The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
describes the etiopathogenesis , clinical features, investigations, differential diagnosis and management and prophylaxis of all important viral lesions affecting the oral cavity
AIDS is defined as a condition indicative of a defect in cell-mediated immunity occurring in a person with no known cause for immunodeficiency other than the presence of HIV.
CDC defined AIDS as
“The occurrence of one or more group of life-threatening opportunistic infections, malignancies, neurologic diseases and other specific illness in patients with HIV infection or with CD4 counts less than 200/cu mm”
describes the etiopathogenesis , clinical features, investigations, differential diagnosis and management and prophylaxis of all important viral lesions affecting the oral cavity
AIDS is defined as a condition indicative of a defect in cell-mediated immunity occurring in a person with no known cause for immunodeficiency other than the presence of HIV.
CDC defined AIDS as
“The occurrence of one or more group of life-threatening opportunistic infections, malignancies, neurologic diseases and other specific illness in patients with HIV infection or with CD4 counts less than 200/cu mm”
Majority of HIV infected individuals show oral manifestations of infection. Early diagnosis and treatment will improve the lifespan of HIV infected individuals.
The presentation explain white lesions in oral cavity and the classification the demonstrate the etiology, histopathology, diagnosis and treatment for each one.
AIDS is a lethal viral infection caused by human immunodeficiency virus (HIV) and is characterized by severe depletion of T4 lymphocytes with associated opportunistic infections.
Oral and perioral lesions are common in patients infected with human immune deficiency virus (HIV), are often the presenting feature, and may predict deterioration in general health and a poor prognosis.
Due to multiple oral conditions and periodontal involvement, periodontists are in a unique position to recognize possible HIV infection in its early stage and to be involved in the oral care of these patients.
Majority of HIV infected individuals show oral manifestations of infection. Early diagnosis and treatment will improve the lifespan of HIV infected individuals.
The presentation explain white lesions in oral cavity and the classification the demonstrate the etiology, histopathology, diagnosis and treatment for each one.
AIDS is a lethal viral infection caused by human immunodeficiency virus (HIV) and is characterized by severe depletion of T4 lymphocytes with associated opportunistic infections.
Oral and perioral lesions are common in patients infected with human immune deficiency virus (HIV), are often the presenting feature, and may predict deterioration in general health and a poor prognosis.
Due to multiple oral conditions and periodontal involvement, periodontists are in a unique position to recognize possible HIV infection in its early stage and to be involved in the oral care of these patients.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
This presentation is helpful for the dental student interested in dealing with the infectious disease AIDS.
The material also includes evidence based article on the relation of the HIV stage on periodontal status.
Oral hiv/certified fixed orthodontic courses by Indian dental academyIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
This is an informative, illustrated presentation about the causes, symptoms, treatment and prevention of HIV AIDS. Gives relevant data, facts and statistics about the disease updated to the most recent 2010 data.
HIV infection
Mode of transmission, pathogenesis, clinical manifestations, laboratory diagnosis, treatment, prevention, prognosis, scope of AIDS vaccine.
Hiv infection /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
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Oral Candidiasis also referred to as oral thrush is commonly encountered in a daily life of a dentist. An overview on this topic for undergraduate students.
This PowerPoint presentation demonstrate a useful review of Oral candidiosis, including its different types, clinical presentations, differential diagnosis, and treatment options.
Adenoviruses, papillomaviruses, parvoviruses and polymovirusesNCRIMS, Meerut
Adenoviruses, papillomaviruses, parvoviruses and polymoviruses are Double stranded DNA Viruses except parvoviruses. Adenoviruses are non enveloped icosahedral symmetry.
Fungi were found by Heinrich Anton de Bary in 1858.
Most fungi cause skin or cosmetic infections while bacteria & viruses cause fatal diseases.
