An overview of the National Institutes of Health new rules that aim to improve the rigor and reproducibility of research, especially research involving animals.
Sharing, Reproducibility, Replication – AN NIH ViewPhilip Bourne
This document discusses challenges to rigor and transparency in scientific research reporting. It outlines principles to address underlying issues like publish or perish incentives and lack of training. The NIH is raising community awareness through workshops and endorsements of reporting principles. NIH is also piloting efforts like evaluating scientific premise in grants, developing reporting checklists, and funding replication studies. Specific to data science, the NIH discusses policies around data sharing, citation and genomic data. It presents the concept of a digital commons for computing platforms, digital objects and search/indexing to support data sharing and analysis.
Biostatistics in R : Clinical Trial applicationsAvinash Chamwad
“Biostatistics in R: Clinical Trial Applications” is an online course offered at Statistics.com. Statistics.com is the leading provider of online education in statistics, and offers over 100 courses in introductory and advanced statistics. Courses typically are taught by leading experts. Some course highlights -
A. Taught by renowned International Faculty (Not self-paced learning)
B. Instructor led and Peer learning
C. Flexible and Convenient schedule
D. Practical Application and Software skills
For more details please contact info@c-elt.com.
Website: www.india.statistics.com
This document provides an overview of a workshop on using the Cochrane Library to train health librarians. The workshop covers introductions, an overview of Cochrane and systematic reviews, a demonstration of searching the Cochrane Library database, and small group work. Participants learn about finding and critically appraising systematic reviews to help inform evidence-based healthcare practices and decisions.
The document provides guidance on selecting evidence-based medicine tools and resources for clinicians. It recommends keeping resources simple, focusing on those that are free or accessible at the point of care. Primary research sites like PubMed and specialized databases like Cochrane and National Guideline Clearinghouse are suggested as starting places. When formulating questions, a systematic search process including guidelines, reviews and primary studies is outlined.
The Cochrane Library is a collection of databases that provides high-quality, systematic reviews of the effects of healthcare interventions. It contains the Cochrane Database of Systematic Reviews, which summarizes conclusions about the effectiveness of interventions based on empirical evidence. Cochrane Reviews are considered the gold standard for systematic reviews because they are conducted to the highest methodological quality and updated regularly. The Cochrane Library also includes databases of controlled trials, reviews of other systematic reviews, methodology research, and economic evaluations to inform evidence-based healthcare decisions.
ProQuest Medical Library provides access to authoritative medical databases and resources. It contains full-text journals and doctoral dissertations across medicine, nursing, allied health, psychology, and health administration. The databases include MEDLINE, Health & Medical Complete, Nursing & Allied Health Source, Psychology Journals, and Health Management, which cover key subjects and include journals with high impact factors. ProQuest Medical Library offers a comprehensive collection of important medical titles and other complementary resources to support research.
This document provides an overview of resources for searching for medical and health-related information. It introduces the Queen Mary University library website and search tools, as well as healthcare-specific search engines like Medline Plus and Evidence Search that search across high-quality web resources. It also describes medical databases like PubMed, Web of Science, and Scopus that contain vast collections of published research articles and references. Strategies for broadening and narrowing database searches are also discussed.
This document discusses systematic reviews and meta-analyses. It provides information on Number Needed to Treat (NNT) and Number Needed to Harm (NNH). It also discusses how to set up a protocol for a systematic review, including determining study design, selection criteria, treatment arms and statistical considerations. The Cochrane Collaboration is mentioned as performing systematic reviews and meta-analyses to evaluate healthcare interventions.
Sharing, Reproducibility, Replication – AN NIH ViewPhilip Bourne
This document discusses challenges to rigor and transparency in scientific research reporting. It outlines principles to address underlying issues like publish or perish incentives and lack of training. The NIH is raising community awareness through workshops and endorsements of reporting principles. NIH is also piloting efforts like evaluating scientific premise in grants, developing reporting checklists, and funding replication studies. Specific to data science, the NIH discusses policies around data sharing, citation and genomic data. It presents the concept of a digital commons for computing platforms, digital objects and search/indexing to support data sharing and analysis.
Biostatistics in R : Clinical Trial applicationsAvinash Chamwad
“Biostatistics in R: Clinical Trial Applications” is an online course offered at Statistics.com. Statistics.com is the leading provider of online education in statistics, and offers over 100 courses in introductory and advanced statistics. Courses typically are taught by leading experts. Some course highlights -
A. Taught by renowned International Faculty (Not self-paced learning)
B. Instructor led and Peer learning
C. Flexible and Convenient schedule
D. Practical Application and Software skills
For more details please contact info@c-elt.com.
Website: www.india.statistics.com
This document provides an overview of a workshop on using the Cochrane Library to train health librarians. The workshop covers introductions, an overview of Cochrane and systematic reviews, a demonstration of searching the Cochrane Library database, and small group work. Participants learn about finding and critically appraising systematic reviews to help inform evidence-based healthcare practices and decisions.
The document provides guidance on selecting evidence-based medicine tools and resources for clinicians. It recommends keeping resources simple, focusing on those that are free or accessible at the point of care. Primary research sites like PubMed and specialized databases like Cochrane and National Guideline Clearinghouse are suggested as starting places. When formulating questions, a systematic search process including guidelines, reviews and primary studies is outlined.
