Vitamin B12 plays an essential role in the production of healthy red blood cells. It acts as a coenzyme facilitating DNA synthesis and is required for the function of an enzyme involved in hemoglobin synthesis. Without sufficient B12, the body cannot produce enough hemoglobin to form functional red blood cells, which can result in large, abnormally shaped cells and decreased oxygen delivery to tissues. Maintaining adequate levels of vitamin B12 as well as other nutrients like folate, iron, and zinc is vital for continuous healthy erythropoiesis and oxygen transport via hemoglobin in red blood cells.
The document discusses normal ranges and interpretation of various clinical laboratory values from a complete blood count (CBC). It provides reference ranges for hemoglobin, hematocrit, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, reticulocytes, white blood cell count, neutrophils, lymphocytes, monocytes, and eosinophils. For each value, it describes potential causes of increases or decreases outside the normal ranges, as well as optimal versus alarm ranges.
Vitamin B12 plays an essential role in red blood cell production and function. It acts as a coenzyme facilitating DNA synthesis and is required for the conversion of homocysteine to methionine, which is necessary for hemoglobin synthesis. Without adequate B12, folate, iron and other nutrients, the body cannot produce healthy red blood cells to carry oxygen throughout the tissues. A deficiency in B12 can lead to abnormally large red blood cells and decreased oxygen transport. Maintaining sufficient levels of B12 and its cofactors is vital for effective erythropoiesis and prevention of anemia.
The document discusses various components of a complete blood count (CBC) including hemoglobin, hematocrit, red blood cell count and indices, white blood cell count and differentials, platelets, and serum iron. It provides the normal ranges for each component as well as potential causes for increases and decreases. The CBC provides important information about the types, populations, and health of blood cells and can help diagnose and assess conditions like anemia, infections, and blood disorders.
This document summarizes information on haemostasis and bleeding disorders. It discusses the mechanisms of haemostasis, screening tests for bleeding disorders, platelet disorders like ITP and TTP, coagulation factor deficiencies like hemophilia A and B, and vessel wall abnormalities. Key points covered are the stages of haemostasis, common causes of thrombocytopenia and thrombocytosis, management of ITP, and clinical features and treatment of disorders like hemophilia, von Willebrand disease, and Henoch-Schonlein purpura.
The document summarizes key concepts about blood, including:
1. Blood is composed of plasma, red blood cells, white blood cells, and platelets. Red blood cells carry oxygen, while white blood cells help fight infection.
2. The production and lifespan of red blood cells is described, along with the different types of white blood cells. Hemostasis and blood clotting are explained briefly.
3. Blood typing is discussed, including the ABO and Rh blood group systems. Compatibility for blood transfusions depends on the presence or absence of antigens on red blood cells.
Blood transports oxygen, nutrients, hormones, and removes waste throughout the body. It consists of plasma and formed elements including red blood cells, white blood cells, and platelets. Centrifuging blood separates its components based on density. Red blood cells carry oxygen and make up about 45% of blood volume. Blood groups are determined by antigens on red blood cells. Hemostasis stops bleeding through vessel constriction, platelet plug formation, and a coagulation cascade involving clotting factors.
This document provides an overview of hematopoiesis, the process by which blood cells are produced. It begins with a discussion of hematopoietic stem cells and their ability to differentiate into various blood cell types. The stages of red blood cell development from pronormoblast to reticulocyte to mature erythrocyte are described. Granulocyte development from myeloblast to mature neutrophil takes 5-12 days. Various hematopoietic growth factors that regulate blood cell production are also listed, including erythropoietin, GM-CSF, G-CSF, M-CSF, and others.
Blood contains nutrients, wastes, gases, cells and heat that it transports around the body. Red blood cells are produced in bone marrow and contain hemoglobin to carry oxygen. Different blood types are classified by antigens on red blood cells, and compatibility must be considered for transfusions to avoid agglutination reactions.
The document discusses normal ranges and interpretation of various clinical laboratory values from a complete blood count (CBC). It provides reference ranges for hemoglobin, hematocrit, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, reticulocytes, white blood cell count, neutrophils, lymphocytes, monocytes, and eosinophils. For each value, it describes potential causes of increases or decreases outside the normal ranges, as well as optimal versus alarm ranges.
Vitamin B12 plays an essential role in red blood cell production and function. It acts as a coenzyme facilitating DNA synthesis and is required for the conversion of homocysteine to methionine, which is necessary for hemoglobin synthesis. Without adequate B12, folate, iron and other nutrients, the body cannot produce healthy red blood cells to carry oxygen throughout the tissues. A deficiency in B12 can lead to abnormally large red blood cells and decreased oxygen transport. Maintaining sufficient levels of B12 and its cofactors is vital for effective erythropoiesis and prevention of anemia.
The document discusses various components of a complete blood count (CBC) including hemoglobin, hematocrit, red blood cell count and indices, white blood cell count and differentials, platelets, and serum iron. It provides the normal ranges for each component as well as potential causes for increases and decreases. The CBC provides important information about the types, populations, and health of blood cells and can help diagnose and assess conditions like anemia, infections, and blood disorders.
This document summarizes information on haemostasis and bleeding disorders. It discusses the mechanisms of haemostasis, screening tests for bleeding disorders, platelet disorders like ITP and TTP, coagulation factor deficiencies like hemophilia A and B, and vessel wall abnormalities. Key points covered are the stages of haemostasis, common causes of thrombocytopenia and thrombocytosis, management of ITP, and clinical features and treatment of disorders like hemophilia, von Willebrand disease, and Henoch-Schonlein purpura.
