This presentation is from 13th chapter of Grainger and Allison--Diagnostic Radiology A TEXTBOOK OF MEDICAL IMAGING.
My aim behind all these presentation is to provide authentic images. As our all radiology revolve around images of diseases. We can put these ppts in our androids for study and references.
45 minutes of suffering (or Anesthesia Grand Rounds on Palliative Care)Mike Aref
Presentation on what palliative care is, comparison with hospice, primary palliative care screening, goals-of-care, definitions of DNR, basics of acute pain management and WHO analgesic ladder.
The lecture I gave for the Indiana University Health Joint Transplant Education and Research Lecture Series on palliative care. That's right, palliative care in transplant patients NOT at the end-of-life.
Consolidating, Improving, and Novel Palliative Care: Order SetsMike Aref
A selection of slides, taken from a series of presentations, showing the evolution of consolidating and developing order sets for delivery of primary palliative care in our healthcare system.
Ethical Issues Regarding Nutrition and Hydration in Advanced IllnessMike Aref
Be able to discuss and clarify “pleasure feeding” with patients and their families
Identify ethical issues with continuing or stopping artificial nutrition and hydration
Understand complications of artificial nutrition and hydration that are not ethically justifiable
Be able to discuss issues of self-dehydration and self-starvation
This presentation is from 13th chapter of Grainger and Allison--Diagnostic Radiology A TEXTBOOK OF MEDICAL IMAGING.
My aim behind all these presentation is to provide authentic images. As our all radiology revolve around images of diseases. We can put these ppts in our androids for study and references.
45 minutes of suffering (or Anesthesia Grand Rounds on Palliative Care)Mike Aref
Presentation on what palliative care is, comparison with hospice, primary palliative care screening, goals-of-care, definitions of DNR, basics of acute pain management and WHO analgesic ladder.
The lecture I gave for the Indiana University Health Joint Transplant Education and Research Lecture Series on palliative care. That's right, palliative care in transplant patients NOT at the end-of-life.
Consolidating, Improving, and Novel Palliative Care: Order SetsMike Aref
A selection of slides, taken from a series of presentations, showing the evolution of consolidating and developing order sets for delivery of primary palliative care in our healthcare system.
Ethical Issues Regarding Nutrition and Hydration in Advanced IllnessMike Aref
Be able to discuss and clarify “pleasure feeding” with patients and their families
Identify ethical issues with continuing or stopping artificial nutrition and hydration
Understand complications of artificial nutrition and hydration that are not ethically justifiable
Be able to discuss issues of self-dehydration and self-starvation
Out-patient Primary and Specialty Palliative CareMike Aref
Presentation on primary and specialty palliative care, covering what is palliative care, basics of primary palliative care including pain and symptom management, and referral criteria for out-patient specialty palliative care.
Scoring Suffering to Address Patient Needs in Palliative Care: The "Maslow Sc...Mike Aref
Introduction
Palliative care patients have been scored by their symptom burden and performance but there is little standardization of their multidimensional suffering, needs, and wants. Maslow’s Hierarchy of Needs is a model for describing these needs as physiological, safety, love/ belonging, esteem, and self-actualization. The functional pain score is a validated method of scoring pain based on patient report and provider assessment. Using these two frameworks, the “Maslow Score” seeks to use Maslow’s Hierarchy to score the current patient situation based on symptom burden, plan, network, and meaning.
Methods
The scores are four-digit codes describing the patient situation at a given time base on team consensus. Each digit is a score from most secure, 0, to most vulnerable, 5. Both written examples and an algorithmic approach have been provided to obtain each score.
Results
Morning huddle has been expedited by utilizing scores recorded the previous day. Also if sudden changes have been reported they can be compared rapidly against a team standard. This triaging helps direct team resources as to whether patients should be reassessed by the entire team or specific members. The discussion has improved assessment of patients from an interdisciplinary perspective. In general, patients cannot improve their network and meaning scores until symptom and planning scores have been optimized.
Discussion
The “Maslow Score” appears to have improved the quality of care that our service delivers by improving efficiency. Further development and study is needed to standardize and validate our method.
