This document discusses paediatric parenteral nutrition. It begins by defining malnutrition and outlining its causes. The goals of nutrition support are then stated as preserving good nutritional status, preventing malnutrition, and providing adequate nutrients to meet metabolic needs. The indications for parenteral nutrition (PN) include inability to meet nutrient requirements orally or enterally to prevent or correct malnutrition. Central and peripheral lines are discussed for administering PN depending on osmolarity and dextrose concentration needs. Fluid, calorie, protein, carbohydrate, lipid, electrolyte, vitamin and trace element requirements are outlined based on age. Compounding problems, monitoring, complications and references are also summarized.
This document provides guidelines for total parenteral nutrition (TPN) in infants. It outlines indications for TPN including prematurity, very low birth weight, gastrointestinal abnormalities, and necrotizing enterocolitis. The goals of TPN are to correct growth restriction, prevent subsequent growth failure, and provide sufficient energy, nitrogen, and nutrients to prevent catabolism and achieve positive nitrogen balance. The document discusses administration routes, components, calculations, and monitoring of TPN. Risks including infections and metabolic complications are also reviewed.
This document provides information on pediatric parenteral nutrition. It discusses enteral versus parenteral routes of feeding and notes that whenever possible, the enteral route is preferred. The document outlines indications for total parenteral nutrition (TPN) in pediatric patients, including very low birth weight neonates and infants with gastrointestinal abnormalities. It also covers assessments needed for nutrition support, including growth curves and caloric requirements. The document discusses macronutrient needs for carbohydrates, proteins, and lipids in pediatric TPN. It concludes with information on electrolyte and micronutrient requirements and considerations for administering and monitoring pediatric parenteral nutrition.
This document discusses pediatric parenteral nutrition. It provides guidelines on:
- Indications for PN in infants and children
- Energy and protein requirements based on age
- Complications of overfeeding such as increased CO2 and respiratory issues
- Guidelines for initiating and advancing macronutrients like dextrose, protein and lipids
- Monitoring for complications like essential fatty acid deficiency
- Use of additives like multivitamins, trace elements, carnitine and selenium
- Calculations for total calories and monitoring of patients on PN
This document discusses fluid and electrolyte requirements in neonates. It notes that total body water is 0.7 L/kg in newborns and 0.6 L/kg at 1 year of age. Fluids are required for infants under 30 weeks gestation or under 1250g, sick term neonates, those with severe birth asphyxia, apnea, respiratory distress syndrome, or sepsis. Fluid amounts range from 100 ml/kg for infants under 1kg to 60 ml/kg for those over 1.5kg on the first day, increasing amounts over subsequent days. Electrolyte requirements for sodium, potassium, and calcium are also outlined. Glucose requirements are noted to be an optimal 4-
This document summarizes oxygen therapy in pediatrics. It discusses the indications for oxygen therapy including conditions like pneumonia, asthma, and heart failure. Methods of oxygen delivery include low-flow devices like nasal cannulas and face masks, and high-flow devices like Venturi masks and CPAP/BiPAP. Detection of hypoxemia can be done through clinical evaluation, pulse oximetry, and blood gas analysis. The document also covers treatment considerations like flow rates, interfaces, and humidification needs. Potential complications of oxygen therapy include CO2 narcosis.
This document discusses fluid calculation and homeostasis in neonates. It notes that water and electrolyte balance is vital but different in neonates compared to older children and adults due to rapid developmental changes. It outlines the physiology of total body water, intracellular water, and extracellular water. It also discusses changes that occur at birth and how to assess hydration status in neonates through monitoring things like urine output, weight, physical exam findings and lab tests. Maintaining appropriate fluid and electrolyte balance is important for health in preterm infants.
This document discusses the nutritional needs of critically ill children in the pediatric intensive care unit (PICU). It notes that malnutrition is common upon admission to the PICU and nutrition may deteriorate without attention. Resting energy expenditure estimates range from 37-62 kcal/kg/day but can be lower with organ failure. Ventilated children typically need 45 kcal/kg/day while requirements increase from 42 kcal/kg/day on day 1 to 50 kcal/kg/day on day 5 and 69 kcal/kg/day on day 12. The combination of enteral and parenteral nutrition has advantages like improved coverage of energy targets and protein-energy balance as well as presumed benefits such as maintaining gut function
This document provides guidelines for total parenteral nutrition (TPN) in infants. It outlines indications for TPN including prematurity, very low birth weight, gastrointestinal abnormalities, and necrotizing enterocolitis. The goals of TPN are to correct growth restriction, prevent subsequent growth failure, and provide sufficient energy, nitrogen, and nutrients to prevent catabolism and achieve positive nitrogen balance. The document discusses administration routes, components, calculations, and monitoring of TPN. Risks including infections and metabolic complications are also reviewed.
This document provides information on pediatric parenteral nutrition. It discusses enteral versus parenteral routes of feeding and notes that whenever possible, the enteral route is preferred. The document outlines indications for total parenteral nutrition (TPN) in pediatric patients, including very low birth weight neonates and infants with gastrointestinal abnormalities. It also covers assessments needed for nutrition support, including growth curves and caloric requirements. The document discusses macronutrient needs for carbohydrates, proteins, and lipids in pediatric TPN. It concludes with information on electrolyte and micronutrient requirements and considerations for administering and monitoring pediatric parenteral nutrition.
