Placebo, The Wonder Drug?
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In this http://interestingsouth.com co-presentation with Miles Campbell of tta.edu.au we propose that it's time consumers signed a consent form that gives their doctors permission to prescribe placebos when the doctor thinks it's the best course of treatment.
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Placebo effect
The placebo effect refers to the positive health effects experienced after taking an inert substance. Placebos are often used in clinical trials and may be prescribed by doctors. The placebo effect is triggered by a person's belief in the treatment and expectation of feeling better. Research shows that factors like pill size, color, and whether it's a pill or injection can influence the strength of the placebo effect. Conversely, the nocebo effect describes negative health effects from inert substances when a person expects negative effects. Both effects demonstrate the power of the mind-body connection and our ability to influence our health through belief and expectation.
Placebo full topic
This document discusses placebos, including their definition, history, mechanisms, clinical utility, individual variation, symptoms/conditions treated, and use in research. Key points include:
- A placebo is an inert substance or procedure used in clinical research trials and practice to compare against actual medical treatments.
- The placebo effect is a therapeutic improvement in a patient from an inert substance due to psychological factors like expectations and conditioning.
- Placebos can activate areas of the brain related to expectations and the release of endorphins, helping to relieve symptoms.
- While placebo effects can last for months in some cases, their clinical significance is considered small and hard to distinguish from reporting bias alone. Placebos are not recommended
Placebo
The placebo effect refers to the improvements in health or symptoms that occur after a placebo treatment despite the treatment having no active therapeutic ingredients. Placebos have been shown to have physiological effects through biochemical responses to the expectation of treatment. While the placebo effect was once thought to be solely psychological, research has demonstrated that placebos can produce real, measurable somatic effects similar to actual medical treatments including surgery. The nocebo effect, where negative expectations lead to adverse health effects, has also been shown to have biological underpinnings. Together, the placebo and nocebo effects show that mind-body connections and expectations play an important role in health beyond just the biochemical properties of treatments.
SRK@SDMIONS;PLACEBO EFFECT;PPT
The document summarizes research on the placebo effect in clinical studies. It discusses how placebos can produce physiological effects through psychoneuroimmunological responses and the patient's expectations of treatment. Studies found placebos helped reduce depression, asthma attacks, and aided wound healing by influencing immune system responses. While placebos may provide relief, their effects are ultimately mediated by the patient's beliefs about the treatment rather than an actual medical intervention.
Placebo & pain
Placebos can produce real physiological effects through mechanisms like decreased anxiety, learning, expectations, and the body's natural painkilling endorphins. Studies show placebo interventions relieve symptoms in 5-55% of patients across conditions like asthma, ulcers, angina, postoperative pain, and back pain. Certain patient and provider factors influence placebo responses; warmth, empathy, and positively conveying realistic optimism about treatment are important.
Placebo Effect.
The document discusses the placebo effect through several sections:
1. It introduces the placebo effect as a psychosomatic phenomenon where symptoms improve from exposure to treatment due to endorphins, even without active ingredients.
2. It explains that the placebo effect is influenced by expectations, meaning, and cultural factors. Alternative medicines generally don't perform better than placebos in controlled trials.
3. It explores strange aspects of the placebo effect like responses in animals/babies, dose-response curves, and placebos seemingly overriding real drugs' effects.
4. The nocebo effect is introduced as the negative counterpart where expecting negative effects can generate or worsen them.
5. A landmark study finding
Placebo Effect
Cure, how placebo works, placebo, placebo effect, What is the placebo effect, Mechanism of the placebo effect, How does the placebo effect works, How are placebos used
Placebo Effect In Clinical Studies
Placebo effect in clinical research is a fascinating and widely researched phenomenon in biomedical research and medicine in general. Presentation is an overview of origins and impact of placebo effect in development of new medicines.
Recommended
Placebo effect
The placebo effect refers to the positive health effects experienced after taking an inert substance. Placebos are often used in clinical trials and may be prescribed by doctors. The placebo effect is triggered by a person's belief in the treatment and expectation of feeling better. Research shows that factors like pill size, color, and whether it's a pill or injection can influence the strength of the placebo effect. Conversely, the nocebo effect describes negative health effects from inert substances when a person expects negative effects. Both effects demonstrate the power of the mind-body connection and our ability to influence our health through belief and expectation.
