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Dr.S.Sethupathy, M.D.,Ph.D.,
Professor and Head,
Division of Biochemistry,RMMC,AU
Thyroid hormone
ο‚— Maintains basal metabolic rate ( Resting metabolic
rate)
ο‚— Hypothyroidism in adults – myxedema
ο‚— In New born causes cretinism – mental retardation
ο‚— So Pregnant women should be screened for thyroid
function
Hypothyroid before and after
Treatment
Sedentary Moderate Heavy
Physical Activity
SDA
RMR
50 % RMR
Energyrequirements
30% RMR
40%
RMR
Protein energy malnutrition
ο‚— Both protein and energy deficiency results in
marasmus
ο‚— Mainly protein deficiency results in kwashiorkar
Overnutrition
ο‚— Excess calorie intake leads to triacylglycerol
accumulation in adipose tissue
ο‚— Body mass index = Weight in Kg / Height in m 2 ( W/
H2 )
ο‚— Non obese 20 – 24.9
ο‚— Over weight 25 – 29.9
ο‚— Obese Gr 1 30 – 34.9
ο‚— Obese Gr 2 35 – 39.9
ο‚— Obese Gr 3 >40
Obesity
Nutritional requirements
65
20
15 2
Lipids
10%
Vitamin C deficiency
ο‚— Scurvy – swelling and bleeding gums, swelling of
joints
ο‚— Rich sources of vitamin C- Amla, lime, orange
ο‚— Pickles have Vitamin C intact
ο‚— Vitamin C gets easily oxidized
ο‚— Only fresh fruits
Scurvy
Vitamin A
ο‚— Required for Vision
ο‚— Deficiency results in night blindness, rough skin (Toad
skin) , eye lens gets dislodged causing blindness
ο‚— Rich sources- Spinach, carrot, papaya, mango,tomato
Vitamin A deficiency- Lt eye blind
Vitamin A deficiency
Vitamin D
ο‚— Maintains calcium absorption for bone growth
ο‚— Deficiency leads to Rickets in children and
osteomalacia in adults
ο‚— Children – bow legs
ο‚— Rich sources- fish liver oil, fish, egg yolk, milk , nuts
and sunlight exposure
ο‚— Morning everyday 20 mins- sunlight exposure
Rickets
Thiamine
ο‚— Thiamine deficiency causes beri beri
ο‚— In wet beri beri – cardiac failure
ο‚— In dry beri beri – neurological manifestations
ο‚— Alcoholics- commonly affected
ο‚— Rich sources- rice bran, unpolished rice, whole wheat,
yeast
Wet and dry beriberi
Niacin
ο‚— Niacin deficiency causes pellagra
ο‚— Features are diarrhoea, dermatitis, dementia
ο‚— Necklace sign – dermatitis in sunlight exposed skin
ο‚— Rich sources - Dried yeast, rice polishing, liver, peanut,
whole cereals, meat and fish
Niacin deficiency
Niacin deficiency
Folic acid
ο‚— Folic acid is needed for RBC maturation
ο‚— Prevents neural tube defect in foetus
ο‚— Deficiency results in macrocytic anaemia
ο‚— Pregnant women should be given folic acid
supplements
ο‚— Rich sources- yeast, green leafy vegetables.
ο‚— Cereals pulses, oil seeds, egg moderate sources
Macrocytic anaemia
Riboflavin
ο‚— Riboflavin is involved in many oxido reduction
reactions
ο‚— Deficiency results in inflammation of tongue
(Glossitis), Lips (cheilosis), angles of mouth (angular
stomatitis)
ο‚— Rich sources - Liver, dried yeast, egg , milk ,whole
cereals , legumes, green leafy vegetables
Angular stomatitis
Glossitis
Vitamin K
ο‚— Required for coagulation
ο‚— Deficiency results in bleeding tendency
ο‚— Bruising tendency, echymotic patches, mucous
membrane hemorrhage, internal bleeding
ο‚— Rich sources- Green leafy vegetables.
ο‚— It is also from intestinal bacterial synthesis.