This document discusses pediatric parenteral nutrition. It provides guidelines on:
- Indications for PN in infants and children
- Energy and protein requirements based on age
- Complications of overfeeding such as increased CO2 and respiratory issues
- Guidelines for initiating and advancing macronutrients like dextrose, protein and lipids
- Monitoring for complications like essential fatty acid deficiency
- Use of additives like multivitamins, trace elements, carnitine and selenium
- Calculations for total calories and monitoring of patients on PN
This document discusses fluid and electrolyte requirements in neonates. It notes that total body water is 0.7 L/kg in newborns and 0.6 L/kg at 1 year of age. Fluids are required for infants under 30 weeks gestation or under 1250g, sick term neonates, those with severe birth asphyxia, apnea, respiratory distress syndrome, or sepsis. Fluid amounts range from 100 ml/kg for infants under 1kg to 60 ml/kg for those over 1.5kg on the first day, increasing amounts over subsequent days. Electrolyte requirements for sodium, potassium, and calcium are also outlined. Glucose requirements are noted to be an optimal 4-
This document summarizes oxygen therapy in pediatrics. It discusses the indications for oxygen therapy including conditions like pneumonia, asthma, and heart failure. Methods of oxygen delivery include low-flow devices like nasal cannulas and face masks, and high-flow devices like Venturi masks and CPAP/BiPAP. Detection of hypoxemia can be done through clinical evaluation, pulse oximetry, and blood gas analysis. The document also covers treatment considerations like flow rates, interfaces, and humidification needs. Potential complications of oxygen therapy include CO2 narcosis.
This document discusses fluid calculation and homeostasis in neonates. It notes that water and electrolyte balance is vital but different in neonates compared to older children and adults due to rapid developmental changes. It outlines the physiology of total body water, intracellular water, and extracellular water. It also discusses changes that occur at birth and how to assess hydration status in neonates through monitoring things like urine output, weight, physical exam findings and lab tests. Maintaining appropriate fluid and electrolyte balance is important for health in preterm infants.
This document discusses the nutritional needs of critically ill children in the pediatric intensive care unit (PICU). It notes that malnutrition is common upon admission to the PICU and nutrition may deteriorate without attention. Resting energy expenditure estimates range from 37-62 kcal/kg/day but can be lower with organ failure. Ventilated children typically need 45 kcal/kg/day while requirements increase from 42 kcal/kg/day on day 1 to 50 kcal/kg/day on day 5 and 69 kcal/kg/day on day 12. The combination of enteral and parenteral nutrition has advantages like improved coverage of energy targets and protein-energy balance as well as presumed benefits such as maintaining gut function
This document provides information on fluid and electrolyte therapy. It discusses indications for IV fluid therapy including severe dehydration. It describes the two components of fluid therapy as maintenance therapy to replace normal losses and replacement therapy to correct existing deficits. The document gives guidelines for calculating maintenance fluid requirements based on body weight and additional fluid needs for conditions like fever. It also provides guidance on calculating and correcting water and electrolyte deficits. The document discusses various fluid solutions and considerations for fluid management in different clinical scenarios like dehydration, hyponatremia, hypernatremia, and hypokalemia.
This document provides information and formulas for calculating pediatric drug and fluid dosages based on adult doses. It discusses Fried's Rule and Young's Rule for calculating drug dosages for infants and children based on their age. Clark's Rule calculates drug dosages based on a child's weight. It also provides the Parkland Burn Formula for calculating fluid replacement after burns based on burn percentage and body surface area. Examples are provided for calculating appropriate pediatric doses and fluid amounts using these formulas.
total parental nutrition in neonate guidlinemandar haval
This document discusses total parenteral nutrition (TPN) in neonates. It begins by describing the history and development of TPN, from early experiments in the 19th century to its modern use. It then discusses appropriate use of TPN in neonates, noting specific conditions where enteral feeding is not possible. The document provides details on components of TPN solutions, including fluids, energy and carbohydrate requirements, protein needs, and lipids. It stresses the importance of meticulous care, monitoring, and early transition to enteral feeding to minimize complications of TPN therapy in neonates.
This document discusses three methods for calculating maintenance fluid requirements: the caloric expenditure method, Holliday-Segar method, and body surface area method. The caloric expenditure method estimates fluid needs based on calories metabolized, with 100-120mL of water needed per 100 calories. The Holliday-Segar method estimates needs based on weight categories. The body surface area method relates caloric expenditure to body surface area. An example calculation is provided for a 2-year old child using each method.
This document discusses assessing and managing dehydration in children. It defines dehydration and lists common causes like gastroenteritis and burns. The assessment of dehydration is difficult but involves factors like weight loss, skin turgor, tears, and urine output. Dehydration is classified as mild, moderate, or severe based on these clinical signs. Oral rehydration solution is given to rehydrate children and recipes for making ORS are provided.
This document discusses neonatal hypocalcemia, including its types, causes, and management. There are two types - early onset within 72 hours requiring calcium supplementation, and late onset after 7 days requiring longer treatment. Hypocalcemia is defined as low serum calcium levels. Causes of early onset include prematurity, maternal conditions, and iatrogenic factors. Management of early onset involves calcium supplementation. Late onset in the first week is usually symptomatic and caused by high phosphate intake. Causes also include hypomagnesemia, vitamin D deficiency, and genetic or metabolic syndromes.
This document discusses neonatal mechanical ventilation. It begins by introducing mechanical ventilation and its importance in improving neonatal survival since the 1960s. It then discusses the benefits of mechanical ventilation in improving gas exchange and decreasing work of breathing. Various indications for ventilation are provided. Common conditions requiring ventilation are also listed. The document goes on to describe different types of ventilators and modes, how to initiate a breath, and studies comparing different modes. It concludes by discussing parameters for conventional ventilation like PIP, PEEP, flow rates, and methods for controlling oxygenation and ventilation.