The Cochrane Library is a collection of databases that provides high-quality, systematic reviews of the effects of healthcare interventions. It contains the Cochrane Database of Systematic Reviews, which summarizes conclusions about the effectiveness of interventions based on empirical evidence. Cochrane Reviews are considered the gold standard for systematic reviews because they are conducted to the highest methodological quality and updated regularly. The Cochrane Library also includes databases of controlled trials, reviews of other systematic reviews, methodology research, and economic evaluations to inform evidence-based healthcare decisions.
ProQuest Medical Library provides access to authoritative medical databases and resources. It contains full-text journals and doctoral dissertations across medicine, nursing, allied health, psychology, and health administration. The databases include MEDLINE, Health & Medical Complete, Nursing & Allied Health Source, Psychology Journals, and Health Management, which cover key subjects and include journals with high impact factors. ProQuest Medical Library offers a comprehensive collection of important medical titles and other complementary resources to support research.
This document provides an overview of resources for searching for medical and health-related information. It introduces the Queen Mary University library website and search tools, as well as healthcare-specific search engines like Medline Plus and Evidence Search that search across high-quality web resources. It also describes medical databases like PubMed, Web of Science, and Scopus that contain vast collections of published research articles and references. Strategies for broadening and narrowing database searches are also discussed.
This document discusses systematic reviews and meta-analyses. It provides information on Number Needed to Treat (NNT) and Number Needed to Harm (NNH). It also discusses how to set up a protocol for a systematic review, including determining study design, selection criteria, treatment arms and statistical considerations. The Cochrane Collaboration is mentioned as performing systematic reviews and meta-analyses to evaluate healthcare interventions.
This document provides guidance on conducting an effective literature search, including:
- Breaking the research question into key concepts using the PICO framework to guide the search
- Identifying synonyms and related terms to broaden search results
- Considering the appropriate level of evidence needed to answer the research question
- Using systematic search techniques that combine subject headings and keywords across multiple databases
- Tips for refining searches such as applying limits, expanding, or narrowing the search strategy based on results
This document discusses academic writing and referencing. It introduces plagiarism and how to avoid it using citations and references. Formatting guidelines are provided for different types of references, including books, book chapters, and journal articles. Students are instructed to use EndNote software to organize their references and generate in-text citations and bibliographies in Word documents. Activities are outlined for students to practice identifying reference elements, entering references into EndNote, and using EndNote's "Cite While You Write" function with a provided exercise.
SSC in Evidence Based Medicine - Internet resources PaulaFunnell
This document provides guidance on different categories of internet sources for medical information. It discusses web search engines that search across high-quality medical websites. It also describes electronic databases that contain large collections of published research references that can be filtered and searched. Finally, it outlines clinical summary resources that synthesize evidence from primary research and present it concisely.
The document discusses the challenges of information overload and reviewer workload in systematic reviews. It notes that the number of trials and systematic reviews published per day has increased dramatically since 1979, from 14 trials per day to 130 trials per day and from 52 systematic reviews per day. Potential solutions proposed include providing more support for methodology research, improving retrievability and linkages between trials and reviews, addressing language barriers, and minimizing bias and optimizing use of reviews. The document also calls for more machine-friendly reporting standards to help with data mining and re-use of research.
The Cochrane Library is a collection of six healthcare databases that contain different types of evidence including Cochrane Reviews (systematic reviews), clinical trials, methodology studies, health technology assessments, and economic evaluations to inform healthcare decision making. It allows users to browse or search across databases, read editorials and special collections, listen to podcasts, and access the Cochrane Journal Club.
Clinical Microbiology - searching for informationPaulaFunnell
This document provides an introduction to searching for medical information through the Queen Mary University library website and various databases and search tools. It outlines key learning objectives around using the library website, searching online for quality health information, and effectively using medical databases and EndNote. Specific databases and search engines introduced include Evidence Search, TRIP, MEDLINE, Web of Science, Scopus, and The Cochrane Library. Search techniques like broadening terms, narrowing searches, phrase searching, and subject headings are also covered.
Presentation to Brighton and Sussex NHS Library and Knowledge Service Journal Club on Rethlefsen ML, Farrell AM, Osterhaus Trzasko LC, Brigham TJ. Librarian
co-authors correlated with higher quality reported search strategies in general
internal medicine systematic reviews. J Clin Epidemiol. 2015 Jun;68(6):617-26.
Keck Year 2 Evidence Based Medicine - Systematic Reviewslynnkysh
This document distinguishes systematic reviews from standard literature reviews and introduces systematic reviews and meta-analyses. It provides definitions, goals, components, authorship requirements, time commitments, and value of systematic reviews compared to standard literature reviews. The document also reviews how to locate reviews, systematic reviews, and meta-analyses in PubMed and introduces the Cochrane Database of Systematic Reviews.
Using alternative scholarly metrics to showcase the impact of your research: ...SC CTSI at USC and CHLA
Date: Feb 7, 2018
Speaker: Caroline Muglia, Co-Associate Dean for Collections and Technical Services; and Head, Resource Sharing and Collection Assessment, USC Libraries
Overview: Scholarship is increasingly being created, disseminated, and measured on digital and social platforms. If Twitter exchanges, Facebook “saves,” and YouTube hits are the new metrics for tracking scholarship, how are we measuring societal and educational impact and outreach? How can researchers display their research impact using social media on promotion and tenure dossiers? This webinar will discuss altmetrics, alternative scholarly metrics that measure the impact and use of scholarship. We will focus on PlumX, the tool used at USC, which combines traditional and new metrics to paint a comprehensive portrait of your scholarly output and its reach in various communities and with different stakeholders.