Placebo full topic
This document discusses placebos, including their definition, history, mechanisms, clinical utility, individual variation, symptoms/conditions treated, and use in research. Key points include:
- A placebo is an inert substance or procedure used in clinical research trials and practice to compare against actual medical treatments.
- The placebo effect is a therapeutic improvement in a patient from an inert substance due to psychological factors like expectations and conditioning.
- Placebos can activate areas of the brain related to expectations and the release of endorphins, helping to relieve symptoms.
- While placebo effects can last for months in some cases, their clinical significance is considered small and hard to distinguish from reporting bias alone. Placebos are not recommended
Placebo
The placebo effect refers to the improvements in health or symptoms that occur after a placebo treatment despite the treatment having no active therapeutic ingredients. Placebos have been shown to have physiological effects through biochemical responses to the expectation of treatment. While the placebo effect was once thought to be solely psychological, research has demonstrated that placebos can produce real, measurable somatic effects similar to actual medical treatments including surgery. The nocebo effect, where negative expectations lead to adverse health effects, has also been shown to have biological underpinnings. Together, the placebo and nocebo effects show that mind-body connections and expectations play an important role in health beyond just the biochemical properties of treatments.
SRK@SDMIONS;PLACEBO EFFECT;PPT
The document summarizes research on the placebo effect in clinical studies. It discusses how placebos can produce physiological effects through psychoneuroimmunological responses and the patient's expectations of treatment. Studies found placebos helped reduce depression, asthma attacks, and aided wound healing by influencing immune system responses. While placebos may provide relief, their effects are ultimately mediated by the patient's beliefs about the treatment rather than an actual medical intervention.
Placebo & pain
Placebos can produce real physiological effects through mechanisms like decreased anxiety, learning, expectations, and the body's natural painkilling endorphins. Studies show placebo interventions relieve symptoms in 5-55% of patients across conditions like asthma, ulcers, angina, postoperative pain, and back pain. Certain patient and provider factors influence placebo responses; warmth, empathy, and positively conveying realistic optimism about treatment are important.
Placebo Effect.
The document discusses the placebo effect through several sections:
1. It introduces the placebo effect as a psychosomatic phenomenon where symptoms improve from exposure to treatment due to endorphins, even without active ingredients.
2. It explains that the placebo effect is influenced by expectations, meaning, and cultural factors. Alternative medicines generally don't perform better than placebos in controlled trials.
3. It explores strange aspects of the placebo effect like responses in animals/babies, dose-response curves, and placebos seemingly overriding real drugs' effects.
4. The nocebo effect is introduced as the negative counterpart where expecting negative effects can generate or worsen them.
5. A landmark study finding
Placebo Effect
Cure, how placebo works, placebo, placebo effect, What is the placebo effect, Mechanism of the placebo effect, How does the placebo effect works, How are placebos used
Placebo Effect In Clinical Studies
Placebo effect in clinical research is a fascinating and widely researched phenomenon in biomedical research and medicine in general. Presentation is an overview of origins and impact of placebo effect in development of new medicines.
Sneha modak ppt
This document discusses clinical research and the placebo effect. It defines observational and interventional clinical studies. It describes the phases of clinical trials from Phase 0 to Phase IV. It explains that the word "placebo" comes from Latin meaning "I shall please." It discusses the placebo effect and nocebo effect, and the potential mechanisms of the placebo effect involving the release of endorphins. Examples of conditions responsive to the placebo effect include cancer, IBS, depression, and Parkinson's disease. A case study found that depressed people who responded to placebos also responded well to real antidepressants.
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This document provides guidance on deprescribing benzodiazepine receptor agonists (BZRAs) used to treat insomnia. It recommends non-drug approaches like cognitive behavioral therapy (CBT) as first-line treatment for insomnia. For patients taking BZRAs, it outlines a gradual tapering process to minimize withdrawal symptoms. Tapering should be individualized and involve both patient education and behavioral strategies to manage insomnia without medications.
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This editorial discusses advances in the treatment of depression, focusing on new drugs that target the opioid receptor system. Specifically, it describes how researchers have found that developing antagonists of the kappa opioid receptor (OPKR) may effectively treat major depression without significantly increasing pleasure responses. Two such drugs currently in clinical trials are highlighted - ALKS-5461, which combines buprenorphine and samidorphan, and LY-2456302/CERC-501 being developed by Eli Lily. The editorial concludes by noting that targeting the endogenous opioid system through OPKR antagonism offers hope for treating treatment-resistant depression and suicidal patients.
What is Placebo effect?