This document discusses oxygen therapy for pediatric COVID-19 patients. It outlines the indications for oxygen therapy including hypoxemia and shock. It then describes the various oxygen delivery systems and methods including nasal cannulas, masks, tents, and positive pressure ventilation. Factors determining the appropriate method are also discussed. The document provides guidance on dosage, monitoring response, and managing complications of oxygen therapy.
A lumbar puncture (also called a spinal tap) is a procedure to collect and look at the fluid (cerebrospinal fluid, or CSF) surrounding the brain and spinal cord. During a lumbar puncture, a needle is carefully inserted into the spinal canal low in the back (lumbar area). Samples of CSF are collected.
This document discusses care of children requiring long-term ventilation. It begins with objectives which include discussing incidence, goals, modes of ventilation, guidelines, monitoring, weaning, complications and nursing management. It then covers incidence rates, the difference between pediatric and adult respiratory systems, types of respiratory failure, functions and definitions related to mechanical ventilation. Various modes of ventilation are described along with initial settings, adjustments, weaning priorities and criteria for extubation. Monitoring, complications and troubleshooting are also addressed. Nursing management is a multidisciplinary team approach. Bundles are discussed as a way to ensure delivery of standard care and assess interventions.
pediatrics emergency, hypoglycemia of infancy.
Glucose level can drop if:
There is too much insulin in the blood (hyperinsulinism). Insulin is a hormone that pulls glucose from the blood.
The baby is not producing enough glucose.
The baby's body is using more glucose than is being produced.
The baby is not able to feed enough to keep glucose level up.
Nutritional Management of Premature InfantsMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
This document discusses the metabolic response and nutritional needs of critically ill children. It notes that critical illness leads to increased caloric and protein needs due to catabolism. Early enteral nutrition within 24 hours is recommended where possible to provide nutrients and prevent wasting, though total parenteral nutrition may be needed if enteral is not feasible. The document outlines the administration, types, indications, and complications of both enteral and parenteral nutrition in critical illness. It also discusses using immunonutrition formulas to help modulate the immune response.
This document discusses parenteral nutrition in newborns. It defines key terms like total body water and insensible water loss. It provides guidelines for fluid, glucose, amino acid, lipid and electrolyte requirements for very low birth weight infants. Close monitoring of electrolytes and renal function is important when providing parenteral nutrition to newborns.
Total parenteral nutrition in the nicu Total parenteral nutrition in the nicuDr Praman Kushwah
This document provides information on total parenteral nutrition (TPN) in the neonatal intensive care unit (NICU). It discusses indications for TPN, nutritional composition including dextrose, amino acids, lipids, additives, and calculations. Potential complications are outlined including parenteral nutrition associated liver disease. Guidelines are provided for calcium, phosphorus, and minimizing metabolic bone disease and cholestasis.
This document discusses feeding guidelines for low birth weight infants. It notes that LBW infants have physiological and biochemical handicaps that require special feeding considerations. Feeding should begin as soon as possible, using expressed breast milk. Initial feeding methods may include gavage, cup, or breast feeding depending on gestational age and abilities. Feedings should be given every 2-3 hours. Human milk fortifier may be needed if the infant is not gaining weight adequately. Growth should be closely monitored and supplements like iron may be required. Intolerance issues should be managed conservatively.
- Neonates requiring IV fluid therapy include those with lethargy/refusal to feed, breathing difficulties, shock, severe asphyxia, or abdominal issues. The aims of fluid therapy are to identify babies needing IV fluids, calculate daily intake, administer measured volumes, and monitor babies receiving IV fluids. Fluid requirements vary based on weight and age, and monitoring includes checking infusion sites, volumes, blood glucose, weight, urine output, and electrolyte levels to properly adjust fluid intake.
This document discusses fluid and electrolyte management in neonates. It outlines the physiological changes in neonates that impact fluid needs, including higher total body water and immature kidney function. It provides guidelines for calculating daily fluid requirements based on gestational age and weight. It describes the use of IV fluids for initial resuscitation and maintenance, adjusting for enteral feedings and weight changes. Conditions requiring IV fluids and formulas for replacing various fluid losses are also summarized.
This document discusses parenteral nutrition for neonates. It covers the goals of fluid and electrolyte management, indications for parenteral nutrition, nutritional goals, composition of infusates including carbohydrates, proteins, lipids, electrolytes and vitamins. It also discusses the steps for calculating a total parenteral nutrition solution, preparation and administration, and potential complications that can arise with parenteral nutrition. The conclusion emphasizes that parenteral nutrition remains essential for preterm and sick neonates, but optimal inputs are still unknown, and some neonates experience extrauterine growth restriction due to excessive caution with nutrition in the NICU.
This document discusses nutrition in surgical patients. It begins with the basics of nutrition including definitions of malnutrition and nutritional requirements. The importance of proper nutrition for surgical patients is described along with methods for nutritional assessment. Both enteral and parenteral nutrition are covered, including indications, contraindications, administration methods, and potential complications. The document emphasizes the importance of a multidisciplinary approach and initiating nutrition support early to optimize surgical outcomes.