This document provides an overview of several databases for finding evidence-based medical information, including the Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effects (DARE), PubMed Clinical Queries, and ACP PIER in STAT!Ref. It describes the types of information contained in each database, such as systematic reviews and meta-analyses, and how to access them through the UMKC Health Sciences Library website.
This document discusses sources of evidence for evidence-based practice. It outlines traditional sources such as textbooks and colleagues as well as evidence-based practice sources. Primary sources include original peer-reviewed papers that can be searched through databases like PubMed. Secondary sources provide synthesized research through systematic reviews and guidelines. Examples given are evidence-based journals, The Cochrane Library, and TRIP Database. A structured approach to database searching is also outlined, including developing a focused question and using keywords, subject headings, and Boolean operators to efficiently search literature.
This document provides an orientation for nursing students on resources available from the library to help with research. It outlines ways to get research help from the library, how to focus a topic and use keywords, details on the Cochrane Library and types of evidence-based articles it contains, effective web searching techniques, and a brief overview of APA citation style.
Presentation slides on Open Science and research reproducibility. Presented by Gareth Knight (LSHTM Research Data Manager) on 18th September 2018, as part of an Open Science event for LSHTM Week 2018.
4th Annual Advancing the Pace of Chemical Risk AssessmentMichelle Angrish
Michelle Angrish presented on using systematic review methods and tools to evaluate new approach methods (NAMs). She described the systematic review workflow, including problem formulation, literature screening and tagging, data extraction, and interactive displays of evidence. She provided a case study on using these methods to identify potential developmental toxicants from the zebrafish literature, which would then be evaluated in mammalian studies. Machine learning tools could help prioritize large amounts of literature and identify relevant studies for further review. Integrating systematic review data with adverse outcome pathway ontologies may help map review findings.
Identifying and tracking research resources using RRIDs: a practical approachdkNET
At this presentation, you will learn (1) Why you need to use Research Resource identifier (RRID) (2) What is Resource Identification Initiative (3) How dkNET.org supports RRID (4) What can you do with RRID
Chandra Shekhar Banerjee successfully completed an online course through Coursera titled "The Data Scientist’s Toolbox" offered by Johns Hopkins University. The course provided an overview of the conceptual ideas and practical tools used by data analysts and scientists such as version control, markdown, git, GitHub, R, and RStudio. It was instructed by Jeffrey Leek, Roger D. Peng, and Brian Caffo of the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health. The statement of accomplishment does not reflect the entire curriculum offered to students enrolled at Johns Hopkins University.
This document outlines the process for conducting a systematic review. It begins by defining a systematic review as a review of research on a clearly formulated question that uses explicit and reproducible methods. It notes systematic reviews aim to identify, appraise, and synthesize all high-quality research evidence relevant to that question. The document then discusses why systematic reviews are important for summarizing evidence, limiting bias, and avoiding errors. It provides examples of how systematic reviews can help establish evidence-based practices. Finally, it describes the typical steps involved in conducting a systematic review, from developing a question to interpreting results.
The document discusses the role of an informationist in supporting clinical research teams. It describes how an informationist was integrated into a breast cancer screening study to improve communication within the team about data, articulate technology issues, and enhance the information skills of team members. The informationist developed resources like a data dictionary, conducted literature reviews, and assisted with systematic reviews and knowledge management. The document also discusses how an informationist provided consultation, collaboration, and dissemination services to a community engagement research group by developing best practices guides, tools for knowledge sharing, and measuring research impact.
Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to KnowLorie Kloda
Librarians can play important roles in supporting systematic reviews and knowledge syntheses by conducting comprehensive literature searches, developing search strategies, managing references, and acquiring the necessary skills through training. As the number of systematic reviews and syntheses grows, standards and guidelines have been developed for conducting reviews. Agencies that fund reviews also recommend or require the involvement of a librarian with the appropriate competencies to support the review process.
The document discusses the importance of ARRIVE guidelines for reporting animal research. ARRIVE guidelines were developed to improve the quality and transparency of reporting preclinical studies involving animals. They consist of a 20-item checklist researchers should include covering topics like the study title/abstract, introduction/objectives, methods, results, and discussion. Following ARRIVE guidelines increases the validity and usefulness of research for guiding future studies and systematic reviews.
This document provides an overview of clinical trials, including definitions, types of research, ethics considerations, trial design, and data management and analysis. It defines clinical trials as research studies that prospectively assign participants to interventions to evaluate health outcomes. Key points include that clinical trials have various phases and are regulated by organizations like the WHO, NIH, and IRB to ensure ethics standards around informed consent and protecting vulnerable groups. Randomization and control groups are discussed as important design aspects, as is the role of sponsors. Data collection, grading scales, statistical analysis, and presenting results are covered as important parts of the research process.
This document provides guidance on conducting an effective literature search, including:
- Breaking the research question into key concepts using the PICO framework to guide the search
- Identifying synonyms and related terms to broaden search results
- Considering the appropriate level of evidence needed to answer the research question
- Using systematic search techniques that combine subject headings and keywords across multiple databases
- Tips for refining searches such as applying limits, expanding, or narrowing the search strategy based on results
This document discusses academic writing and referencing. It introduces plagiarism and how to avoid it using citations and references. Formatting guidelines are provided for different types of references, including books, book chapters, and journal articles. Students are instructed to use EndNote software to organize their references and generate in-text citations and bibliographies in Word documents. Activities are outlined for students to practice identifying reference elements, entering references into EndNote, and using EndNote's "Cite While You Write" function with a provided exercise.