The document summarizes key concepts about blood, including:
1. Blood is composed of plasma, red blood cells, white blood cells, and platelets. Red blood cells carry oxygen, while white blood cells help fight infection.
2. The production and lifespan of red blood cells is described, along with the different types of white blood cells. Hemostasis and blood clotting are explained briefly.
3. Blood typing is discussed, including the ABO and Rh blood group systems. Compatibility for blood transfusions depends on the presence or absence of antigens on red blood cells.
Blood transports oxygen, nutrients, hormones, and removes waste throughout the body. It consists of plasma and formed elements including red blood cells, white blood cells, and platelets. Centrifuging blood separates its components based on density. Red blood cells carry oxygen and make up about 45% of blood volume. Blood groups are determined by antigens on red blood cells. Hemostasis stops bleeding through vessel constriction, platelet plug formation, and a coagulation cascade involving clotting factors.
This document provides an overview of hematopoiesis, the process by which blood cells are produced. It begins with a discussion of hematopoietic stem cells and their ability to differentiate into various blood cell types. The stages of red blood cell development from pronormoblast to reticulocyte to mature erythrocyte are described. Granulocyte development from myeloblast to mature neutrophil takes 5-12 days. Various hematopoietic growth factors that regulate blood cell production are also listed, including erythropoietin, GM-CSF, G-CSF, M-CSF, and others.
Blood contains nutrients, wastes, gases, cells and heat that it transports around the body. Red blood cells are produced in bone marrow and contain hemoglobin to carry oxygen. Different blood types are classified by antigens on red blood cells, and compatibility must be considered for transfusions to avoid agglutination reactions.
This document discusses blood physiology, specifically blood cells and red blood cells. It covers the types of blood cells, the process of hematopoiesis where blood cells are produced, and the development and regulation of red blood cells. Red blood cells transport oxygen and carbon dioxide through hemoglobin. Hemoglobin is composed of heme and globin and carries oxygen through various reactions. The life cycle and breakdown of red blood cells is also summarized.
This document discusses diseases of the haemopoietic system. It begins by describing blood cells and bone marrow haemopoiesis. The main types of diseases are then outlined as anaemias, haematological malignancies, and bleeding disorders. Iron deficiency anaemia is discussed in detail as the most common type of anaemia. It is caused by blood loss, increased demands, malabsorption or dietary deficiencies. Clinical features include pallor, spoon-shaped nails, and cognitive effects in children. Laboratory tests can identify microcytic hypochromic blood cells characteristic of iron deficiency.
The summary provides an overview of the key components of the hematologic system including:
- Bone marrow is the primary site of blood cell production and contains red and yellow marrow.
- The three main cellular components of blood are erythrocytes, leukocytes, and thrombocytes which are involved in oxygen transport, immune function, and hemostasis respectively.
- Important blood groups are ABO and Rh which determine transfusion compatibility.
- Common lab tests include complete blood count, coagulation studies, and blood typing to evaluate the hematologic system.
This chapter will discuss blood composition, the physical and chemical properties of blood, blood cells including erythrocytes, leukocytes and platelets, hemostasis, blood groups, and principles of blood transfusion. Specifically, it will cover the components and characteristics of plasma, hematopoiesis and the life cycle of red blood cells, the roles and regulation of white blood cells and platelets, and the clinical significance of blood groups and cross-matching for transfusion.
This document discusses the analysis of blood components. It covers:
- The functions of blood including oxygen transport, waste removal, temperature regulation, and more.
- Types of blood testing done in hematology, immunology, blood banking, and chemistry sections.
- Components of a complete blood count including red blood cell count, white blood cell count, hemoglobin, hematocrit, and differential white blood cell count.
- The different blood cell types - red blood cells, white blood cells (granulocytes and agranulocytes), platelets, and their roles in the body.
- Procedures for examining blood smears and determining cell counts are also outlined.
The document discusses the blood and its components. It states that blood contributes to homeostasis by transporting respiratory gases, nutrients, and hormones to and from cells. Blood also helps regulate pH and temperature, and provides protection through clotting and immune defenses. The document describes the constituents of blood including plasma and formed elements such as red blood cells, white blood cells, and platelets. It discusses hematopoiesis, the production of blood cells in the bone marrow, as well as abnormalities in erythropoiesis like anemia and polycythemia.
This document summarizes key concepts about blood physiology. It describes the components of blood, including red blood cells and hemoglobin, which transports oxygen. It discusses blood groups and reasons for transfusion reactions. It also outlines the process of hemostasis that restricts blood loss from damaged vessels, and the consequences of thrombosis. Additionally, it covers immunity and defense against microbes, the roles of hematopoietic growth factors and cytokines, and the mechanisms of innate, acquired, humoral, and cellular immunity.
The haemopoietic system document describes:
1. The haemopoietic system produces blood through haemopoiesis in the yolk sac, liver, spleen, and bone marrow. Diseases of the system include cytopenias from decreased production or increased destruction of blood cells, and cytosis like leukaemias.
2. Anaemia is a reduction in red blood cells or haemoglobin. Causes include blood loss, reduced production, and increased destruction. Morphological types are normocytic normochromic, microcytic hypochromic, and macrocytic.
3. Important hereditary haemolytic anaemias discussed are hereditary spherocytosis, glucose-6-phosphate
Erythropoietin (EPO) secreted by kidney
Inhibitor: High concentration of O2 in kidney
Life span of RBC: 120 days
RBC metabolism: anaerobic glycolysis [reason for
Heinz body and G6PD deficiency anemia]
RBC destruction: spleen and macrophage in liver,
bone marrow [reason for spherocytosis and
elliptocytosis]
RBC regeneration: bone marrow
RBC reserve: about 25% of total RBC
RBC production: 2.4×1011/day
physiology of Blood for nursery students dina merzeban
1. Red blood cells are biconcave disks that carry oxygen and carbon dioxide via hemoglobin. They require iron, vitamin B12, and folic acid for synthesis and maturation.
