Are alignments on trucks and buses a green procedure or a money drain (part 13)Lyna Manufacturing Inc.
Tire Lyna is the only one single product that protects the entire casing from heat and oxidation damage, it will self balance wheel ends, maintain correct tire pressure and will self repair punctures up to 1/2". In slower moving tires we have testimonials of sealing rock gashes of up to 3 inches.
This is a presentation delivered to the APWA Florida Chapter's Suncoast Branch on innovations currently available in pavement rejuvenation and preservation.
This CAI Approved Course is intended to educate association managers on the basic scientific elements of pavement preservation and deterioration and ways to manage them over time.
Are alignments on trucks and buses a green procedure or a money drain (part 13)Lyna Manufacturing Inc.
Tire Lyna is the only one single product that protects the entire casing from heat and oxidation damage, it will self balance wheel ends, maintain correct tire pressure and will self repair punctures up to 1/2". In slower moving tires we have testimonials of sealing rock gashes of up to 3 inches.
This is a presentation delivered to the APWA Florida Chapter's Suncoast Branch on innovations currently available in pavement rejuvenation and preservation.
This CAI Approved Course is intended to educate association managers on the basic scientific elements of pavement preservation and deterioration and ways to manage them over time.
Adhesives for • Design • Manufacturing • Assembly • Maintenence • Repair & Overhaul
Permabond’s history of developing and manufacturing engineering adhesives spans four decades and three continents.
Today, Permabond Engineering Adhesives Ltd (Europe & Asia) and Permabond LLC (Americas) provide technological solutionsto engineers all over the world, with officesand facilities in America, Asia and Europe, backed by a high-tech ISO 9001:2008 certified production plant in Europe.
This brochure contains information on our most popular products, if you don’t see exactly what you need, or
would like assistance in selecting the best product for your application, please contact us:
This course assists Community Managers in understanding the basic financial benefits of Pavement Preservation and continued maintenance of pavement assets.
Presentation by Scott Metcalf on "Pavement Preservation" for the CalAPA Spring Asphalt Pavement Conference & Equipment Expo, April 20-21, 2016, in Ontario, CA.
As the saying goes, Good roads cost money, and bad roads cost more. Hear the latest from the world of pavement preservation and how preservation strategies can stretch tight road maintenance dollars, as well as when maintenance becomes rehabilitation.
Developing roads in Southern Africa will definitely trigger a continental transformation with huge potential to facilitate access to education and health. “If you build the roads, there are environmental costs, but if you don’t, there are developmental costs,” says Jeff Sayer of James Cook University in Cairns, Australia.
We have the worldwide rights to sell a patented exhaust system. In a nutshell here is what it does:
* Creates a fuel savings of 15-25%
* Reduces emissions by up to 35%
* Increases engine torque by 20-30%
* Increases horsepower by 20%
A technological break-through, resulting from almost three decades of research and development. FuelAid Systems and Optimizers harness the science of fluid conditioning to improve combustion efficiency and increase fuel economy.
When properly installed, FuelAid systems cause fuel to take on a millivoltage charge which breaks up molecular clusters, causing better burning. Emissions are greatly reduced as a result.
The non invasive molecular optimization technology is capable of delivering the proper magnetic field necessary to break up the electrons in the fuel and reach the Rayleigh Limit - defined by NASA as the correct charge, and the number of electrons, to induce the desired effect.
All of this is a fancy way of saving that FuelAid Systems save money and reduce emissions, passively, using proven scientific theory. No driver training required.
Many people assume they are buying quality fuel that meets the required specifications; diesel fuel cleanliness is rarely questioned. But higher fuel systems operating pressures, lower system tolerances and tighter filtration have pushed fuel cleanliness into the maintenance spotlight.
Adhesives for • Design • Manufacturing • Assembly • Maintenence • Repair & Overhaul
Permabond’s history of developing and manufacturing engineering adhesives spans four decades and three continents.
Today, Permabond Engineering Adhesives Ltd (Europe & Asia) and Permabond LLC (Americas) provide technological solutionsto engineers all over the world, with officesand facilities in America, Asia and Europe, backed by a high-tech ISO 9001:2008 certified production plant in Europe.
This brochure contains information on our most popular products, if you don’t see exactly what you need, or
would like assistance in selecting the best product for your application, please contact us:
This course assists Community Managers in understanding the basic financial benefits of Pavement Preservation and continued maintenance of pavement assets.
Presentation by Scott Metcalf on "Pavement Preservation" for the CalAPA Spring Asphalt Pavement Conference & Equipment Expo, April 20-21, 2016, in Ontario, CA.
