Slides from the presentation Lou Garrison gave on Novel Approaches to Value Assessment Within the Cost-Effectiveness Framework at the ISPOR Value Summit in Washington DC on October 19th, 2018.
Care guidelines developing clinical case reporting recommendations – pubricaPubrica
The case report guidelines were developed using a three-phase consensus process that included (1) literature research and interviews before the conference to produce items for the reporting criteria, (2) a face-to-face meeting to draught reporting guidelines and (3) post-meeting feedback, review, and pilot testing, followed by finalization of the case report guidelines.
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Reference: https://pubrica.com/services/research-services/case-report-writing/
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When you order our services, we promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Bio statistical experts | High-quality Subject Matter Experts.
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Care guidelines developing clinical case reporting recommendations – pubricaPubrica
The case report guidelines were developed using a three-phase consensus process that included (1) literature research and interviews before the conference to produce items for the reporting criteria, (2) a face-to-face meeting to draught reporting guidelines and (3) post-meeting feedback, review, and pilot testing, followed by finalization of the case report guidelines.
Learn More : https://bit.ly/3HEzHbs
Reference: https://pubrica.com/services/research-services/case-report-writing/
Why Pubrica:
When you order our services, we promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Bio statistical experts | High-quality Subject Matter Experts.
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
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United Kingdom: +44-1618186353
4th Annual Advancing the Pace of Chemical Risk AssessmentMichelle Angrish
This presentation describes how systematic review methods and tools that harness the power of artificial intelligence can be deployed a la carte depending on scoping, planning, and problem formulation.
Care guidelines developing clinical case reporting recommendations – pubricaPubrica
The case report guidelines were developed using a three-phase consensus process that included (1) literature research and interviews before the conference to produce items for the reporting criteria, (2) a face-to-face meeting to draught reporting guidelines and (3) post-meeting feedback, review, and pilot testing, followed by finalization of the case report guidelines.
Learn More : https://bit.ly/3HEzHbs
Reference: https://pubrica.com/services/research-services/case-report-writing/
Why Pubrica:
When you order our services, we promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Bio statistical experts | High-quality Subject Matter Experts.
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44-1618186353
Care guidelines developing clinical case reporting recommendations – pubricaPubrica
The case report guidelines were developed using a three-phase consensus process that included (1) literature research and interviews before the conference to produce items for the reporting criteria, (2) a face-to-face meeting to draught reporting guidelines and (3) post-meeting feedback, review, and pilot testing, followed by finalization of the case report guidelines.
Learn More : https://bit.ly/3HEzHbs
Reference: https://pubrica.com/services/research-services/case-report-writing/
Why Pubrica:
When you order our services, we promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Bio statistical experts | High-quality Subject Matter Experts.
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44-1618186353
4th Annual Advancing the Pace of Chemical Risk AssessmentMichelle Angrish
This presentation describes how systematic review methods and tools that harness the power of artificial intelligence can be deployed a la carte depending on scoping, planning, and problem formulation.
Using alternative scholarly metrics to showcase the impact of your research: ...SC CTSI at USC and CHLA
Date: Feb 7, 2018
Speaker: Caroline Muglia, Co-Associate Dean for Collections and Technical Services; and Head, Resource Sharing and Collection Assessment, USC Libraries
Overview: Scholarship is increasingly being created, disseminated, and measured on digital and social platforms. If Twitter exchanges, Facebook “saves,” and YouTube hits are the new metrics for tracking scholarship, how are we measuring societal and educational impact and outreach? How can researchers display their research impact using social media on promotion and tenure dossiers? This webinar will discuss altmetrics, alternative scholarly metrics that measure the impact and use of scholarship. We will focus on PlumX, the tool used at USC, which combines traditional and new metrics to paint a comprehensive portrait of your scholarly output and its reach in various communities and with different stakeholders.
