receptors for collagen, thrombin, ADP; aggregation is mediated by integrin GP IIb/IIIa; testing includes aggregometry and PFA-100; inherited disorders impact receptors like Glanzmann thrombasthenia or Bernard-Soulier syndrome; and acquired causes include medications like aspirin or clopidogrel that inhibit platelet activation pathways.
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This document discusses various laboratory tests used to investigate hemostasis and coagulation disorders. It outlines five primary screening tests, including platelet count, bleeding time, prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen level. More specific coagulation factor assays and tests of fibrinolysis are also mentioned. Details are provided on procedures for common coagulation tests like PT, PTT, thrombin time (TT) and activated coagulation time (ACT). The document discusses the clinical implications of abnormal results and potential interfering factors for interpretation.
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- structure of platelet
-definition of anti-platelet drugs
-classification of anti-platelet drugs
-guidelines for anti-platelets drugs.
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Hemostasis
Hemostasis is the process of preventing blood loss from broken blood vessels. It is achieved through three main mechanisms: vascular constriction, platelet plug formation, and blood coagulation. Vascular constriction occurs when smooth muscle contracts after vessel wall trauma. Platelets aggregate at the injury site to form a plug and provide clotting factors. Blood coagulation activates clotting factors through the extrinsic and intrinsic pathways, ultimately converting prothrombin to thrombin which converts fibrinogen to fibrin forming a clot. Clots are dissolved by plasmin which degrades fibrin, and several factors prevent excessive clotting.
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Medical problem 3 4
The document discusses laser theory and the carbon dioxide laser. It describes how lasers work using stimulated emission to produce coherent, collimated light. Carbon dioxide lasers were the first to be developed in 1964 and are well absorbed by water, making them suitable for oral soft tissue applications. The CO2 laser causes cellular vaporization through its photo-thermal effects and lateral thermal damage of up to 500 micrometers. This results in hemostasis and reduced post-surgical bacteremia compared to other techniques. Lasers can cause reversible or irreversible tissue damage depending on the power settings and exposure time.
Dr Michael Toffler: 10-Year Experience Using L-PRF in Ridge and Sinus Augment...
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Platelet Rich Plasma in Orthopaedics
PRP therapy is a new branch gaining popularity in the recent past. This ppt gives a brief advantages and applications of PRP in field of orthopaedics.
PRP
El documento describe los factores de crecimiento plaquetarios y su papel en la regulación del crecimiento celular. Los factores de crecimiento son señales proteicas que regulan funciones como el crecimiento, proliferación y supervivencia celular. Se liberan de las plaquetas y activan vías de señalización intracelular que conducen a la expresión génica involucrada en la regeneración tisular. La terapia con plasma rico en plaquetas utiliza estos factores de crecimiento para promover la cicatrización de tejidos.
PRP IN EGYPT
This document provides guidelines for the use of platelet rich plasma (PRP) including definitions, indications, contraindications, protocols, techniques and safety recommendations. PRP involves extracting a patient's own blood, processing it to concentrate the platelets, and injecting the PRP back into the patient to promote healing. It summarizes research showing PRP is effective for tendinopathies, ligament sprains, muscle strains, joints, and fracture non-unions. Proper protocols including informed consent, sterile technique, imaging guidance and follow up are recommended to ensure safety and efficacy.
Using Platelet Rich Plasma for Orthopedic Conditions
Platelet Rich Plasma is an excellent option, often with far better results than traditional methods, for musculoskeletal problems involving joint, tendons, and ligaments.
Platelet rich plasma
Platelet rich plasma (PRP) involves injecting a patient's own concentrated platelets and growth factors into injured areas to stimulate healing. PRP is used to treat tendon injuries, muscle strains, ligament sprains, joint injuries like arthritis or meniscus tears, and bone regeneration. It has also been used for wound healing after surgery, cardiac care, skin repair, cosmetic procedures, and dental applications. Case studies show PRP helped regenerate bone prior to dental implant placement in 89% of patients and reduced pain and accelerated recovery for a patient who received a PRP injection for a ruptured Achilles tendon.