Organ transplantation, Immunosuppressive drugs,Anticancer drugs, Broad-spectrum antimicrobials ,HIV-disease leads to Immunosuppression causing Opportunistic Fungal Infections
Opportunity for Dentists (BDS/MDS )to relocate to United kingdom -Register as a DENTAL HYGIENIST/ DENTAL THERAPIST without Board exams and after approval you can register in GDC as a DH/DT and start working as a DH/DT Immediately and get paid.
You can complete the whole process in 3-4 months.Salary range for DH/DT is around 2500-3500 Pounds per month.
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If you are interested Please contact us for more details.
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Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals
who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry,
Periodontics and General Dentistry.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
I –Aligners are made with FDA approved transparent thermoplastic materials using 3D scanning, 3D Printing and finally Trays with Pressure vacuum formers.
Dear Doctor,
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Indian Dental Academy
Leader in continuing dental education
www.indiandentalacademy.com
skype:indiandentalacademy
+919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Cytotoxicity of silicone materials used in maxillofacial prosthesis / dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Diagnosis and treatment planning in completely endntulous arches/dental coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Properties of Denture base materials /rotary endodontic coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Use of modified tooth forms in complete denture occlusion / dental implant...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
3. INTRODUCTION
• HIV INFECTION serious disorder affecting
immune system
• Body’s normal defenses against infection break
down
• Host is vulnerable to life-threatening infections/
conditions including malignances.
www.indiandentalacademy.com
4. AIDS most advanced stage of HIV infection
• THE PROGRESSION OF HIV TO AIDS IS DEFINED BY CD4
COUNT < 200/Cu.mm OR ABOUT 14% OF CD4- T
HELPER CELLS
www.indiandentalacademy.com
5. • AIDS is defined as a condition indicative of a defect in
cell mediated immunity occurring in a person with no
known cause for immunodeficiency other than the
presence of HIV.
• Acquired - not inherited
• Immune - attacks the immune system
• Deficiency - by destroying certain WBC
• Syndrome- a group of symptoms / illnesses that occur
as a result of the HIV Infection.
www.indiandentalacademy.com
6. • Before 1956 – patients from Central Africa – reported with
strange pneumonia - Gay fever ( GRID)
• Extra ordinary out break of Pneumocystis Carinii pneumonia
and Kaposi’s Sarcoma in previously fit young men -
Los Angeles and NewYork
• In 1981, the HIV epidemic has spread beyond gay males,
Haitians, and hemophiliacs, and affected many people
worldwide.
• 1982 – condition began to be referred as AIDS
HISTORICAL REVIEW
www.indiandentalacademy.com
7. • 1st report of AIDS – by US CDC – in morbidity mortality
weekly report
• In 1986, the initial cases of AIDS was found in chennai–
by Dr. Sunithi solomon
www.indiandentalacademy.com
8. CDC – 1993 - AIDS Definition
“The occurrence of one or more group of life-
threatening opportunistic infections,
malignancies, neurologic diseases and other
specific illness in patients with HIV infection or
with CD4 counts less than 200/cu mm”
www.indiandentalacademy.com
11. PATHOGENESISHIV in blood
stream
Entrapped in
lymphnodes
Presence of virus
evokes antigenic
stimulation
Activates CD4
T cells,
macrophage