This document provides information on fluid and electrolyte therapy. It discusses indications for IV fluid therapy including severe dehydration. It describes the two components of fluid therapy as maintenance therapy to replace normal losses and replacement therapy to correct existing deficits. The document gives guidelines for calculating maintenance fluid requirements based on body weight and additional fluid needs for conditions like fever. It also provides guidance on calculating and correcting water and electrolyte deficits. The document discusses various fluid solutions and considerations for fluid management in different clinical scenarios like dehydration, hyponatremia, hypernatremia, and hypokalemia.
This document provides information and formulas for calculating pediatric drug and fluid dosages based on adult doses. It discusses Fried's Rule and Young's Rule for calculating drug dosages for infants and children based on their age. Clark's Rule calculates drug dosages based on a child's weight. It also provides the Parkland Burn Formula for calculating fluid replacement after burns based on burn percentage and body surface area. Examples are provided for calculating appropriate pediatric doses and fluid amounts using these formulas.
total parental nutrition in neonate guidlinemandar haval
This document discusses total parenteral nutrition (TPN) in neonates. It begins by describing the history and development of TPN, from early experiments in the 19th century to its modern use. It then discusses appropriate use of TPN in neonates, noting specific conditions where enteral feeding is not possible. The document provides details on components of TPN solutions, including fluids, energy and carbohydrate requirements, protein needs, and lipids. It stresses the importance of meticulous care, monitoring, and early transition to enteral feeding to minimize complications of TPN therapy in neonates.
This document discusses three methods for calculating maintenance fluid requirements: the caloric expenditure method, Holliday-Segar method, and body surface area method. The caloric expenditure method estimates fluid needs based on calories metabolized, with 100-120mL of water needed per 100 calories. The Holliday-Segar method estimates needs based on weight categories. The body surface area method relates caloric expenditure to body surface area. An example calculation is provided for a 2-year old child using each method.
This document discusses assessing and managing dehydration in children. It defines dehydration and lists common causes like gastroenteritis and burns. The assessment of dehydration is difficult but involves factors like weight loss, skin turgor, tears, and urine output. Dehydration is classified as mild, moderate, or severe based on these clinical signs. Oral rehydration solution is given to rehydrate children and recipes for making ORS are provided.
This document discusses neonatal hypocalcemia, including its types, causes, and management. There are two types - early onset within 72 hours requiring calcium supplementation, and late onset after 7 days requiring longer treatment. Hypocalcemia is defined as low serum calcium levels. Causes of early onset include prematurity, maternal conditions, and iatrogenic factors. Management of early onset involves calcium supplementation. Late onset in the first week is usually symptomatic and caused by high phosphate intake. Causes also include hypomagnesemia, vitamin D deficiency, and genetic or metabolic syndromes.
This document discusses neonatal mechanical ventilation. It begins by introducing mechanical ventilation and its importance in improving neonatal survival since the 1960s. It then discusses the benefits of mechanical ventilation in improving gas exchange and decreasing work of breathing. Various indications for ventilation are provided. Common conditions requiring ventilation are also listed. The document goes on to describe different types of ventilators and modes, how to initiate a breath, and studies comparing different modes. It concludes by discussing parameters for conventional ventilation like PIP, PEEP, flow rates, and methods for controlling oxygenation and ventilation.
This document discusses oxygen therapy for pediatric COVID-19 patients. It outlines the indications for oxygen therapy including hypoxemia and shock. It then describes the various oxygen delivery systems and methods including nasal cannulas, masks, tents, and positive pressure ventilation. Factors determining the appropriate method are also discussed. The document provides guidance on dosage, monitoring response, and managing complications of oxygen therapy.
A lumbar puncture (also called a spinal tap) is a procedure to collect and look at the fluid (cerebrospinal fluid, or CSF) surrounding the brain and spinal cord. During a lumbar puncture, a needle is carefully inserted into the spinal canal low in the back (lumbar area). Samples of CSF are collected.
This document discusses care of children requiring long-term ventilation. It begins with objectives which include discussing incidence, goals, modes of ventilation, guidelines, monitoring, weaning, complications and nursing management. It then covers incidence rates, the difference between pediatric and adult respiratory systems, types of respiratory failure, functions and definitions related to mechanical ventilation. Various modes of ventilation are described along with initial settings, adjustments, weaning priorities and criteria for extubation. Monitoring, complications and troubleshooting are also addressed. Nursing management is a multidisciplinary team approach. Bundles are discussed as a way to ensure delivery of standard care and assess interventions.
pediatrics emergency, hypoglycemia of infancy.
Glucose level can drop if:
There is too much insulin in the blood (hyperinsulinism). Insulin is a hormone that pulls glucose from the blood.
The baby is not producing enough glucose.
The baby's body is using more glucose than is being produced.
The baby is not able to feed enough to keep glucose level up.
Nutritional Management of Premature InfantsMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
This document discusses the metabolic response and nutritional needs of critically ill children. It notes that critical illness leads to increased caloric and protein needs due to catabolism. Early enteral nutrition within 24 hours is recommended where possible to provide nutrients and prevent wasting, though total parenteral nutrition may be needed if enteral is not feasible. The document outlines the administration, types, indications, and complications of both enteral and parenteral nutrition in critical illness. It also discusses using immunonutrition formulas to help modulate the immune response.
This document discusses parenteral nutrition in newborns. It defines key terms like total body water and insensible water loss. It provides guidelines for fluid, glucose, amino acid, lipid and electrolyte requirements for very low birth weight infants. Close monitoring of electrolytes and renal function is important when providing parenteral nutrition to newborns.