The document discusses the placebo effect, which is when a fake or inactive treatment seems to improve a patient's condition due to their expectation that it will help. Expectation plays a large role, and the more a patient believes a treatment will work, the more likely they are to experience benefits. The placebo effect is influenced by many factors like positive thought, stress reduction, and cultural meanings around medical treatment. However, deliberately prescribing placebos, known as placebopathy, is considered unethical as it involves deceiving patients and could delay treatment of real conditions.
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The document discusses the distinction between illness and cure, noting that this distinction may be unclear. It provides two examples: benzodiazepines for panic disorder, which initially reduce symptoms but can worsen the disorder after discontinuation; and cognitive behavioral therapy (CBT) for panic disorder, which produces symptoms to help patients understand and overcome their disorder, providing a long-lasting cure. The document questions whether "Too Big to Fail" policies cure financial crises or exacerbate underlying issues.
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This document provides information about antidepressant medication, including how they work, when they are used, potential side effects, and treatment duration. It explains that antidepressants are thought to work by increasing serotonin and norepinephrine in the brain, and are often prescribed alongside therapy for moderate to severe depression and anxiety. Common side effects include nausea, headaches, and sexual difficulties, though some are short-lived. People may need to take antidepressants for different lengths of time, from just 12 months to indefinitely, and stopping medication requires medical supervision.
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Tai Chi is an ancient Chinese exercise that can help improve insomnia. A study found that patients with chronic heart failure who participated in 12 weeks of Tai Chi training experienced significantly decreased time spent in unstable sleep states and improved sleep stability compared to a control group. This enhanced sleep may benefit blood pressure, heart rate, and quality of life for heart failure patients. A separate study on older women with osteoarthritis found that 12 weeks of Tai Chi led to reductions in pain and stiffness by 35% and 29% respectively, and improved ability to perform daily tasks by 29%, compared to no changes in a control group. Tai Chi appears to be a beneficial exercise for managing arthritis symptoms and physical functioning.
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This summary focuses on two articles that correlate stress and external factors. The first article by Theodore. B. Vanitallie, (2002) examines the pathology of stress while the research experiment by Bloch, M. (2007) investigates the effect of divorce on stress levels and physiological responses.
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1) Adherence therapy is a collaborative approach that aims to improve medication adherence in young people with psychosis by addressing concerns and ambivalence about treatment.
2) A study found that adherence therapy training for early psychosis staff resulted in lower relapse rates in patients compared to the previous 12 months. Both staff and patients found the approach acceptable and helpful.
3) However, maintaining adherence therapy skills over time and implementing it within real-world time constraints remain challenges.
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Quetiapine XR provides advantages over the immediate release formulation for patients and clinicians. It allows for once-daily dosing, simplifies titration, and facilitates reaching therapeutic doses earlier through an initial higher dose. This makes adherence more likely. Studies also found Quetiapine XR had a better tolerability profile with less sedation and orthostatic hypotension compared to the immediate release formulation. Quetiapine more broadly has benefits for treating depression, psychosis, and behavioral symptoms associated with various neurological conditions due its antidepressant, antipsychotic, and sleep promoting effects with a low risk of side effects.
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This document summarizes research on using light therapy to treat seasonal affective disorder (SAD) in adult women. It conducted a literature review of 35 articles on light therapy and SAD, finding that light therapy significantly decreased depressive symptoms associated with SAD when compared to placebo treatments. Specifically, a minimum of 4 weeks of bright light therapy proved more effective than placebo therapies in reducing symptoms. However, the document also noted that further research is still needed to standardize treatment protocols and create more effective placebos to better evaluate light therapy's efficacy.
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This document summarizes guidelines for managing schizophrenia through pharmacological and psychosocial treatment. It discusses using antipsychotic medications such as second generation antipsychotics for acute episodes and maintaining treatment. Clozapine is recommended for treatment-resistant cases. Psychosocial interventions like family therapy, cognitive behavioral therapy, social skills training, supported employment, and substance abuse rehabilitation are described. Long-acting injectable antipsychotics can help with treatment adherence. The overall goal of management is achieving remission of symptoms and optimal functioning through a combination of medical and psychosocial support.
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1) The study found that placebo analgesia activates the endogenous opioid system by examining the effects of naloxone on placebo responses.
2) Subjects received either naloxone or saline before a thermal pain test, where one area was treated with a placebo cream. Naloxone reduced both behavioral and neural placebo effects.