Lecture to course on team science taught in the MS in Clinical Investigation program, Graduate School of Biomedical Sciences, University of Massachusetts Medical School.
Difference between cohort, cross sectional and case control study - Scientifi...Pubrica
In Brief:
1. Cross-sectional studies, case-control studies and cohort studies are collectively known as observational studies.
2. Observations and not interventions are carried out by the investigator.
3. This will act as a quick reference table for researchers and authors.
4. This blog tries to discuss each of the observational studies methods laying emphasis on what their strengths and weaknesses are by comparing them.
Learn More: https://pubrica.com/academy/
Contact us:
Web: https://pubrica.com/
Email: sales@pubrica.com
WhatsApp: 91 9884350006
United Kingdom: 44-1143520021
An overview of the National Institutes of Health new rules that aim to improve the rigor and reproducibility of research, especially research involving animals.
Guidelines to authors in Writing an effective Medical Case Report - Scientifi...Pubrica
Medical Case reports (or the case study or the case history) disseminate clinical practices, examines clinical scenarios, and illustrates a diagnostic or therapeutic problem experienced by one or several patients. MCRs can be from any area of medicine, nursing, dentistry, and veterinary science.
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Learn More: https://pubrica.com/services/research-services/case-report-writing/
Contact:
Web: https://pubrica.com/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United kingdom : +44-1143520021
5 Tips for Writing an Effective Case Report - In medicine, a case report is a detailed report of the signs, symptoms, diagnosis, treatment, and follow-up of an individual patient. It describes an unexpected presentation of an illness.
Writing a case report is an integral part of scientific writing
Evidence based nursing practice is one of most important for perfect and accurate in terms of saving a life.this presentation covers almost all aspect of EBD
Using alternative scholarly metrics to showcase the impact of your research: ...SC CTSI at USC and CHLA
Date: Feb 7, 2018
Speaker: Caroline Muglia, Co-Associate Dean for Collections and Technical Services; and Head, Resource Sharing and Collection Assessment, USC Libraries
Overview: Scholarship is increasingly being created, disseminated, and measured on digital and social platforms. If Twitter exchanges, Facebook “saves,” and YouTube hits are the new metrics for tracking scholarship, how are we measuring societal and educational impact and outreach? How can researchers display their research impact using social media on promotion and tenure dossiers? This webinar will discuss altmetrics, alternative scholarly metrics that measure the impact and use of scholarship. We will focus on PlumX, the tool used at USC, which combines traditional and new metrics to paint a comprehensive portrait of your scholarly output and its reach in various communities and with different stakeholders.
Lecture to course on team science taught in the MS in Clinical Investigation program, Graduate School of Biomedical Sciences, University of Massachusetts Medical School.
Difference between cohort, cross sectional and case control study - Scientifi...Pubrica
In Brief:
1. Cross-sectional studies, case-control studies and cohort studies are collectively known as observational studies.
2. Observations and not interventions are carried out by the investigator.
3. This will act as a quick reference table for researchers and authors.
4. This blog tries to discuss each of the observational studies methods laying emphasis on what their strengths and weaknesses are by comparing them.
Learn More: https://pubrica.com/academy/
Contact us:
Web: https://pubrica.com/
Email: sales@pubrica.com
WhatsApp: 91 9884350006
United Kingdom: 44-1143520021
An overview of the National Institutes of Health new rules that aim to improve the rigor and reproducibility of research, especially research involving animals.
Guidelines to authors in Writing an effective Medical Case Report - Scientifi...Pubrica
Medical Case reports (or the case study or the case history) disseminate clinical practices, examines clinical scenarios, and illustrates a diagnostic or therapeutic problem experienced by one or several patients. MCRs can be from any area of medicine, nursing, dentistry, and veterinary science.
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Learn More: https://pubrica.com/services/research-services/case-report-writing/
Contact:
Web: https://pubrica.com/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United kingdom : +44-1143520021
5 Tips for Writing an Effective Case Report - In medicine, a case report is a detailed report of the signs, symptoms, diagnosis, treatment, and follow-up of an individual patient. It describes an unexpected presentation of an illness.