PRP Platelet Rich Plasma for Hair Regrowth by Dr. Alan Bauman
This document discusses the use of platelet rich plasma (PRP) for hair regrowth. PRP contains growth factors that stimulate hair follicle growth and cycling. When injected into the scalp along with an extracellular matrix material, PRP has been shown to promote hair growth in cases of androgenetic alopecia and alopecia areata. The presentation reviews literature supporting PRP treatment, describes how to prepare and apply PRP injections, and discusses tools to measure hair growth outcomes.
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Dr Michael Toffler: 10-Year Experience Using L-PRF in Ridge and Sinus Augment...
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Using Platelet Rich Plasma for Orthopedic Conditions
Using Platelet Rich Plasma for Orthopedic Conditions
PRP Platelet Rich Plasma for Hair Regrowth by Dr. Alan Bauman
PRP Platelet Rich Plasma for Hair Regrowth by Dr. Alan Bauman
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Trends in local anesthetic injection techniques
This document discusses several new technologies for administering local anesthetic injections to children in a painless manner, including computer-controlled syringes, vibrating devices attached to syringes, jet injections using high pressure, and a potential future option using nanorobots instilled onto the gums. The goal is to reduce pain experienced during dental procedures to avoid damaging children's future responses to needed dental care.
Model Analysis
This document provides an overview of model analysis for mixed dentition. It defines study models and their objectives. Various types of model analyses are described, including those for mixed dentition like Moyer's analysis, which uses measurements of erupted mandibular incisors to estimate the sizes of unerupted canines and premolars. The goals and procedures of mixed dentition analysis are outlined, such as determining if there is enough space for permanent teeth. Factors considered include tooth sizes, arch perimeter, and expected changes during development.
PUBLISHING
This document provides guidelines for publishing manuscripts in medical/dental journals. It discusses various types of manuscripts like case reports, case series, research articles, and systematic reviews. It explains guidelines for each type like CARE guidelines for case reports and CONSORT guidelines for clinical trials. It also discusses the peer review process, impact factor, indexing/abstracting of journals, and tips for manuscript acceptance. Overall, the document serves as a useful reference for authors to understand the publishing process and guidelines for improving the quality of their manuscripts.
Invisalign in pediatric dentistry
Clear aligners are a revolutionary orthodontic treatment method that uses custom-made, removable, clear plastic aligners to gradually move teeth into the desired position. The treatment utilizes CAD/CAM technology to digitally plan and guide tooth movements through sequential aligner trays worn for two weeks each. Clear aligners are a viable treatment option for less complex malocclusions and offer advantages like aesthetics, comfort, and reduced treatment time compared to traditional braces. However, clear aligners also have limitations in the types of tooth movements that can be accurately achieved. Careful patient selection and use of ancillary devices may be needed to optimize clinical outcomes.
Minimal Intervention Dentistry
The document discusses the principles of minimal intervention dentistry (MID). It begins with the history and definitions of MID, highlighting key figures like GV Black, Hyatt, and Mount who advanced the concept. The document outlines the philosophy of MID, including the golden triangle of reduction, recognition, and repair. It discusses the caries process and various methods for caries detection and risk assessment, emphasizing early detection. The document then covers the minimal intervention approach, including caries removal techniques, cavity designs, and restorative materials used in MID. It concludes by noting the dental public health significance and articles supporting MID.
Radiograpgy in Pediatric Dentistry
The document discusses radiography techniques used in pediatric dentistry. It begins with an introduction and definitions of key terms like radiation and dental radiographs. The history of radiography is then outlined, noting important discoveries and advancements over time. Common radiographic techniques for pediatric patients are described, including bitewing, periapical, and panoramic radiographs. Guidelines for obtaining quality radiographs and selecting appropriate techniques based on a patient's age are also provided.
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This document provides an overview of questionnaire surveys and their design. It discusses key aspects of developing and conducting a questionnaire survey such as defining objectives, conceptualizing variables, exploring concepts through focus groups and interviews, designing the questionnaire, and testing methods. The document also covers factors that affect questionnaire surveys, advantages and disadvantages, psychology of asking questions, and ensuring validity and reliability. The overall summary is that this document outlines best practices for designing and implementing a rigorous questionnaire survey from start to finish.