3) Brain regions involved in pain processing like the rACC, PAG, and RVM showed stronger responses to placebo that were blocked by naloxone, indicating the role of endogenous opioids. The main pathway of placebo analgesia involves PAG -> RVM -> spinal cord.
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Basic introduction to clinical trials and the placebo effect. Definitions, examples and cartoons illustrating the subject. Ends with short info on informed consent.
Placebo presentation
The document discusses the placebo effect and explores what placebo is, how belief can cure people and influence the physical body, and why the placebo effect works for some but not others. It examines evidence that placebo activates the endogenous opioid and immune systems in the brain. While the placebo effect seems to have evolved to conserve energy, harnessing its power ethically as a medicine requires more research on individual differences and how social contexts like a supportive doctor can enhance the effect.
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The document discusses treatment evaluation and placebo effects, noting that placebos can produce real physiological or psychological effects through mechanisms like expectations, conditioning, and personality factors, even when a person knows they are taking an inert substance. Placebos have been shown to be effective for a wide range of conditions from depression to pain to irritable bowel syndrome. While placebos may be pharmacologically inert, they are not necessarily psychologically or therapeutically inert.
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Advances in The Therapy of Depression_Crimson Publishers
This editorial discusses advances in the treatment of depression, focusing on new drugs that target the opioid receptor system. Specifically, it describes how researchers have found that developing antagonists of the kappa opioid receptor (OPKR) may effectively treat major depression without significantly increasing pleasure responses. Two such drugs currently in clinical trials are highlighted - ALKS-5461, which combines buprenorphine and samidorphan, and LY-2456302/CERC-501 being developed by Eli Lily. The editorial concludes by noting that targeting the endogenous opioid system through OPKR antagonism offers hope for treating treatment-resistant depression and suicidal patients.
What is Placebo effect?
The document discusses the placebo effect, which is when a fake or inactive treatment seems to improve a patient's condition due to their expectation that it will help. Expectation plays a large role, and the more a patient believes a treatment will work, the more likely they are to experience benefits. The placebo effect is influenced by many factors like positive thought, stress reduction, and cultural meanings around medical treatment. However, deliberately prescribing placebos, known as placebopathy, is considered unethical as it involves deceiving patients and could delay treatment of real conditions.
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Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
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This document provides an overview of evidence-based psychiatry. It defines evidence-based medicine and outlines the key steps, including formulating an answerable clinical question using PICO, finding the best evidence, appraising the evidence, and applying it to individual patients. The document discusses different types of studies and how to evaluate their results, focusing on sensitivity, specificity, odds ratios, and other statistical concepts. It emphasizes integrating individual clinical expertise with the best available external evidence.
The Strategist Original Duality
The document discusses the distinction between illness and cure, noting that this distinction may be unclear. It provides two examples: benzodiazepines for panic disorder, which initially reduce symptoms but can worsen the disorder after discontinuation; and cognitive behavioral therapy (CBT) for panic disorder, which produces symptoms to help patients understand and overcome their disorder, providing a long-lasting cure. The document questions whether "Too Big to Fail" policies cure financial crises or exacerbate underlying issues.
Antidepressant medication advice for adults
This document provides information about antidepressant medication, including how they work, when they are used, potential side effects, and treatment duration. It explains that antidepressants are thought to work by increasing serotonin and norepinephrine in the brain, and are often prescribed alongside therapy for moderate to severe depression and anxiety. Common side effects include nausea, headaches, and sexual difficulties, though some are short-lived. People may need to take antidepressants for different lengths of time, from just 12 months to indefinitely, and stopping medication requires medical supervision.
Complementary and Alternative Medicine - Tai Chi for Insomnia
Tai Chi is an ancient Chinese exercise that can help improve insomnia. A study found that patients with chronic heart failure who participated in 12 weeks of Tai Chi training experienced significantly decreased time spent in unstable sleep states and improved sleep stability compared to a control group. This enhanced sleep may benefit blood pressure, heart rate, and quality of life for heart failure patients. A separate study on older women with osteoarthritis found that 12 weeks of Tai Chi led to reductions in pain and stiffness by 35% and 29% respectively, and improved ability to perform daily tasks by 29%, compared to no changes in a control group. Tai Chi appears to be a beneficial exercise for managing arthritis symptoms and physical functioning.