Vitamin K deficiency
Iron
ο‚— Required for hemoglobin synthesis and so RBC
formation
ο‚— Deficiency results in diminished hemoglobin and so
hypochromic and microcytic anaemia
ο‚— Pregnant women should be given iron supplements
ο‚— Rich sources- meat, spinach ,dried fruit, sea food,
beans
Iron deficiency anaemia
Thank
you

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Nutrition

  • 1. Dr.S.Sethupathy, M.D.,Ph.D., Professor and Head, Division of Biochemistry,RMMC,AU
  • 2.
  • 3. Thyroid hormone ο‚— Maintains basal metabolic rate ( Resting metabolic rate) ο‚— Hypothyroidism in adults – myxedema ο‚— In New born causes cretinism – mental retardation ο‚— So Pregnant women should be screened for thyroid function
  • 4. Hypothyroid before and after Treatment
  • 5. Sedentary Moderate Heavy Physical Activity SDA RMR 50 % RMR Energyrequirements 30% RMR 40% RMR
  • 6. Protein energy malnutrition ο‚— Both protein and energy deficiency results in marasmus ο‚— Mainly protein deficiency results in kwashiorkar
  • 7.
  • 8. Overnutrition ο‚— Excess calorie intake leads to triacylglycerol accumulation in adipose tissue ο‚— Body mass index = Weight in Kg / Height in m 2 ( W/ H2 ) ο‚— Non obese 20 – 24.9 ο‚— Over weight 25 – 29.9 ο‚— Obese Gr 1 30 – 34.9 ο‚— Obese Gr 2 35 – 39.9 ο‚— Obese Gr 3 >40
  • 11. Vitamin C deficiency ο‚— Scurvy – swelling and bleeding gums, swelling of joints ο‚— Rich sources of vitamin C- Amla, lime, orange ο‚— Pickles have Vitamin C intact ο‚— Vitamin C gets easily oxidized ο‚— Only fresh fruits
  • 13. Vitamin A ο‚— Required for Vision ο‚— Deficiency results in night blindness, rough skin (Toad skin) , eye lens gets dislodged causing blindness ο‚— Rich sources- Spinach, carrot, papaya, mango,tomato
  • 14. Vitamin A deficiency- Lt eye blind
  • 16. Vitamin D ο‚— Maintains calcium absorption for bone growth ο‚— Deficiency leads to Rickets in children and osteomalacia in adults ο‚— Children – bow legs ο‚— Rich sources- fish liver oil, fish, egg yolk, milk , nuts and sunlight exposure ο‚— Morning everyday 20 mins- sunlight exposure
  • 18. Thiamine ο‚— Thiamine deficiency causes beri beri ο‚— In wet beri beri – cardiac failure ο‚— In dry beri beri – neurological manifestations ο‚— Alcoholics- commonly affected ο‚— Rich sources- rice bran, unpolished rice, whole wheat, yeast
  • 19. Wet and dry beriberi
  • 20. Niacin ο‚— Niacin deficiency causes pellagra ο‚— Features are diarrhoea, dermatitis, dementia ο‚— Necklace sign – dermatitis in sunlight exposed skin ο‚— Rich sources - Dried yeast, rice polishing, liver, peanut, whole cereals, meat and fish
  • 23. Folic acid ο‚— Folic acid is needed for RBC maturation ο‚— Prevents neural tube defect in foetus ο‚— Deficiency results in macrocytic anaemia ο‚— Pregnant women should be given folic acid supplements ο‚— Rich sources- yeast, green leafy vegetables. ο‚— Cereals pulses, oil seeds, egg moderate sources
  • 25. Riboflavin ο‚— Riboflavin is involved in many oxido reduction reactions ο‚— Deficiency results in inflammation of tongue (Glossitis), Lips (cheilosis), angles of mouth (angular stomatitis) ο‚— Rich sources - Liver, dried yeast, egg , milk ,whole cereals , legumes, green leafy vegetables
  • 28. Vitamin K ο‚— Required for coagulation ο‚— Deficiency results in bleeding tendency ο‚— Bruising tendency, echymotic patches, mucous membrane hemorrhage, internal bleeding ο‚— Rich sources- Green leafy vegetables. ο‚— It is also from intestinal bacterial synthesis.
  • 30. Iron ο‚— Required for hemoglobin synthesis and so RBC formation ο‚— Deficiency results in diminished hemoglobin and so hypochromic and microcytic anaemia ο‚— Pregnant women should be given iron supplements ο‚— Rich sources- meat, spinach ,dried fruit, sea food, beans