Writing a case report is an integral part of scientific writing
Evidence based nursing practice is one of most important for perfect and accurate in terms of saving a life.this presentation covers almost all aspect of EBD
ACT500 Research Evaluation TablesArticle 1 Measuring Perfo.docxbobbywlane695641
ACT500: Research Evaluation Tables
Article 1: Measuring Performance
Insert reference in APA formatting, 6th ed. 4th printing
Research Topic
The topic is a broad subject. The topic is not the problem to be solved; that comes later. Example: Balanced Scorecard
Problem or Opportunity
The problem is established with factual data and is found in the introductory portion of the research article or report.
Purpose for the Research
The purpose of the study defines what the researcher wants to find out and is found in the introductory section of the research article. Sometimes the purpose contains a research question/s.
Research Methods
A researcher makes a decision about the broad nature of a research approach: typically quantitative/confirmatory or qualitative/exploratory. Research design strategies are driven by the chosen research approach and the research purpose. Research design strategies include: types of data collected, how the data is collected, and what preparation of data is used, analytical techniques, and presentation of information.
Audience
The groups, associates, profession, and/or individuals that the researcher suggests might benefit from the findings of this study
Research Evaluation
Assess the study’s Research Methods and Analytic Techniques. Are the research methods and analytic techniques applicable to solving practical management questions? Why or why not? You must substantiate your position with credible resources and examples.
Discuss how your organization might or might not use the findings from these studies. Substantiate your opinion with concrete examples.
Article 2: Incremental Analysis
Insert reference in APA formatting, 6th ed. 4th printing
Research Topic
The topic is a broad subject. The topic is not the problem to be solved; that comes later. Example: Cost Behavior
Problem or Opportunity
The problem is established with factual data and is found in the introductory portion of the research article or report.
Purpose for the Research
The purpose of the study defines what the researcher wants to find out and is found in the introductory section of the research article. Sometimes the purpose contains a research question/s.
Research Methods
A researcher makes a decision about the broad nature of a research approach: typically quantitative/confirmatory or qualitative/exploratory. Research design strategies are driven by the chosen research approach and the research purpose. Research design strategies include: types of data collected, how the data is collected, and what preparation of data is used, analytical techniques, and presentation of information.
Audience
The groups, associates, profession, and/or individuals that the researcher suggests might benefit from the findings of this study
Research Evaluation
Assess the study’s Research Methods and Analytic Techniques. Are the methods and analytic techniques applicable to solving practical management questions? Why or why not? You must substantiate your position wit.
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Part 6 Disseminating Results Create a 5-minute, 5- to 6-sli.docxsmile790243
Part 6: Disseminating Results
Create a 5-minute, 5- to 6-slide narrated PowerPoint presentation of your Evidence-Based Project:
· Be sure to incorporate any feedback or changes from your presentation submission in Module 5.
· Explain how you would disseminate the results of your project to an audience. Provide a rationale for why you selected this dissemination strategy.
Points Range: 81 (81%) - 90 (90%)
The narrated presentation accurately and completely summarizes the evidence-based project. The narrated presentation is professional in nature and thoroughly addresses all components of the evidence-based project.
The narrated presentation accurately and clearly explains in detail how to disseminate the results of the project to an audience, citing specific and relevant examples.
The narrated presentation accurately and clearly provides a justification that details the selection of this dissemination strategy that is fully supported by specific and relevant examples.
The narrated presentation provides a complete, detailed, and specific synthesis of two outside resources related to the dissemination strategy explained. The narrated presentation fully integrates at least two outside resources and two or three course-specific resources that fully support the presentation.