Indiana University Health University Hospital Palliative Care ServicesMike Aref
Introduction
In the past three years, Indiana University Health (IUH) University Hospital Palliative Care Services has expanded its size and scope. Our mission remains to treat the suffering of patients with chronic, progressive illnesses, their families, and their providers through symptom optimization and the search for meaning. While continuing to work with patients near the end-of-life and transitioning to hospice we have increasingly been involved with complex patients whose deaths are not imminent or even expected.
Our Team
The team has transitioned from a part-time to a full-time physician, a new full-time nurse practitioner, a new position in a nurse clinical coordinator, increased time for out part-time social worker, and continued part-time chaplain.
New Opportunities for Palliative Care
IUH University Hospital sees some of the sickest of the sick including advanced liver failure, advanced pulmonary disease, and transplant patients. Our service has become involved in alleviating suffering in pancreatic, liver, renal, and multivisceral transplant patients. Our expertise in opiates has placed us in a unique position to assist with patients having pain due to opioid-hyperalgesia and narcotic bowel syndrome. In addition we have started seeing more hepatology, oncology, hematology, and pulmonary patients earlier in their disease.
Out-Patient Services
We have expanded our service to now include out-patient, currently by embedding within other clinics at University Hospital including seeing patient in the multidisciplinary oncology clinic, hematology, digestive and liver disease clinic, and surgical out-patient clinic. In the near future we hope to have dedicated clinic space within the geriatrics clinic.
Esra Nelvi Siagian, Pusat Bahasa, Kementerian Pendidikan Nasional, Jakarta, Indonesian : Problematika Pengajaran Bahasa Indonesia Sebagai Bahasa Asing di Universitas di Australia
Out-patient Primary and Specialty Palliative CareMike Aref
Presentation on primary and specialty palliative care, covering what is palliative care, basics of primary palliative care including pain and symptom management, and referral criteria for out-patient specialty palliative care.
Scoring Suffering to Address Patient Needs in Palliative Care: The "Maslow Sc...Mike Aref
Introduction
Palliative care patients have been scored by their symptom burden and performance but there is little standardization of their multidimensional suffering, needs, and wants. Maslow’s Hierarchy of Needs is a model for describing these needs as physiological, safety, love/ belonging, esteem, and self-actualization. The functional pain score is a validated method of scoring pain based on patient report and provider assessment. Using these two frameworks, the “Maslow Score” seeks to use Maslow’s Hierarchy to score the current patient situation based on symptom burden, plan, network, and meaning.
Methods
The scores are four-digit codes describing the patient situation at a given time base on team consensus. Each digit is a score from most secure, 0, to most vulnerable, 5. Both written examples and an algorithmic approach have been provided to obtain each score.
Results
Morning huddle has been expedited by utilizing scores recorded the previous day. Also if sudden changes have been reported they can be compared rapidly against a team standard. This triaging helps direct team resources as to whether patients should be reassessed by the entire team or specific members. The discussion has improved assessment of patients from an interdisciplinary perspective. In general, patients cannot improve their network and meaning scores until symptom and planning scores have been optimized.
Discussion
The “Maslow Score” appears to have improved the quality of care that our service delivers by improving efficiency. Further development and study is needed to standardize and validate our method.
Indiana University Health University Hospital Palliative Care ServicesMike Aref
Introduction
In the past three years, Indiana University Health (IUH) University Hospital Palliative Care Services has expanded its size and scope. Our mission remains to treat the suffering of patients with chronic, progressive illnesses, their families, and their providers through symptom optimization and the search for meaning. While continuing to work with patients near the end-of-life and transitioning to hospice we have increasingly been involved with complex patients whose deaths are not imminent or even expected.
Our Team
The team has transitioned from a part-time to a full-time physician, a new full-time nurse practitioner, a new position in a nurse clinical coordinator, increased time for out part-time social worker, and continued part-time chaplain.
New Opportunities for Palliative Care
IUH University Hospital sees some of the sickest of the sick including advanced liver failure, advanced pulmonary disease, and transplant patients. Our service has become involved in alleviating suffering in pancreatic, liver, renal, and multivisceral transplant patients. Our expertise in opiates has placed us in a unique position to assist with patients having pain due to opioid-hyperalgesia and narcotic bowel syndrome. In addition we have started seeing more hepatology, oncology, hematology, and pulmonary patients earlier in their disease.