TNF ALPHA, IL-6
INCREASED NO OF CD4
www.indiandentalacademy.com
13. Oral manifestations
• Represent earliest manifestations
• First meeting regarding oral problems – 1986 –
European Economic Community in Copenhagen
• 1989 - j. pindborg revised
• 1989 - WHO collaborative center and EC Clearing
house
• Revised classification by EC Clearing house - 1992
www.indiandentalacademy.com
14. Sept 1992 revised classification of oral lesions associated with
adult HIV INFECTION
• GROUP 1 : LESIONS STRONGLY ASSOCIATED WITH HIV
INFECTION
• CANDIDIASIS : pseudomembranous , erythematous
• Oral hairy leukoplakia
• Non – hodgkins lymphoma
• Kaposi’s sarcoma
• Periodontal disease –
• linear gingival erythema
• Necrotising ulcerative gingivitis
• Necrotising ulcerative periodontitis
www.indiandentalacademy.com
15. • Group 2 : lesions less commonly associated with HIV
infection
• BACTERIAL: M. AVIUM INTERCELLULARE
M. TB
• MELANOTIC HYPERPIGMENTATION
• NECROTISING ULCERATIVE STOMATITIS
• SALIVARY GLAND DISEASE – DRY MOUTH
UNI/BILATERAL SWELLING OF MAJOR SALIVARY
GLANDS
• THROMBOCYTOPENIC PURPURA
• ULCERATION OTHERWISE NOT SPECIFIED
www.indiandentalacademy.com
19. RECURRENT APHTHOUS STOMATITIS
VIRAL INFECTIONS
• CYTOMEGALO VIRUS
• MOLLUSCUM CONTAGIOSUM
“ Classification & Diagnostic Criteria For Oral Lesions In
H.I.V. Infections. EC – Clearing House On Oral Problems
Related To H.I.V. Infection & W.H.O. Collaborative
Centre On Oral Manifestations Of Immunodeficiency
Virus J Oral Pathol Med 1993; 22: 289-91”
www.indiandentalacademy.com
20. CLASSIFICATION OF OROFACIAL LESIONS
ASSOCIATED WITH HIV IN PEDIATRIC PATIENTS
GROUP 1 – LESIONS COMMONLY ASSOCIATED WITH
HIV IN PEDIATRIC PATIENTS
• Candidiasis
• HSV Infection
• Linear gingival erythema
• Recurrent aphthous ulcers
major /minor /herpetiform
www.indiandentalacademy.com
21. • GROUP 2 – LESIONS LESS COMMONLY ASSOCIATED
WITH HIV IN PEDIATRIC PTS
• BACTERIAL INFECTIONS OF ORAL TISSUES
• PERIODONTAL – NUG , NUP
• NUS
• SEBORRHEIC DERMATITIS
• VIRAL INFECTIONS – CMV , HPV , MOLLUSCUM
CONTAGIOSUM , VARICELLA ZOSTER , HERPES ZOSTER
, VARICELLA , XEROSTOMIA
www.indiandentalacademy.com
22. • GROUP 3 – LESIONS STRONGLY ASSOCIATED WITH
HIV ( RARE IN CHILDREN)
• NEOPLASM , KS , NON HODGKIN’S LYMPHOMA
OHL , TB RELATED ULCERS
• Ramos – Gomez Fj , Flait Zc , Catapanop , Et.Al
Classification , Diagnostic Criteria & Treatment
Recommendations For Oro Facial Manifestations In
Hiv Infected Pediatric Patients. Collaborative Work
Group On Oral Manifestations Of Pediatric Hiv
Infection. J Clin Pediatric Dent 1999;23:85-96
www.indiandentalacademy.com
23. GROUP 1
1.ORO PHARYNGEAL CANDIDIASIS ( OPC)
• One of initial manifestation of HIV
• 90% of untreated
• 60% - atleast 1 episode per yr with frequent recurrences
• Chiefly caused by yeast – c.albicans
• Other : c. glabrata, c.dubliniensis
• C. tropicalis, c.parapsilosis, c.kruseii
• C.novergensis
www.indiandentalacademy.com
24. • Pseudomembranous : commonest form
• characterized by Creamy yellow curd
like plaques that can be easily removed
with wiping with a cotton gauze
or tongue depressor,
often leaving a red, raw base.
Erythematous Form (atrophic) is characterized by reddish
macular lesion .
• loss of papillations when involving the tongue dorsum.www.indiandentalacademy.com
25. • Angular cheilitis affects the labial
commissures & results in
cracking, ulceration &
pseudomembrane formation.
• Hyperplastic: appear white and hyperplastic
• white areas are due to hyperkeratosis
• Non scrapable
• Confused with hairy leukoplakia.
www.indiandentalacademy.com
26. • Diagnostic modalities: based on clinical appearance and
response to empirical antifungal therapy.
