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College of V entering
ary Science
Proddatur
Andhra ptadesh
Plasma proteins
1) Serum albumin
2) Serum globulin
3) Fibrinogen
The serum consists of particularly albumin and globulin. The fibrinogen is observed
in serum because of its conversion into fibrin especially during the process of blood
clot. Due to this, the albumin and globulins are generally termed as serum albumin
and serum globulin
PLASMA PROTEINS
NORMAL VALUES
• The normal values of plasma proteins include
• Serum albumin 4.7 g/dL – 7.3 g/dL ( 6.4 to 8.3 g/dL)
• Serum globulin 2.3 g/dL
• Fibrinogen 0.3 g/dL
• Total Proteins 7.3 g/dL ( 6.4 to 8.3 g/dL)
• ALBUMIN GLOBULIN RATIO
• The ratio between plasma level of albumin and globulin is termed as Albumin/ Globulin ( A/G ) ratio.
This ratio informs about a very diseases related to kidney or liver. Normal A/G ratio is 2:1.
METHODS OF SEPARATION OF PLASMA PROTEINS
• Cohns Fractional Precipitation Method
• Electrophoretic Method
• Gel Filtration Chromatography
• Immunoelectrophoretic Method
• Precipitation Method
• Sating Out Method
• Ultra Centrifugation Method
PROPERTIES & ORIGIN
• PROPERTIES OF PLASMAPROTEINS INCLUDE
• Buffer Action
• Molecular weight
• Oncotic pressure
• Spoecific Gravity
•
• SITE OF ORIGIN OF PLASMA PROTEINS INCLUDE
• In EMBRYO
• IN ADULTS
ANCTIONS OF PLASMA PROTEINS
• Role in coagulation of blood
• Role in defense mechanism of body
• Role in erythrocyte sedimentation rate (ESR)
• Role in maintenance of osmotic pressure in blood
• Role as reserve proteins
• Role in suspension stability of red blood cells ( RBC )
• Role in transport mechanism
• Role in production of trephone substances
• Role in viscosity of blood
CONDITION IN WHICH PLASMA PROTEINS
INCREASE (HYPER PROTEINEMIA)
• Alcoholism
• Acute infections such as acute hepatitis and acute nephritis
• Dehydration
• Excess of glucocorticoids
• Hemolysis
• Leukemia
• Rheumatoid arthritis
• Respiratory distress syndrome
CONDITIONS IN WHICH PLASMA PROTEINS
DECREASES ( HYPOPROTEINEMIA )
• Burns
• Chronic infections namely chronic hepatitis and chronic nephritis
• Cirrhosis of liver
• Haemorrhage
• Malnutrition
• Pregnancy
• Prolonged starvation
• CONDITIONS IN WHICH ALBUMIN INCREASE
• Congestive hear failure
• Dehydration
• Excess of glucocorticoids
• CONDITIONS IN WHICH ALBUMIN DECREASES
• Burns
• Cirrhosis of liver
• Excess intake of water
• Hypothyroidism
• Malnutrition
• Nephrosis
• CONDITIONS IN WHICH GLOBULIN INCREASES:-
• Chronic infections
• Cirrhosis of liver
• Nephrosis
• Rheumatoid arthritis
•
• CONDITIONS IN WHICH GLOBULIN DECREASES:-
• Acute hemolytic anemia
• Emphysema
• Glomerulo nephritis
• Hypo gamma globulinemia
• CONDITIONS IN WHICH FIBRINOGEN INCREASES:
• Acute infections
• Glomerlo nephritis
• Myo cardial infarction
• Rhematoid arthritis
• Stroke
• Trauma
•
• CONDITIONS IN WHICH FIBRINOGEN DECREASES:-
• Liver disorder
• Use of anasbolic steroids
• Use of phenobarbital
• CONDITIONS IN WHICH A/G RATIO INCREASES-
• Excess of glcocorticoids
• Hypothyroidism
• Hypo gamma globulinemia
• Intake of more carbohydrate or protein diet.
•
• CONDITIONS IN WHICH A/G RATIO DECREASES:-
• Liver disorder
• Nephrosis
• REFERENCES:-
• A.D.A.M. Medical Encyclopedia. Albumin Blood (Serum) Test. Updated January 24, 2021. Accessed
November 24, 2022. https://medlineplus.gov/ency/article/003480.htm
• A.D.A.M. Medical Encyclopedia. Comprehensive Metabolic Panel. Updated January 24, 2021. Accessed
November 24, 2022. https://medlineplus.gov/ency/article/003468.htm
• A.D.A.M. Medical Encyclopedia. Total Protein. Updated May 1, 2021. Accessed November 24, 2022.
