SlideShare a Scribd company logo
NIH Rigor and Reproducibility:
Use of Animals in Research
F. Claire Hankenson, Director of CAR
and Attending Veterinarian
J.R. Haywood, Assistant Vice President
for Regulatory Affairs
Rigor and Reproducibility of Research
NIH Review Criteria
• Scientific Premise
• Rigorous Experimental Design
• Consideration of Sex and Other Relevant
Biological Variables
• Authentication of Key Biological and/or
Chemical Resources
From: NIH Notice – Enhancing Reproducibility through
Rigor and Transparency (NOT-OD-15-103)
Recent Publications and Comments
Core Reporting Standards: Animal Studies
• Randomization
• Blinding
• Sample size estimation
• Data handling (inclusion/exclusion criteria)
• Landis, et al Nature 490:187-191, 2012
• Standards
• Replicates
• Statistics
Professional Society Recommendations
General Guidelines and Standards
http://www.plosbiology.org/article/fetchObject.action?uri=info:doi/10.
1371/journal.pbio.1000412&representation=PDF
Institute for Laboratory Animal Research. Guidance for the Description of Animal
Research in Scientific Publications. 2011. The National Academies Press
Workshops on the Topic
http://www.the-
aps.org/mm/SciencePolicy/Ag
ency-Policy/Reproducibility
Workshops on the Topic
http://nas-sites.org/ilar-
roundtable/roundtable-
activities/reproducibility/
Discussion of parameters
to be considered for in
vivo work

More Related Content

What's hot

Searching for evidence - PTY5EHR
Searching for evidence - PTY5EHRSearching for evidence - PTY5EHR
Searching for evidence - PTY5EHR
La Trobe University Library - College of SHE
 
EBD session 3
EBD session 3EBD session 3
EBD session 3
PaulaFunnell
 
SSC in Evidence Based Medicine - Internet resources
SSC in Evidence Based Medicine - Internet resources SSC in Evidence Based Medicine - Internet resources
SSC in Evidence Based Medicine - Internet resources
PaulaFunnell
 
Bastian twin-beasts-2015
Bastian twin-beasts-2015Bastian twin-beasts-2015
Bastian twin-beasts-2015
Hilda Bastian
 
Cohcrane Library
Cohcrane LibraryCohcrane Library
Cohcrane Library
digibonnie
 
Clinical Microbiology - searching for information
Clinical Microbiology - searching for informationClinical Microbiology - searching for information
Clinical Microbiology - searching for information
PaulaFunnell
 
Journal club 2015 07-15 tom
Journal club 2015 07-15 tomJournal club 2015 07-15 tom
Journal club 2015 07-15 tom
tomroper
 
Keck Year 2 Evidence Based Medicine - Systematic Reviews
Keck Year 2 Evidence Based Medicine - Systematic ReviewsKeck Year 2 Evidence Based Medicine - Systematic Reviews
Keck Year 2 Evidence Based Medicine - Systematic Reviews
lynnkysh
 
Using alternative scholarly metrics to showcase the impact of your research: ...
Using alternative scholarly metrics to showcase the impact of your research: ...Using alternative scholarly metrics to showcase the impact of your research: ...
Using alternative scholarly metrics to showcase the impact of your research: ...
SC CTSI at USC and CHLA
 
Sanders final-mdm-searching
Sanders final-mdm-searchingSanders final-mdm-searching
Sanders final-mdm-searching
Susan Sanders
 
searching for evidence
searching for evidencesearching for evidence
searching for evidence
IAU Dent
 
Nurs 300
Nurs 300 Nurs 300
Nurs 300
msclibrary
 
Why should my institution support RRIDs?
Why should my institution support RRIDs?Why should my institution support RRIDs?
Why should my institution support RRIDs?
Neuroscience Information Framework
 
Enhance your rese​arch impact through open science
Enhance your rese​arch impact through open scienceEnhance your rese​arch impact through open science
Enhance your rese​arch impact through open science
London School of Hygiene and Tropical Medicine
 
4th Annual Advancing the Pace of Chemical Risk Assessment
4th Annual Advancing the Pace of Chemical Risk Assessment4th Annual Advancing the Pace of Chemical Risk Assessment
4th Annual Advancing the Pace of Chemical Risk Assessment
Michelle Angrish
 
Identifying and tracking research resources using RRIDs: a practical approach
Identifying and tracking research resources using RRIDs:  a practical approachIdentifying and tracking research resources using RRIDs:  a practical approach
Identifying and tracking research resources using RRIDs: a practical approach
dkNET
 
Coursera datascitoolbox 2015
Coursera datascitoolbox 2015Coursera datascitoolbox 2015
Coursera datascitoolbox 2015
Chandra Shekhar Banerjee
 
Systematic review
Systematic reviewSystematic review
Systematic review
Aboubakr Elnashar
 
