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Peptic ulcer
This document discusses treatments for peptic ulcer. It begins by outlining the objectives of understanding classification of treatments, mechanisms of action, and which treatments are used depending on condition. It then introduces specific treatments which act directly on receptors, drugs, or bacteria involved. Specific treatments discussed include proton pump inhibitors, H2 blockers, muscarinic blockers, gastric blockers, antibiotics, and NSAIDs. Non-specific treatments involve managing stress, diet, alternative therapies, and surgery is discussed for cases that do not heal or continue bleeding. The document provides details on the mechanisms and examples of drugs for several common specific treatments for reducing acid secretion and treating Helicobacter pylori infection.
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Peptic ulcer
- 1. NUR FARRA NAJWA BINTIABDUL AZIM 082015100035 PEPTIC ULCER (MANAGEMENTS)
- 2. OBJECTIVE To understandthe basic classification of treatments. To understand the mechanism of each treatments. To distinguish different treatment used depends on condition. To list the drugs by treatments used.
- 3. INTRODUCTION Specific treatments Act specifically Receptors Drugs Bacteria Non-specific treatments Surgery • During and after treatments • Avoid alcohol • Avoids ciggarates • Follow up with endoscopy
- 4. TREATMENTS Gastric pits Gastric glands Chiefcell Parietal cell G- cell Endocromaffin cell HCL Ach Histamine Gastrin PPI Gastrin blockers H2 blockers Muscarinic blockers SPECIFIC TREATMENTS NSAIDS H. Pylori bacteria
- 5. TREATMENT H2 Receptor Blocker Block H2 receptor Block histamine release Less HCL secretion Famotidine, Ranitidine, Cimetidine, Nizatidine ProtonPump Inhibitor Inhibit activity of H+ K+ ATPas Inhibit HCL secretion Omeprazole
- 6. TREATMENT Muscarinic Blockers Block M1 and M3 receptors Acetylcholine notact on parietal cell Inhibit HCL secretion Atropine Gastrin Blockers Reduce HCL secretion Proglumide
- 7. TREATMENTS Antibiotics Helicobacter pylori bacteria Kill the bacteria Amoxicillin NSAIDS Stops or limitthe uses Aspirin, ibuprofen For Healing And Coating Sucralfate, misoprostol, Bismuth subsalicylate
- 8. TREATMENTS NON-SPECIFIC TREATMENTS Altered Behaviour Altered Physiology ANATACIDS • relieves pain immediately andtemporary YOGA THERAPY ADEQUATE SLEEP REST AVOIDS •Spicy food •Alcohol Use COLD MILK
- 9.
- 10. SUMMARY TREATMENTS SPECIFIC HCL SECRETION - Protonpump inhibitors - H2 blockers -Muscarinic blockers -Gastric blockers OTHERS - Antibiotics - NSAIDS - Healing and coating NON- SPECIFIC STRESS -Food -Drugs -Therapy SURGERY
- 11. REFERENCES Barrett Ganong’sReview Of Physiology 24th Edition Textbook Of Medical Physiology, GK Pal
- 12.