Obturation Techniques in Primary Teeth
This document describes and compares various obturation techniques that can be used for filling root canals in primary teeth. It begins by defining obturation and describing the goal of creating a fluid-tight seal to prevent reinfection. It then provides details on 12 different techniques: endodontic pressure syringe, Lentulo spiral, mechanical syringe, incremental filling technique, Jiffy tube, tuberculin syringe, reamer technique, insulin syringe technique, disposable injection technique, NaviTip, bi-directional spiral, and Pastinject. For each technique, it discusses advantages such as ease of use and ability to fully fill canals, as well as disadvantages like difficulty with placement and increased risk of voids
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This document provides information about nasoalveolar molding (NAM) for treating cleft lip and palate. It defines cleft lip and cleft palate, and describes presurgical NAM which reshapes the alveolar and nasal segments before surgical repair. The key steps of NAM include taking an impression, fabricating an acrylic molding plate with a nasal stent, inserting the plate and using tape for retention, and making weekly adjustments to reshape the tissues over 3-5 months before surgery. The goals of NAM are to decrease the cleft deformity and improve symmetry, with benefits such as reducing the need for future bone grafts or surgeries.
Local anesthesia & details of surgical instruments in pedodontics
The document discusses details of surgical instruments used in pediatric dentistry, focusing on needles and local anesthesia. It provides a brief history of local anesthesia development. It then describes the composition of local anesthetic solutions, including the anesthetic agent, vasoconstrictor, reducing agent, preservative, fungicide, isotonic agent, and vehicle. It also classifies local anesthetics and discusses their metabolism. Finally, it discusses various needles, syringes, and cartridges used to administer local anesthesia, emphasizing factors important for pediatric patients such as needle gauge and length.
anticipatory guidance
This document provides anticipatory guidance for various stages of child development from infancy through adolescence. It begins with definitions of anticipatory guidance and caries risk assessment. It then covers topics like prenatal counseling, development of oral tissues, oral hygiene, teething, diet and nutrition, fluoride needs, non-nutritive habits, speech development, and more. Guidelines are provided for different age groups from 6-12 months to adolescence. The document aims to educate parents and caregivers to promote optimal oral health at each stage of development.
Management of maxillary canine impaction
The document provides information on comprehensive management of impacted canine teeth. It discusses the prevalence, classification, diagnosis and various treatment options for impacted canines. Some key points:
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- Classification systems are based on the position of the impacted canine crown relative to the dental arch and occlusal plane.
- Diagnosis involves clinical examination, radiographs such as panoramic and CBCT images to determine the location and relationship of the impacted tooth.
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Banding
This document provides information on banding instruments and procedures in pediatric dentistry. It discusses the history of bands, various band materials and sizes, advantages and disadvantages of bands, ideal band material requirements, instruments used for banding, and banding techniques. The key points are:
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- Stainless steel is commonly used due to properties like resistance to tarnish and springiness. Band sizes vary based on tooth type.
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Final
Tumors can affect the host locally, hormonally, and systemically. Locally, tumors can cause compression, obstruction, tissue destruction, and bleeding. Hormonally, tumors may cause paraneoplastic syndromes like hypoglycemia or hypercalcemia. Systemically, tumors can cause cachexia, fever, and anorexia. The immune system responds to tumors through cellular immunity using cytotoxic T cells and NK cells, and humoral immunity with antibody production. However, tumors evade immune responses through antigen loss, immunosuppression, and apoptosis of cytotoxic T cells. Immunotherapy uses active methods like vaccines or passive methods like antibodies to stimulate anti-tumor immunity.
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This document provides an overview of bacterial genetics. It discusses the structure and function of bacterial genetic material, including DNA and RNA. It describes protein synthesis through transcription and translation. It also covers extrachromosomal genetic elements in bacteria, bacterial variation, mutation, and gene transfer. The key topics covered include the lac operon and its role in regulating lactose metabolism, different types of mutations and their effects, and the mechanisms of genetic variation and antibiotic resistance in bacteria.
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This document discusses various spaces in the mandible that can become infected from dental infections, including the submental, sublingual, submandibular, masseteric, pterygomandibular, and temporal spaces. It describes the anatomy and boundaries of each space, potential causes of infection, clinical signs and symptoms, and surgical approaches for incision and drainage. Infections can spread between spaces if not properly treated.
