Persistent abdominal pain in men, what happend?walterHu5
Persistent abdominal pain in men can be related to many conditions, like prostatitis, urethritis. Foe these diseases, take herbal medicine Diuretic and Anti-inflammatory Pill to get a relief.
The dedicated professionals at College Station Urology provide the best urological care for the detection, treatment and prevention of urological diseases-Premier Texas Urology screening, diagnosis and treatment in one place
A Hernia occurs when there is a weakness or hole in the peritoneum (muscular wall). The function of peritoneum is to keep the organs in the abdominal region in place. In here if the organs or tissues are pushed out to form a bulge, then it is said to be herniated. They are commonly found in the abdomen, upper thigh and groin region. They are usually not life threatening but in some cases surgery is advised to avoid potentially dangerous complications.
Read More: https://www.narayanahealth.org/hernia/
Dysmenorrhea and related disorders by dr alka mukherjee dr apurva mukherjee n...alka mukherjee
Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. The secondary forms of dysmenorrhea are associated with endometriosis and adenomyosis and may represent the key symptom. The diagnosis is suspected on the basis of the clinical history and the physical examination and can be confirmed by ultrasound, which is very useful to exclude some secondary causes of dysmenorrhea, such as endometriosis and adenomyosis. The treatment options include non-steroidal anti-inflammatory drugs alone or combined with oral contraceptives or progestins.
Persistent abdominal pain in men, what happend?walterHu5
Persistent abdominal pain in men can be related to many conditions, like prostatitis, urethritis. Foe these diseases, take herbal medicine Diuretic and Anti-inflammatory Pill to get a relief.
The dedicated professionals at College Station Urology provide the best urological care for the detection, treatment and prevention of urological diseases-Premier Texas Urology screening, diagnosis and treatment in one place
A Hernia occurs when there is a weakness or hole in the peritoneum (muscular wall). The function of peritoneum is to keep the organs in the abdominal region in place. In here if the organs or tissues are pushed out to form a bulge, then it is said to be herniated. They are commonly found in the abdomen, upper thigh and groin region. They are usually not life threatening but in some cases surgery is advised to avoid potentially dangerous complications.
Read More: https://www.narayanahealth.org/hernia/
Dysmenorrhea and related disorders by dr alka mukherjee dr apurva mukherjee n...alka mukherjee
Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. The secondary forms of dysmenorrhea are associated with endometriosis and adenomyosis and may represent the key symptom. The diagnosis is suspected on the basis of the clinical history and the physical examination and can be confirmed by ultrasound, which is very useful to exclude some secondary causes of dysmenorrhea, such as endometriosis and adenomyosis. The treatment options include non-steroidal anti-inflammatory drugs alone or combined with oral contraceptives or progestins.
This PPT covers the Pathophysiology of Dysmenorrhoea also known as mentrual cramp. It includes type of dysmenorrhea, pathophysiology, causes, symptoms and Diagnosis
Dr. Ellen Wilson joined the University of Texas Southwestern Medical Center as an associate professor and practitioner in 2001. As a gynecology, reproductive endocrinology, and pediatric and adolescent gynecology specialist, Dr. Ellen Wilson has treated patients for an array of conditions, including fibroid tumors and endometriosis.
DO YOU KNOW WHICH “HERNIA” YOU ARE SUFFERING FROM?KMBasha
A hernia occurs when an organ or a fatty tissue pushes through a weak opening in the muscle. The hernia can be classified into different types depending on which area it occurs. There could be various reasons for hernia like damage in the muscle or strenuous exercise or overweight. A hernia is not self curable it needs a surgical repair.
Explains about the importance of diet in Ayurveda and in special the postnatal herbal diet which makes the women to slim down after parturition and prevent the common puerperal
complaints.
Overview and Management of Vaginismus in Malaysia. Case-based discussion. 2nd National Mind and Body Seminar: Vaginismus Dare to Treat at Putrajaya, 27th October 2017.
Dyspareunia & vulvodynia by dr alka mukherjee dr apurva mukherjee nagpur m.s....alka mukherjee
Pain during or after sexual intercourse is known as dyspareunia. Although this problem can affect men, it is more common in women. Women with dyspareunia may have pain in the vagina, clitoris or labia. There are numerous causes of dyspareunia, many of which are treatable. Common causes include the following:
• Vaginal dryness
• Atrophic vaginitis, a common condition causing thinning of the vaginal lining in postmenopausal women
• Side effects of drugs such as antihistamines and tamoxifen (Nolvadex and other brands)
• An allergic reaction to clothing, spermicides or douches
• Endometriosis, an often painful condition in which tissue from the uterine lining migrates and grows abnormally inside the pelvis
• Inflammation of the area surrounding the vaginal opening, called vulvar vestibulitis
• Skin diseases, such as lichen planus and lichen sclerosus, affecting the vaginal area
• Urinary tract infections, vaginal yeast infections, or sexually transmitted diseases
• Psychological trauma, often stemming from a past history of sexual abuse or trauma
Symptoms
Women with dyspareunia may feel superficial pain at the entrance of the vagina, or deeper pain during penetration or thrusting of the penis. Some women also may experience severe tightening of the vaginal muscles during penetration, a condition called vaginismus.