SSC in Evidence Based Medicine - Internet resources PaulaFunnell
This document provides guidance on different categories of internet sources for medical information. It discusses web search engines that search across high-quality medical websites. It also describes electronic databases that contain large collections of published research references that can be filtered and searched. Finally, it outlines clinical summary resources that synthesize evidence from primary research and present it concisely.
The document discusses the challenges of information overload and reviewer workload in systematic reviews. It notes that the number of trials and systematic reviews published per day has increased dramatically since 1979, from 14 trials per day to 130 trials per day and from 52 systematic reviews per day. Potential solutions proposed include providing more support for methodology research, improving retrievability and linkages between trials and reviews, addressing language barriers, and minimizing bias and optimizing use of reviews. The document also calls for more machine-friendly reporting standards to help with data mining and re-use of research.
The Cochrane Library is a collection of six healthcare databases that contain different types of evidence including Cochrane Reviews (systematic reviews), clinical trials, methodology studies, health technology assessments, and economic evaluations to inform healthcare decision making. It allows users to browse or search across databases, read editorials and special collections, listen to podcasts, and access the Cochrane Journal Club.
Clinical Microbiology - searching for informationPaulaFunnell
This document provides an introduction to searching for medical information through the Queen Mary University library website and various databases and search tools. It outlines key learning objectives around using the library website, searching online for quality health information, and effectively using medical databases and EndNote. Specific databases and search engines introduced include Evidence Search, TRIP, MEDLINE, Web of Science, Scopus, and The Cochrane Library. Search techniques like broadening terms, narrowing searches, phrase searching, and subject headings are also covered.
Presentation to Brighton and Sussex NHS Library and Knowledge Service Journal Club on Rethlefsen ML, Farrell AM, Osterhaus Trzasko LC, Brigham TJ. Librarian
co-authors correlated with higher quality reported search strategies in general
internal medicine systematic reviews. J Clin Epidemiol. 2015 Jun;68(6):617-26.
Keck Year 2 Evidence Based Medicine - Systematic Reviewslynnkysh
This document distinguishes systematic reviews from standard literature reviews and introduces systematic reviews and meta-analyses. It provides definitions, goals, components, authorship requirements, time commitments, and value of systematic reviews compared to standard literature reviews. The document also reviews how to locate reviews, systematic reviews, and meta-analyses in PubMed and introduces the Cochrane Database of Systematic Reviews.
Using alternative scholarly metrics to showcase the impact of your research: ...SC CTSI at USC and CHLA
Date: Feb 7, 2018
Speaker: Caroline Muglia, Co-Associate Dean for Collections and Technical Services; and Head, Resource Sharing and Collection Assessment, USC Libraries
Overview: Scholarship is increasingly being created, disseminated, and measured on digital and social platforms. If Twitter exchanges, Facebook “saves,” and YouTube hits are the new metrics for tracking scholarship, how are we measuring societal and educational impact and outreach? How can researchers display their research impact using social media on promotion and tenure dossiers? This webinar will discuss altmetrics, alternative scholarly metrics that measure the impact and use of scholarship. We will focus on PlumX, the tool used at USC, which combines traditional and new metrics to paint a comprehensive portrait of your scholarly output and its reach in various communities and with different stakeholders.
This document provides an overview of several databases for finding evidence-based medical information, including the Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effects (DARE), PubMed Clinical Queries, and ACP PIER in STAT!Ref. It describes the types of information contained in each database, such as systematic reviews and meta-analyses, and how to access them through the UMKC Health Sciences Library website.
This document discusses sources of evidence for evidence-based practice. It outlines traditional sources such as textbooks and colleagues as well as evidence-based practice sources. Primary sources include original peer-reviewed papers that can be searched through databases like PubMed. Secondary sources provide synthesized research through systematic reviews and guidelines. Examples given are evidence-based journals, The Cochrane Library, and TRIP Database. A structured approach to database searching is also outlined, including developing a focused question and using keywords, subject headings, and Boolean operators to efficiently search literature.
This document provides an orientation for nursing students on resources available from the library to help with research. It outlines ways to get research help from the library, how to focus a topic and use keywords, details on the Cochrane Library and types of evidence-based articles it contains, effective web searching techniques, and a brief overview of APA citation style.
Presentation slides on Open Science and research reproducibility. Presented by Gareth Knight (LSHTM Research Data Manager) on 18th September 2018, as part of an Open Science event for LSHTM Week 2018.
4th Annual Advancing the Pace of Chemical Risk AssessmentMichelle Angrish
Michelle Angrish presented on using systematic review methods and tools to evaluate new approach methods (NAMs). She described the systematic review workflow, including problem formulation, literature screening and tagging, data extraction, and interactive displays of evidence. She provided a case study on using these methods to identify potential developmental toxicants from the zebrafish literature, which would then be evaluated in mammalian studies. Machine learning tools could help prioritize large amounts of literature and identify relevant studies for further review. Integrating systematic review data with adverse outcome pathway ontologies may help map review findings.