The informationist in team science
The informationist in team scienceThe informationist in team science

What's hot (19)

Searching for evidence - PTY5EHR
Searching for evidence - PTY5EHRSearching for evidence - PTY5EHR
Searching for evidence - PTY5EHR
 
EBD session 3
EBD session 3EBD session 3
EBD session 3
 
SSC in Evidence Based Medicine - Internet resources
SSC in Evidence Based Medicine - Internet resources SSC in Evidence Based Medicine - Internet resources
SSC in Evidence Based Medicine - Internet resources
 
Bastian twin-beasts-2015
Bastian twin-beasts-2015Bastian twin-beasts-2015
Bastian twin-beasts-2015
 
Cohcrane Library
Cohcrane LibraryCohcrane Library
Cohcrane Library
 
Clinical Microbiology - searching for information
Clinical Microbiology - searching for informationClinical Microbiology - searching for information
Clinical Microbiology - searching for information
 
Journal club 2015 07-15 tom
Journal club 2015 07-15 tomJournal club 2015 07-15 tom
Journal club 2015 07-15 tom
 
Keck Year 2 Evidence Based Medicine - Systematic Reviews
Keck Year 2 Evidence Based Medicine - Systematic ReviewsKeck Year 2 Evidence Based Medicine - Systematic Reviews
Keck Year 2 Evidence Based Medicine - Systematic Reviews
 
Using alternative scholarly metrics to showcase the impact of your research: ...
Using alternative scholarly metrics to showcase the impact of your research: ...Using alternative scholarly metrics to showcase the impact of your research: ...
Using alternative scholarly metrics to showcase the impact of your research: ...
 
Sanders final-mdm-searching
Sanders final-mdm-searchingSanders final-mdm-searching
Sanders final-mdm-searching
 
searching for evidence
searching for evidencesearching for evidence
searching for evidence
 
Nurs 300
Nurs 300 Nurs 300
Nurs 300
 
Why should my institution support RRIDs?
Why should my institution support RRIDs?Why should my institution support RRIDs?
Why should my institution support RRIDs?
 
Enhance your rese​arch impact through open science
Enhance your rese​arch impact through open scienceEnhance your rese​arch impact through open science
Enhance your rese​arch impact through open science
 
4th Annual Advancing the Pace of Chemical Risk Assessment
4th Annual Advancing the Pace of Chemical Risk Assessment4th Annual Advancing the Pace of Chemical Risk Assessment
4th Annual Advancing the Pace of Chemical Risk Assessment
 
Identifying and tracking research resources using RRIDs: a practical approach
Identifying and tracking research resources using RRIDs:  a practical approachIdentifying and tracking research resources using RRIDs:  a practical approach
Identifying and tracking research resources using RRIDs: a practical approach
 
Coursera datascitoolbox 2015
Coursera datascitoolbox 2015Coursera datascitoolbox 2015
Coursera datascitoolbox 2015
 
Systematic review
Systematic reviewSystematic review
Systematic review
 
The informationist in team science
The informationist in team scienceThe informationist in team science
The informationist in team science
 

Similar to NIH rigor and reproducibility.use of animals in research.msu 2.16

Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to Know
Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to KnowSystematic Reviews and Knowledge Syntheses: What a Librarian Needs to Know
Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to Know
Lorie Kloda
 
Arrive Guidelines for Preclinical Studies
Arrive Guidelines for Preclinical StudiesArrive Guidelines for Preclinical Studies
Arrive Guidelines for Preclinical Studies
Cognibrain Healthcare
 
Clinical Trials
Clinical TrialsClinical Trials
Clinical Trials
flasco_org
 
ARRIVE Guidelines
ARRIVE GuidelinesARRIVE Guidelines
ARRIVE Guidelines
Cognibrain Healthcare
 
FAIRness and Accountability BioIT 2019 FAIR track
FAIRness and Accountability BioIT 2019 FAIR trackFAIRness and Accountability BioIT 2019 FAIR track
FAIRness and Accountability BioIT 2019 FAIR track
Helena Deus
 
SLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
SLAS2015 JALA & JBS Author Workshop: How to Get Your Work PublishedSLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
SLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
SLAS (Society for Laboratory Automation and Screening)
 
Evidence Based Practice
Evidence Based PracticeEvidence Based Practice
Evidence Based Practice
Sreeraj S R
 
Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"
Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"
Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"
The Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics
 
Digital Scholar Webinar: Transparent, Open, and Reproducible Research
Digital Scholar Webinar: Transparent, Open, and Reproducible ResearchDigital Scholar Webinar: Transparent, Open, and Reproducible Research
Digital Scholar Webinar: Transparent, Open, and Reproducible Research
SC CTSI at USC and CHLA
 
