Esomeprazole is effective for treating peptic ulcer disease and preventing rebleeding from ulcers. It works by irreversibly blocking the proton pump in the stomach, strongly inhibiting acid production. This allows platelet aggregation and clot stabilization at a gastric pH above 6. Esomeprazole maintains inhibitory effects on acid for a longer period than other PPIs, significantly reducing rebleeding rates following ulcer treatment. As a result, esomeprazole is recommended for treating bleeding ulcers and preventing their recurrence.
PEPTIC ULCER DISEASE- EPIGASTRIC PAIN
#surgicaleducator #epigastricabdominalpain #pepticulcerdisease #usmle #babysurgeon #surgicaltutor
• Dear Viewers,
• Greetings from “Surgical Educator”
• Today I have uploaded a video on Peptic Ulcer Disease- a didactic lecture.
• It is one of the common surgical problems you see in surgical wards.
• I have discussed the various causes for Epigastric pain, epidemiology, etiopathogenesis, clinical features, investigations, complications and treatment of Peptic Ulcer Disease.
• I have also included a mind map and a treatment algorithm for Peptic Ulcer Disease.
• I hope the video will be very useful and you will enjoy it.
• You can watch all my surgical teaching videos in the following link:
• youtube.com/c/surgicaleducator
• Thank you for watching the video.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
PEPTIC ULCER DISEASE- EPIGASTRIC PAIN
#surgicaleducator #epigastricabdominalpain #pepticulcerdisease #usmle #babysurgeon #surgicaltutor
• Dear Viewers,
• Greetings from “Surgical Educator”
• Today I have uploaded a video on Peptic Ulcer Disease- a didactic lecture.
• It is one of the common surgical problems you see in surgical wards.
• I have discussed the various causes for Epigastric pain, epidemiology, etiopathogenesis, clinical features, investigations, complications and treatment of Peptic Ulcer Disease.
• I have also included a mind map and a treatment algorithm for Peptic Ulcer Disease.
• I hope the video will be very useful and you will enjoy it.
• You can watch all my surgical teaching videos in the following link:
• youtube.com/c/surgicaleducator
• Thank you for watching the video.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
3. The Stomach Functions & Glands
Acts as storage tank for food
Breaking down the food into a liquidly mixture called chyme
Mixing enzymes which is are chemicals that break down food.
Delivers chyme to the small intestine
Glands:
Cardiac
Pyloric
Gastric contain parietal cells that produce and secret HCL (primary site of action for
many acid controller drugs.
4. Parietal cells
Parietal cells, are the stomach epithelium cells that secrete gastric acid
The parietal cell contains receptor for gastrin histamine (H2) & acethylcholine (M3)
When acetylcholine, histamine or gastrin (released from G cells into the blood) bind to the
parietal cell receptors, that stimulate acid secretion from a H+,K+ ATPase (the proton
pump) on the canalicular surface.
Olbe, L., Carlsson, E., & Lindberg, P. (2003).Nature Reviews Drug Discovery, 2, 132-139.
5. Parietal Cells
Gastric acid is secreted by parietal cells of
the stomach in response to stimuli such as
the presence of food in the stomach or
intestine and the taste, smell, sight or
thought of food. Such stimuli result in the
activation of histamine, acetylcholine or
gastrin receptors (the H2, M3 and CCK2
receptors, respectively) located in the
basolateral membrane of the parietal cell,
which initiates signal transduction
pathways that converge on the activation
of the H+K+-ATPase the final step of acid
secretion.
Inhibition of this proton pump has the
advantage that it will reduce acid secretion
independently of how secretion is
stimulated, in contrast to other
pharmacological approaches to the
regulation of acid secretion; for example,
the inhibition of acid secretion by H2
receptor antagonists can be overcome by
food-induced stimulation of acid secretion
via gastrin or acetylcholine receptors.
Olbe, L., Carlsson, E., & Lindberg, P. (2003).Nature Reviews Drug Discovery, 2, 132-139.
6. Acid Controlling Agents – Proton Pump
Inhibitors
Mechanism of Action: Irreversibly bind to H+/K+ ATPase enzyme
Result: ALL gastric acid secretion is blocked
Proton Pump Inhibitors:
Esomeperazole works by binding irreversibly to the H+/K+ ATPase in the proton pump.
Because the proton pump is the final pathway for secretion of hydrochloric acid by the parietal
cells in the stomach, its inhibition dramatically decreases the secretion of hydrochloric acid into
the stomach and alters gastric pH. This is the same mechanism of action as omeprazole and
the other PPIs.
Lansoprazole
Omeprazole
Pantoprazole
Rabeprazole
Olbe, L., Carlsson, E., & Lindberg, P. (2003).Nature Reviews Drug Discovery, 2, 132-139.