Total parenteral nutrition in the nicu Total parenteral nutrition in the nicuDr Praman Kushwah
This document provides information on total parenteral nutrition (TPN) in the neonatal intensive care unit (NICU). It discusses indications for TPN, nutritional composition including dextrose, amino acids, lipids, additives, and calculations. Potential complications are outlined including parenteral nutrition associated liver disease. Guidelines are provided for calcium, phosphorus, and minimizing metabolic bone disease and cholestasis.
This document discusses feeding guidelines for low birth weight infants. It notes that LBW infants have physiological and biochemical handicaps that require special feeding considerations. Feeding should begin as soon as possible, using expressed breast milk. Initial feeding methods may include gavage, cup, or breast feeding depending on gestational age and abilities. Feedings should be given every 2-3 hours. Human milk fortifier may be needed if the infant is not gaining weight adequately. Growth should be closely monitored and supplements like iron may be required. Intolerance issues should be managed conservatively.
- Neonates requiring IV fluid therapy include those with lethargy/refusal to feed, breathing difficulties, shock, severe asphyxia, or abdominal issues. The aims of fluid therapy are to identify babies needing IV fluids, calculate daily intake, administer measured volumes, and monitor babies receiving IV fluids. Fluid requirements vary based on weight and age, and monitoring includes checking infusion sites, volumes, blood glucose, weight, urine output, and electrolyte levels to properly adjust fluid intake.
This document discusses fluid and electrolyte management in neonates. It outlines the physiological changes in neonates that impact fluid needs, including higher total body water and immature kidney function. It provides guidelines for calculating daily fluid requirements based on gestational age and weight. It describes the use of IV fluids for initial resuscitation and maintenance, adjusting for enteral feedings and weight changes. Conditions requiring IV fluids and formulas for replacing various fluid losses are also summarized.
This document discusses parenteral nutrition for neonates. It covers the goals of fluid and electrolyte management, indications for parenteral nutrition, nutritional goals, composition of infusates including carbohydrates, proteins, lipids, electrolytes and vitamins. It also discusses the steps for calculating a total parenteral nutrition solution, preparation and administration, and potential complications that can arise with parenteral nutrition. The conclusion emphasizes that parenteral nutrition remains essential for preterm and sick neonates, but optimal inputs are still unknown, and some neonates experience extrauterine growth restriction due to excessive caution with nutrition in the NICU.
This document discusses nutrition in surgical patients. It begins with the basics of nutrition including definitions of malnutrition and nutritional requirements. The importance of proper nutrition for surgical patients is described along with methods for nutritional assessment. Both enteral and parenteral nutrition are covered, including indications, contraindications, administration methods, and potential complications. The document emphasizes the importance of a multidisciplinary approach and initiating nutrition support early to optimize surgical outcomes.
This document discusses nutrition for preterm infants, including classifications of prematurity, growth charts, fetal nutrition stores, types and methods of feeding, typical feeding progression based on gestational age, energy and fluid requirements, guidelines for fluid management, risks and prevention of necrotizing enterocolitis, total parenteral nutrition protocols and complications, and important vitamins and minerals for newborns such as vitamin K, vitamin D, iron, and folic acid.
This document discusses rumination disorder in a 16-year-old female patient. Rumination disorder involves repeatedly regurgitating and rechewing or reswallowing food after eating. It is considered a learned behavior rather than a medical condition. Treatment involves behavioral therapy like relaxation techniques and diaphragmatic breathing. For severe cases with weight loss, enteral nutrition may be needed. Multidisciplinary teams including nutrition, psychology, and gastroenterology have been shown to help patients learn to stop the rumination behavior through programs that focus on eating skills.
This document provides an overview of total parenteral nutrition (TPN). It discusses indications for TPN including malnutrition and inability to absorb nutrients enterally. Components of TPN include carbohydrates, proteins, lipids, electrolytes, vitamins and minerals. Requirements are calculated based on ideal body weight and stress factors. TPN can be administered continuously or cyclically through central or peripheral lines. Complications include mechanical issues, metabolic disturbances, and infections. Careful monitoring is required when a patient is on TPN.
This document provides an overview of nutrition in surgical patients. It discusses the basics of nutrition including caloric and protein requirements. The importance of nutrition for surgical patients is described along with the complications of malnutrition like infection and poor wound healing. Methods of nutritional assessment involving history, exams, and labs are outlined. Both enteral and parenteral nutrition are covered, including indications, contraindications, administration methods, and potential complications. The take home messages emphasize the importance of meeting caloric needs to avoid complications, using enteral nutrition when possible, and closely monitoring patients on nutrition support.
This document discusses nutrition support for critically ill patients in the intensive care unit (ICU). It provides a brief history of ICU nutrition and outlines the basis for nutritional support. Nutritional support is important to address the catabolism and malnutrition that often develops in critically ill patients. Enteral nutrition is preferred over parenteral nutrition when possible due to lower risks of infection and preservation of gut function. The document reviews nutritional requirements, supplementation, routes of administration including enteral and parenteral options, and potential complications of nutrition support.
- Critically ill patients are at high risk of malnutrition due to poor nutrient intake and increased metabolic demands.
- Early enteral nutrition within 48 hours is recommended to improve outcomes when possible. Parenteral nutrition may be considered after 1 week if enteral nutrition is not feasible.
- Nutrition support aims to meet caloric and protein goals to reduce catabolism and support anabolism while avoiding overfeeding. Standard enteral formulas are preferred over specialty formulas.
- Careful monitoring is needed to optimize delivery of nutrition and minimize risks like aspiration while the patient's condition and ability to tolerate feeds is changing.