Identifying and tracking research resources using RRIDs: a practical approachdkNET
At this presentation, you will learn (1) Why you need to use Research Resource identifier (RRID) (2) What is Resource Identification Initiative (3) How dkNET.org supports RRID (4) What can you do with RRID
Chandra Shekhar Banerjee successfully completed an online course through Coursera titled "The Data Scientist’s Toolbox" offered by Johns Hopkins University. The course provided an overview of the conceptual ideas and practical tools used by data analysts and scientists such as version control, markdown, git, GitHub, R, and RStudio. It was instructed by Jeffrey Leek, Roger D. Peng, and Brian Caffo of the Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health. The statement of accomplishment does not reflect the entire curriculum offered to students enrolled at Johns Hopkins University.
This document outlines the process for conducting a systematic review. It begins by defining a systematic review as a review of research on a clearly formulated question that uses explicit and reproducible methods. It notes systematic reviews aim to identify, appraise, and synthesize all high-quality research evidence relevant to that question. The document then discusses why systematic reviews are important for summarizing evidence, limiting bias, and avoiding errors. It provides examples of how systematic reviews can help establish evidence-based practices. Finally, it describes the typical steps involved in conducting a systematic review, from developing a question to interpreting results.
The document discusses the role of an informationist in supporting clinical research teams. It describes how an informationist was integrated into a breast cancer screening study to improve communication within the team about data, articulate technology issues, and enhance the information skills of team members. The informationist developed resources like a data dictionary, conducted literature reviews, and assisted with systematic reviews and knowledge management. The document also discusses how an informationist provided consultation, collaboration, and dissemination services to a community engagement research group by developing best practices guides, tools for knowledge sharing, and measuring research impact.
Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to KnowLorie Kloda
Librarians can play important roles in supporting systematic reviews and knowledge syntheses by conducting comprehensive literature searches, developing search strategies, managing references, and acquiring the necessary skills through training. As the number of systematic reviews and syntheses grows, standards and guidelines have been developed for conducting reviews. Agencies that fund reviews also recommend or require the involvement of a librarian with the appropriate competencies to support the review process.
The document discusses the importance of ARRIVE guidelines for reporting animal research. ARRIVE guidelines were developed to improve the quality and transparency of reporting preclinical studies involving animals. They consist of a 20-item checklist researchers should include covering topics like the study title/abstract, introduction/objectives, methods, results, and discussion. Following ARRIVE guidelines increases the validity and usefulness of research for guiding future studies and systematic reviews.
This document provides an overview of clinical trials, including definitions, types of research, ethics considerations, trial design, and data management and analysis. It defines clinical trials as research studies that prospectively assign participants to interventions to evaluate health outcomes. Key points include that clinical trials have various phases and are regulated by organizations like the WHO, NIH, and IRB to ensure ethics standards around informed consent and protecting vulnerable groups. Randomization and control groups are discussed as important design aspects, as is the role of sponsors. Data collection, grading scales, statistical analysis, and presenting results are covered as important parts of the research process.
The ARRIVE guidelines were created by the National Centre for the Replacement, Refinement and Reduction of Animals in Research to improve reporting standards for preclinical studies. The guidelines provide a checklist of essential information to include in preclinical study manuscripts, such as the species, strain and characteristics of animals used, experimental methods, results with measures of precision, and implications for the 3Rs of animal research. While some items may not apply to all studies, the checklist aims to promote transparent, accurate and reproducible reporting of preclinical research.
FAIRness and Accountability BioIT 2019 FAIR trackHelena Deus
1. The document discusses fairness and accountability in health care data, specifically addressing expectations versus reality in making data FAIR (Findable, Accessible, Interoperable, Reusable).
2. It notes that for data to be truly FAIR, scientists must be equipped with the proper legal, technological and incentive tools to do so, and there needs to be agreement on what expectations of FAIR mean.
3. The document argues that while FAIR is important, it is not enough for health data - data access and usage policies must also be addressed to ensure appropriate data sharing and protection of privacy.
JALA Editor-in-Chief Edward Kai-Hua Chow, Ph.D., of National University of Singapore shared step-by-step advice on how to design and write scientific research papers more clearly and effectively to improve their chances for successful publication at the recently held conference in Washington, DC. Learn what editors want, what they don't want and how reviewers evaluate manuscripts by reviewing slides from the session.
The document discusses evidence-based practice (EBP) and outlines the key steps in the EBP process. It defines EBP as integrating the best available research evidence, clinical expertise, and patient values. The 6 essential steps are: 1) ask, 2) acquire, 3) appraise, 4) apply, 5) audit, and 6) disseminate results. Higher levels of evidence like systematic reviews and randomized controlled trials provide stronger evidence than expert opinion. The document also reviews study designs and databases for finding evidence.
Efforts to place the patient at the center of medical research, spurred by the Affordable Care Act’s founding of the Patient Centered Outcomes Research Institute, have begun to change the way clinical research is conceptualized and conducted. Such efforts hold great promise, but also raise potential challenges for ethical oversight. How should oversight bodies approach the presence of patients in potentially unfamiliar research roles, such as investigator? What forms of patient involvement in research, if any, warrant increased scrutiny from oversight bodies? How do we keep the patient voice from being ‘captured’ by special interest groups? This symposium brought together a diverse group of patients and community members, policymakers, bioethicists, and regulatory officials to address these and other issues.