7. ROLE OF PPI AS ACID SUPPRESSION
AGENT
• Pharmacological agents that suppress acid secretion are widely considered
the standard of care for the prevention of ulcer re-bleeding after initial
endoscopic hemostasis in ulcer with high risk stigmata (those with active
bleeding, non bleeding visible vessel and possibly adherent clot)1-5
• The therapeutic goal in these patients is to achieve an intragastric
pH>6, a point at which the clotting process is optimized and any
formed clot is stabilized
1. Lin H-J, et al.Arch Intern Med 1998; 158: 54-8. 2. Lau JWY, et al. N Eng J Med 2000; 343: 310-6. 3. Liontiadis GI, et al.Aliment Pharmacol ther 2005; 22: 169-74. 4.
Sung JJ, et al.Ann Intern Med 2003; 139: 237-43. 5. Barkun A, et al. Gastroenterology 2004; 126:A78 (Abstract). 6.Vorder Bruegge WF, et al. J Clin Gastroenterol 1990;
12: (Suppl 2): S35-40. 7. van Resburg, et al.Am J Gastroenterol 2003; 98: 2635-41
8. GASTRIC PH: RATIONALE FOR ACID SUPPRESSION
FOR MANAGEMENT PEPTIC ULCER
Gastric
pH
Clinical Effect
>4 Pepsin inactivated
>5 99% acid neutralized
>6
Functional coagulation
and platelet aggregation
>7 Pepsin destruction
Vorder Bruegge J Clin Gastroenterol. 1990;12:S35.
Stress Ulcer Prophylaxis
Reduction of rebleeding after
endoscopic intervention
9. Peptic Ulcer
Peptic ulcers are open sores that develop in the inner lining of the stomach and the upper part of the small
intestine. The most common symptom of peptic ulcers is abdominal pain.
Peptic ulcers include:
Stomach ulcers that occur in the stomach
Duodenal ulcers that occur in the duodenum (duodenum)
11. Symptoms of Peptic Ulcer
Pain in the stomach. This pain arises due to irritation of the stomach acid that wets the wound.
Usually, the pain appears at night and gets worse when the stomach is empty. In more severe
conditions, the pain felt can spread to the neck, navel, to the back.
Indigestion.
Vomiting or vomiting blood — which may appear red or black Dark blood in the stool, or black or
mushy stools
Difficulty breathing, Feeling weak, Nausea or vomiting, Unexplained weight loss, Changes in
appetite
12. Cause
Helicobacter pylori infection
Use of non-steroidal anti-inflammatory drugs, such as ibuprofen, aspirin, or diclofenac.
Smoking and drinking habits.
Stress that is not immediately addressed.
Health problems, such as pancreatic tumors and radiation treatment to the stomach area.
13. Complications
◦ Bleeding in the stomach
◦ Perforation
◦ Peritonitis (inflammation of the thin lining of the inner wall of the
abdomen)
◦ Obstruction
◦ Stomach cancer.
14.
15. •. 2015 Nov;32(11):1160-76.
ACG. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding.
Twice-daily PPI
therapy from days
4–14 after
indexendoscopy
reduces further
bleeding as
compared to once-
daily PPI in high-risk
patients who
received endoscopic
therapy followed by
3 days of high-dose
PPI therapy. This is
a new
recommendation
based on evidence
that became
available after
publication of the
2012 ACG
Guidelines.
18. •. 2015 Nov;32(11):1160-76.
In patients with a history of ulcers
receiving NSAID therapy, PPIs
with or without celecoxib are
recommended and the
administration of VPZis suggested
for the prevention of ulcer
recurrence.
Inpatients with a history of ulcers
receiving LDA therapy, PPIs or
VPZ are recommended and the
administration of ahistamine 2-
receptor antagonist is suggested
for the preventionof ulcer
recurrence.
Kamada, Tomoari, et.al. Evidence-based clinical practice guidelines for peptic ulcer disease
19. Kamada, Tomoari, et.al. Evidence-based clinical practice guidelines for peptic ulcer disease
20. Kamada, Tomoari, et.al. Evidence-based clinical practice guidelines for peptic ulcer disease
21. •. 2015 Nov;32(11):1160-76.
NICE. Managing peptic ulcer disease on adults. 2021
Initial treatment, for people using NSAIDs with diagnosed peptic ulcer, stop the
use of NSAIDs where possible. Offer full-dose PPI or H2RA therapy for 8 weeks
and, if H. pylori is present, subsequently offer eradication therapy.
Esomeprazole is first choice to treat peptic ulcer caused by NSAID &
Helicobacter pylori infection.