• Microscopic Examination : swab - budding yeast cells,
pseudohyphae, or filaments
• KOH & PAS - improve Visualization of Fungal elements in
cytologic specimens.
• Culture on Sabouraud dextrose agar medium for 24 to 48
hours
www.indiandentalacademy.com
27. 2. Oral hairy leukoplakia
• 2nd most common hiv associated mucosal lesion
• Caused by EBV virus
• latently infects 90% of the population worldwide
without causing disease.
• OHL occurs in pts with CD4+ T cell counts < 400
• Used as a marker of disease activity
• affects men more than women
www.indiandentalacademy.com
28. Clinical features :
• Site : lateral borders of tongue,
dorsum
• Rarely FOM, buccal mucosa
• Bilaterally as painless, faint white vertical streaks/
thickened & furrowed areas with shaggy keratotic
surface ( hyper keratotic hair like projections)
• Vertical striations imparts a corrugated appearance.
• Non scrapable lesion
• Asymptomatic
www.indiandentalacademy.com
29. • PROVISIONAL DIAGNOSIS : clinical characteristics
• PRESUMPTIVE DIAGNOSIS : HISTOPATHOLOGY
• hyperkeratosis & acanthosis leading to corrugations,
Koilocytosis, Nuclear beading, chromatin
margination
• DEFINITIVE DIAGNOSIS : VIRAL DEMONSTRATION
• Fluorescent In Situ Hybridisation
• IHC, PCR, EM
www.indiandentalacademy.com
30. 3. KAPOSI SARCOMA
• Angiogenic disorder in which multi centric neoplastic
proliferation of vascular, spindle cell components
occurs in response to circulating growth factors.
• Wahman et.al. cofactor model : inf, host, env
• Chang et.al., moore et.al. – HHV 8, KSHV
• Four types : Classic,
• African type
• Transplant associated, AIDS related
www.indiandentalacademy.com
31. AIDS RELATED
• seen in 55% homosexual pts
• Represents 1st sign of progression of AIDS
• Many cutaneous lesions are seen
• Oral lesions can occur on any mucosal surface
• Mainly on hard palate, maxillary gingiva,
• Also – tongue, uvula, tonsils, pharynx
• Associated with cervical lymphadenopathy
• Salivary gland enlargement
www.indiandentalacademy.com
32. Multiple Flat,
blue/red/purpl
e patches
Coalesce to
form plaques
Surface papules
/ nodules
develop
Lesion becomes
exophytic,
ulcerate and
bleed
Asymptomatic initially
• May cause discomfort during speech, eating
• on palate, alv . Ridge : resorption - tooth loss
• compromise airways
Diagnosis : biopsy
Patch stage
Plaque stage
Nodular stage
www.indiandentalacademy.com
33. NON HODGKINS LYMPHOMA
• Second most common neoplasm associated with
AIDS
• HIV pts are 60 times at risk
• Lesions tend to present as large, painful, ulcerated
mass on palate, gingival tissues.
• Biopsy – for definitive diagnosis
www.indiandentalacademy.com
34. 4.A. Linear gingival erythema
• As distinctive fiery red band of marginal gingival tissue
without ulceration or attachment loss, prone to
bleeding
• Some times extend beyond the MGJ.