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Autism spectrum disorder (ASD) is a developmental disorder characterized by impaired social communication and repetitive behaviors. Reported prevalence is approximately 1% of children. Children with ASD often experience psychiatric issues like aggression, anxiety, and mood symptoms. While medications are often prescribed, children with ASD generally respond less favorably than peers. Current evidence shows risperidone and aripiprazole can effectively treat irritability, and methylphenidate can treat ADHD symptoms, but side effects are common. More treatment options are still needed to address the core symptoms of ASD.
Stress And External Factors
This summary focuses on two articles that correlate stress and external factors. The first article by Theodore. B. Vanitallie, (2002) examines the pathology of stress while the research experiment by Bloch, M. (2007) investigates the effect of divorce on stress levels and physiological responses.
Quatiapine ppt
Quetiapine (brand name Seroquel) is an antipsychotic medication used to treat schizophrenia, bipolar disorder, depression, and other mental health conditions. It works by affecting dopamine and serotonin levels in the brain. Generic versions have been found to be equivalent to the brand name when rated by the FDA. Common side effects include drowsiness, dizziness, and dry mouth. It is important to take quetiapine as prescribed by your doctor and notify them immediately of any severe side effects. Community support workers should follow care plans, monitor for side effects, and ensure clients stay hydrated when taking quetiapine.
Effect of Adherence Therapy in Young People with Psychosis
1) Adherence therapy is a collaborative approach that aims to improve medication adherence in young people with psychosis by addressing concerns and ambivalence about treatment.
2) A study found that adherence therapy training for early psychosis staff resulted in lower relapse rates in patients compared to the previous 12 months. Both staff and patients found the approach acceptable and helpful.
3) However, maintaining adherence therapy skills over time and implementing it within real-world time constraints remain challenges.
Quetiapine in Clinical Neurological Practice
Quetiapine XR provides advantages over the immediate release formulation for patients and clinicians. It allows for once-daily dosing, simplifies titration, and facilitates reaching therapeutic doses earlier through an initial higher dose. This makes adherence more likely. Studies also found Quetiapine XR had a better tolerability profile with less sedation and orthostatic hypotension compared to the immediate release formulation. Quetiapine more broadly has benefits for treating depression, psychosis, and behavioral symptoms associated with various neurological conditions due its antidepressant, antipsychotic, and sleep promoting effects with a low risk of side effects.
EBP Light Therapy- Hulse
This document summarizes research on using light therapy to treat seasonal affective disorder (SAD) in adult women. It conducted a literature review of 35 articles on light therapy and SAD, finding that light therapy significantly decreased depressive symptoms associated with SAD when compared to placebo treatments. Specifically, a minimum of 4 weeks of bright light therapy proved more effective than placebo therapies in reducing symptoms. However, the document also noted that further research is still needed to standardize treatment protocols and create more effective placebos to better evaluate light therapy's efficacy.
Schizophrenia management
This document summarizes guidelines for managing schizophrenia through pharmacological and psychosocial treatment. It discusses using antipsychotic medications such as second generation antipsychotics for acute episodes and maintaining treatment. Clozapine is recommended for treatment-resistant cases. Psychosocial interventions like family therapy, cognitive behavioral therapy, social skills training, supported employment, and substance abuse rehabilitation are described. Long-acting injectable antipsychotics can help with treatment adherence. The overall goal of management is achieving remission of symptoms and optimal functioning through a combination of medical and psychosocial support.
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1) The study found that placebo analgesia activates the endogenous opioid system by examining the effects of naloxone on placebo responses.
2) Subjects received either naloxone or saline before a thermal pain test, where one area was treated with a placebo cream. Naloxone reduced both behavioral and neural placebo effects.
3) Brain regions involved in pain processing like the rACC, PAG, and RVM showed stronger responses to placebo that were blocked by naloxone, indicating the role of endogenous opioids. The main pathway of placebo analgesia involves PAG -> RVM -> spinal cord.
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Basic introduction to clinical trials and the placebo effect. Definitions, examples and cartoons illustrating the subject. Ends with short info on informed consent.
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The document discusses the placebo effect and explores what placebo is, how belief can cure people and influence the physical body, and why the placebo effect works for some but not others. It examines evidence that placebo activates the endogenous opioid and immune systems in the brain. While the placebo effect seems to have evolved to conserve energy, harnessing its power ethically as a medicine requires more research on individual differences and how social contexts like a supportive doctor can enhance the effect.