22. EFFECT OF PPIS ON OUTCOMES IN PATIENTS WITH
PUD BLEEDING ( COHRANE META ANALYSIS )
*Number of trials
0 0.5 1 1.5 2
Re-bleeding (19*)
Surgical Intervention (17*)
Outcome at 30 days after randomization
Odds Ratio (95% CI)
Mortality (9*)
0.53
0.46
0.59
Favors PPI Favors control
Modified from Leontiadis et al, The Cochrane Database of Systematic Reviews 2005 + update in 2006; Barkun et al., AJG 2004
PPI improve mortality in patients w HRS only if they
have initially undergone endoscopic hemostasis (i.e.:
mainly high-dose IV)
Also, these findings have been confirmed
in a “real-life” setting
23. PEPTIC ULCER BLEEDING STUDY WITH
ESOMEPRAZOLE IV
Sung JJ, et al. Aliment Pharmacol Ther 2008;27:666–77
oral treatment
(27 days)
i.v. treatment
(72 hours)
(0max 24 hours)
Esomeprazole i.v.,
80 mg for 30 minutes
followed by
esomeprazole i.v., 8
mg/hour for 71.5 hours
Placebo i.v. for
30 minutes followed
by placebo i.v. for
71.5 hours
Esomeprazole oral,
40 mg once daily
R
Esomeprazole oral,
40 mg once daily
Enrolment phase:
Endoscopic therapy
• Conduct in 91 centers in 16 countries – multicenter
• Including 3 ethnic (asian, african and caucasian) - heterogenous
• Used placebo as control – controlled study
24. ENDPOINT PRIMER:
RE-BLEEDING RATE AT 72 FIRST HOURS
0
2
4
6
8
10
12
Esomeprazole Placebo
5,9
10,3
%
patients
with
re-bleeding
42.7%
Sung JJ, et al. Aliment Pharmacol Ther 2008;27:666–77
26. Conclusion: Esomeprazole, given as a continuous high-
dose intravenous infusion followed by an oral regimen
after successful endoscopic therapy for Peptic Ulcer
Bleeding, was well tolerated, with no apparent safety
concerns from either the high-dose intravenous
treatment or oral phases.
27. •. 2015 Nov;32(11):1160-76.
Conclusion: In this phase 3, multicenter, randomized trial
conducted in China, esomeprazole showed a numerical
trend towards superior clinical benefit over cimetidine in the
prevention of rebleeding in patients who had successfully
undergone initial hemostatic therapy of a bleeding peptic
ulcer, with a similar safety and tolerability profile
28. Esomeprazole
• Esomeprazole is the S-isomer of omeprazole.it has a better
pharmacokinetic and pharmacodynamic profile than
omeprazole.1
• Pharmacodynamics: in an acidic environment, esomeprazole is
protonated and becomes the active form, then binds to the
sulfhydryl group in the proton pump of parietal cells and
inhibits gastric acid production.1
• Esomeprazole reduces acid secretion through inhibition of
the H+, K+-ATPase in gastric parietal cells. Esomeprazole acts as
an exosome inhibitor by blocking the exosome release via the
inhibition of V-H+-ATPases.2
• Esomeprazole increases gastric pH better than omeprazole,
lansoprazole, pantoprazole and rabeprazole.1
1. Hoed & Kuipers. Expert Rev. Gastroenterol. Hepatol 2010.
2. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.
29. Indications of Esomeprazole Intravenous
Gastric anti-secretory treatment when the oral route is not possible, such as:
Gastro esophageal reflux disease in patients with esophagitis and/or severe
symptoms of reflux; Healing of gastric ulcers associated with NSAIDs
therapy.
The short-term maintenance of hemostasis and prevention of rebleeding in
patients following therapeutic endoscopy for acute bleeding gastric or
duodenal ulcers.
Mims Indonesia
30. Body Physiology
• Platelet Aggregation stability need PH > 6.1 • Pepsin activity decreases sharply after pH > 4:
The main target of PPI treatment.2
1. Green FW, et al. Gastroenterology 1978;74:38–43
2. Berstad A. Scand J Gastroenterol 1970;5:343-8
31. Esomeprazole has been shown to be more effective in maintaining pH
> 4 vs other PPIs
Miner P et al. Am J Gastroenterol 2006;101:404–5, 406
32. PERCENTAGE OF TIME PH>6 DURING
FIRST 3 HOURS WITH ESOMEPRAZOLE
I.V. (HEALTHY VOLUNTEERS)
0
20
40
60
80
100
Mean fraction of first 3 hours (%)
*p<0.05 versus 80 mg + 8 mg/hour
Baseline 40 mg
+ 8 mg/hour
80 mg
+ 4 mg/hour
80 mg
+ 8 mg/hour
120 mg
+8 mg/hour
120 mg (2hours)
+ 8 mg/hour
2%
23.3%*
36.6%*
46.7% 47.7% 43.3%
Röhss K, et al. Intl J Clin Pharm Ther 2007;45:345–54
n=25 n=23 n=24 n=24 n=22 n=20