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PERSISTENT DIARRHEA.pptx
1. APPROACH TO ACHILD WITH PERSISTERN
DIARRHEA
Presenter
Muhwezi Chris Badiga
2. outline
• Introduction
• Pathophysiology of diarrhea
• Causes of persistent diarrhea
• DDX
• Classification
• Severe persistent diarrhea
• Non severe persistent diarrhea
• Management of causes
• Follow up
4. Pathophysiology
• The absorption and secretion of water and electrolytes throughout the gastrointestinal
tract is a finely balanced, dynamic process and, when there is loss of this balance
caused either by decreased absorption or increased secretion, diarrhea results.
• Diarrhea remains a major cause of morbidity and mortality worldwide, accounting for 3
million deaths per year in young children.
Diarrhea can be considered to be either osmotic or secretory.
• Osmotic diarrhea occurs when excessive osmotically active particles are present in the
lumen, resulting in more fluid passively moving into the bowel lumen down the osmotic
gradient.
• Secretory diarrhea occurs when the bowel mucosa secretes excessive amounts of fluid
into the gut lumen, either due to activation of a pathway by a toxin, or due to inherent
abnormalities in the enterocytes.
6. Parasites
• In HIV infected children ( isospora and
cryptosporidium)
• Giardia lamblia
• Cyclospora
• Entamoeba histolytica
Underlying malnutrition
Food induced diarrhea
• Lactose intolerance
• Carbohydrate malabsorption
• Cow-milk protein intolerance
• Food allergy
• Celiac disease
Antibiotic associated diarrhea
7.
8.
9.
10. Classification;
• Persistent diarrhea is classified depending association of the
condition with dehydration ;
A. Severe persistent diarrhea
B. Non-severe persistent diarrhea
11. A; severe persistent diarrhea
• This involves infants or children with diarrhea lasting 14 days or more
with signs of dehydration
• They require hospital treatment
• Assess the child for signs of dehydration
12.
13. Management plan;
• Treat the child with treatment plan B or C depending on the severity of the dehydration
status.
1. Treatment plan C for severely dehydrated children
introduce an iv line and give the fluids as follows
Children below 12 months
6 hours For the first hour 30ml/kg
For the rest 5 hours 70ml/kg
Children of 12 months and above
3 hours For the first 30 minutes 30ml/kg
For the rest 2 ½ hours 70 ml/kg
14. • In the process of giving the above fluids, assess the child for signs and
dehydration and fluid overload every 15-30 minutes
• Then give ORS (at 5ml/kg) as soon as the child can drink – usually
after 3-4 hours in infants and 1-2 hours in older children
• Reassess an infant after 6 hours and classify dehydration. The chose
the appropriate treatment plan (A, B or C) to continue treatment.
• When severe dehydration is corrected, start the child on Zinc
15. 2. Treatment plan B for some dehydration
• This is for children with some dehydration
• Treatment is done using ORS and the amount given is determined as follows;
• The approximate amount of ORS required (in mL) can also be calculated by multiplying the child’s weight (in kg) by 75.
• If the child wants more ORS than shown, give more.
• Show the mother how to give ORS solution.
– Give frequent small sips from a cup.
– If the child vomits, wait 10 min, then continue, but more slowly.
– Continue breastfeeding whenever the child wants.
Age ≤ 4 months 4 to ≤ 12
months
12 months
to ≤ 2 years
2 years
to ≤ 5 years
Weight < 6 kg 6-< 10 kg 10-< 12 kg 12-19 kg
200-400 ml 400-700 ml 700-900 ml 900-1400ml
16. • After 4 h:
– Reassess the child and classify him or her for dehydration.
– Select the appropriate plan to continue treatment.
– Begin feeding the child in the clinic.
• If the mother must leave before completing treatment:
– Show her how to prepare ORS solution at home.
– Show her how much ORS to give to finish the 4-h treatment at home.
– Give her enough ORS packets to complete rehydration. Also give her
two packets as recommended in plan A.