2. White blood cells include granulocytes like neutrophils, eosinophils, and basophils, and agranulocytes like lymphocytes and monocytes. They protect the body from pathogens and destroy abnormal cells.
3. Blood typing involves the presence or absence of antigens A, B, and Rh factor. Type O blood is the universal donor while type AB is the universal recipient. Sensitization can occur in Rh-negative mothers carrying Rh-positive fetuses.
The document discusses blood and its components. It describes how blood is made up of plasma, red blood cells, white blood cells, and platelets. Red blood cells transport oxygen and carbon dioxide, white blood cells protect against infection, and platelets help the blood clot to stop bleeding. The document provides details on the formation, functions, and counts of the different blood cell types.
Sickle cell anemia is a hereditary hemolytic anemia caused by a point mutation in the beta globin gene, resulting in abnormal hemoglobin S. This leads to polymerization of hemoglobin and distortion of red blood cells. Clinical manifestations include anemia, bone pain, acute chest syndrome, and organ damage to tissues like the spleen, liver, and kidneys. The condition is diagnosed through blood tests detecting hemoglobin electrophoresis patterns and genetic testing.
The document summarizes key components and functions of the circulatory system, including the heart, blood vessels, and blood. It describes how blood transports nutrients, gases, hormones, and waste throughout the body while also playing roles in temperature regulation and homeostasis. Specific components of blood such as plasma, red blood cells, white blood cells, and platelets are defined along with their functions. The formation and breakdown of red blood cells is also summarized.
Blood is connective tissue in fluid form that carries oxygen and nutrients throughout the body. It consists of plasma and formed elements including red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and transport oxygen and carbon dioxide. White blood cells help fight infection and disease. The main types of white blood cells are neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Erythropoiesis is the process where red blood cells are formed in the bone marrow. Hemoglobin in red blood cells binds to oxygen and carbon dioxide during respiration. Blood tests like complete blood count, ESR, and PCV are used to analyze blood components and detect diseases.
The document provides an overview of hematology and the components of blood. It describes how blood circulates from the heart through arteries and veins, and how gases are exchanged in capillaries. The main components of blood are plasma, red blood cells, white blood cells, and platelets. It details the formation of blood cells through hematopoiesis in the bone marrow, and the different types of white blood cells. Common blood tests like complete blood count and disorders of the blood components are also summarized.
This document summarizes key topics in hematology, including cellular components of blood, components of blood such as red blood cells, white blood cells and platelets, diseases that affect these components, blood typing, transfusion, and coagulation disorders. Some of the major areas covered are red blood cell production and diseases like sickle cell disease and polycythemia, white blood cell disorders including leukemia and lymphoma, platelet disorders, and bleeding disorders like hemophilia. Treatment approaches focus on following general guidelines, supportive care, and preventing further injury or infection.
2008 my lecture introduction to hematologyBruno Mmassy
Manage all clotting disorders by providing supportive care, controlling bleeding if present, and transporting promptly for definitive care. Monitor closely for signs of worsening condition.
Blood transports vital substances like oxygen and nutrients throughout the body. It is composed of plasma and three main cell types - red blood cells, white blood cells, and platelets. Red blood cells are produced in the bone marrow and carry oxygen to tissues via hemoglobin. They circulate for about 120 days before being broken down. White blood cells help protect the body from disease. Platelets help the blood clot and stop bleeding from broken blood vessels. The blood also contains proteins, gases, and other nutrients.
Blood is a connective tissue composed of plasma and cells. It transports oxygen, nutrients, hormones, and waste products throughout the body. Blood contains red blood cells, white blood cells, and platelets suspended in plasma. Red blood cells contain hemoglobin and transport oxygen and carbon dioxide. White blood cells help fight infection. Platelets help form blood clots to stop bleeding. The document discusses blood components, functions, disorders, and blood grouping in detail.
Red blood cells, white blood cells, and platelets are the three main components of blood. Red blood cells transport oxygen and carbon dioxide, white blood cells provide immunity, and platelets help with clotting to stop bleeding. The document discusses the structure and function of each blood component in detail over several pages.
Hematology is the study of blood, blood-forming organs, and blood diseases. It includes treatment of blood disorders and cancers. Blood is composed of plasma and formed elements including red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and carry oxygen throughout the body. White blood cells are part of the immune system and help fight infection. Platelets help with blood clotting. Blood is produced through hematopoiesis in the bone marrow and regulated by various factors.
The human body contains approximately 5 liters of blood composed of plasma and cellular elements. Plasma is 55% of blood and contains water, proteins, electrolytes, and other substances. Cellular elements include red blood cells containing hemoglobin, white blood cells for immunity, and platelets for clotting. Blood transports oxygen, nutrients, wastes, hormones, and more throughout the body.
This document discusses blood physiology, specifically blood cells and red blood cells. It covers the types of blood cells, the process of hematopoiesis where blood cells are produced, and the development and regulation of red blood cells. Red blood cells transport oxygen and carbon dioxide through hemoglobin. Hemoglobin is composed of heme and globin and carries oxygen through various reactions. The life cycle and breakdown of red blood cells is also summarized.
