The document outlines the challenges of moving forward with biofortification according to Dr. Denis T. Kyetere, Director General of NARO. Some of the key challenges include the existence of natural genetic variation but the need to introgress traits into adapted varieties, the time and selection methods required for breeding, developing sustainable seed systems to ensure adequate high-quality seed supply, the additional costs of extension services, and addressing cross-cutting issues like demand creation, consumer acceptance, product quality demonstration, and market development.