As the saying goes, Good roads cost money, and bad roads cost more. Hear the latest from the world of pavement preservation and how preservation strategies can stretch tight road maintenance dollars, as well as when maintenance becomes rehabilitation.
Developing roads in Southern Africa will definitely trigger a continental transformation with huge potential to facilitate access to education and health. “If you build the roads, there are environmental costs, but if you don’t, there are developmental costs,” says Jeff Sayer of James Cook University in Cairns, Australia.
We have the worldwide rights to sell a patented exhaust system. In a nutshell here is what it does:
* Creates a fuel savings of 15-25%
* Reduces emissions by up to 35%
* Increases engine torque by 20-30%
* Increases horsepower by 20%
A technological break-through, resulting from almost three decades of research and development. FuelAid Systems and Optimizers harness the science of fluid conditioning to improve combustion efficiency and increase fuel economy.
When properly installed, FuelAid systems cause fuel to take on a millivoltage charge which breaks up molecular clusters, causing better burning. Emissions are greatly reduced as a result.
The non invasive molecular optimization technology is capable of delivering the proper magnetic field necessary to break up the electrons in the fuel and reach the Rayleigh Limit - defined by NASA as the correct charge, and the number of electrons, to induce the desired effect.
All of this is a fancy way of saving that FuelAid Systems save money and reduce emissions, passively, using proven scientific theory. No driver training required.
Many people assume they are buying quality fuel that meets the required specifications; diesel fuel cleanliness is rarely questioned. But higher fuel systems operating pressures, lower system tolerances and tighter filtration have pushed fuel cleanliness into the maintenance spotlight.
The following presentation reviews the programs being instituted by the Membership Development Committee of the Grand Lodge of Florida for 2019 and 2020
Presentation on Project Management basics and tools for professionals in the Public Works industry. Given to members of the Santa Fe Branch on May 3, 2017 in Alachua County, Florida.
The Public Works Institute includes a small presentation on the basics of effective project management. Project Management is a cornerstone of the role of any public works professional, especially supervisors or managers.
This presentation is for the Florida Public Works Institute classes in St. Petersburg, Florida. Time Management is an essential skill for supervisors and managers not only in managing people but projects as well. This presentation outlines the necessity for the skill and tips for how to hone it.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. What is Pavement
Preservation?
• Asset Management Principles:
– Life Cycle Cost Benefit
– Maintaining Early to keep in “Like New”
Condition
• Pavement “Value”
• Preventive Maintenance
– Oil Changes?
– Change the Air Filter in your A/C Unit?
– Mow your lawn?
– All Examples of Preventive Maintenance
3. It’s kind of like going to the
dentist
Preventative Medicine is the
model we want to shoot for
In infrastructure, the longer we
wait the bigger the bill
When you brush your teeth, do
you brush only the worst teeth?
Why then would we only
address the worst roads?
4. The 2018 Corvette Stingray MSRP
$55,000
– Cost to change the oil?
– Cost to replace the engine?
Pretty easy choice right?
Imagine not changing the oil
in your taxpayer funded $78M
piece of equipment, every year!
5. The biggest challenge you
face on your roads?
They don’t last long
enough for the
amount of funding
you have!
What then is the
solution?
Is it more money?
What is the cost of inaction? A ton!
6. 0
20
40
60
80
100
Years
PCI“The Right Time”
Pavement Strategies
Rejuvenation
High Density Mineral Bond
Crack Seal
Micro-Surfacing
Cape Seal
Asphalt Overlay
Hot In-Place Recycling
Cold In-Place Recycling
Full Depth Reclamation
9. Common belief, HMA lasts
20 years then, we resurface
The typical Public Works Agency did the
same thing. Resurface, wait 20 years,
rinse (mill) and repeat.
13. The first significant
hardening of the
asphalt cement takes
place in the pugmill or
drum mixer where
heated aggregate is
mixed with hot asphalt
cement. During this
short mixing time, the
asphalt cement, which
is in very thin films, is
exposed to high
temperatures ranging
from 275 to 350º F.
Why Asphalt Deteriorates
Aging Begins
14. The roadway begins to deteriorate the moment it’s
paved. The worst part is it’s exponential. The viscosity
of the asphalt binder can go from 10-15K poise when
it’s only a few months old to several hundred thousand
after only a few years. In Florida this is how most roads
fail.
Oxidation takes its toll
Aging continues
16. Thus, the secret of ensuring
a long service life of asphalt
in pavements is to retard
the aging process.