This document discusses diseases of the haemopoietic system. It begins by describing blood cells and bone marrow haemopoiesis. The main types of diseases are then outlined as anaemias, haematological malignancies, and bleeding disorders. Iron deficiency anaemia is discussed in detail as the most common type of anaemia. It is caused by blood loss, increased demands, malabsorption or dietary deficiencies. Clinical features include pallor, spoon-shaped nails, and cognitive effects in children. Laboratory tests can identify microcytic hypochromic blood cells characteristic of iron deficiency.
The summary provides an overview of the key components of the hematologic system including:
- Bone marrow is the primary site of blood cell production and contains red and yellow marrow.
- The three main cellular components of blood are erythrocytes, leukocytes, and thrombocytes which are involved in oxygen transport, immune function, and hemostasis respectively.
- Important blood groups are ABO and Rh which determine transfusion compatibility.
- Common lab tests include complete blood count, coagulation studies, and blood typing to evaluate the hematologic system.
This chapter will discuss blood composition, the physical and chemical properties of blood, blood cells including erythrocytes, leukocytes and platelets, hemostasis, blood groups, and principles of blood transfusion. Specifically, it will cover the components and characteristics of plasma, hematopoiesis and the life cycle of red blood cells, the roles and regulation of white blood cells and platelets, and the clinical significance of blood groups and cross-matching for transfusion.
This document discusses the analysis of blood components. It covers:
- The functions of blood including oxygen transport, waste removal, temperature regulation, and more.
- Types of blood testing done in hematology, immunology, blood banking, and chemistry sections.
- Components of a complete blood count including red blood cell count, white blood cell count, hemoglobin, hematocrit, and differential white blood cell count.
- The different blood cell types - red blood cells, white blood cells (granulocytes and agranulocytes), platelets, and their roles in the body.
- Procedures for examining blood smears and determining cell counts are also outlined.
The document discusses the blood and its components. It states that blood contributes to homeostasis by transporting respiratory gases, nutrients, and hormones to and from cells. Blood also helps regulate pH and temperature, and provides protection through clotting and immune defenses. The document describes the constituents of blood including plasma and formed elements such as red blood cells, white blood cells, and platelets. It discusses hematopoiesis, the production of blood cells in the bone marrow, as well as abnormalities in erythropoiesis like anemia and polycythemia.
This document summarizes key concepts about blood physiology. It describes the components of blood, including red blood cells and hemoglobin, which transports oxygen. It discusses blood groups and reasons for transfusion reactions. It also outlines the process of hemostasis that restricts blood loss from damaged vessels, and the consequences of thrombosis. Additionally, it covers immunity and defense against microbes, the roles of hematopoietic growth factors and cytokines, and the mechanisms of innate, acquired, humoral, and cellular immunity.
The haemopoietic system document describes:
1. The haemopoietic system produces blood through haemopoiesis in the yolk sac, liver, spleen, and bone marrow. Diseases of the system include cytopenias from decreased production or increased destruction of blood cells, and cytosis like leukaemias.
2. Anaemia is a reduction in red blood cells or haemoglobin. Causes include blood loss, reduced production, and increased destruction. Morphological types are normocytic normochromic, microcytic hypochromic, and macrocytic.
3. Important hereditary haemolytic anaemias discussed are hereditary spherocytosis, glucose-6-phosphate
Erythropoietin (EPO) secreted by kidney
Inhibitor: High concentration of O2 in kidney
Life span of RBC: 120 days
RBC metabolism: anaerobic glycolysis [reason for
Heinz body and G6PD deficiency anemia]
RBC destruction: spleen and macrophage in liver,
bone marrow [reason for spherocytosis and
elliptocytosis]
RBC regeneration: bone marrow
RBC reserve: about 25% of total RBC
RBC production: 2.4×1011/day
physiology of Blood for nursery students dina merzeban
1. Red blood cells are biconcave disks that carry oxygen and carbon dioxide via hemoglobin. They require iron, vitamin B12, and folic acid for synthesis and maturation.
2. White blood cells include granulocytes like neutrophils, eosinophils, and basophils, and agranulocytes like lymphocytes and monocytes. They protect the body from pathogens and destroy abnormal cells.
3. Blood typing involves the presence or absence of antigens A, B, and Rh factor. Type O blood is the universal donor while type AB is the universal recipient. Sensitization can occur in Rh-negative mothers carrying Rh-positive fetuses.
The document discusses blood and its components. It describes how blood is made up of plasma, red blood cells, white blood cells, and platelets. Red blood cells transport oxygen and carbon dioxide, white blood cells protect against infection, and platelets help the blood clot to stop bleeding. The document provides details on the formation, functions, and counts of the different blood cell types.
Sickle cell anemia is a hereditary hemolytic anemia caused by a point mutation in the beta globin gene, resulting in abnormal hemoglobin S. This leads to polymerization of hemoglobin and distortion of red blood cells. Clinical manifestations include anemia, bone pain, acute chest syndrome, and organ damage to tissues like the spleen, liver, and kidneys. The condition is diagnosed through blood tests detecting hemoglobin electrophoresis patterns and genetic testing.
The document summarizes key components and functions of the circulatory system, including the heart, blood vessels, and blood. It describes how blood transports nutrients, gases, hormones, and waste throughout the body while also playing roles in temperature regulation and homeostasis. Specific components of blood such as plasma, red blood cells, white blood cells, and platelets are defined along with their functions. The formation and breakdown of red blood cells is also summarized.
Blood is connective tissue in fluid form that carries oxygen and nutrients throughout the body. It consists of plasma and formed elements including red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and transport oxygen and carbon dioxide. White blood cells help fight infection and disease. The main types of white blood cells are neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Erythropoiesis is the process where red blood cells are formed in the bone marrow. Hemoglobin in red blood cells binds to oxygen and carbon dioxide during respiration. Blood tests like complete blood count, ESR, and PCV are used to analyze blood components and detect diseases.
