This document discusses three profitability ratios: return on sales (ROS), operating margin, and return of investment (ROI). ROS measures net income as a percentage of net sales and indicates how much profit is generated from each dollar of sales. Operating margin measures operating income as a percentage of net sales to show profitability after variable costs. ROI measures net income as a percentage of total non-current assets and working capital to evaluate how effectively a company generates income from its invested capital. Examples are provided to demonstrate calculating each ratio using financial data from an income statement and balance sheet. Key points about interpreting each ratio are also summarized.