This document discusses the case of a 36-year-old woman presenting with intermittent high blood pressure, sweating, and panic attacks who is suspected of having pheochromocytoma. For initial treatment, alpha blockade with phenoxybenzamine is recommended for at least 1-3 weeks before surgery to prevent hypertensive crisis during the operation. Laparoscopic surgery is preferred for smaller tumors, while larger tumors typically require open surgery. Following successful removal of the tumor, most patients become normotensive, though some may remain hypertensive and require further treatment and monitoring.
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A supercool powerpoint about thyroid cancer that is very hard to understand unless I am speaking to you and filling in the blanks so check out my blog and look for a related post:
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HIV in USA
Outline:
The universal health coverage in US
Health policy in USA.
Comment about the individualism Vs collectivism in US.
Discuss main risk factors for CVD and the strategy to counter these risks.
Absolute contra-indications for liver transplantation.
Incidence, prevalence, & mortality of HIV/AIDS.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Case B
36 year old woman is seen at the outpatient clinic
because of intermittent high blood pressure.
She complains about periodic sweating and
panic attacks.
there is intermittent tremor, palpitation and
elevated blood pressure.
During these attacks blood pressure is 210/110
4. Treatment
is surgical excision of the tumor,
following preoperative treatment
of hypertension, which is usually
curative (unless metastatic)
5. Treatment Options for Patients With Pheochromocytoma
Pheochromocytoma Standard Treatment Options
Localized Pheochromocytoma Surgery
Regional Pheochromocytoma Surgery
Metastatic Pheochromocytoma Surgery
Palliative therapy
Recurrent Pheochromocytoma Surgery
Palliative therapy
6. Preoperative Medical Preparation
• Alpha-adrenergic blockade
• should be initiated at the time of diagnosis and
maximized preoperatively to prevent potentially life-threatening
cardiovascular complications, which can
occur as a result of excess catecholamine secretion
during surgery.
Complications may include the following:
• Hypertensive crisis.
• Arrhythmia.
• Myocardial infarction.
• Pulmonary edema.
7. Phenoxybenzamine
(a nonselective alpha-antagonist)
is the
usual drug of choice
prazosin, terazosin, and
doxazosin (selective alpha-1-
antagonists) are alternative
choices
Prazosin, terazosin,
and doxazosin are
shorter acting than
phenoxybenzamine
The duration of
postoperative
hypotension is
theoretically less
than with
phenoxybenzamine
• A preoperative treatment
period of 1 to 3 weeks
is usually sufficient
8. • If tachycardia develops
or if blood pressure
control is not optimal
with alpha-adrenergic
blockade
• a beta-adrenergic blocker
(e.g., metoprolol or
propranolol) can be added
but only after alpha-blockade.
• Beta-adrenergic
blockade must never be
initiated before alpha-adrenergic
blockade
9. Sodium nitroprusside and
phentolamine ( rapid acting
alpha blocker ) should be
available in cases sudden
sever hypertension develops.
Propranolol
120-240 mg
daily
Treatment
Phenoxybenzamine (
20 -80 mg daily
initially in divide
doses )
Common side effects include headache,
palpitation, orthostatic hypotension and
tachycardia
10. surgery
• Laparoscopic surgery is being used
more often for tumors smaller than 6
than 6 cm but for larger tumors, an
an open operation is probably safer.
safer.
• Both anterior transabdominal
laparoscopic adrenalectomy as well
well as posterior retroperitoneoscopic
retroperitoneoscopic adrenalectomy
adrenalectomy have been
demonstrated to be safe for the
majority of patients with a modestly
modestly sized.
11. Surgical outcome and post-operative follow-up
Following surgical removal of Pheochromocytoma 80% of patients
are expected to become normotensive.
Around 20% of patients will remain hypertensive without
biochemical evidence of residual tumor, however, due to associated
essential hypertension or due to acquired renovascular changes.
Plasma catecholamine or urinary metanephrines should be
measured two weeks after surgery. If the biochemical tests are still
diagnostically high, residual or metastatic tumor should be
suspected.
Plasma catecholamines or urinary metanephrines should be
measured every three months for the first year and then annually
even in normotensive patients.
12. Summary:
Alpha blockade with phenoxybenzamine is started at least 7 to 10 days
before operation to allow for expansion of blood volume.
Only once this is achieved is beta blockade considered. If beta blockade
is started too soon, unopposed alpha stimulation can precipitate a
hypertensive crisis.
Laparoscopic surgery is being used more often for tumors smaller than 6
cm but for larger tumors, an open operation is probably safer.
Catecholamines are hormones that increase the heart rate, blood pressure, rate of breathing and amount of energy available to the body. Adrenaline is the most common and well-known catecholamine. The adrenal medulla releases extra adrenaline in response to stress. This increase is known as the "fight or flight response"—i.e. the body is ready to fight or run. Pheochromocytomas are rare tumors that make too much adrenaline.
Adequate α-blockade is defined as supine arterial pressure not greater than 160/90
Beta-adrenergic receptor blockade with proranolol is contraindicated until alpha-adrenergic receptor blockade is complete, to avoid unopposed α-
Vasoconstriction
doing so blocks beta-adrenergic receptor-mediated vasodilation and results in unopposed alpha-adrenergic receptor-mediated vasoconstriction, which can lead to a life-threatening crisis