The document provides an overview of hematology and the components of blood. It describes how blood circulates from the heart through arteries and veins, and how gases are exchanged in capillaries. The main components of blood are plasma, red blood cells, white blood cells, and platelets. It details the formation of blood cells through hematopoiesis in the bone marrow, and the different types of white blood cells. Common blood tests like complete blood count and disorders of the blood components are also summarized.
This document summarizes key topics in hematology, including cellular components of blood, components of blood such as red blood cells, white blood cells and platelets, diseases that affect these components, blood typing, transfusion, and coagulation disorders. Some of the major areas covered are red blood cell production and diseases like sickle cell disease and polycythemia, white blood cell disorders including leukemia and lymphoma, platelet disorders, and bleeding disorders like hemophilia. Treatment approaches focus on following general guidelines, supportive care, and preventing further injury or infection.
2008 my lecture introduction to hematologyBruno Mmassy
Manage all clotting disorders by providing supportive care, controlling bleeding if present, and transporting promptly for definitive care. Monitor closely for signs of worsening condition.
Blood transports vital substances like oxygen and nutrients throughout the body. It is composed of plasma and three main cell types - red blood cells, white blood cells, and platelets. Red blood cells are produced in the bone marrow and carry oxygen to tissues via hemoglobin. They circulate for about 120 days before being broken down. White blood cells help protect the body from disease. Platelets help the blood clot and stop bleeding from broken blood vessels. The blood also contains proteins, gases, and other nutrients.
Blood is a connective tissue composed of plasma and cells. It transports oxygen, nutrients, hormones, and waste products throughout the body. Blood contains red blood cells, white blood cells, and platelets suspended in plasma. Red blood cells contain hemoglobin and transport oxygen and carbon dioxide. White blood cells help fight infection. Platelets help form blood clots to stop bleeding. The document discusses blood components, functions, disorders, and blood grouping in detail.
Red blood cells, white blood cells, and platelets are the three main components of blood. Red blood cells transport oxygen and carbon dioxide, white blood cells provide immunity, and platelets help with clotting to stop bleeding. The document discusses the structure and function of each blood component in detail over several pages.
Hematology is the study of blood, blood-forming organs, and blood diseases. It includes treatment of blood disorders and cancers. Blood is composed of plasma and formed elements including red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and carry oxygen throughout the body. White blood cells are part of the immune system and help fight infection. Platelets help with blood clotting. Blood is produced through hematopoiesis in the bone marrow and regulated by various factors.
The human body contains approximately 5 liters of blood composed of plasma and cellular elements. Plasma is 55% of blood and contains water, proteins, electrolytes, and other substances. Cellular elements include red blood cells containing hemoglobin, white blood cells for immunity, and platelets for clotting. Blood transports oxygen, nutrients, wastes, hormones, and more throughout the body.
The document summarizes key aspects of the blood system and blood components. It discusses how blood circulates through the cardiovascular system, transporting oxygen, nutrients, hormones, and removing waste. It describes the functions of blood including respiration, nutrient distribution, waste excretion, temperature regulation, immunity, and blood clotting. It provides details on blood volume, constituents such as red blood cells, white blood cells, platelets and plasma. It also summarizes the development and life cycle of red blood cells.
Blood is composed of plasma and formed elements including red blood cells, white blood cells, and platelets. Plasma is 55% of blood volume and is composed mainly of water along with dissolved proteins, minerals, glucose, and waste products. Red blood cells contain hemoglobin and transport oxygen throughout the body. White blood cells are part of the immune system and defend against pathogens. Platelets help the blood clot and maintain integrity of blood vessels. The bone marrow produces blood cells through hematopoiesis, regulated by various cytokines and hormones. The ABO blood group system involves antigens on red blood cells and antibodies in plasma that determine blood type.
This document provides an overview of hematologic function and alterations. It discusses the components of blood including plasma and blood cells. Key points include:
- Blood transports oxygen, nutrients, ions and hormones and helps regulate pH, temperature and provides immune defenses.
- The cellular portion of blood contains red blood cells, white blood cells and platelets. Hematopoiesis is the lifelong process of blood cell formation from stem cells in the bone marrow.
- Anemia is a condition of low red blood cell count or hemoglobin and can be caused by blood loss, decreased production or increased destruction of red blood cells. Common types of anemia include iron-deficiency anemia and hemolytic anemia.
This document provides an introduction to the anatomy and physiology of the circulatory system. It begins by outlining the learning objectives of being able to describe the basic components of blood, compare red and white blood cells, and describe blood plasma and serum. It then provides sections on the circulatory system, anatomy, blood composition, functions of blood including transport of oxygen, nutrients, waste removal, and protection. It describes the cells found in blood including red blood cells, white blood cells, and platelets. It also provides details on blood plasma and hematopoiesis.
Blood is a complex tissue composed of plasma and formed elements suspended within it. Plasma is 55% of blood volume and contains water, salts, enzymes and proteins. Formed elements include red blood cells (RBCs), white blood cells (WBCs), and platelets. RBCs contain hemoglobin and carry oxygen, while WBCs help fight infection. Platelets assist in blood clotting. The liver and kidneys help regulate blood composition and pH. Hematopoiesis occurs in bone marrow and produces new blood cells through stem cell differentiation.
This document summarizes key aspects of human anatomy and physiology related to hematology. It discusses the composition and functions of blood, the formation of blood cells through hematopoiesis in the bone marrow, and the roles of the three main types of blood cells - red blood cells, white blood cells, and platelets. It also describes the blood clotting process and fibrinolysis that helps control bleeding and maintain blood flow.