Digital Scholar Webinar: Transparent, Open, and Reproducible ResearchSC CTSI at USC and CHLA
This document discusses transparent, open, and reproducible research. It summarizes several replication studies that attempted to replicate experiments from psychology, economics, and social science journals. The replication rates varied between 33-66% for significant effects in the same direction as the original. Effect sizes were typically smaller in the replications. The document argues that the scientific system, including incentives and norms, contributes to limited replicability. Open science practices like registered reports and preprints are presented as solutions to improve transparency and accelerate discovery.
This document describes a collaboration between Findacure, a UK charity focused on rare diseases, and Elsevier to mobilize informational resources for congenital hyperinsulinism (CHI), a rare genetic disease. Elsevier will provide Findacure access to its extensive literature database and text mining capabilities to summarize what is known about CHI mechanisms, identify potential drug targets, and find approved drugs that may treat CHI. The collaboration aims to support Findacure's efforts to drive research, develop treatments, and help patients by providing structured, analyzed information extracted from Elsevier's literature and linking researchers and institutions working on CHI.
This document discusses the categorization and review of quality improvement (QI) projects by Institutional Review Boards (IRBs). It defines key terms like research and QI. It describes how QI projects fall on a continuum between clinical practice and clinical research. The document outlines the different levels of IRB review including exempt, expedited and full board review based on the level of risk. It discusses current controversies around the appropriate role and scope of IRB review for QI projects. A case study of a QI project that was initially deemed exempt but later required further IRB review is also summarized.
This document summarizes a presentation about publishing research data with Scientific Data. It discusses the benefits of sharing research data, including generating more analyses and reuse. It outlines Scientific Data's process for publishing Data Descriptors, which include both human-readable articles and machine-readable metadata. Data Descriptors can be published at any point in the research process. The presentation notes that Data Descriptors provide credit for data generators, enable discovery and reuse of data, and have resulted in data being cited and reused in different fields and by the public.
The Department of Health and Human Services has approved a study proposed by MAPS to research the effects of smoked or vaporized marijuana on 50 veterans with treatment-resistant PTSD. The review committee noted improvements made to the study including modifications to improve subject safety and additional information provided about the research team. Based on these changes, the committee has cleared the study to purchase research-grade marijuana from NIDA. The committee encourages MAPS to consider further suggestions to strengthen the study such as redefining "treatment resistant", employing an independent entity for data management and analysis, and simplifying the study protocol.
Presentation at Rare Disease conference in San-AntonioAnton Yuryev
Elsevier has significantly reduced the cost of drug development for rare diseases through drug repurposing. They have brought together knowledge about drug targets, effects, and disease biology to identify drugs and nutraceuticals approved by the FDA that could potentially be repositioned to treat rare diseases, eliminating the need for new drug development and clinical trials. Using automated queries of Elsevier knowledgebases, they can provide summaries of potential treatments for a given rare disease, including key researchers and institutions, relevant drug targets, and approved drugs that may be effective - reducing the cost of repositioning existing drugs to under $500,000.
Citations—often termed as intellectual transactions, acknowledgment of intellectual debts, and conceptual association—are a link between the author’s current study and already published work. It not only provides credibility to the author’s work but also helps funders evaluate the impact of the research study. Citation indexes are maintained for information retrieval of both cited and citing work, facilitating the literature search process. It also helps authors in identifying the number of citations that their papers have received. Citation data is considered as a legitimate measure to rank authors, journals, and publishers. Through this webinar, we aim to provide information about citation indexing and how authors and publishers can get indexed in established citation databases.
PLOS Biology is launching a new section focused on meta-research to increase transparency in biosciences research. Meta-research examines issues related to research design, methods, reporting, evaluation and rewards. This will include exploring sources of bias, data sharing standards, and assessment metrics. Registered Reports will also be introduced, which accept studies for publication based on proposed methods rather than results, reducing bias against negative findings. However, most research data is lost within 10-15 years, highlighting the need for improved data sharing policies to maximize the value of research findings.
Search Concepts, Methods, Resources, and ToolsJohn Pell
These are slides I used for a presentation to a group of graduate students about to undertake their field work for their capstone project in public health. The aim of the presentation was to provide guidance for topic selection, developing research questions, creating search strategies, conducting searches, and managing search results. The concepts and and methods are informed by standards for systematic review but are presented at a more general and less rigorous level.
This document discusses clinical data publishing at Scientific Data. It describes how data descriptors for clinical studies have both human-readable and machine-readable components. It also notes that while clinical researchers generally support sharing clinical trial data, they have specific concerns about patient privacy. Examples of initiatives that enable controlled access to clinical data, like Yale Open Data Access, are provided. The document discusses Scientific Data's aim to identify repositories that can archive clinical data and facilitate specialist peer review while maintaining privacy. It also references guidance on publishing descriptions of non-public clinical datasets.
Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...CTSI at UCSF
Overview of UCSF-CTSI Comparative Effectiveness Large Dataset Analysis Core with emphasis on large, public data sets for studying the health of adults and the care they receive.
Similar to NIH rigor and reproducibility.use of animals in research.msu 2.16 (20)
This document summarizes a new faculty research orientation breakout session at MSU. It discusses MSU's focus on interdisciplinary global research through its international centers and programs. Charts show MSU's international research awards by theme from 2007-2016 and engagement by region from 2006-2015, with most projects in Africa and Asia. It promotes building international partnerships in research to achieve MSU's vision as a World Grant university.