During the FHWA EDC workshop
the secret was revealed…
17. How to preserve your roads
without increasing funding!
What if there was a
way to get
someone else to
pay 80% of your
preservation
program?
That’s what we’ve
discovered and
want to share with
you.
Preservation extends life by 50%
18. So how is it less costly
earlier than later?
• Basic Cost Benefit Model –
– If a Road costs $150,000 to build (per
lane mile) and it has a 20 year life cycle
in 100 years you will spend $750,000 on
that mile of road.
– If you preserve with a $1 per SY
treatment early and then every five years
going forward, the asset can now last 40
years.
• If we estimate ~$7,000 per Lane Mile to
preserve
• $150,000 + ($7,000*4 treatments) = $178,000
for 40 Years
• In 100 years you will spend $445,000
24. Rejuvenation
• Maltenes are the unstable component of
asphalt binder and they are affected by air,
UV rays, water, temperature changes, etc.
• It is the loss of the Maltenes from the
asphalt binder in the upper 3/8”-1/2” of
asphalt pavements that start the asphalt
deterioration process.
26. What are these things?
• Polar Compounds (Nitrogen Bases)
– Highly Reactive petroleum resins that act as a colloidal
dispersion stabilizer or “peptizer” for the asphaltene core; they
impact ductile and tensile strength properties to the mixture
• First Acidaffins
– Aromatic resinous petro-hydrocarbons, with or without S, O
and N, and provide a homologous or chemically compatible
dispersion agent for the peptized asphaltene
• Second Acidaffins
– Straight Chain or Cyclic unsaturated petro-hydrocarbons
(olefinic) which are semi-oily; semi-resinous physically. They
promote resistance to moisture intrusion and formulate proper
adhesion qualities to asphaltic concrete
• Paraffins (Saturates)
– Either straight or branch chain saturated hydrocarbons
(naphthene-aromatics) and are the truly OILY component of
asphaltic concrete and function as a gelling agent for the
asphalt compounds
27. How Rejuvenators work
Maltene based rejuvenators work by changing the
chemistry of the asphalt binder by replenishing the lost
maltenes back into the asphalt binder restoring its
asphaltene to maltene ratio back to nearly new levels
This in turn softens the pavement surface
restoring its flexibility and resistance to cracking
28. These products also work to provide a
long lasting seal of the pavement’s
surface preventing the intrusion of air
and moisture into it
How Rejuvenators work
29. Fog Seal COATING -
Seals the surface
Petroleum Maltene Based REJUVENATOR -
Penetrates down into pavement & seals the surface, CANNOT be worn away
30. Rejuvenation has now been
proven scientifically in three
distinct ways
1) With viscosity testing,
using the Dynamic
Sheer Rheometer
(DSR)
2) International
Roughness Index (IRI)
3) 3D high resolution
imaging!
2018 Polk County, Florida
31. Reclamite® Program - Tamarac
Below you can see the results of the viscosity
tests after treatment with Reclamite
The lower numbers illustrate how effective
Reclamite was reducing or softening the
asphalt binder
36. International Roughness Index
Binder Street
IRI values show the
treated section is less than
half as rough as the
untreated section.
This shows significant
effectiveness 14 years
after only one treatment of
Reclamite
37. 3D Imaging Data
Binder Street
“The way the 3D system quantifies raveling is by
breaking the image into tiles and color coding
the tiles that are considered “failed” in
blue. Again, there is a profound difference in
the surface that was treated versus the
untreated area.” Rob Olenoski, ICC
38. So… how do we test it?
1. ASTM Test D-2006-70 or “Free Maltene
Distribution”
1. “Rostler Method” – Determines the rejuvenator
efficacy and determines the ratio of resinous to oily
maltenes in the pavement surface
2. https://www.pavementpreservation.org/wp-
content/uploads/2017/03/FPPC335_Asphalt_Rejuve
nation.pdf
39. Bio-Based Products
Bio-Based products have come to market
that serve as solvents for the asphalt they
are applied to. These meet the criteria of
ASTM Test D-2007 or “SARA” but not that
of 2006-70.
Warnings:
• May disrupt the Asphalt Matrix
• May cause hazardous material issues
with roadway
• High VOCs
40. How to preserve your roads
without increasing funding!
With several Federal
Grant programs we
can actually get up
to 80% of your first
project paid for!
If you are interested
we can help the
City to apply for
the FHWA grant
for pavement
preservation! Preservation extends life by 50%