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The document discusses treatment evaluation and placebo effects, noting that placebos can produce real physiological or psychological effects through mechanisms like expectations, conditioning, and personality factors, even when a person knows they are taking an inert substance. Placebos have been shown to be effective for a wide range of conditions from depression to pain to irritable bowel syndrome. While placebos may be pharmacologically inert, they are not necessarily psychologically or therapeutically inert.
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El documento describe el efecto placebo y su uso en investigaciones clínicas. Explica que el efecto placebo se refiere a la mejoría de síntomas de un paciente tratado con una sustancia sin efectos farmacológicos directos, debido a factores psicológicos. También analiza los dilemas éticos del uso de placebos en ensayos clínicos y establece que se justifica siempre que se obtenga consentimiento informado y no existan tratamientos efectivos disponibles.
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The document reports on 3 experiments that examined the placebo effect of marketing actions, specifically price discounts. Experiment 1 found that participants who received an energy drink at a discounted price ($0.89 vs the regular $2.89 price) solved more puzzles than those who paid the regular price, but only when expectations were high. Experiment 2 ruled out alternative explanations for these results. Experiment 3 provided further support that response expectancies mediate the placebo effect of price by manipulating expectations. The research demonstrated that marketing actions like price promotions can influence the actual efficacy of products through nonconscious placebo effects.
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Mind over Matter and Positive Psychology
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Placebos can have real physiological effects through expectation and conditioning, but distinguishing the "true" placebo effect requires removing confounding factors. Studies show placebos reduce pain as measured by brain imaging similarly to opioids, but the effect is removed when combined with an opioid antagonist. A trial of asthma treatments found no difference between a placebo inhaler and no treatment when using an objective outcome measure and a cross-over design without patient expectations.
drug-actions.pdf
This document discusses the concepts of pharmacokinetics and pharmacodynamics. Pharmacokinetics refers to how the body affects a drug, including absorption, distribution, metabolism and excretion of drugs over time. Key concepts covered include how drug formulation, environmental pH, plasma protein binding and liver/kidney function impact these processes. Pharmacodynamics refers to how drugs act on the body through their receptors and physiological effects.
Neuropharmacology: Anxiety Disorders
This document summarizes several anxiety disorders including generalized anxiety disorder, panic disorder, phobias, obsessive compulsive disorder, and post-traumatic stress disorder. It discusses the primary symptoms and epidemiology of each disorder. It also outlines several first-line and second-line treatment options, including cognitive behavioral therapy, SSRIs, benzodiazepines, and psychosurgery. Additionally, it reviews several animal models used to study anxiety and the neurochemistry of the GABA and serotonin systems in relation to anxiety disorders.
Healthy sleep patterns
This document discusses healthy sleep patterns and sleep disorders. It begins by introducing the importance of restful sleep and common sleep disorders. It then defines key terms in sleep medicine like sleep tech, sleep doctor, polysomnogram, and events. The stages of sleep are explained along with treatments like CPAP and BIPAP. Alternative herbal treatments for sleep are mentioned alongside resources for further information.
Deep sleep and stress
The document discusses the importance of sleep for health and provides tips for improving sleep. It notes that sleep between 11 PM - 1 AM is important for optimal functioning as it allows for deep sleep and REM sleep. It warns that lack of sleep can increase risks of various diseases and conditions. The document recommends getting checked for chiropractic subluxations, losing weight, avoiding stimulants before bed, keeping a regular sleep schedule and dark/cool bedroom to promote better sleep.
Cartoon Introduction to Evidence in Medicine
An anecdote is a personal story that does not provide strong evidence on its own due to small sample sizes, reporting bias, and lack of a control group. Larger controlled studies are needed to establish if a treatment is truly effective. Placebos can still provide relief from expectations even without active ingredients, so anecdotal reports do not prove the underlying cause of improvement. Herbal remedies contain active chemical compounds that can impact the body like pharmaceutical drugs, but their effects and safe dosages are often less clearly defined.
02 friday post lunch 10-24-14
This document provides information about Person-Centered Planning and self-advocacy for people with disabilities. It discusses how Person-Centered Planning began in 1974 as an alternative to the terms "retarded" and "handicapped." The planning process focuses on the individual, learning about their preferences, needs, and goals. It emphasizes that the person with a disability should be at the center of their plan, not their parents or other family members. Examples of self-advocacy stories are also mentioned. Resources for Person-Centered Planning and disability rights are listed at the end.