This document discusses blood cells and immunity. It begins by describing the three main types of blood cells - red blood cells (RBCs), white blood cells (WBCs), and platelets. RBCs transport oxygen and carbon dioxide, WBCs fight infection and disease, and platelets help with blood clotting. The document then focuses on hematopoiesis, the formation of blood cells in the bone marrow, and the life cycles and functions of RBCs, WBCs like neutrophils and macrophages, and platelets. It also covers blood types, immunity, the inflammatory response, and various blood disorders like anemia.
1. The document discusses blood cells, blood types, and blood clotting. It provides details on red blood cells, white blood cells, platelets, hematopoiesis, and hemoglobin.
2. Red blood cells transport oxygen and carbon dioxide throughout the body. White blood cells provide immunity by destroying pathogens through phagocytosis. Platelets are involved in blood clotting.
3. Hematopoiesis is the formation of blood cells from stem cells in the bone marrow. Hemoglobin in red blood cells binds oxygen in the lungs and transports it to tissues while also carrying carbon dioxide back to the lungs.
The document summarizes key points about blood and the cardiovascular system:
- Blood consists of plasma and cellular components including red blood cells, white blood cells, and platelets.
- Red blood cells transport oxygen to tissues via hemoglobin and remove carbon dioxide. White blood cells help fight infection. Platelets initiate blood clotting to stop bleeding.
- The liver and kidneys play important roles in blood production and regulation via the hormone erythropoietin. Issues like anemia and sickle cell disease affect blood cell production and function.
This document provides information about the blood and lymphatic system. It discusses how blood is composed of plasma and formed elements such as red blood cells, white blood cells and platelets. It also describes the functions of blood such as transporting oxygen, nutrients, hormones and waste products around the body. Additionally, the document discusses blood groups and the ABO and rhesus blood typing systems which determine transfusion compatibility.
The cardiovascular system chapter discusses the functions, composition, and formation of blood. Blood functions include transportation, regulation, and protection. Blood composition includes plasma and formed elements such as red blood cells, white blood cells, and platelets. Red blood cells are formed through erythropoiesis and contain hemoglobin, while white blood cells help defend the body against infection and disease. Blood also contains different blood groups defined by antigens on red blood cells.
The document discusses the composition and functions of human blood. Blood is composed of plasma and formed elements such as red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and transport oxygen throughout the body. White blood cells are part of the immune system and help fight infection. Platelets assist in blood clotting. Blood also regulates pH and temperature levels. The liver and kidneys help maintain proper blood composition.
Blood is composed of plasma and blood cells suspended in plasma. Plasma is mostly water but also contains proteins, electrolytes, nutrients, waste products, hormones and gases. The three main types of blood cells are red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and transport oxygen and carbon dioxide. White blood cells help fight infection. Platelets help with blood clotting to stop bleeding. Transfusions require matching blood types to avoid rejection reactions from antibodies in the plasma.
Hematology is the study of blood and blood components. The document discusses the components of blood including red blood cells, white blood cells, platelets, and plasma. It describes their functions such as oxygen transport, immune response, and blood clotting. Various blood disorders are also summarized like anemia, which can result from blood loss, decreased production, or increased destruction. The stages of blood cell production and normal ranges for blood counts are also outlined.
Lecture 1: Hematology introducion For TID and HIV Medicine MSc studentsMulugeta Gobezie
This document provides an overview of basic hematology and hematopoiesis. It defines hematology as the study of blood and discusses the organization of blood and blood forming organs. Key points include: hematopoiesis occurs primarily in the bone marrow and involves the production of red blood cells, white blood cells, and platelets from stem cells; the spleen, liver, lymph nodes and thymus also play roles in blood cell production and filtration; and abnormalities in hematopoiesis can provide early signs of disease.
This document provides information about Yinkfu Marcel Ndamnsah and Dr. Shei Claude Nfor who are studying Medical Laboratory Science as a Bachelor of Science at Shalom University. It includes their contact information and field of study. The document also contains 6 units that cover topics related to hematology and types of anemia, including definitions, processes, causes, signs and symptoms, and treatments. The units discuss hematocrit, erythropoiesis, the lifespan and destruction of erythrocytes, different types of anemia, polycythemias, and leucopoiesis.
This document provides an overview of a lecture on blood and hematopoiesis. It discusses the composition of blood including the different cell types. It covers topics like hemopoiesis, erythropoiesis, classification of anemias, hemoglobin and related disorders, white blood cells, blood coagulation, and some common blood diseases. The key cell types discussed in more detail include erythrocytes, neutrophils, eosinophils, basophils, and their roles in the immune response. Common blood disorders like sickle cell anemia and thalassemia are also summarized.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
4. Blood… The Basics
Haematopoiesis = the production of all blood cells
including formation, development, and differentiation.
Where Do Blood Cells Come From?
Blood cells develop from haematopoietic stem cells
and are formed in the bone marrow via
haematopoiesis.
These stem cells transform into red blood cells (RBC),
white blood cells (WBC), and platelets.
Ineffective haematopoiesis results in insufficient
numbers of RBC and results in one of several forms of
anaemia.
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6. Blood… The Basics
Composition of whole blood:
plasma 55%
red blood cells (RBC) 41%
white blood cells (WBC) 4%
Functions of blood:
transporting oxygen to tissues and organs
transporting waste to the lungs
forming blood clots to prevent excess blood loss
carrying cells and antibodies that fight infection
bringing waste products to kidneys and liver for
filtration
regulating body temperature
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7. Plasma
Plasma is a mixture of water, sugar, fat, protein, and
salts.