Postnatal care (PNC) for the mother should respond to her special needs, starting within an hour after the delivery of the placenta and extending through the following six weeks. The care includes the prevention, early detection and treatment of complications, and the provision of counselling on breastfeeding, birth spacing, immunization and maternal nutrition. To standardise the PNC service, you are advised to use the screening, counselling and postnatal care cards. These cards ensure that you have covered all the essential steps in every home visit.
this ppt is beneficial for nursing and obstetric and gynaecology students.
In general, constipation and uterine adenomyosis have no closed relations. Since adenomyosis amy affect fertility, so take herbal medicine Fuyan Pill to get a cure.
Herbal Formula Fuyan Pill Helps Women Overcome Infertility Via Restoring Pelv...FFragrant
Herbal formula Fuyan Pill helps women overcome infertility caused by many diaseases, like blocked fallopian tubes, hydrosalpinx, endometriosis, adenomyosis, PID, etc.
This PPT covers the Pathophysiology of Dysmenorrhoea also known as mentrual cramp. It includes type of dysmenorrhea, pathophysiology, causes, symptoms and Diagnosis
Dr. Ellen Wilson joined the University of Texas Southwestern Medical Center as an associate professor and practitioner in 2001. As a gynecology, reproductive endocrinology, and pediatric and adolescent gynecology specialist, Dr. Ellen Wilson has treated patients for an array of conditions, including fibroid tumors and endometriosis.
DO YOU KNOW WHICH “HERNIA” YOU ARE SUFFERING FROM?KMBasha
A hernia occurs when an organ or a fatty tissue pushes through a weak opening in the muscle. The hernia can be classified into different types depending on which area it occurs. There could be various reasons for hernia like damage in the muscle or strenuous exercise or overweight. A hernia is not self curable it needs a surgical repair.
Explains about the importance of diet in Ayurveda and in special the postnatal herbal diet which makes the women to slim down after parturition and prevent the common puerperal
complaints.
Overview and Management of Vaginismus in Malaysia. Case-based discussion. 2nd National Mind and Body Seminar: Vaginismus Dare to Treat at Putrajaya, 27th October 2017.
Dyspareunia & vulvodynia by dr alka mukherjee dr apurva mukherjee nagpur m.s....alka mukherjee
Pain during or after sexual intercourse is known as dyspareunia. Although this problem can affect men, it is more common in women. Women with dyspareunia may have pain in the vagina, clitoris or labia. There are numerous causes of dyspareunia, many of which are treatable. Common causes include the following:
• Vaginal dryness
• Atrophic vaginitis, a common condition causing thinning of the vaginal lining in postmenopausal women
• Side effects of drugs such as antihistamines and tamoxifen (Nolvadex and other brands)
• An allergic reaction to clothing, spermicides or douches
• Endometriosis, an often painful condition in which tissue from the uterine lining migrates and grows abnormally inside the pelvis
• Inflammation of the area surrounding the vaginal opening, called vulvar vestibulitis
• Skin diseases, such as lichen planus and lichen sclerosus, affecting the vaginal area
• Urinary tract infections, vaginal yeast infections, or sexually transmitted diseases
• Psychological trauma, often stemming from a past history of sexual abuse or trauma
Symptoms
Women with dyspareunia may feel superficial pain at the entrance of the vagina, or deeper pain during penetration or thrusting of the penis. Some women also may experience severe tightening of the vaginal muscles during penetration, a condition called vaginismus.
Postnatal care (PNC) for the mother should respond to her special needs, starting within an hour after the delivery of the placenta and extending through the following six weeks. The care includes the prevention, early detection and treatment of complications, and the provision of counselling on breastfeeding, birth spacing, immunization and maternal nutrition. To standardise the PNC service, you are advised to use the screening, counselling and postnatal care cards. These cards ensure that you have covered all the essential steps in every home visit.
this ppt is beneficial for nursing and obstetric and gynaecology students.
In general, constipation and uterine adenomyosis have no closed relations. Since adenomyosis amy affect fertility, so take herbal medicine Fuyan Pill to get a cure.
Herbal Formula Fuyan Pill Helps Women Overcome Infertility Via Restoring Pelv...FFragrant
Herbal formula Fuyan Pill helps women overcome infertility caused by many diaseases, like blocked fallopian tubes, hydrosalpinx, endometriosis, adenomyosis, PID, etc.
Blocked fallopian tube and menstrual cycleFFragrant
Blocked fallopian tubes usually have nothing to do with the menstruation. For, For blocked fallopian tubes, herbal medicine Fuyan Pill can be a noce choice.