This document provides an overview and introduction for new faculty attending a research orientation at Michigan State University. It discusses the importance and expectations of research at MSU, as well as resources and support available to faculty researchers. Key points include:
- MSU aims to have world-class research programs that address today's problems and advance knowledge. Research is important for education, outreach, and attracting top students and faculty.
- Faculty are expected to actively pursue research excellence and funding, publish in top journals, involve students, and use resources like the libraries and Office of Research and Graduate Studies for support.
- The document reviews compliance requirements and resources for topics like animal and human subjects research, as well as how to report
This document discusses scaling up data in digital agriculture from small plot studies to entire fields and landscapes. It presents data on grain yield and nitrogen levels in soil from studies of continuous corn and corn-soybean-wheat crop rotations. The document also mentions the use of variable corn hybrids and virtual reality technologies in digital agriculture and acknowledges the contributions of the author's lab and funding sources.
This study investigated using MRI and liver contrast agent uptake to detect diabetes and pre-diabetes. Three groups of mice (normal controls, mild diabetes model ob/ob mice, and OATP transporter knockout mice) underwent MRI before and after injection of Eovist, Multihance, or Magnevist (negative control). Eovist and Multihance showed greater liver enhancement in controls compared to ob/ob and knockout mice, indicating reduced hepatic transporter levels in diabetes models. Additionally, ob/ob mice had decreased liver clearance and increased kidney levels of Eovist and Multihance, corresponding to lower hepatic OATP expression. Therefore, MRI of liver contrast agent uptake has potential to noninvas
Advanced Genome Engineering Services and Transgenic Model Generation
at MSU’s Transgenic and Genome Editing Facility
Huirong Xie, Elena Demireva, Nate Kauffman, Richard Neubig
This document summarizes challenges in developing an automated system for detecting and quantifying transplanted cells in MRI scans. Key challenges include determining the optimal classification unit and feature representation for identifying spots corresponding to transplanted cells, and developing methods to train machine learning models using only small amounts of labeled training data. The authors contribute a labeled MRI database of over 20,000 manual labels, and present results showing their system can detect transplanted cells in MRI scans with up to 97.3% accuracy in vivo and 99.8% in vitro using transfer learning to train on a small subset of labeled data.
The document provides information on re-budgeting awards and viewing/updating report tracking in KC. It outlines the steps to re-budget an award, including searching for an award, creating a new budget version, and submitting budget revisions. It also describes how to search award report tracking by PI or award, view report details, and update the report preparer, status, and other fields. Users are encouraged to practice these steps using the provided classroom exercises.
The document provides instructions for creating budgets in KC, Kansas City's grants management system. It discusses setting up budget parameters such as periods, rates, and personnel. Users can generate expenses across periods, add line items for personnel and non-personnel expenses, and view summaries of period and project totals. The process aims to simplify budget creation while ensuring compliance with sponsor requirements.
This document provides instructions for generating institutional proposals, editing institutional proposal records, creating and updating negotiations, and verifying COI compliance and training in Kuali Coeus. It describes how to generate an institutional proposal when a proposal development document is submitted, and the options for generating new or versioning existing proposals depending on the proposal type. It also outlines how to edit institutional proposal records to correct data, create negotiation documents to track proposal activities, and update negotiation documents with new activities.
The document provides instructions for creating proposals in the KC system at Michigan State University. It discusses the key steps, which include selecting the proposal type and lead unit, adding required information like the project title and dates, assigning permissions to other users, completing sponsor and program details, linking to Grants.gov opportunities, and adding key personnel. The document emphasizes that at least one person should be assigned the aggregator role in addition to the creator, and that the narrative writer role is recommended for PIs.
Back to the Future: Plastics from Plants and Cars that Run on Electricity, presented by Thomas Gregory, owner/consultant for Borealis Technology Solutions at the Michigan State University Bioeconomy Institute on 10-12-16.
Arend Hintze, Department of Integrative Biology, Department of Computer Science and Engineering, and BEACON Center for the Study of Evolution in Action at Michigan State University, presents his computational analysis of evolutionary processes at the Michigan State University Bioeconomy Institute on 10-12-16.
Domicology aims to change the construction management paradigm by focusing on community and economic development through the deconstruction and reuse of materials from abandoned homes. The document discusses how domicology shifts the focus from new construction to maximizing the value of existing building materials in the supply chain. It notes that the upper Great Lakes region has an abundance of lower-value materials available from the estimated 264,660 vacant homes that could provide over 1.5 billion board feet of lumber and $3.45 billion worth of reclaimed materials. The document also examines the need for further research on markets for difficult to reuse materials and optimal transportation and shipping methods to facilitate reuse under the new domicology paradigm.
Domicology is the study of the economic, social, and environmental factors relating to the life cycle of structures, from planning and construction to reuse, abandonment, demolition, and material reuse. Domicologists seek to identify innovative tools and policies to address challenges with structural abandonment in a sustainable way and reduce the negative impacts of abandoned properties. Currently, the public sector bears the burden and costs of cleaning up abandoned structures, but domicology proposes an alternative paradigm where the private sector incorporates financial assurances into construction to fund future deconstruction, returning the parcel to its original state without blight or costs to taxpayers.
The document discusses advancing the field of domicology, which is the study of policies and practices around structural abandonment, for more sustainable construction. Currently, demolition is the preferred solution when structures are abandoned, but this creates large amounts of waste and pollution. Alternative solutions like refurbishing and retrofitting abandoned structures are more sustainable but require new strategies and best practices. Research is needed to develop techniques for reuse, recycling, and life cycle cost modeling to incorporate the impacts of abandonment and demolition. Advancing solutions in domicology is key to achieving overall sustainability in construction.