Plasma transports the following substances around
the body:
blood cells
nutrients
waste products
antibodies
clotting proteins
chemical messengers (hormones, proteins) to
maintain fluid balance.
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8. Red Blood Cells (RBC)/Erythrocytes
Most abundant cell in the blood, (40-45 % of total blood
volume).
RBC start as immature cells in bone marrow
Released into blood stream after about seven days.
RBC have no nucleus meaning they can easily change shape
and fit through the various blood vessels in your body.
Average RBC lifespan 120 days.
As RBC travel through small blood vessels their cell
membranes may be damaged.
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9. Erythrocytes are biconcave discs
with very shallow centres.
This shape:
optimises the ratio of surface
area to volume, facilitating gas
exchange.
enables them to fold up as they
move through narrow blood
vessels.
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10. Erythropoiesis
RBC production is called erythropoiesis which:
occurs in bone marrow via a complex sequence of
tightly regulated steps.
stimulated by the hormone erythropoietin (EPO).
EPO is largely produced and secreted by the kidneys,
with about 10% produced and secreted by the liver.
EPO secretion is up-regulated in response to low oxygen levels
(hypoxia) in the blood, as a compensatory mechanism.
In a negative-feedback loop, as oxygen saturation rises, EPO
secretion falls, and vice versa, maintaining homeostasis.
An overproduction of RBC produces polycythaemia.
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11. White Blood Cells (WBC) / Leukocytes)
WBC protect the body from infection - account for approximately 1%
of total blood volume
Neutrophils 40-60% of total WCC
Kill and digest bacteria and fungi.
First line of defence when infection strikes. “immediate
response” Live <24 hours
Lymphocytes (B & T Cells) 20-40% of total WCC
Create antibodies to defend against bacteria, viruses, and other
harmful invaders
T lymphocytes regulate function of other immune cells and
directly attack infected cells and tumours
B lymphocytes make antibodies (proteins that specifically target
bacteria, viruses, and other foreign materials)
23/1112
12. White Blood Cells (WBC) / Leukocytes)
Monocytes 2-8% total WCC
longer lifespan
break down bacteria
Eosinophils 1-4% total WCC
attack and kill parasites, destroy cancer cells and help
with allergic responses
Basophils 0.5-1% total WCC
Small cells that sound an alarm when infectious
agents invade the blood
Secrete chemicals including histamine
Band 0% to 3% (Young neutrophils)
Barragan, Myriam, Misty Good, and Jay K. Kolls. “Regulation of Dendritic Cell Function by Vitamin D.” Nutrients 7, no. 9 (September 21, 2015): 8127–51. https://doi.org/10.3390/nu7095383.
23/1113
13. Platelets / Thrombocytes
Major function of platelets = aiding coagulation or clotting by
gathering at injury sites
Platelets stick to the lining of the injured blood vessel
and form a platform for coagulation
A Fibrin clot then forms, covering the wound to prevent
blood from leaking out
Fibrin clot forms the initial scaffolding upon which new
tissue forms
Increased platelets
Cause unnecessary clotting and increased risk of strokes
and heart attack
Decreased platelets - Cause extensive bleeding
23/1114
14. Haemoglobin (Hb)
Haemoglobin is comprised of
Haem = iron & protoporphyrin
Globin = protein
Hb is contained in the RBC and gives blood its red
pigment
Primary functions:
Transports oxygen from the lungs to the rest
of the body
Transports carbon dioxide from the body to
the lungs for exhalation
23/1115
15. In the lungs, Hb picks up oxygen, which binds to
the iron ions, forming oxyhaemoglobin.
The bright red, oxygenated Hb travels to the
body tissues, where it releases some of the
oxygen molecules, becoming darker red
deoxyhaemoglobin, sometimes referred to
as reduced Hb.
Oxygen release depends on the need for
oxygen in the surrounding tissues, so Hb
rarely if ever leaves all of its oxygen behind.
Haemoglobin (Hb)
23/1116
16. Haematocrit (Hct)
Haematocrit is the ratio of RBC to total
blood volume (cells and plasma).
Hct is useful in the determination of
oxygen deprivation states including
anaemias, altered blood volume states,
nutritional deficiencies,
haemoglobinopathies and certain chronic
diseases.
23/1117
17. Oxygenation and Saturation
Hb is vital for oxygenation
Oxygen saturation refers to the percentage of Hb sites occupied
by oxygen in a patient’s blood, and may be monitored using a
pulse oximeter, applied to the patient’s finger.
An oximeter:
sends two wavelengths of light (one red, one infrared) through the finger
a photodetector measures the light as it exits, (Hb absorbs light differentially
depending upon its oxygen saturation).
the oximeter measures the amount of light received against the amount
absorbed by the partially oxygenated Hb
presents the data as percent saturation.
Normal pulse oximeter range is 98–100%.
Decreased saturation % reflects hypoxemia, or low blood oxygen.
23/1118
18. Deoxygenated Blood Vs Oxygenated Blood
Deoxygenated blood versus Oxygenated blood
23/1119
19. Vital Nutrients for Erythropoiesis
Healthy Erythropoiesis produces a staggering 2 million+ cells per second.
A number of raw materials must be present in adequate amounts for healthy
RBC production.
These include
Nutrients essential for production and maintenance of all cells (glucose,
lipids, amino acids)
As well as
Iron
Copper, Zinc
B12
Folate, B6, B2
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20. Iron (Fe)
Each haem group in a Hb molecule contains an ion of the trace
mineral Fe.