Out-Patient Services
We have expanded our service to now include out-patient, currently by embedding within other clinics at University Hospital including seeing patient in the multidisciplinary oncology clinic, hematology, digestive and liver disease clinic, and surgical out-patient clinic. In the near future we hope to have dedicated clinic space within the geriatrics clinic.
Esra Nelvi Siagian, Pusat Bahasa, Kementerian Pendidikan Nasional, Jakarta, Indonesian : Problematika Pengajaran Bahasa Indonesia Sebagai Bahasa Asing di Universitas di Australia
Carle Palliative Care Journal Club 1/15/2020Mike Aref
A journal club review and criticism of J Natl Cancer Inst. 2019 Dec 17. pii: djz233. doi: 10.1093/jnci/djz233 Emergency Department Visits for Opioid Overdoses Among Patients with Cancer by Jairam V, Yang DX, Yu JB, Park HS.
Basics of palliative care including symptom management: pain, dyspnea, nausea and constipation; family meetings, goals-of-care, end-of-life care, and artificial nutrition.
Palliative care is about providing well-being and the highest quality of life to patients with serious, progressive, chronic life-limiting illness, including during the dying process.
Carle Palliative Care Journal Club for 7/3/18Mike Aref
Journal club review of "Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial" by D. Hui et. al. in JAMA. 2017 Sep 19;318(11):1047-1056.
Three hour slide deck for basics of palliative care including what is palliative care, symptom management (pain, dyspnea, nausea, constipation), goals-of-care, family meetings, comfort care, and issues around artificial nutrition.
Carle General Surgery Grand Rounds presentation on palliative care symptom management, specifically pain, nausea, constipation, and malignant bowel obstruction.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
Physiology of Chest X-Ray
1. The
Physics and Physiology
of the Chest X-ray
Michael Aref, MD, PhD
Department of Nuclear, Plasma, and Radiological
Engineering
Internal Medicine Residency Program
College of Medicine
University of Illinois at Urbana-Champaign
2. Röntgen
In a dark room Röntgen passed
an electrostatic charge through
a cathode tube generating a
faint shimmering in a nearby
barium platinocyanide screen.
An invisible ray
An x-ray
had passed from the tube to the
screen.
Father of Diagnostic
Radiology
3.
4. Attenuation
I x = Ι0ε
−µξ
Intensity, I, decreases exponentially with thickness, x.
The attenuation coefficient, μ, increases with increasing
density, ρ, and vice versa
5. Radiological Densities
Biological Chemical Density, ρ
Composition Composition (kg/L)
Air N2, O2, CO2 1.2
CH3(CH2)m(CH=CHCH2)n(
Fat CH2)pCOO- 900
Water H2O 1000
(Soft Tissue)
Bone Ca10(PO4)6(OH)2 3160
Metal (hydroxyapatite)
Blood Minute Fe 7000
18. High IQ ABC’s
Identification
Quality
Airway, aorta, and adenopathy
Bones and breast shadow
Cardiac silhouette
Diaphragm
Everything else
Fields, fluid, and foreign
objects
Gastric air bubble
History
24. 61-year-old woman with dyspnea
The inferior margin of the
opacity in the right upper
thorax is due to the
B. major fissure in RUL collapse
without a hilar mass.
C. minor fissure in RUL collapse
with a hilar mass.
D. minor fissure in RUL collapse
without a hilar mass.
E. major fissure in RUL collapse
with a hilar mass.
25. 61-year-old woman with dyspnea
The inferior margin of the
opacity in the right upper
thorax is due to the
B. major fissure in RUL collapse
without a hilar mass.
C. minor fissure in RUL collapse
with a hilar mass.
D. minor fissure in RUL collapse
without a hilar mass.
E. major fissure in RUL collapse
with a hilar mass.
26. 61-year-old woman with dyspnea
The inferior margin of the
opacity in the right upper
thorax is due to the
B. major fissure in RUL collapse
without a hilar mass.
C. minor fissure in RUL collapse
with a hilar mass.
D. minor fissure in RUL collapse
without a hilar mass.
E. major fissure in RUL collapse
with a hilar mass.
27. 45-year-old woman with chronic
cough
All of the following are true
with regard to right middle
lobe collapse except
B. a triangular opacity is
superimposed on the heart on
the lateral radiograph.
C. the right heart border is
obscured.
D. the minor fissure is inferiorly
displaced.
E. the right heart border is
shifted to the left.