• The lesion redness is disproportional to the amount of
plaque and persists after removal of plaque
• HP : reveals little inflammation
• Clinical redness represents vascular reponse with no
lymphocytic infiltration.www.indiandentalacademy.com
36. 5.B. Necrotising ulcerative gingivitis
• Fusospirochaetal infection
• Involves primarily free gingiva , crest of gingiva, id
papilla
• Rarely soft palate, tonsil
• Occurs at any age, middle age – common
• Stress, immunosuppression, malnutrition, trauma,
smoking
www.indiandentalacademy.com
37. • Painful , hyperemic gingiva & sharply punched out
crater like erosions of id papilla of sudden onset
• Ulcerated remanants bleed when touched
• Covered by greyish pseudomembrane
• Ulcers tend to spread to all margins
• Pt c/o inability to eat, fetid odour
• Excessive salivation, metallic taste
• Systemic manifestations
www.indiandentalacademy.com
39. 5.C.Necrotising ulcerative periodontitis
• characterized by recession and increased attachment
loss with shallow probing depths, bleeding, tissue
sloughing, loss of id papillae, fetid odor, and moderate
pain.
• Periods of activity (tissue necrosis and loss) may be
followed by
• periods of quiescence (healing with no signs of
inflammation, but evidence of permanent residual
tissue loss) www.indiandentalacademy.com
41. • Typical : P. gingivalis, P. intermedia, T.denticola,
Actinobacillus actinomycetemcomitans
• Atypical bacteria seen in NUP ( HIV PTS) : Bulleidia
Extructa, Dialister, fusobacterium, selenomonas,
peptostreptococcus, veillonella
• Condition may be exacerbated by Candida, herpes like
viruses & by an HIV disease–related increased
inflammatory cytokine response
• Fusobacterium necrophorum plays a major role in
progression of NUP to noma.
www.indiandentalacademy.com
42. • Diagnostic modalities : clinical appearance
Measurements of recession, periodontal probing
depths, attachment levels, and mobility
• Imaging : of areas of NUP involvement may show loss
of crestal cortication associated with rapid alveolar
bone loss.
www.indiandentalacademy.com
43. GROUP II
A) Mycobacterial infections
• MAC, M.TB
• Approx 1/3rd of AIDS-related deaths worldwide are due to
TB
• increased reactivation of latent TB infections as well as
higher primary rates of TB
• Pulmonary TB is the most common
• Extrapulmonary disease affecting the liver, spleen,or
kidney may occur in patients with CD4 < 100 cells/mm3www.indiandentalacademy.com
44. ORAL MANIFESTATIONS :
• Primary TB : gingiva, tooth extraction sockets, buccal
folds
• Sec. TB : tongue, palate, lips, alveolar mucosa & jaw
bones
• present as ulcers or nodules, vesicles, fissures,,
plaques, granulomas and verrucous proliferations.
• single or multiple, painful or painless
www.indiandentalacademy.com
45. • Ulcer – irregular, ragged, undermined edges,
minimal induration , with yellowish granular base
• Tongue : lateral border, ant. Dorsum, base of tongue
• Painful, grayish-yellow, firm well demarcated
• Palate : Small granulomas or ulcerations
• Lips : shallow granulating ulcers
• TB OSTEOMYELITIS
• TB SIALADENITIS
www.indiandentalacademy.com
47. B) MELANOTIC HYPERPIGMENTATION
• HIV pts hyperpigmentation of oral mucosa , skin, nails
occurs suddenly
Due to
• Direct result of HIV infection
• Adrenocortical destruction due to several infections
associated with hiv
• Medication intake : ketoconazole, zidovudine
www.indiandentalacademy.com
48. C) NECROTISING ULCERATIVE STOMATITIS
• NUG, NUP, NUS – different clinical stages of same disease (
robinson et.al)
• Collectively – necrotising gingivostomatitis
• NUS is an outcome of NUG/P progressing beyond mucogingival
demarcation
• Sometimes arise on mucosa seperately
• NUS involves mainly soft tissues, may extend into underlying
bone causing massive tissue destruction.
