This document discusses the case of a 57-year-old female patient with von Hippel-Lindau (VHL) disease who presented with decreased vision in her left eye due to retinal hemangioblastoma. She underwent two unsuccessful laser treatments but photodynamic therapy (PDT) resulted in significant resolution of the serous retinal detachment and cystoid macular edema. PDT was concluded to be an effective treatment for exudative retinal detachment caused by retinal hemangioblastomas in patients with VHL disease.