Ped488 dyslipidemia s 11
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Dyslipidemia refers to abnormal blood lipid or lipoprotein levels and is linked to increased risk of cardiovascular disease. It involves high levels of triglycerides and/or cholesterol, which circulate in the bloodstream within lipoprotein particles. Lifestyle factors like diet, physical activity, smoking, and alcohol can influence lipid levels. Regular aerobic exercise of moderate intensity for 30-60 minutes per day at least 5 days per week is an effective way to improve lipoprotein profiles through increased calorie expenditure and weight control, particularly by raising HDL levels and lowering triglycerides.
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Ped488 dyslipidemia s 11
- 4. Overview of Lipoprotein Metabolic Pathways
Editor's Notes
- Triglycerides <150 Normal 150-199 Borderline high 200-499 High > Very High Total Cholesterol <200 Desia
- New class of agents: HMG-CoA reductase inhibitors (Lovastatin (mevacor) and Simvastatin (zocor) reduce levels of total and LDL-chol more powerfully and simultaneously boost HDL Bile Acids-administered as a powdered resin dissolved in liquid or as tablets. Resins inhibit the intestinal reabsorption of bile and its transport in the portal circulation to the liver. This loss of bile stimulates the up-regulation of hepatic (liver) LDL receptor activity that reduces plasma LDL levels. These drugs are most effective when give with the fattiest meal as it encounters bile in the gut. Major side effects are constipation, bloating and gas and they interfere with absorption of fat soluble vitamins. Fibric Acids-reduces elevated TG levels-well tolerated with few side effects Nicotinic acid-useful for those with low HDL or elevated TG-main effect is to inhibit lipolysis which reduces the quantity of plasma FFA and their available transport to the lever which reduces their synthesis into TG
- *These drugs have a powerful effect on lowering LDL and raising HDL by blocking an enzyme needed to produce cholesterol in the liver