Written Expression and Formatting—Paragraph Development and Organization:
Paragraphs make clear points that support well-developed ideas, flow logically, and demonstrate continuity of ideas. Sentences are carefully focused—neither long and rambling nor short and lacking substance. A clear and comprehensive purpose statement and introduction is provided which delineates all required criteria.
Points Range: 5 (5%) - 5 (5%)
Paragraphs and sentences follow writing standards for flow, continuity, and clarity.
A clear and comprehensive purpose statement, introduction, and conclusion is provided which delineates all required criteria.
Written Expression and Formatting—English Writing Standards:
Correct grammar, mechanics, and proper punctuation.
Points Range: 5 (5%) - 5 (5%)
Uses correct grammar, spelling, and punctuation with no errors.
Evidenced Based Change
Leslie Hill
Walden University
Introduction/PurposeChange is inevitable.Health care organizations need change to improve.There are challenges that need to be addressed(Baraka-Johnson et al. 2019).Challenges should be addressed using evidence-based research.These changes enhance professionalism therefore improving quality of care and quality of life.The purpose of this paper is to identify an existing problem in health care and suggest a change idea that would be effective in addressing the problem. The paper also articulates risks associated with the change process, how to distribute the change information and how to implement change successfully.
Organizational CultureThe Organization is a hospice facilityOffers end of life care for pain and symptom managementThe health care providers cu.
EVIDENCE-BASED PRACTICE IN NURSING.docxHaraLakambini
-Evidence-based Practice in Nursing
-Steps of Evidence-Based Practice
-Hierarchy of Evidence | Quantitative Questions
-Elements of Evidence-Based Practice
-Nursing Research
-Types of Research
-Rights of Human Subject
-Comparison of Nursing Process with Research Process Table
-Performance Improvement in Nursing
-Examples of Performance Improvement Models
-Relationship between Evidence-Based Practice, Research, and Performance Improvement
-Similarities and Differences among Evidence-Based Practice, Research, and Performance Improvement
On 31 October 2019, Adrian Towse and Chris Henshall from the Office of Health Economics (OHE) presented at the G20 meeting on antimicrobial drugs R&D in Paris organised by the Wellcome Trust. The topic of their presentation was HTA and payment mechanisms for new drugs to tackle antimicrobial resistance.
This presentation looks at ways in which governments can set prices, including “cost plus”, value, and the external referencing of prices elsewhere. It looks at the role that competition can play in keeping down prices. In that context it briefly discusses pricing proposals being considered in Malaysia. It makes the case for using HTA to inform pricing decisions.
Adrian Towse
% GDP spending in UK, G5 countries and OECD upper middle income countries. W...Office of Health Economics
This presentation looks at rates of GDP spend on health care, distinguishing between categories of country (i.e. levels of GDP pre capita). It looks at the relationship between rates of spending and moves to universal health coverage, and explores alternative ways of increasing expenditure and making decisions about which services to provide with the money available.
The role of real world data and evidence in building a sustainable & efficien...Office of Health Economics
This presentation defines RWD and RWE in the context of digital health, and looks at potential uses for RWD and RWE. It briefly sets out the current landscape in Malaysia and looks at the challenges in using RWE. In particular, the issues of access, governance and ensuring good quality are considered.
The aim of this educational symposium was to discuss why we should seek value across the health care system and how we can apply existing research methods to measure the value of services. While considerable political attention in developed countries continues to be focused on drug spending, there is also growing awareness of the significant contribution of non-drug components of health care (e.g., hospital services and inefficient care delivery) to overall spending growth and patient affordability. At the same time, there is growing interest in making greater use of value assessment and value-based payment to control spending and better align it with care quality. In order to promote greater value, and to do so in ways that respond to the needs of payers and patients, it is essential to assess value across both drug- and non-drug interventions and health care services. This panel will offer expert viewpoints to identify and discuss gaps in value information, rationale and approaches to track and reduce system-wide low value care, and research methods for how to measure health care services.