• If NUS extends from oral mucosa to involve facial skin, it will
result in noma
www.indiandentalacademy.com
49. Hiv
infects lc
cells
Depletion
of lc cells
Decreased
local
immune
response
Increased
susceptibility
to infections
NPD,
NUS
STIMULATES
CYTOTOXIC T-
CELL RESPONSE
PATHOGENESIS
www.indiandentalacademy.com
50. D)UNI/BILATERAL SWELLING OF MAJOR SALIVARY GLANDS
• HIV-associated lymphoepithelial lesions which are
known as hiv associated salivary gland lesions ( HIV
SGD)
• Hyperplastic reactive lymphadenopathy,
• Benign lymphoepithelial cysts,
• Malignant : lymphoma, ks
• benign neoplasms
• Bacterial , mycobacterial , and viral infectionswww.indiandentalacademy.com
51. • Diffuse Infiltrative Lymphocytosis Syndrome (Dils)
• In 3% of hiv pts multiple lymphoepithelial cysts
proliferate in parotid gland
• Painful enlargement of gland
• Lesion involves entire parotid parenchyma, so presents
as localised mass
• Not moveable, Tender on palpation
• Tense , due fluid accumulation in multiple cysts
• Reduced salivary gland function : xerostomia, sicca
symptoms
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52. • In HIV +ve, CT scan showing multiple hypodense areas
is suggestive of DILS .
Histopathology :
• Characterized by persistent infiltration of CD8 cells that
have the ability to destroy HIV-infected cells
• lymphocytic infiltration involving the salivary glands (~
to Sjogren syndrome)
• Differentiation : DILS also involves lungs, kidney, git
• Sj autoab’s will be absent in pts with DILS
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53. • Fine-needle aspirates can be useful in differential
diagnosis of salivary gland masses
• Confirmatory - histopathologic diagnosis
• If ct shows a defined mass, then superficial
parotidectomy
• If no defined mass is seen in ct then incisional biopsy
• Immunohistochemical analysis from a biopsy are
essential to determine the nature of the salivary gland
enlargement.
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54. E) THROMBOCYTOPENIC PURPURA
• HIV related immune thrombocytopenic purpura
• Immune mediated destruction
• Circulating immune complexes are non specifically
deposited on platelet membrane, resulting in
reticuloendothelial clearance.
• Us studies , HIV directly infects megakaryocytes , leading
to impaired production
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55. • Thrombotic thrombocytopenic purpura is also
seen in HIV pts.
• Other causes of thrombocytopenia in HIV :
• Infections / neoplastic conditions involving
bone marrow
• Any medication causing myelosuppression
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56. F) ULCERATIONS NOT OTHERWISE SPECIFIED
• single or multiple, well-circumscribed, extremely
painful
• often with a pseudomembrane, > 0.5 cm to 2/ 3 cm
• may have a recurrent pattern/ not
• may last for several weeks, healing with scarring.
• Typically found on nonkeratinized epithelial mucosa
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57. • In immune-suppressed patients ulcers are deeper
and devoid of the classic erythematous halo at ulcer
margin
• Biopsy should be obtained for lesions lasting > 3
weeks
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58. G) VIRAL
1)HSV : In HIV pts presents
• as an erythematous pruritus that develops into
painful vesicles and ulcerates over a brief period,
accompanied by painful regional lymphadenopathy.
• HSV infection may involve all oral mucosa
• Both keratinised & non keratinised
• can be more prolonged and severe than in HIV-ve
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60. • VERRUCA VULGARIS ( COMMON WART)
• cutaneous lesion, less common on mucos memb
• Numerous finger like projections
• Resulting in lesion with rough, verrucous, cauliflower
like surface
• Well circumscribed, pendculated/sessile
• Contagious, capable of spreading to other parts
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61. • CONDYLOMA ACCUMINATUM ( veneral wart)
• Soft, pink nodules which proliferate & coalesce rapidly
to form diffuse papillomatous clusters of varying size
• Occurs on moist, intertriginous areas
• Seen on tongue, commissures
• Also present on other mucosal surfaces
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62. • FOCAL EPITHELIAL HYPERPLASIA
• Most contagious oral papillary lesion
• Well circumscribed numerous soft, flat,sessile, non
papillomatous papules are distributed throughout oral
mucosa
• Site : labial, buccal, lingual mucosa, Gingiva, tonsil
• Differs from other HPV infections : extreme acanthosis,
hyperplasia, but minimal production of surface
projections
• Mucosa is 8-10 times thicker than normal.