Presentation by Michaela TerAvest, assistant professor of Biochemistry and Molecular Biology at Michigan State University, at the MSU Bioeconomy Institute in Holland, Mich., on Mar. 16, 2016.
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
This report explores the significance of border towns and spaces for strengthening responses to young people on the move. In particular it explores the linkages of young people to local service centres with the aim of further developing service, protection, and support strategies for migrant children in border areas across the region. The report is based on a small-scale fieldwork study in the border towns of Chipata and Katete in Zambia conducted in July 2023. Border towns and spaces provide a rich source of information about issues related to the informal or irregular movement of young people across borders, including smuggling and trafficking. They can help build a picture of the nature and scope of the type of movement young migrants undertake and also the forms of protection available to them. Border towns and spaces also provide a lens through which we can better understand the vulnerabilities of young people on the move and, critically, the strategies they use to navigate challenges and access support.
The findings in this report highlight some of the key factors shaping the experiences and vulnerabilities of young people on the move – particularly their proximity to border spaces and how this affects the risks that they face. The report describes strategies that young people on the move employ to remain below the radar of visibility to state and non-state actors due to fear of arrest, detention, and deportation while also trying to keep themselves safe and access support in border towns. These strategies of (in)visibility provide a way to protect themselves yet at the same time also heighten some of the risks young people face as their vulnerabilities are not always recognised by those who could offer support.
In this report we show that the realities and challenges of life and migration in this region and in Zambia need to be better understood for support to be strengthened and tuned to meet the specific needs of young people on the move. This includes understanding the role of state and non-state stakeholders, the impact of laws and policies and, critically, the experiences of the young people themselves. We provide recommendations for immediate action, recommendations for programming to support young people on the move in the two towns that would reduce risk for young people in this area, and recommendations for longer term policy advocacy.
UN WOD 2024 will take us on a journey of discovery through the ocean's vastness, tapping into the wisdom and expertise of global policy-makers, scientists, managers, thought leaders, and artists to awaken new depths of understanding, compassion, collaboration and commitment for the ocean and all it sustains. The program will expand our perspectives and appreciation for our blue planet, build new foundations for our relationship to the ocean, and ignite a wave of action toward necessary change.
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.Christina Parmionova
The best available, up-to-date information on all fishing and related vessels that appear on the illegal, unregulated, and unreported (IUU) fishing vessel lists published by Regional Fisheries Management Organisations (RFMOs) and related organisations. The aim of the site is to improve the effectiveness of the original IUU lists as a tool for a wide variety of stakeholders to better understand and combat illegal fishing and broader fisheries crime.
To date, the following regional organisations maintain or share lists of vessels that have been found to carry out or support IUU fishing within their own or adjacent convention areas and/or species of competence:
Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR)
Commission for the Conservation of Southern Bluefin Tuna (CCSBT)
General Fisheries Commission for the Mediterranean (GFCM)
Inter-American Tropical Tuna Commission (IATTC)
International Commission for the Conservation of Atlantic Tunas (ICCAT)
Indian Ocean Tuna Commission (IOTC)
Northwest Atlantic Fisheries Organisation (NAFO)
North East Atlantic Fisheries Commission (NEAFC)
North Pacific Fisheries Commission (NPFC)
South East Atlantic Fisheries Organisation (SEAFO)
South Pacific Regional Fisheries Management Organisation (SPRFMO)
Southern Indian Ocean Fisheries Agreement (SIOFA)
Western and Central Pacific Fisheries Commission (WCPFC)
The Combined IUU Fishing Vessel List merges all these sources into one list that provides a single reference point to identify whether a vessel is currently IUU listed. Vessels that have been IUU listed in the past and subsequently delisted (for example because of a change in ownership, or because the vessel is no longer in service) are also retained on the site, so that the site contains a full historic record of IUU listed fishing vessels.
Unlike the IUU lists published on individual RFMO websites, which may update vessel details infrequently or not at all, the Combined IUU Fishing Vessel List is kept up to date with the best available information regarding changes to vessel identity, flag state, ownership, location, and operations.
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
NIH rigor and reproducibility.use of animals in research.msu 2.16
1. NIH Rigor and Reproducibility:
Use of Animals in Research
F. Claire Hankenson, Director of CAR
and Attending Veterinarian
J.R. Haywood, Assistant Vice President
for Regulatory Affairs
3. NIH Review Criteria
• Scientific Premise
• Rigorous Experimental Design
• Consideration of Sex and Other Relevant
Biological Variables
• Authentication of Key Biological and/or
Chemical Resources
From: NIH Notice – Enhancing Reproducibility through
Rigor and Transparency (NOT-OD-15-103)
7. General Guidelines and Standards
http://www.plosbiology.org/article/fetchObject.action?uri=info:doi/10.
1371/journal.pbio.1000412&representation=PDF
Institute for Laboratory Animal Research. Guidance for the Description of Animal
Research in Scientific Publications. 2011. The National Academies Press
8. Workshops on the Topic
http://www.the-
aps.org/mm/SciencePolicy/Ag
ency-Policy/Reproducibility
9. Workshops on the Topic
http://nas-sites.org/ilar-
roundtable/roundtable-
activities/reproducibility/