Will Women Have Abnormal Menstrual Cycle When Diagnosing Blocked Fallopian Tube?FFragrant
Women with blocked fallopian tubes can have normal menstrual cycle. However, it can affect fertility, so treatment is necessary, like herbal medicine Fuyan Pill.
Women's reproductive organs have a unique structure, quickly leading to gynecological diseases if they ignore them. For some gynecological diseases, like endometriosis, blocked fallopian tubes, etc., herbal medicine Fuyan Pill can be a nice option.
Are Fallopian Tubes Open to Women Without Pregnancy?LeoPearson
Whether the fallopian tube is open usually has nothing to do with pregnancy. Once your falloapin tubes are blocked, seek herbal medicine Fuyan Pill for treatment.
Managing Adenomyosis- Optimal Duration for Short-Acting Contraceptive Pills.pptxFFragrant
Adenomyosis needs lonig-time managment. And herbal medicine Fuyan Pill should be more effective than short-acting contraceptive pills due to its fewer side effects.
Adenomyosis Beast- When Short-Acting Contraceptives Become Your Ally.pptxFFragrant
Patients with adenomyosis can take short-acting contraceptives to relieve symptoms. And they can select herbal medicine Fuyan Pill without side effects.
Preparing for Pregnancy? Beware of These 3 Factors Linked to Blocked Fallopia...FFragrant
Women should notice 3 factors linked to blocked fallopian tubes when preparing for pregnancy. And they can choose herbal medicine Fuyan Pill to achieve positive results.
One Fallopian Tube and Your Fertility- A Comprehensive Guide to Pregnancy Pre...FFragrant
Many women can conceive for one fallopian tube. However, if you have tubal conditions, you should seek active treatments. Herbal medicine Fuyan Pill can be your consideration.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. When inflammation occurs in female
internal genitalia and its surrounding
connective tissue, pelvic peritoneum, etc., it
is named pelvic inflammatory disease.
Pelvic inflammatory disease can cause many
physical problems, such as painful
menstruation and abdominal pain.
So, can it cause diarrhea?
3. A
B
Pelvic inflammatory disease can cause diarrhea because the
uterus is located in front of the rectum. If women suffer from
pelvic inflammation, uterine posterior pelvic congestion
(before the pelvic congestion is heavier), it will make uterine
congestion become soft, being closer to the rectum, causing
pressure on sacral nerve and producing a feeling of falling.
At the moment, uterus squeezes rectum,
stimulates rectum mucous membrane to
contract, thus causing the urge to defecate.
4. This kind of condition appears more in female early
menstrual period, menstruation, and when being
pregnant for 40 days or so. Often, antidiarrheal drugs are
ineffective.
Through the treatment of pelvic inflammatory disease for a
period of time, inflammation disappears, diarrhea will also
be cured.
5. If pregnant women suffer from pelvic
inflammatory disease, pelvic cavity and uterine
congestion will become more obvious, and
inflammation spreads to the rectum, it will
stimulate the rectum and cause diarrhea.
6. C
B
A
Pelvic inflammatory disease is mostly as a result of the
pathogen through abortion, childbirth caused by reproductive
trauma or placenta stripping surface or menstrual
endometrium stripping surface and genital operation of the
wound surface invasion.
Pathogenic bacteria can enter the
vagina from the anus, vulva, up
along the mucosa, through the
cervix, endometrium, via the
fallopian tube spreading to ovary
and abdominal cavity.
7. Many females have
menstrual diarrhea
symptoms while
they do not care
about it too much.
Some did not have
further examination
after they failed to
take the drug on
their own.
It is suggested that
females after
discovering this
symptom should
exclude causes of
diseases in time,
and treat pelvic
inflammatory
disease actively.
8. By contrast with western medicine, this herbal medicine
won't lead to any side effects or drug resistance during the
long-term treatment.
Patients with chronic pelvic inflammatory disease and
abdominal mass can be treated with traditional Chinese
medicine or western medicine.
Among them, the herbal medicine Fuyan Pill is a useful
option for female health.
9. Some patients
suffering from
chronic pelvic
inflammatory
disease choose to
take antibiotics to
solve slightly
uncomfortable
feeling.
If you do so for a
long period of time,
it will lead to
vaginal flora
disorders, and
cause increased
vaginal secretions,
with white-bean-
dregs-like
leucorrhea.
10. Patients diagnosed with acute or subacute
pelvic inflammatory disease must follow
the doctor's advice to actively undergo the
treatment. Patients are supposed to rest in
bed or take a semi-decubitus position.
It helps to limit inflammation and
discharge secretions. Patients with chronic
pelvic inflammatory disease should not be
too tired, and they should combine work
and rest.
11. Females should also control the sexual
frequency. As you may not realize, most
cases of pelvic inflammatory disease
feature sexually active females. So if you
can take good care of your sexual life and
pay much attention to your personal
hygiene, you will be able to avoid pelvic
inflammatory disease to a certain degree.