https://medlineplus.gov/ency/article/003483.htm
• A.D.A.M. Medical Encyclopedia. Protein Electrophoresis – Serum. Updated January 25, 2022. Accessed
November 24, 2022. https://medlineplus.gov/ency/article/003540.htm

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Plasma proteins_ Dr.Muralinath_Dr.c. kalyan

  • 1. College of V entering ary Science Proddatur Andhra ptadesh
  • 2. Plasma proteins 1) Serum albumin 2) Serum globulin 3) Fibrinogen The serum consists of particularly albumin and globulin. The fibrinogen is observed in serum because of its conversion into fibrin especially during the process of blood clot. Due to this, the albumin and globulins are generally termed as serum albumin and serum globulin PLASMA PROTEINS
  • 3. NORMAL VALUES • The normal values of plasma proteins include • Serum albumin 4.7 g/dL – 7.3 g/dL ( 6.4 to 8.3 g/dL) • Serum globulin 2.3 g/dL • Fibrinogen 0.3 g/dL • Total Proteins 7.3 g/dL ( 6.4 to 8.3 g/dL)
  • 4. • ALBUMIN GLOBULIN RATIO • The ratio between plasma level of albumin and globulin is termed as Albumin/ Globulin ( A/G ) ratio. This ratio informs about a very diseases related to kidney or liver. Normal A/G ratio is 2:1.
  • 5. METHODS OF SEPARATION OF PLASMA PROTEINS • Cohns Fractional Precipitation Method • Electrophoretic Method • Gel Filtration Chromatography • Immunoelectrophoretic Method • Precipitation Method • Sating Out Method • Ultra Centrifugation Method
  • 6. PROPERTIES & ORIGIN • PROPERTIES OF PLASMAPROTEINS INCLUDE • Buffer Action • Molecular weight • Oncotic pressure • Spoecific Gravity • • SITE OF ORIGIN OF PLASMA PROTEINS INCLUDE • In EMBRYO • IN ADULTS
  • 7. ANCTIONS OF PLASMA PROTEINS • Role in coagulation of blood • Role in defense mechanism of body • Role in erythrocyte sedimentation rate (ESR) • Role in maintenance of osmotic pressure in blood • Role as reserve proteins • Role in suspension stability of red blood cells ( RBC ) • Role in transport mechanism • Role in production of trephone substances • Role in viscosity of blood
  • 8. CONDITION IN WHICH PLASMA PROTEINS INCREASE (HYPER PROTEINEMIA) • Alcoholism • Acute infections such as acute hepatitis and acute nephritis • Dehydration • Excess of glucocorticoids • Hemolysis • Leukemia • Rheumatoid arthritis • Respiratory distress syndrome
  • 9. CONDITIONS IN WHICH PLASMA PROTEINS DECREASES ( HYPOPROTEINEMIA ) • Burns • Chronic infections namely chronic hepatitis and chronic nephritis • Cirrhosis of liver • Haemorrhage • Malnutrition • Pregnancy • Prolonged starvation
  • 10. • CONDITIONS IN WHICH ALBUMIN INCREASE • Congestive hear failure • Dehydration • Excess of glucocorticoids • CONDITIONS IN WHICH ALBUMIN DECREASES • Burns • Cirrhosis of liver • Excess intake of water • Hypothyroidism • Malnutrition • Nephrosis
  • 11. • CONDITIONS IN WHICH GLOBULIN INCREASES:- • Chronic infections • Cirrhosis of liver • Nephrosis • Rheumatoid arthritis • • CONDITIONS IN WHICH GLOBULIN DECREASES:- • Acute hemolytic anemia • Emphysema • Glomerulo nephritis • Hypo gamma globulinemia
  • 12. • CONDITIONS IN WHICH FIBRINOGEN INCREASES: • Acute infections • Glomerlo nephritis • Myo cardial infarction • Rhematoid arthritis • Stroke • Trauma • • CONDITIONS IN WHICH FIBRINOGEN DECREASES:- • Liver disorder • Use of anasbolic steroids • Use of phenobarbital
  • 13. • CONDITIONS IN WHICH A/G RATIO INCREASES- • Excess of glcocorticoids • Hypothyroidism • Hypo gamma globulinemia • Intake of more carbohydrate or protein diet. • • CONDITIONS IN WHICH A/G RATIO DECREASES:- • Liver disorder • Nephrosis
  • 14. • REFERENCES:- • A.D.A.M. Medical Encyclopedia. Albumin Blood (Serum) Test. Updated January 24, 2021. Accessed November 24, 2022. https://medlineplus.gov/ency/article/003480.htm • A.D.A.M. Medical Encyclopedia. Comprehensive Metabolic Panel. Updated January 24, 2021. Accessed November 24, 2022. https://medlineplus.gov/ency/article/003468.htm • A.D.A.M. Medical Encyclopedia. Total Protein. Updated May 1, 2021. Accessed November 24, 2022. https://medlineplus.gov/ency/article/003483.htm • A.D.A.M. Medical Encyclopedia. Protein Electrophoresis – Serum. Updated January 25, 2022. Accessed November 24, 2022. https://medlineplus.gov/ency/article/003540.htm