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63. 3) VARICELLA ZOSTER:
• Acute ubiquitous extremely contagious disease occuring in
children, young adults
• Maculopapular rash, vesicular eruptions which begins on
trunk, spreads centrifugally ( face & extremities)
• Occurs in successive crops.
• Skin lesions rupture , form superficial crusting , heals by
desquamation
• Can occur anywhere on oral mucosa
• Vesicles rupture to form eroded ulcers with red margins.
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64. • HERPES ZOSTER
• In HIV latent VZV is reactivated by
Immunocompromised state
• Lymphomas like Hodgkins , T Cell Leukemia
• Prodrome : Deep aching / burning pain
• Dermatomatic/ zosteriform distribution of vesicles
• Unilateral, clustered distribution of vesicles, ulcers
• Thoracic > lumbar> craniofacial areas
• V1 is most commonly involved
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65. • Post herpetic neuralgia :
• Pain that persists for 30/120 days after onset of rash.
• Occurs at any age
• More common in elderly pts
• Cli. Features: persistent pain, hyperesthesia,
parasthesia, allodynia for months or yrs after zoster
lesions have healed.
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68. ACTINOMYCOSIS
• Actinomyces – filamentous bacteria
• living as commensal organisms in the human oral
cavity and respiratory and digestive tracts
• Becoming invasive when, through a mucosal lesion,
they gain access to the subcutaneous tissue.
• Infection is always endogenous. Doesnot occur by
person to person contact.
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69. • Presents as a chronic, fluctuant mass
• Located at the border of the mandible
• Pain is rare, slight fever
• Initially, the mass may be surrounded by
induration or erythema; later, it may become
tender to palpation, on account of a central
necrosis process
• Becoming progressively larger within weeks or
months
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70. • Mass breaks down and abscess, sinuses are formed
• Discharging pus contain typical yellow sulphur
granules
• Skin overlying abscess is purplish,red indurated has
appearance of wood.
• Infection may extend into adjoining soft tissue as well
as bone
• Leads actinomycotic osteomyelitis
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72. Epitheloid (bacillary) angiomatosis
• Vascular proliferation that ~ ks
• First described in 1983 in HIV pts
• Occurs when CD4 count < 100/cumm
• Rarely seen in immunocompetent pts
• Mucocutaneous disorder
• Lesions – vascular papules that grow to form nodules
• Diagnosis : hp
• Which demonstrate presence of causative bacteria
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74. 4)Fungal other than candidiasis
• cryptococcus neoformans
• Geotrichum
• Histoplasma
• Mucoracea
• Aspergillus flavus
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75. Cryptococcosis:
• Cryptococcus neoformans
• Meningoencephalitis
• Symptoms include headache, nausea, irritability,
and diminished cognitive function
• physical findings include cranial nerve palsies,
hyperreflexia, and papilledema.
• Rarely, intraoral ulcerations may occur in mucosal
tissues with dissemination of cryptococcosis
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76. • Histoplasmosis
• Primary infection – self limiting pulmonary infection.
• Heals with fibrosis, calcification
• In HIV PTS progressive disseminated form
• Predilection for RE SYSTEM
• Involves liver, spleen, lymphnodes, bone marrow
• Oral histoplasmosis in HIV occurs alone/ as a part of
disseminated infection.
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77. • Oral : nodular / ulcerative/ vegetative lesions
• Ulcerated areas covered by pseudomembrane
• Indurated margins
• Dissemination of histoplasmosis to the oral mucosa
may occur primarily on the gingival, tongue, palate,
and buccal mucosa.
• Gingival lesions will appear as diffuse granulomatous
inflammation with progressive alveolar bone erosion
and loosening of teeth
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78. ASPERGILLOSIS
• Aspergillus spore is found in decaying vegetation and
in the immunocompromised host may cause acute
invasive pulmonary aspergillosis.