This document discusses nutrition support in surgery patients. It notes that the aim of nutrition support is to identify malnourished patients and meet their nutritional needs, as malnutrition increases risks of complications and mortality. It covers nutritional requirements, types of malnutrition, nutritional assessment techniques, indications for enteral and parenteral nutrition support, complications of both, and combinations of enteral and parenteral feeding.
The document discusses malnutrition in critical illness and factors that favor its development. It outlines the consequences of malnutrition, including impaired immune function, wound healing, organ dysfunction, and increased risk of death. The document provides guidelines on nutritional assessment and determining energy and protein requirements in critical illness. It discusses the benefits of early enteral nutrition over parenteral nutrition.
Cerebral Palsy, Autism, and Cleft Palate/Lip were presented. Cerebral Palsy is an umbrella term for disorders affecting movement caused by brain damage. Autism Spectrum Disorder is characterized by impaired social skills, communication, and repetitive behaviors. Cleft Palate/Lip is a birth defect where the lip and/or roof of the mouth do not fully form.
1. Critical illness such as sepsis can lead to catabolism and muscle wasting. Early enteral or parenteral nutrition is recommended to improve outcomes.
2. Malnutrition is common in patients with conditions like liver or renal failure, burns, neurological disorders, and short bowel syndrome. Nutritional support aims to meet caloric and protein needs based on the individual's condition.
3. Enteral nutrition is preferred over parenteral when possible due to lower risks of infection and other complications. Early initiation of feeding within 24-48 hours of admission is recommended for many critically ill patients.
I presented a hyperemesis case for a Case Study Seminar where university faculty were invited to attend and RD\'s from the community could receive CPE\'s for attending.
This document summarizes a presentation on enteral nutrition for pediatric patients with gastrointestinal impairment. It discusses various conditions that can cause GI impairment including short bowel syndrome, cystic fibrosis, and Crohn's disease. It reviews the available research on different formula types for these conditions, including elemental, semi-elemental, and polymeric formulas. Guidelines are provided on selecting the appropriate formula based on a patient's age, diagnosis, and degree of GI impairment. Breast milk, hydrolyzed formulas, and elemental formulas are also discussed as options for infants and children with severe impairment.
This document summarizes a presentation on enteral nutrition for pediatric patients with gastrointestinal impairment. It discusses various conditions that can cause GI impairment including short bowel syndrome, cystic fibrosis, and Crohn's disease. It reviews the available research on different formula types for these conditions, including elemental, semi-elemental, and polymeric formulas. Guidelines are provided on selecting the appropriate formula based on a patient's age, diagnosis and degree of GI impairment. Breast milk, hydrolyzed formulas, and elemental formulas are also discussed as options for infants and children with severe GI issues.
nutritional need of critical ill childmannparashar
The document discusses nutrition in critically ill children, including components of energy requirements, the importance of proper nutrition, goals of providing nutrition, methods of nutritional assessment, estimating energy requirements using various equations, protein, carbohydrate and lipid requirements, fluid requirements, enteral and parenteral nutrition, complications of enteral and parenteral nutrition, and nursing diagnoses related to nutrition in critically ill children.
This document discusses nutrition in surgical patients. It begins by outlining the goals of nutritional support, which include identifying patients at risk of malnutrition, preventing or reversing catabolism, and meeting energy requirements. It then covers topics like malnutrition, nutritional assessment tools, estimating energy needs, and administration of enteral and parenteral nutrition. The key points are that nutritional support should begin preoperatively for high-risk patients or if oral intake won't resume within 7 days post-op, and the enteral route is preferred over parenteral nutrition when possible.
Nutrition for children and adolescents with chronic kidney diseaseFarragBahbah
This document discusses nutrition for children with chronic kidney disease. It outlines the importance of nutritional assessment and monitoring growth parameters like height and weight at least twice as frequently for these children compared to healthy children. The goals of nutrition management are to maintain optimal nutrition status, avoid uremic toxicity, and reduce risk of chronic issues. Causes of poor nutritional status in these children include reduced appetite and intake due to various factors. The document recommends individualizing nutritional intervention based on an assessment of each child's needs, age, and preferences. Energy needs should be 100% of estimated needs based on age and activity level.
This document provides information on cystic fibrosis including signs and symptoms, nutrition implications, and treatment. It then presents a case study on a 9.8 month old female patient with CF who was admitted for metabolic insufficiencies. Initial assessment found the patient was underweight. Recommendations included increasing formula intake and supplements. Follow up found weight gain and increased intake meeting goals. Further advancement of formula was recommended.
This document summarizes a case study of a 15-year-old female patient (KK) admitted to the hospital with suspected inflammatory bowel disease (IBD). KK presented with abdominal pain, vomiting, diarrhea, and weight loss. Initial assessments found KK to be malnourished with low albumin and electrolyte levels. She was started on TPN to address her inadequate oral intake. Over subsequent follow-ups, KK showed signs of improvement with decreasing stool output and weight gain, though her intake remained restricted and TPN was adjusted due to lab abnormalities. The case study evaluated KK's nutrition status and needs in the context of managing her suspected IBD.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
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2. INTRODUCTIONINTRODUCTION
Malnutrition
pathologic state of varying severity with clinical features caused
by deficiency, excess, or imbalance of essential nutrients.
The cause may be
primary (involving the quantity or quality of food consumed)
secondary (involving alterations in nutrient requirements, utilization, or
excretion).