Role Substitution, Skill Mix, and Provider Efficiency and Effectiveness : Les...Office of Health Economics
Graham participated in an organised session on Monday July 15th 2019. In the session he presented his paper with his co-author Ioannis Laliotis from the London School of Economics. The paper revisits the relationship between workforce and maternity outcomes in the English NHS in an attempt to contribute knowledge to an important policy question for which there has been a paucity of research.
This research explores the feasibility of introducing an Outcome-Based Payment approach for new cancer drugs in England. A literature review explored the current funding landscape in England, the available evidence on existing OBP schemes internationally, and
which outcomes cancer patients value most. Two focus groups and an online survey with patients and carers, as well as interviews with NHS and government stakeholders, healthcare
professionals, and pharmaceutical industry representatives, provided additional evidence on the feasibility and suitability of OBP schemes
Understanding what aspects of health and quality of life are important to peopleOffice of Health Economics
Poster presentation from the EuroQol Plenary Meeting 2019, Brussels, Belgium. By Koonal Shah, Brendan Mulhern, Patricia Cubi-Molla, Bas Janssen, and David Mott.
Koonal presented as part of an organised session on ‘moving beyond conventional economic approaches in palliative and end of life care’. He summarised the empirical evidence on the extent of pubic support for an end of life premium, before discussing some novel approaches that have been used in recent studies. His presentation was discussed by Helen Mason of Glasgow Caledonian University.
Author(s) and affiliation(s): Koonal Shah, Office of Health Economics
Event: iHEA Congress
Date: 17/07/2019
Location: Basel, Switzerland
Assessing the Life-Cycle Value Added of Second Generation Antipsychotics in S...Office of Health Economics
This research presented in a poster at HTAi 2019, Cologne (Germany) by a team of OHE and IHE researchers, estimates the value added by second generation antipsychotics over their life-cycle in the UK and Sweden. It concludes that considering the entire life-cycle, the value added by SGAs to the system is higher than the expected value estimated at launch. P&R decisions should consider how to measure, capture and take into account the value added by medicines over the long-run.
Author(s) and affiliation(s): Mikel Berdud (Office of Health Economics, London), Niklas Wallin-Bernhardsson (Institute for Health Economics, Stockholm), Bernarda Zamora (Office of Health Economics, London), Peter Lindgren (Institute for Health Economics, Stockholm), Adrian Towse (Office of Health Economics, London)
Event: HTAi 2019 Annual Meeting
Date: 18/06/2019
Location: Cologne, Germany
There is growing recognition that HTA and contracting systems for antimicrobials need to be adapted to help fight the threat of antimicrobial resistance (AMR), but there is little agreement on how. This poster reports findings from a literature review, expert interviews and face-to-face discussions at a Forum on the current HTA and payment systems for antibiotics across Europe and a number of recommendations for adapting these systems to respond to the challenges of AMR.
Author(s) and affiliation(s): Margherita Neri (OHE) Grace Hampson (OHE) Christopher Henshall (OHE visiting fellow, independent consultant) Adrian Towse (OHE)
Event: HTAi annual conference 2019
Date: 18/06/2019
Location: Cologne, Germany
Assessing the Life-cycle Value Added of Second-Generation Antipsychotics in S...Office of Health Economics
This study aims to guide access decisions and drive the discussion on access and price, through recognition of the dynamic nature of value added by pharmaceutical innovation over the long-run. The analysis of the life-cycle value of risperidone estimates the value generated in the UK and Sweden. Results show that health systems were able to appropriate most of the life-cycle value generated, and this is larger than estimated at launch.