Mobilizing informational resources webinar
Mobilizing informational resources   webinarMobilizing informational resources   webinar
Mobilizing informational resources webinar
Ann-Marie Roche
 
Qi Irb Presentation
Qi Irb PresentationQi Irb Presentation
Qi Irb Presentation
hedavidson
 
Gaining credit for sharing research data
Gaining credit for sharing research dataGaining credit for sharing research data
Gaining credit for sharing research data
Varsha Khodiyar
 
HHS Doblin
HHS DoblinHHS Doblin
HHS Doblin
Norman Gates
 
Presentation at Rare Disease conference in San-Antonio
Presentation at Rare Disease conference in San-AntonioPresentation at Rare Disease conference in San-Antonio
Presentation at Rare Disease conference in San-Antonio
Anton Yuryev
 
How to Get Indexed in International Citation Databases
How to Get Indexed in International Citation DatabasesHow to Get Indexed in International Citation Databases
How to Get Indexed in International Citation Databases
SC CTSI at USC and CHLA
 
Aries systems eemug 2021 manuscript eval services panel sci score v2_edits
Aries systems eemug 2021 manuscript eval services panel sci score v2_editsAries systems eemug 2021 manuscript eval services panel sci score v2_edits
Aries systems eemug 2021 manuscript eval services panel sci score v2_edits
Anita Bandrowski
 
2015 12 ebi_ganley_final
2015 12 ebi_ganley_final2015 12 ebi_ganley_final
2015 12 ebi_ganley_final
Emma Ganley
 
Search Concepts, Methods, Resources, and Tools
Search Concepts, Methods, Resources, and ToolsSearch Concepts, Methods, Resources, and Tools
Search Concepts, Methods, Resources, and Tools
John Pell
 
Clinical Data Publishing at Scientific Data
Clinical Data Publishing at Scientific DataClinical Data Publishing at Scientific Data
Clinical Data Publishing at Scientific Data
Varsha Khodiyar
 
Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...
 Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud... Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...
Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...
CTSI at UCSF
 

Similar to NIH rigor and reproducibility.use of animals in research.msu 2.16 (20)

Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to Know
Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to KnowSystematic Reviews and Knowledge Syntheses: What a Librarian Needs to Know
Systematic Reviews and Knowledge Syntheses: What a Librarian Needs to Know
 
Arrive Guidelines for Preclinical Studies
Arrive Guidelines for Preclinical StudiesArrive Guidelines for Preclinical Studies
Arrive Guidelines for Preclinical Studies
 
Clinical Trials
Clinical TrialsClinical Trials
Clinical Trials
 
ARRIVE Guidelines
ARRIVE GuidelinesARRIVE Guidelines
ARRIVE Guidelines
 
FAIRness and Accountability BioIT 2019 FAIR track
FAIRness and Accountability BioIT 2019 FAIR trackFAIRness and Accountability BioIT 2019 FAIR track
FAIRness and Accountability BioIT 2019 FAIR track
 
SLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
SLAS2015 JALA & JBS Author Workshop: How to Get Your Work PublishedSLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
SLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
 
Evidence Based Practice
Evidence Based PracticeEvidence Based Practice
Evidence Based Practice
 
Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"
Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"
Eric G. Campbell, "IRB Oversight of PCOR: A National Survey of IRB Chairs"
 
Digital Scholar Webinar: Transparent, Open, and Reproducible Research
Digital Scholar Webinar: Transparent, Open, and Reproducible ResearchDigital Scholar Webinar: Transparent, Open, and Reproducible Research
Digital Scholar Webinar: Transparent, Open, and Reproducible Research
 
Mobilizing informational resources webinar
Mobilizing informational resources   webinarMobilizing informational resources   webinar
Mobilizing informational resources webinar
 
Qi Irb Presentation
Qi Irb PresentationQi Irb Presentation
Qi Irb Presentation
 
Gaining credit for sharing research data
Gaining credit for sharing research dataGaining credit for sharing research data
Gaining credit for sharing research data
 
HHS Doblin
HHS DoblinHHS Doblin
HHS Doblin
 
Presentation at Rare Disease conference in San-Antonio
Presentation at Rare Disease conference in San-AntonioPresentation at Rare Disease conference in San-Antonio
Presentation at Rare Disease conference in San-Antonio
 
How to Get Indexed in International Citation Databases
How to Get Indexed in International Citation DatabasesHow to Get Indexed in International Citation Databases
How to Get Indexed in International Citation Databases
 
Aries systems eemug 2021 manuscript eval services panel sci score v2_edits
Aries systems eemug 2021 manuscript eval services panel sci score v2_editsAries systems eemug 2021 manuscript eval services panel sci score v2_edits
Aries systems eemug 2021 manuscript eval services panel sci score v2_edits
 
2015 12 ebi_ganley_final
2015 12 ebi_ganley_final2015 12 ebi_ganley_final
2015 12 ebi_ganley_final
 
Search Concepts, Methods, Resources, and Tools
Search Concepts, Methods, Resources, and ToolsSearch Concepts, Methods, Resources, and Tools
Search Concepts, Methods, Resources, and Tools
 
Clinical Data Publishing at Scientific Data
Clinical Data Publishing at Scientific DataClinical Data Publishing at Scientific Data
Clinical Data Publishing at Scientific Data
 
Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...
 Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud... Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...
Investigating the Health of Adults: Leveraging Large Data Sets For Your Stud...
 