On average <20% of ingested Fe is absorbed.
Haem Fe, (animal foods), is absorbed more efficiently than non-
haem Fe (plant foods).
Fe2+ (Ferrous) = a salt containing iron in its lowest valence
state, Fe2+.
Fe3+ (Ferric) = form of Fe that can be bound to its transport
protein transferrin, for transport to body cells.
Upon absorption, Fe becomes part of the body’s total iron pool.
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21. Iron (Fe)
The bone marrow, liver, and spleen can store Fe in the protein compounds
ferritin and haemosiderin
Ferroportin transports Fe across the intestinal cell plasma membranes
and from its storage sites into tissue fluid where it enters the blood.
When EPO stimulates the production of erythrocytes, iron is released
from storage, bound to transferrin, and carried to the red marrow
where it attaches to erythrocyte precursors.
Iron deficiency will cause low Hb.
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22. Copper (Cu)
Cu is a trace mineral, and a component of two plasma proteins,
hephaestin and ceruloplasmin.
Hephaestin and ceruloplasmin are vital for Hb production.
Hephaestin enables Fe to be absorbed by intestinal cells,
and is located in the intestinal villi.
Ceruloplasmin transports Cu.
Both hephaestin and ceruloplasmin enable the oxidation of Fe
from Fe2+ (ferrous) to Fe3+ ferric).
Cu deficiency causes decreased levels of the Fe transporter
molecules, meaning iron can accumulate in tissues, where it
can eventually lead to organ damage. Haem synthesis also
decreases.
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23. Zinc (Zn)
The trace mineral Zn
functions as a co-enzyme that
facilitates the synthesis of
the haem portion of Hb.
23/1124
24. B12 & Folate – partners for life!
Vitamin B12 functions as a co-enzymes that facilitates DNA synthesis..
B12 is critical for the synthesis of new cells, including erythrocytes.
Methylcobalamin is required for the function of the folate-dependent
enzyme methionine synthase.
Methionine synthase is an enzyme required for the synthesis of the
amino acid methionine from homocysteine.
Vitamin B-12 contributes to Hb synthesis by activating succinyl CoA
Succinyl CoA is a haem precursor.
Without vitamin B12, you cannot make enough haem to produce
functional RBC!!!
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25. Folate
Folate functions as a coenzymes that facilitate
DNA synthesis.
Erythroblasts require folate for proliferation
during their differentiation.
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26. Erythrocyte Lifespan
Erythrocytes live up to 120 days in the circulation.
After 120 days worn-out cells are removed by macrophages.
The components of the degraded erythrocytes are further processed as follows:
Globin, the protein portion of Hb, is broken down into amino acids, sent back
to the bone marrow to be used in erythropoiesis.
The remaining (non-phagocytized) Hb is broken down in the circulation,
releasing its alpha and beta chains that are removed from circulation by the
kidneys.
The Fe contained in the haem portion of Hb may be stored in the liver or
spleen, primarily as ferritin or hemosiderin, or carried through the
bloodstream by transferrin to the red bone marrow for recycling into new
erythrocytes.
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27. Bilirubin
The non-Fe portion of haem is degraded into the waste product
biliverdin, (green pigment), and then bilirubin (yellow pigment).
Bilirubin binds to albumin and travels in the blood to the liver
In the liver bilirubin is used to manufacture bile, which is released into the intestines
to emulsify dietary fats.
In the large intestine, bacteria breaks the bilirubin apart from the bile and converts
it to urobilinogen and then stercobilin, which is then eliminated in the faeces.
(Broad-spectrum antibiotics typically eliminate these bacteria and subsequently
alter the colour of the faeces).
The kidneys also remove circulating bilirubin and other related metabolic by
products such as urobilins and secrete them into the urine.
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28. Pigment Breakdown
The breakdown pigments formed from the destruction of Hb can be seen in
a variety of presentations:
Biliverdin from damaged RBCs produces some colouration in bruising
If bilirubin cannot be removed effectively from circulation it causes the
yellowish tinge of jaundice.
Stercobilins within faeces produce the typical brown colour.
Yellow colour of urine is associated with the urobilins.
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30. Vitamin B6
As well as Folate, B12, and iron,
vitamin B6 also has a crucial role in
erythropoiesis.
Vitamin B6 is also essential for RBC
metabolism.
http://lpi.oregonstate.edu/mic/vitamins/vitamin-B6
23/1131
31. Hop on Hop off – The Little Red Bus
Think of the RBC as a bus. Once made it takes on board Hb it sets off for the the
tissues and then returns back to the lungs.
(B12, folate, Fe, Zn, B6 & B2 are like the building materials for the bus (RBC),
essential for healthy erythropoiesis).
Waiting in the lungs are oxygen molecules which hop on the bus (into the RBC)
and immediately bond to the iron in the Hb (oxygen sits next to Fe & they hold
hands).
The bus carries on to tissues/organs and when it arrives, the doors open, the
oxygen molecules separate from the Hb and exit the bus.
The RBC then return to the lungs, taking with them some waste products.
The bus drives this same route endlessly, repeating the process.
23/1132
32. Take Home Summary of B12 and RBC Health
Without adequate supplies of iron, folate, B6, Zn, B2 and B12, individuals are
unable to make healthy RBC!
B12 deficiency deforms the shape of the RBC’s, typically making them bigger
(Macrocytosis), however there are exceptions to this (for example in
concurrent B12 and iron deficiency).
If an individual has low or very low B12 levels, they won’t be able to make
healthy RBC, and the strangely shaped RBC won’t be able to carry Hb.
The decreased oxygenation in the body causes fatigue, impaired
concentration and so on.
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