(A.S.P.E.N 2002)(A.S.P.E.N 2002)
Primary malnutrition
common cause of morbidity & mortality in the developing
countries
nearly 40% of children under 5 years of age are affected
3. INTRODUCTIONINTRODUCTION
Malnutrition due to the effects of acute or chronic disease →
negative effect on recovery or response to therapy.
There is an association between malnutrition, mortality and
morbidity
good nutritional profile → responsive to clinical treatment.
(Spagnuolo et al 2010)
4. INTRODUCTIONINTRODUCTION
Preterm neonates
limited energy reserves
nutrients for
tissue growth and development
the energy and catabolic cost of any morbidity.
(Morgan & Kovar 1992)(Morgan & Kovar 1992)
Nutritional compromise during critical period of rapid brain
growth (30 weeks’ gestation to 6 months of life) → could
permanently impair cognitive function
(Lucas et al 1998)
5. GOALS OF NUTRITION SUPPORT
To preserve a good nutritional status
To prevent malnutrition
To provide therapy to help patients with various
disorders
To provide adequate nutritient to meet metabolicTo provide adequate nutritient to meet metabolic
needs
To improve the nutritional and metabolic condition
To avoid complications
To improve patient outcomes
(Kolaric et al 2006, Spagnuolo et al 2010)
6. In preparing and planning for a patient to receive PN,
the goals should be clearly stated by determining the
patient’s
(1) nutritional requirements,(1) nutritional requirements,
(2) baseline metabolic parameters,
(3) anticipated PN duration,
(4) accessibility of central veins,
(5) the most appropriate device for placement, and
(6) the complications of therapy.
ASPEN 2002
7. THERAPEUTIC GOALS OF PN
The therapeutic goal of PN in children
to maintain nutritional status and to achieve balanced
somatic growth.
Somatic growth spurt occur in early infancy and
adolescence
sensitive to energy restriction because of high basal andsensitive to energy restriction because of high basal and
anabolic requirements.
To provide sufficient nutrients parenterally to sustain
growth in infants and children suffering from intestinal
failure or severe functional intestinal immaturity
ASPEN 2002, Horn 2003, Koletzko et al 2005.
8. INDICATIONS FOR PN
Patient is unable to meet their nutrient requirements orally or
enterally
→to prevent or correct malnutrition or to sustain appropriate
growth. (B)
The maximum period of tolerable undernutrition depends on the
patient’s age, baseline nutrition status, and underlying medical
conditions
PN should be initiated
within 1 day of birth in neonates
within 5 to 7 days in pediatric patients (C)
depending on age, baseline nutritional status, and underlying
medical conditions
ASPEN 2002, Horn 2003, Koletzko et al 2005
a short PN course of < 5 days is unlikely to give significant nutrition
benefits
Spagnuolo et al 2010
9. Central Line
• hypertonic solution with
higher osmolarity.
•full PN support in children.
Peripheral Line
• Not to exceed 900 mOsm/L
• limited to dextrose
concentrations of less
than 12.5%.
ADMINISTRATION OF PN
Venous
Access
•Prolonged PN
•associated with infectious
and mechanical
complications
•rarely indicated
• partial PN
supplementation
• bridge therapy for
patients awaiting
central access
•Short term (usu. < 2 weeks)
ASPEN 2002, Horn 2003, Koletzko et al 2005
10. FLUID REQUIREMENTS
Fluid needs vary with the age & weight of the child and should be
adjusted accordingly.
Total water requirements consist of
the maintenance needs
replacement of ongoing losses (insensible water loss, urinary losses,
and stool losses)
replacement of deficits.
ASPEN 2002, Horn 2003, Koletzko et al 2005
renal failure
congestive heart failure, etc
Decrease fluid req
Fever
phototherapy
hyperventilation
hypermetabolism
gastrointestinal losses, etc
Increase fluid req
11. FLUID REQUIREMENTS
Body weight Fluid requirements
< 10 kg 100 ml/kg per day
11 – 20 kg 1,000 ml per day + 50 ml/kg for
ASPEN 2002, Horn 2003, Koletzko et al 2005
11 – 20 kg 1,000 ml per day + 50 ml/kg for
each kg above 10 kg
> 20 kg 1,500 ml per day + 20 ml/kg for
each kg above 20 kg
12. CALORIC REQUIREMENTS
Energy in a child is required for both maintenance of body
metabolism as well as for growth
ASPEN 2002, Horn 2003, Koletzko et al 2005
Estimation Of Caloric Requirements
110 – 120 kcal/kg/dayPre-term 110 – 120 kcal/kg/dayPre-term
90 – 100 kcal/kg/day0 – 1 year
75 – 90 kcal/kg/day1 – 7 year
60 – 75 kcal/kg/day7 – 12 year
30 – 60 kcal/kg/day12 – 18 year
ASPEN 2002, Koletzko et al 2005
14. PROTEN REQUIREMENTS
Protein (amino acids) requirements should be adjusted according to the
age of the child. (B)
Amino acid preparation → crystalline, branched amino acids
Amino acids are generally not metabolized to supply energy but to
provide structural and visceral proteins and enzymes
Age Protein requirements (g/kg/day)
Low birth weight 3 – 4
Full-term 2 – 3Full-term 2 – 3
1 to 10 years 1.0 – 1.2
Adolescence
Boys
Girls
0.9
0.8
1 to 10 years 1.0 – 1.2
Critically ill
child/adolescent
1.5
ASPEN 2002, Kolaric et al 2006
15. CARBOHYDRATE REQUIREMENTS
Carbohydrates are the main sources of energy → should
comprise 40% to 50% of the caloric intake in infants and
children. (C)
The most commonly used carbohydrate is glucose → readily
used by all body tissues
Initial glucose concentration usually 5-10%
Gradually increase up to 17.5% - 20%
Concentration > 12.5% → central venous accessConcentration > 12.5% → central venous access
Total amount should not exceed daily amount the body can
utilize. If exceeded:
fatty liver
insulin resistance
hyperglycemia
Carbohydrate administration should be closely monitored and
adjusted in the postoperative period in neonates and children
to avoid hyperglycemia.