Author(s) and affiliation(s): Mikel Berdud(1), Niklas Wallin-Bernhardsson(2), Bernarda Zamora(1), Peter Lindgren(2), and Adrian Towse(1) (1) Office of Health Economics (2) The Swedish Institute for. Health Economics
Event: XXXIX JORNADAS DE ECONOMÍA DE LA SALUD
Date: 12/06/2019
Location: Albacete, Spain
Prescribed Specialised Services (PSS) Commissioning for Quality and Innovation (CQUIN) schemes were launched in 2013 in England with the aim of improving the quality of specialised care and achieving value for money. During this presentation, Marina Rodes Sanchez described the key features of the schemes and discussed its strengths and weaknesses based on international pay-for-performance literature.
Author(s) and affiliation(s): Yan Feng, Queen Mary University of London; Søren Rud Kristensen, Imperial College London; Paula Lorgelly, King’s College London; Rachel Meacock, University of Manchester; Marina Rodes Sanchez, Office of Health Economics; Luigi Siciliani, University of York; Matt Sutton, University of Manchester
Event: XXXIX Spanish Health Economics Association Conference
Date: 12/06/2019
Location: Albacete, Spain
In this session, Meng Li sets out estimates of real option value for drugs arguing that option value matters and can be calculated. Adrian Towse sets out likely payer concerns about incorporating real option value into decision making. Meng Li responds to these concerns. Jens Grueger sets out how industry considers investment opportunities, arguing that if patients (and society) have preferences these need to be reflected in P&R decisions.
Author(s) and affiliation(s): Meng Li, Postdoctoral Research Fellow, Leonard D Schaeffer Center, University of Southern California, Los Angeles, CA, USA. Adrian Towse, Emeritus Director, Office of Health Economics, London, UK Jens Grueger, formerly Head of Global Access, Senior Vice President at F. Hoffmann-La Roche
Event: ISPOR 2019
Location: New Orleans, USA
Date: 21/05/2019
MCDA OR WEIGHTED CEA BASED ON THE QALY? WHICH IS THE FUTURE FOR HTA DECISION ...Office of Health Economics
In this ISPOR session Chuck Phelps and Adrian Towse debated the case for and against using MCDA to support HTA decision making, as compared to weighting or augmenting a QALY based ICER approach. Chuck Phelps argued for use of MCDA, Adrian Towse for weighting the QALY. Nancy Devlin set the scene and moderated.
Author(s) and affiliation(s): Nancy Devlin, Director, Centre for Health Policy, University of Melbourne, Australia Adrian Towse, Emeritus Director, Office of Health Economics, London, UK Chuck Phelps, University of Rochester, Rochester, NY USA
Event: ISPOR 2019
Location: New Orleans, USA
Date: 21/05/2019
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Novel Approaches to Value Assessment Within the Cost-Effectiveness Framework: An Introduction
1. Novel Approaches to Value Assessment
Within the Cost-Effectiveness Framework:
An Introduction
ISPOR Value Summit
Washington, D.C,
Oct. 19, 2018
Lou Garrison, PhD
The Comparative Health Outcomes, Policy, and Economics
(CHOICE) Institute
School of Pharmacy, Univ. of Washington
Seattle WA 98195
1
2. Panelists
• Lou Garrison, Ph.D., University of Washington, Seattle, WA, USA
“An introduction”
• Jeroen Jansen, PhD, Innovation and Value Initiative, Los Angeles,
CA, USA
“Moving beyond conventional cost-effectiveness analysis?”
• Nancy Devlin, PhD, Office of Health Economics, London, UK
“Extending the scope of patient-reported outcomes and QALYs”
• Susan Griffin, PhD., University of York, York, UK
“Distributional cost-effectiveness analysis (CEA)”
DISCUSSION
2
3. Overall Objective of the Special Task Force
The Special Task Force (STF) will produce a scientific
policy white paper that reviews relevant perspectives
and appropriate approaches and methods to support
the construction and use of high-quality health care
value frameworks that will enable more efficient health
sector decision-making in the US.