The neurochemical basis of exercise
This document discusses the complex neurochemistry underlying exercise and human behavior. It notes that every individual's brain chemistry and response to exercise is unique due to genetic and environmental factors. While certain neurotransmitters like dopamine and endorphins generally promote exercise motivation and pain suppression, their levels and effects vary significantly between individuals. The document advocates that trainers and coaches recognize this bioindividuality and psychoindividuality to develop more effective, personalized training programs. It also stresses that more research is still needed to fully understand how exercise impacts the brain.
Placebo
Dr. Nazuk Sharma will present on placebos, including:
1. Defining placebos and exploring their history and mechanisms of action.
2. Examining factors that influence placebo response and their applications in clinical trials and research.
3. Discussing ethics and guidelines around the use of placebos in human research.
Sbsbbeb e71218134012 (1).pptx
Dr. Nazuk Sharma presented on placebos. Some key points:
1. A placebo is a dummy medicine containing no active substance that can produce physiological or psychological effects through a patient's expectations.
2. Placebos have been used since the 18th century and the placebo effect is thought to be mediated by factors like conditioning, expectations, and the endogenous opioid system.
3. Placebo response rates in clinical trials average around 35% but can be as high as 70-80% when patients don't know they are receiving placebos. Placebos are used in clinical trials to compare to active treatments and identify placebo responders.
Placebo.pptx
Placebos are inactive substances or interventions that are used in controlled studies for comparison with potentially active drugs. Placebos are harmless substances given to patients to make them feel better through the power of suggestion, even though they contain no actual medical treatment. Common examples of placebos include sugar pills used in clinical trials. The main difference between placebos and drugs is that placebos have no actual physiological effect - any improvement in symptoms is due to the placebo effect, whereas drugs produce consistent, physiological effects regardless of suggestion.
Bensing ICCH09 Plenary PowerPoint
This plenary took place on Monday, October 5, at 8:30 am during the International Conference on Communication in Healthcare (ICCH) 2009, in Miami Beach, Florida, USA.
The Silent Healer; The Role of Communication in the Placebo Effect
Jozien Bensing, PhD, was born in 1950 in Tilburg, the Netherlands. After finishing her formal education as clinical psychologist at Utrecht University, she started a research career at the Netherlands Institute for General Practitioners. She is founder and first president of the European Association of Communication in Health Care. In 1985 she became director of the Netherlands Institute for Health Services Research. She was appointed as full professor of Health Psychology at Utrecht University in 1991. She is a member of several councils and committees on the interface between the scientific world and healthcare, such as the Netherlands Society of Sciences, the Dutch Royal Academy of Sciences, the Dutch Health Council and the National Advisory Council on Health Research. She supervised more than 20 PhD-theses and wrote more than 200 publications, mostly on healthcare communication and related issues.
In 2003 Jozien Bensing became the first non-American to receive the international George Engel Award for “outstanding research contributing to the theory, practice and teaching of effective healthcare communication and related skills” from the American Academy on Physician and Patient
(now AACH). In 2004 she received a royal decoration (‘Officer of the Order of Orange Nassau’) for her work in translating scientific knowledge into public. She received the prestigious SPINOZA-award for her research on doctor-patient communication in 2006; in 2007 she was chosen to become a member of the Royal Netherlands Academy of Sciences, which consists of the top-200 most prestigious Dutch scientists.
Tues 11am wrobel anticonvulsant pipeline
The document summarizes several new and emerging anticonvulsant drugs in development or recently approved. Brivaracetam is a cleaner version of levetiracetam with fewer side effects. Fenfluramine is being developed for Dravet syndrome. Cenobamate has shown significant efficacy in phase 2 trials and may be approved in 2018. Epidiolex contains highly purified cannabidiol and has shown efficacy in reducing seizures in phase 3 trials. Everolimus is now approved as an adjunctive treatment for seizures caused by tuberous sclerosis complex based on positive phase 3 results. Fish oil supplementation has also shown promise in reducing seizure frequency. Ganaxolone targets GABA receptors and may be safer than benz
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Natural pills such as Night Fire helps to produce more seminal fluid, increase sperm volume, boost libido, enhance stamina, strengthen reproductive system, and give back to back rock hard erection.
Brain Power for Peace: Building Global Relations through Neuroplasticity
Building neuroplasticity, or the brain's ability to change, reform, and reorganize information, can improve cognitive, emotional, and prosocial functions at any age. We will provide an overview of this cutting-edge neuroscience and facilitate discussions on how Rotarians can enhance negotiating skills and increase prosocial behaviors in their community. Let us inspire you to build peaceful global relations through driving neuroplasticity in a positive direction.