Tetanus
Tetanus is a medical condition caused by a toxin produced by Clostridium tetani bacteria. It is characterized by prolonged contraction of skeletal muscle fibers. The toxin enters the body through breaks in the skin like wounds, burns, or puncture wounds. Incubation periods can last up to months but symptoms usually appear within 2 weeks. Generalized tetanus is the most common type and causes painful muscle spasms, lockjaw, and stiffness. It can be life-threatening if not properly treated with a tetanus immunoglobulin and antibiotic like metronidazole.
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This document discusses various topics related to antimicrobial agents including classification, mechanisms of action, uses, and adverse effects. It describes different classes of antibiotics such as beta-lactams, sulfonamides, fluoroquinolones, and their characteristics. It provides information on classification based on source and mechanism of action. Common uses and adverse effects of these antibiotics are also summarized. The document also includes several multiple choice questions related to antimicrobial therapy.
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9
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Platelet rich fibrin
- 1. GDC Platelet Rich Plasma Dr Ramesh R Kannur dental College
- 2. GDC Definition • PRP (Pletelet rich plasma) :concentrated source of autologous PLTs. • Platelet concentrate • APG(Autologous platelet gel) • Buffy coat
- 3. GDC Α-granules • At least 7 different growth factors that stimulate bone & soft tissue healing • PDGF • TGF • VEGF • EGF
- 4. GDC Α-granules • Do not contain insulin-like growth factors nor BMP • Adhesion molecule fibronectin vitronectin fibrin
- 5. GDC The role of PLT in wound healing • Injury • PLT activation • Within 10 min, granule migrate to the cell membrane surface and secrete growth factors ( inactive)
- 7. GDC 7 days later • PLT exhausted after 7 days • Macrophage by low oxygen tension, acidity, lactate concentration • Secrete same growth factors • Activated until it is down regulated by the restoration of normal oxygen tension
- 8. GDC Day 3rd
- 9. GDC 17days • Graft is completely permeated by new capillaries • Initial osteoid formation • Osteoclast resorb osteoid and BMP released • New bone formation and maturation
- 10. GDC Days 14
- 11. GDC Growth factors in PLT
- 12. GDC PDGF(pletelet-derived growth factors) • PDGF • Promoting angiogenesis, re-epithelization,formation of granulation tissue • Chemotaxis for mesenchymal cell,monocyte,neutrophiles
- 13. GDC TGF(transforming growth factor) • TGF • Stimulate cell replication similar to PDGF • Stimulate matrix production and guide differentiation towards cartilage or bone
- 14. GDC • Most potent multifuctional regulator of bone cell metabolism
- 15. GDC VEGF(vascular endothelial growth factor) • Effects on endothelial cells
- 16. GDC EGF(epithelial growth facator) • Effect limited on the basal cells of skin and mucus membrane
- 17. GDC The mechanism of growth factor effects on cells Inactive state
- 19. GDC Clinical effects of PRP on bone regeneration Platelet RBC Normal blood PRP
- 20. GDC • 4~7 times above a concentration of platelets than peripheral blood plates level • Bone mineral density 1.6~2,2 times increased • Rapid bone formation & earlier maturation.
- 21. GDC Trabecular area Native mandible Autogenous BG PRP
- 22. GDC Clinical effects of PRP on soft tissue healing • Split thickness skin graft
- 23. GDC 6 days Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue
- 24. GDC 6 months Thrombin side scarring hypo and hyper- pigmentation area PRP side less scarring Much less pigmentation change
- 25. GDC Patient discomfort • Patient discomfort decrease
- 27. GDC 6days ↔ ↔
- 28. GDC 1 months
- 29. GDC Mechanism • Growth factors contained PRP stimulated complete revascularization earlier and more complete • Early epithelial covering of exposed granulation tissue and C.T, the development of dermis is the mechanism that reduced scarring and a maximum regeneration of normal skin pigmentation
- 30. GDC Bovine thrombin issue • Bovine thrombin + CaCl2 clot initiator to activate PRP • CJD mad cow disease • Postop bleeding 100mg/ml of bovine factor
- 31. GDC Contraindications • Pre-existing coagulation defect : thrombocytopenia, hypofibrinogen • Hypersensitivity to bovine thrombin
- 32. GDC Clinical Application Chronic & Non-Healing Wounds Ears, Nose and Throat Surgery Gerneral Surgery Neurosurgery Ophthalmology Oral Surgery, Peridontal, Dental Implant Orthopedic Surgery Reconstructive / Plastic Surgery Urology