17. Explain the four rules of home treatment:
• Give extra fluid.
• 2. Give zinc supplements.
• 3. Continue feeding.
• 4. Know when to return to the clinic
18. • Supplementary multivitamins and minerals
• Give all children with persistent diarrhea daily supplementary multivitamins and minerals for 2
weeks.
• These should provide as broad a range of vitamins and minerals as possible, including at least two
recommended daily allowances of folate, vitamin A, zinc, magnesium and copper.
• As a guide, one recommended daily allowance for a child aged 1 year is:
folate, 50 μg
zinc, 10 mg
vitamin A, 400 μg
iron, 10 mg
copper, 1 mg
magnesium, 80 mg
19. B; Non severe persistent diarrhea
• Children with non-severe persistent diarrhea do not require hospital
treatment
• but need special feeding and extra fluids at home.
• Children with diarrhea lasting 14 days or more but with no signs of
dehydration or severe malnutrition
20. Treatment plan
• Management involve using treatment plan A, the childe is treated as
an out patient
• Supplementary multivitamins and minerals are given as above.
Treatment plan A
• Counsel the mother on the four rules of home treatment: give extra
fluid. Give zinc supplements. Continue feeding. Know when to return
to the clinic.
21. 1. Give as much extra fluid as the child will take.
• Tell the mother to:
– Breastfeed frequently and for longer at each feed.
– If the child is exclusively breastfed, give ORS or clean water in
addition to breast milk
– If the child is not exclusively breastfed, give one or more of the
following: ORS solution, food-based fluids (such as soup, rice water and
yoghurt drinks) or clean water.
22. • It is especially important to give ORS at home when:
– the child has been treated according to plan B or plan C during this
visit.
– the child cannot return to a clinic if the diarrhea gets worse.
• Teach the mother how to mix and give ORS. Give the mother two
packets of ORS to use at home.
• Show the mother how much fluid to give in addition to the usual
fluid intake:
≤ 2 years: 50–100 ml after each loose stool
≥ 2 years: 100–200 ml after each loose stool
23. • Tell the mother to:
– Give frequent small sips from a cup.
– If the child vomits, wait 10 min. Then continue, but more slowly.
– Continue giving extra fluid until the diarrhea stops.
• 2. Give zinc supplements.
• Tell the mother how much zinc to give:
≤ 6 months: half tablet (10 mg) per day for 10–14 days
≥ 6 months: one tablet (20 mg) per day for 10–14 days
24. • Show the mother how to give zinc supplement:
– For infants, dissolve the tablet in a small amount of clean water,
expressed
milk or ORS in a small cup or spoon.
– Older children can chew the tablet or drink it dissolved in a small
amount of clean water in a cup or spoon.
• Remind the mother to give the zinc supplement for the full 10–14
days.
• 3. Continue feeding.
• 4. Know when to return to the clinic.
25. Manage the cause of the persistent diarrhea as follows
• Examine every child with persistent diarrhea for non-intestinal infections such as pneumonia,
sepsis, urinary tract infection, oral thrush and otitis media, and treat appropriately
• Treat persistent diarrhea with blood in the stools with an oral antibiotic effective for Shigella.
• Give oral metronidazole at 10 mg/kg three times a day for 5 days only if:
– microscopic examination of fresh faeces reveals trophozoites of Entamoeba histolytica within red
blood cells; or
– trophozoites or cysts of giardia are seen in the faeces, or
– two different antibiotics that are usually effective for Shigella locally have been given without
clinical improvement.
– if stool examination is not possible, when diarrhea persists for > 1 month.
26. Follow-up
• Ask the mother to bring the child back for reassessment after 5 days, or
• earlier if the diarrhea worsens or other problems develop.
• Fully reassess children who have not gained weight or whose diarrhea has
• not improved in order to identify the cause, such as dehydration or
infection,
• which requires immediate attention or admission to hospital.
• Those who have gained weight and who have three or fewer loose stools
per day may resume a normal diet for their age.