Drug development and delivery system in BME
Drug delivery system introduction and its application in biomedical engineering
Introduction to Evidence Based Medicine
The document provides an introduction to evidence-based medicine (EBM). It defines EBM as using the best current evidence from clinical research in medical decision making. EBM requires considering both research evidence and a patient's values and preferences. Reliable evidence comes from systematic reviews and meta-analyses of multiple studies rather than individual studies or expert opinions. Practicing EBM involves forming a clear clinical question, finding the best evidence, critically evaluating it, and applying the results to patient care. While evidence-based studies aim to be rigorous, their results could still mislead due to biases or other limitations if not properly appraised.
jenkuskyP101_MHC_BenzoForPharmacists_011617.ppt
The document discusses benzodiazepine overuse and its consequences. It provides background on the history and mechanism of action of benzodiazepines. It reviews currently available benzodiazepines and how they differ in terms of pharmacokinetics. It discusses appropriate clinical uses of benzodiazepines as well as risks like abuse, withdrawal, and side effects. It notes increasing benzodiazepine prescriptions and quantities in the US have corresponded to rising emergency department visits and death rates, especially when combined with opioids or alcohol. Combining benzodiazepines with other substances greatly increases risks of serious outcomes.
Drug discoverydevelopment2011
The document outlines the multi-step process of drug discovery and development. Key steps include:
1) Choosing a disease target and drug target. Common targets are diseases in developed countries.
2) Identifying a "lead compound" with some bioactivity against the target through screening natural products, synthetic libraries, or modifying existing drugs.
3) Optimizing the lead through structure-activity relationship studies and analog synthesis to improve potency and selectivity and identify the pharmacophore responsible for activity.
4) Testing analogs in animal and human clinical trials to determine toxicity, efficacy, and pharmacokinetics before patenting and commercialization. The process aims to continually improve drug properties while avoiding side effects.
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This open letter to the editor-in-chief of the Australian Financial Review requests that the newspaper stop an ongoing smear campaign by one of its journalists, Joe Aston, against venture capitalist Elaine Stead. The letter notes that Stead won a defamation case against Aston but he has continued attacking her in his columns. The signatories view Stead as an effective investor and want her to be able to continue her career without harassment now that the court has ruled in her favor. They are also concerned about the reputational impacts on the broader Australian tech venture capital industry.
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The document is a satirical pitch deck that humorously exaggerates common startup pitch tropes:
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Shhh is born from the belief that there is meaningful experience to be discovered when a group of people share a space and are still and silent.
Many people miss out on meaningful reflective times that are created in silent ceremonies, because they don't share the history, beliefs, culture or practices that are associated with most rituals in modern society.
Anyone from any background is welcome to share the silent space created by Shhh with others, and be confident that they will not be expected to listen to, judge or defend anyone's views or beliefs.
Find out more at <a>www.weallneedabitofshhh.com</a>
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Placebo, The Wonder Drug?
- 1. Placebos, wonder drugs? Miles Campbell and Alan Jones
- 3. Imagine a wonder drug... • Placebo: a substance or procedure that has no known specific activity for the condition being treated. • Pills, creams, inhalants, injections, ultrasound, sham surgery, acupuncture... even the practitioner • Effectiveness as high as 90% of trial participants
- 4. Common household placebos
- 5. Why such a bad rep? • Drug testing assumes placebos are a baseline • But they do have an effect • 75% of the effect of anti-depression meds may be due to placebo effect* Kirsch, I. Sapirstein, G. (1998) Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication.
- 6. Nocebos
- 7. Designing the best placebos Low expectancy strength, discount price Low expectancy strength, full price High expectancy strength, discount price High expectancy strength, full price
- 8. Designing the best placebos 11 10.1 9 7.4 7 5.8 4.2 4 2 0 Low expectancy strength, discount price Low expectancy strength, full price High expectancy strength, discount price High expectancy strength, full price
- 9. New AMA* guidelines * American Medical Association
- 10. New AMA* guidelines * American Medical Association ell, ye s! H
- 13. More info • Draft placebo consent form: • http://tinyurl.com/placeboconsent • Research and articles we’ve used: • http://tinyurl.com/placeboresources • These slides: • http://www.slideshare.net/bigyahu • Photo credits: • Why such a bad rep? - Selva • Nocebo - Akácio S.
Editor's Notes
- A kiss to make it feel better, homeopathy, echinacea, cough syrup, religion