• Aspergillus species have also been isolated from the
air and environmental surfaces of hospital settings
• Hospitalized immunosuppressed individuals may be at
increased risk.
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79. • Invade blood vessels causing thrombosis and infarction
of the perivascular tissues.
• Less commonly Aspergillus invades the sinuses and can
progress through the underlying soft tissue and bone to
cause palatal and oral lesions, typically described as
black or yellow necrotic lesions of the soft tissue
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80. Recurrent aphthous stomatitis
• Most commonly reported type of ulcers in HIV +ve
pts
• Etiology remains undetermined
• Ulcers appear clinically as painful, round-to-oval,
yellow or white, & are surrounded by a halo of
erythema.
• HIV-positive patients usually experience increased
frequency and severity of typical minor aphthous
ulcers
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82. CYTO MEGALO VIRUS :
• May cause oral ulceration in HIV-positive pts with
• disseminated cytomegalovirus (CMV) disease
• Ulcers may occur anywhere in the oral cavity
• Resemble MAU in size.
• Instead of an erythematous margin, CMV ulcers
appear necrotic with a white halo.
• Deep tissue biopsy with biopsy punch or scalpel is
used to confirm diagnosis
• . www.indiandentalacademy.com
83. • large intracellular inclusion bodies are characteristic of
infection.
• Patients may develop CMV retinitis, esophagitis, colitis,
pneumonitis, and neurological disease
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84. Molluscum contagiosum
• Infection of skin caused by pox virus
• Shiny, white, skin coloured dome shaped papules that
often demonstrate a central depressed crater.
• In pts with AIDS numerous lesions may be present
• No tendency to undergo spontaneous resolution
• Hp : large intracytoplasmic inclusions are seen
• Molluscum bodies
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86. CONCLUSION
• Dentists play an important role in managing
the oral health of patients with HIV disease
• Knowledge of HIV oral lesion clinical
appearance, lesion symptoms and behavior,
various treatment approaches, and anticipated
response to treatment are important for oral
disease control and oral health maintenance
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87. REFERENCES
• Lauren L Patton, Oral Lesions Associated With Human
Immunodeficiency Virus Disease. Dent Clin N Am 57
(2013) 673- 698
• Nicholas G Mosca, Alicia Rose Hathorn , HIV Positive
Patients : Dental Managent Considerations. Dent Clin
N Am 50 (2006) 635-657
• Charles E Barr, Michael Glick , Diagnosis And
Management Of Oral & Cutaneous Lesions In HIV -1
Disease. Dent Clin N Am 10 (1998)25-45
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88. • Burkets Oral Medicine , 11th Edition, Bc Decker Inc
Hamilton 2008
• Robert E Marx, Diane Stern Oral And Maxillofacial
Pathology: A Rationale For diagnosis & Treatment.
1st edition, Quintessence.2003
• R Rajendran B Sivapathasundharam Shafer’s
Textbook Of Oral Pathology. 5th Edition, Elsevier,
2008
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89. HIV does not make people dangerous
to know, so you can shake their
hands and give them a hug: Heaven
knows they need it !!
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Editor's Notes
AIDS CAUSED BY HIV….
European – listed out 3o lesions
Mc occurs in 3 forms in hiv : opc, vv, eso….candida are normal inhabitants…1/3rd in normal, 2/3rd in aids
Only apparent azole refractory strains warrant antifungal sensitivity testing.
1985 – greenspan……type of human herpes virus
Asymp….becomes symp when super infected with candida.
1872…..ARE, MIHSK
Dd : ecchymosis, vascular lesions, low grade mucoepidermoid ca
Vincents, trench mouth…in 1999 am ac of perio reclass nug nup as necrotising perio disease….
OSTEO : difficulty in eating, trismus, paraesthesia of lower lip, lymphadenopathy , Loosening of teeth