3
4. ISPOR Initiative on U.S. Value Assessment
Frameworks
Source: STF Final Report, Section 1 (Neumann et al, Value
Health, Feb. 2018)
5. Yes, 4
Yes, but…,
11
No, 3
N=18
83% responded “yes” but most noted
qualifications:
1. CUA contains limitations or is incomplete
(n=5)
2. CUA is one of many possible approaches
(n=3)
3. The approach must utilize appropriate
measures (n=3)
Expert Advisory Board survey question: Do you believe that cost-
utility analysis is a valid approach for measuring the value of
healthcare interventions?
Key suggested alternatives to CUA included:
• Expanded/extended/enhanced/modified CUA analysis
(n=4)
• Value assessment focused on willingness to pay (WTP)
(n=2)
• Alternatives to CUA (e.g. multi-criteria decision analysis)
(n=2)
6. ISPOR Special Task Force on
US Value Assessment Frameworks
Leadership Group
Lou Garrison, PhD (co-chair) University of Washington, Seattle, WA, USA
Peter J. Neumann, ScD (co-chair) Tufts University School of Medicine, Boston, MA, USA
Richard J. Willke, PhD (CSO) ISPOR, Lawrenceville, NJ, USA
Members
Anirban Basu, PhD, University of Washington, Seattle, WA, USA
Patricia M. Danzon, PhD The Wharton School, University of Pennsylvania, Philadelphia PA, USA
Jalpa Doshi, PhD University of Pennsylvania, Philadelphia PA, USA
Michael Drummond, MCom, DPhil University of York, York, UK
Darius Lakdawalla, PhD, University of Southern California, Los Angeles, CA, USA
Mark V. Pauly, PhD, The Wharton School, University of Pennsylvania, Philadelphia PA, USA
Charles E. Phelps, PhD, University of Rochester, Gualala, CA, USA
Scott D. Ramsey, MD, PhD University of Washington, Seattle, WA, USA
Adrian Towse, MA, MPhil Office of Health Economics, London, UK
Milton C. Weinstein, PhD Harvard University, Cambridge, MA, USA
7. ISPOR Initiative on US Value Assessment
Frameworks
STF Final Report. Feb. 2018
8. What is “Value”?
• From an economic perspective:
– Value is what someone is (actually) willing to pay or forgo
to obtain something (opportunity cost)
• Implications:
– Varies across individuals, across indications for the same
medicine, and dynamically over time (as more evidence
becomes available and competitors emerge).
– Difficult to measure in health care because of insurance
– In principle, we would ask a plan member about their
willingness to pay the incremental insurance premium (or
taxes). In practice, the amount is too small to be
estimated reliably. 8
10. Recommendation II: Base health plan coverage and
reimbursement decisions on an evaluation of the incremental
costs and benefits of healthcare technologies as is provided by
cost-effectiveness analysis.
1. Cost-per-QALY analyses
have strengths and limitations
2. Frameworks that focus on
coverage/reimbursement
should consider cost per QALY,
as a starting point
3. Consider elements not
normally included in CEAs
(e.g., severity of illness, equity,
risk protection) but more
research needed.
Source: STF Final Report Section 7 (Garrison, Neumann, et al,
Value Health, Feb. 2018)
11. STF Report Section 3: The Case for Augmented Cost-
Effectiveness Analysis and Net Monetary Benefit
12. Value
Quality-
adjusted
life-years
(QALYs)
gained
Net costs
Productivity
Adherence-
improving
factors
Reduction in
uncertainty
Fear of
contagion
Insurance
value
Severity of
disease
Value of
hope
Real option-
value
Equity
Scientific
spillovers
Green circles: core elements of value
Light blue circles: common but inconsistently used
elements of value
Dark blue circles: potential novel elements of value
Blue line: value element in traditional payer
perspective
Red line: value element also included in societal
perspective.
Potential Elements of
Value for
Augmented Cost-
Effectiveness Analysis
(ACEA)
Note on physicians: 2-3 respondents did not thing this perspective SHOULD be accounted for in CUA.
Could break up yes into two shades and include qualifications