ASPEN 2002, Koletzko et al 2005 , Kolaric et al 2006
16. LIPID REQUIREMENTS
providing high energy needs without carbohydrate
overload
carbohydrate overload
→ increase in CO2 levels in blood (hypercapnia)
→ hyperglycaemia due to insulin resistance
supplementing essential fatty acids
low osmolality → good use in peripheral applicationslow osmolality → good use in peripheral applications
20% lipid emulsion preferred over 10%
10% has higher phospholipid to triglyceride ratio → decreased
lipid clearance & elevated TG levels
Initiate: 1 g/kg/day
Max: 2 – 3 g/kg/day
Older children
Initiate: 0.5 g/kg/day
Max: 3 – 4 g/kg/day
Neonate
Koletzko et al 2005 , Kolaric et al 2006
17. ELECTROLYTES REQUIREMENTS
Electrolytes are added to PN according to patient’s individual
requirements based on blood chemistry
The basic daily requirements influenced by multiple factors:
increased body temperature
abnormal losses through the gastroenterological tractabnormal losses through the gastroenterological tract
(vomiting, diarrhoea)
increased anabolism (starvation),
increased loss of water through damaged skin in burn patients,
heart and kidney malfunctions,
medical drug therapy,
external factors (humidity, outside temperature).
Horn 2003, , Kolaric et al 2006
19. VITAMINS & TRACE ELEMENTS
Essential in the metabolism of carbohydrates, protein and fats
Water soluble vitamins
Soluvit N (Paeds) – 1ml/kg BW (max 10 ml)
Lipid soluble vitamins
Vitalipid N Infant – 4 ml/kg BW (max 10 ml) – for chidren <
11 years11 years
Vitalipid N Adult – 10 ml – for patients over 11 years
Trace elements
Proven essential :
Zinc, copper, iodine, iron, manganese, chromium, cobalt,
selenium, molybdenum
Peditrace – 1 ml/kg/day (max 15 ml)
20. COMPOUNDING PROBLEM
Precipitation
A precipitate is solid matter formed in the solution.
E.g.
Calcium and phosphatesCalcium and phosphates
Phosphate and trace elements
Trace elements and amino acids
22. COMPLICATIONS OF PN
Catheter related sepsis
Pneumothorax
Dislocation of catheter
Air embolism
Venous thrombosis
Mechanical
Hypo/hyperglycemia
Allergic reaction to AA / fats
Electrolytes disturbances
Thrombocyte & neutrophil
dysfunction
Metabolic
Venous thrombosis
Infiltration & phlebitis
Blockage of TPN infusion
dysfunction
Hepatic dysfunction
Metabolic acidosis
Inadequate feeding
Over feeding
Refeeding syndrome
Nutritional
Catheter-related sepsis
Other Infections
Infectious
23. REFERENCESA.S.P.E.N. Board of Directors and the Clinical Guidelines Task Force. 2002.
Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric
Patients. J Parenteral Enteral Nutr 26:1SA-138SA.
Chawla, D., Thukral , A., Agarwal, R., et al. 2008. Parenteral nutrition. AIIMS- NICU
protocols. New Delhi: All India Institute of Medical Sciences.
Horn, V. 2003. Paediatric parenteral nutrition. Hospital Pharmacist 10: 58-62.
Kolaric, A., Pukšič, M. & Goričanec, D. 2006. Solutions preparing for total parenteralKolaric, A., Pukšič, M. & Goričanec, D. 2006. Solutions preparing for total parenteral
nutrition for children. Proceedings of the 7th WSEAS International Conference on
Mathematics & Computers in Biology & Chemistry, Cavtat, Croatia: June 13-15
(pp1-6).
Koletzko, B., Goulet, O., Hunt, J., et al. 2005. Guidelines on paediatric parenteral
nutrition of the European Society of Paediatric Gastroenterology, Hepatology and
Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and
Metabolism (ESPEN), supported by the European Society of Paediatric Research
(ESPR). Journal of Pediatric Gastroenterology and Nutrition 41: S1–S4.
Liesje Nieman. 2008. Parenteral Nutrition in the NICU. Nutrition Dimension.
http://www.nutritiondimension.com/.
24. REFERENCES
Lucas, A., Morley, R. & Cole, T.J. 1998. Randomised trial of early diet in preterm
babies and later intelligence quotient.BMJ 317: 1481-1487.
Shulman R.J. & Phillips. S. 2003. Parenteral nutrition in infants and children. JPGN
36: 587–607.
Spagnuolo, M.I., Pirozzi, M.R. & Guarino, A. 2010. Enteral and parenteral nutrition in
pediatric patients: main clinical indications and the fundamental role of artificial
nutrition to avoid malnutrition. Nutritional Therapy & Metabolism: 28: 21-4.
Ziegler, T.R. 2009. Parenteral Nutrition in the Critically Ill Patient. N Engl J Med 361:
1088-97.