28. 45-year-old woman with chronic
cough
All of the following are true
with regard to right middle
lobe collapse except
B. a triangular opacity is
superimposed on the heart on
the lateral radiograph.
C. the right heart border is
obscured.
D. the minor fissure is inferiorly
displaced.
E. the right heart border is
shifted to the left.
29. 45-year-old woman with chronic
cough
All of the following are true
with regard to right middle
lobe collapse except
B. a triangular opacity is
superimposed on the heart on
the lateral radiograph.
C. the right heart border is
obscured.
D. the minor fissure is inferiorly
displaced.
E. the right heart border is
shifted to the left.
30. 62-year-old man with a cough
productive of blood-tinged sputum
Signs of left lower lobe collapse
include all of the following except
B. obscuration of the lateral wall of the
descending thoracic aorta.
C. inferior displacement of the left
hilum.
D. obliteration of the posterior aspect
of the left hemidiaphragm on the
lateral view.
E. triangular opacity in the left
retrocardiac area on the frontal
view.
F. shift of the major fissure toward the
anterior chest wall on the lateral
view.
31. 62-year-old man with a cough
productive of blood-tinged sputum
Signs of left lower lobe collapse
include all of the following except
B. obscuration of the lateral wall of the
descending thoracic aorta.
C. inferior displacement of the left
hilum.
D. obliteration of the posterior aspect
of the left hemidiaphragm on the
lateral view.
E. triangular opacity in the left
retrocardiac area on the frontal
view.
F. shift of the major fissure toward the
anterior chest wall on the lateral
view.
32. 62-year-old man with a cough
productive of blood-tinged sputum
Signs of left lower lobe collapse
include all of the following except
B. obscuration of the lateral wall of the
descending thoracic aorta.
C. inferior displacement of the left
hilum.
D. obliteration of the posterior aspect
of the left hemidiaphragm on the
lateral view.
E. triangular opacity in the left
retrocardiac area on the frontal
view.
F. shift of the major fissure toward the
anterior chest wall on the lateral
view.
33. 49-year-old woman with cough
Signs of left upper lobe collapse
include all of the following except
B. crescent of air around the transverse
section of the aortic arch resulting
from hyperexpansion of the
superior segment of the left lower
lobe.
C. anterior displacement of the left
major fissure on the lateral view.
D. obscuration of the left heart border.
E. tracheal deviation to the left.
F. inferior displacement of the left
hilum.
34. 49-year-old woman with cough
Signs of left upper lobe collapse
include all of the following except
B. crescent of air around the transverse
section of the aortic arch resulting
from hyperexpansion of the
superior segment of the left lower
lobe.
C. anterior displacement of the left
major fissure on the lateral view.
D. obscuration of the left heart border.
E. tracheal deviation to the left.
F. inferior displacement of the left
hilum.
35. 49-year-old woman with cough
Signs of left upper lobe collapse
include all of the following except
B. crescent of air around the transverse
section of the aortic arch resulting
from hyperexpansion of the
superior segment of the left lower
lobe.
C. anterior displacement of the left
major fissure on the lateral view.
D. obscuration of the left heart border.
E. tracheal deviation to the left.
F. inferior displacement of the left
hilum.
37. 40-year-old man with fever and
dyspnea
The most likely
diagnosis is
B. massive left pleural
effusion.
C. total atelectasis of the left
lung.
D. right pneumothorax.
E. aplasia of the left lung.
F. mediastinal hematoma.
38. 40-year-old man with fever and
dyspnea
The most likely
diagnosis is
B. massive left pleural
effusion.
C. total atelectasis of the left
lung.
D. right pneumothorax.
E. aplasia of the left lung.
F. mediastinal hematoma.
39. Tall, 21-year-old man who noted the sudden onset of
dyspnea, and right-sided pleuritic chest pain
The most likely diagnosis is
B. pulmonary embolism.
C. overinflation associated with
asthma.
D. pneumothorax.
E. normal chest, with a skin fold
projected over the right
hemithorax.E. left lower lobe
atelectasis.
40. Tall, 21-year-old man who noted the sudden onset of
dyspnea, and right-sided pleuritic chest pain
The most likely diagnosis is
B. pulmonary embolism.
C. overinflation associated with
asthma.
D. pneumothorax.
E. normal chest, with a skin fold
projected over the right
hemithorax.E. left lower lobe
atelectasis.
41. 62-year-old man with dyspnea that
increased over 2 days
The most likely
diagnosis is
B. left pleural effusion.
C. collapse of the left lung.
D. right pneumothorax.
E. collapse of the right lung.
F. mediastinal hematoma.
42. 62-year-old man with dyspnea that
increased over 2 days
The most likely
diagnosis is
B. left pleural effusion.
C. collapse of the left lung.
D. right pneumothorax.
E. collapse of the right lung.
F. mediastinal hematoma.
46. 64-year-old man, Navy veteran, with a
cough productive of blood-tinged sputum
The most likely diagnosis is
B. progressive massive fibrosis,
due to silicosis.
C. pneumonia in a patient with
chronic interstitial lung
disease.
D. lung cancer in a patient with
asbestosis.
E. rounded atelectasis in a
patient with asbestosis.
F. berylliosis.
47. 64-year-old man, Navy veteran, with a
cough productive of blood-tinged sputum
The most likely diagnosis is
B. progressive massive fibrosis,
due to silicosis.
C. pneumonia in a patient with
chronic interstitial lung
disease.
D. lung cancer in a patient with
asbestosis.
E. rounded atelectasis in a
patient with asbestosis.
F. berylliosis.
48. 55-year-old man who worked as a
coal miner for 30 years
The most likely diagnosis is
B. progressive massive fibrosis,
due to silicosis.
C. pneumonia in a patient with
chronic interstitial lung
disease.
D. lung cancer in a patient with
asbestosis.
E. rounded atelectasis in a
patient with asbestosis.
F. berylliosis.
49. 55-year-old man who worked as a
coal miner for 30 years
The most likely diagnosis is
B. progressive massive fibrosis,
due to silicosis.
C. pneumonia in a patient with
chronic interstitial lung
disease.
D. lung cancer in a patient with
asbestosis.
E. rounded atelectasis in a
patient with asbestosis.
F. berylliosis.
51. 53-year-old man scheduled for
coronary artery bypass grafting
Characteristics suggesting
that a nodule is benign are
B. size of the nodule does not
change over 2 years.
C. it contains central
calcification.
D. CT attenuation values within
the nodule are greater than
200 Hounsfield units (Hu).
E. all of the above.
52. 53-year-old man scheduled for
coronary artery bypass grafting
Characteristics suggesting
that a nodule is benign are
B. size of the nodule does not
change over 2 years.
C. it contains central
calcification.
D. CT attenuation values within
the nodule are greater than
200 Hounsfield units (Hu).
E. all of the above.
53. 64-year-old man with cough and weight loss
and a 50-pack-per-year history of tobacco use
The best description of the
chest radiograph is
B. mass in the left upper lobe.
C. left upper lobe collapse.
D. mediastinal mass.
E. consolidation of the left
upper lobe.
F. enlargement of the left
pulmonary artery.
54. 64-year-old man with cough and weight loss
and a 50-pack-per-year history of tobacco use
The best description of the
chest radiograph is
B. mass in the left upper lobe.
C. left upper lobe collapse.
D. mediastinal mass.
E. consolidation of the left
upper lobe.
F. enlargement of the left
pulmonary artery.
55. 64-year-old man with cough and weight loss
and a 50-pack-per-year history of tobacco use
The best description of the
chest radiograph is
B. mass in the left upper lobe.
C. left upper lobe collapse.
D. mediastinal mass.
E. consolidation of the left
upper lobe.
F. enlargement of the left
pulmonary artery.
56. 70-year-old woman with uterine carcinoma
treated with surgical resection 3 years ago
The most likely cause of the
multiple pulmonary nodules
is
B. metastasis.
C. herpes simplex pneumonia.
D. histoplasmosis.
E. Wegener's granulomatosis.
F. arteriovenous malformations
57. 70-year-old woman with uterine carcinoma
treated with surgical resection 3 years ago
The most likely cause of the
multiple pulmonary nodules
is
B. metastasis.
C. herpes simplex pneumonia.
D. histoplasmosis.
E. Wegener's granulomatosis.
F. arteriovenous malformations
61. 32-year-old man with fever, cough,
and hemoptysis
Which of the following
is not an accurate
descriptor of the opacity
in the left upper lobe
B. Lobar distribution
C. Ill-defined margins
D. Reticular pattern
E. Air bronchograms
F. Airspace disease
62. 32-year-old man with fever, cough,
and hemoptysis
Which of the following
is not an accurate
descriptor of the opacity
in the left upper lobe
B. Lobar distribution
C. Ill-defined margins
D. Reticular pattern
E. Air bronchograms
F. Airspace disease
63. 57-year-old man with fever and a
cough productive of purulent sputum
Which one of the following
best explains the opacity in
the left hemithorax?
B. Collapse of the left upper lobe
due to bronchial obstruction
C. Airspace consolidation of the
lingula
D. Empyema loculated within
the left major fissure
E. Carcinoma in the left upper
lobe
64. 57-year-old man with fever and a
cough productive of purulent sputum
Which one of the following
best explains the opacity in
the left hemithorax?
B. Collapse of the left upper lobe
due to bronchial obstruction
C. Airspace consolidation of the
lingula
D. Empyema loculated within
the left major fissure
E. Carcinoma in the left upper
lobe
65. 69-year-old man with progressive dyspnea,
orthopnea, and pedal edema and a history of
hypertension
Which of the following best
describes the chest
radiograph?
B. Normal heart size, alveolar
pulmonary edema
C. Cardiomegaly, interstitial
pulmonary edema, and small
bilateral pleural effusions
D. Unilateral interstitial disease
E. Cardiomegaly, oligemia in the
right lung
66. 69-year-old man with progressive dyspnea,
orthopnea, and pedal edema and a history of
hypertension
Which of the following best
describes the chest
radiograph?
B. Normal heart size, alveolar
pulmonary edema
C. Cardiomegaly, interstitial
pulmonary edema, and small
bilateral pleural effusions
D. Unilateral interstitial disease
E. Cardiomegaly, oligemia in the
right lung
70. 45-year-old man with increasing dyspnea and
abdominal swelling of 1-week duration
Which of the following radiographic signs
suggest the presence of pleural effusion?
B. Meniscus-shaped opacity in a posterior
costophrenic angle on the lateral projection
C. Biconvex lens-shaped opacity projecting in
the midthorax on the lateral projection
D. Fluid levels that have different lengths on the
PA and lateral views in a hemithorax
E. Homogeneous increased density in a
hemithorax with preservation of the vascular
shadows in the lungs
F. Separation of the gastric air bubble from the
inferior lung margin by more than 2 cm
71. 45-year-old man with increasing dyspnea and
abdominal swelling of 1-week duration
Which of the following radiographic signs
suggest the presence of pleural effusion?
B. Meniscus-shaped opacity in a posterior
costophrenic angle on the lateral projection
C. Biconvex lens-shaped opacity projecting in
the midthorax on the lateral projection
D. Fluid levels that have different lengths on the
PA and lateral views in a hemithorax
E. Homogeneous increased density in a
hemithorax with preservation of the vascular
shadows in the lungs
F. Separation of the gastric air bubble from the
inferior lung margin by more than 2 cm
72. 62-year-old woman with worsening shortness of breath and
mild hemoptysis 1 day after receiving IV chemotherapy
The most likely cause for her
dyspnea and hemoptysis is
B. pulmonary metastases.
C. malignant pleural effusion.
D. pulmonary embolism.
E. septic emboli.
F. drug-related pneumonitis.
73. 62-year-old woman with worsening shortness of breath and
mild hemoptysis 1 day after receiving IV chemotherapy
The most likely cause for her
dyspnea and hemoptysis is
B. pulmonary metastases.
C. malignant pleural effusion.
D. pulmonary embolism.
E. septic emboli.
F. drug-related pneumonitis.
74. 62-year-old woman with worsening shortness of breath and
mild hemoptysis 1 day after receiving IV chemotherapy
The most likely cause for her
dyspnea and hemoptysis is
B. pulmonary metastases.
C. malignant pleural effusion.
D. pulmonary embolism.
E. septic emboli.
F. drug-related pneumonitis.
76. References
Paul and Juhl’s Essentials of Radiologic Imaging,
11th edition
Felson’s Principles of Chest Roentgenology, 2nd
edition
Chen MYM, Pope TL, and Ott DJ, Basic
Radiology, The McGraw-Hill Companies, 2008