More from Michigan State University Research

NFRO interdisciplinary international 081617
NFRO interdisciplinary international 081617NFRO interdisciplinary international 081617
NFRO interdisciplinary international 081617
Michigan State University Research
 
Web accessible nfro 2017 as of 08152017
Web accessible nfro 2017 as of 08152017Web accessible nfro 2017 as of 08152017
Web accessible nfro 2017 as of 08152017
Michigan State University Research
 
SmartAg/Food Engineering Overview
SmartAg/Food Engineering OverviewSmartAg/Food Engineering Overview
SmartAg/Food Engineering Overview
Michigan State University Research
 
The Internet of Plants
The Internet of PlantsThe Internet of Plants
The Internet of Plants
Michigan State University Research
 
Digital Agriculture
Digital AgricultureDigital Agriculture
A New Magnetic Resononance Imaging Biomarker for Diabetes
A New Magnetic Resononance Imaging Biomarker for DiabetesA New Magnetic Resononance Imaging Biomarker for Diabetes
A New Magnetic Resononance Imaging Biomarker for Diabetes
Michigan State University Research
 
MSU Transgenic and Genome Editing Facility
MSU Transgenic and Genome Editing FacilityMSU Transgenic and Genome Editing Facility
MSU Transgenic and Genome Editing Facility
Michigan State University Research
 
Intelligent and Automatic In vivo Detection and Quantification of Transplante...
Intelligent and Automatic In vivo Detection and Quantification of Transplante...Intelligent and Automatic In vivo Detection and Quantification of Transplante...
Intelligent and Automatic In vivo Detection and Quantification of Transplante...
Michigan State University Research
 
Re-budgeting & Report Tracking in KC
Re-budgeting & Report Tracking in KCRe-budgeting & Report Tracking in KC
Re-budgeting & Report Tracking in KC
Michigan State University Research
 
Budget Development in KC
Budget Development in KCBudget Development in KC
Budget Development in KC
Michigan State University Research
 
Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...
Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...
Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...
Michigan State University Research
 
Proposal Development in KC
Proposal Development in KCProposal Development in KC
Proposal Development in KC
Michigan State University Research
 
Thomas D. Gregory 9 14-16
Thomas D. Gregory 9 14-16Thomas D. Gregory 9 14-16
Thomas D. Gregory 9 14-16
Michigan State University Research
 
Taking an ancient path towards artificial intelligence 10-12-16
Taking an ancient path towards artificial intelligence 10-12-16Taking an ancient path towards artificial intelligence 10-12-16
Taking an ancient path towards artificial intelligence 10-12-16
Michigan State University Research
 
Michigan State University coffee break: building a budget 10-20-16
Michigan State University coffee break: building a budget 10-20-16Michigan State University coffee break: building a budget 10-20-16
Michigan State University coffee break: building a budget 10-20-16
Michigan State University Research
 
Domicology: Changing the CEM Paradigm
Domicology: Changing the CEM ParadigmDomicology: Changing the CEM Paradigm
Domicology: Changing the CEM Paradigm
Michigan State University Research
 
Removal of Abandoned Properties Deconstruction vs.Demolition
Removal of Abandoned Properties Deconstruction vs.DemolitionRemoval of Abandoned Properties Deconstruction vs.Demolition
Removal of Abandoned Properties Deconstruction vs.Demolition
Michigan State University Research
 
Advancing the Science of Domicology
Advancing the Science of DomicologyAdvancing the Science of Domicology
Advancing the Science of Domicology
Michigan State University Research
 
Advancing Domicology for Sustainable Construction
Advancing Domicology for Sustainable ConstructionAdvancing Domicology for Sustainable Construction
Advancing Domicology for Sustainable Construction
Michigan State University Research
 
Harnessing Microbe-Electrode Interactions for Bioenergy
Harnessing Microbe-Electrode Interactions for BioenergyHarnessing Microbe-Electrode Interactions for Bioenergy
Harnessing Microbe-Electrode Interactions for Bioenergy
Michigan State University Research
 

More from Michigan State University Research (20)

NFRO interdisciplinary international 081617
NFRO interdisciplinary international 081617NFRO interdisciplinary international 081617
NFRO interdisciplinary international 081617
 
Web accessible nfro 2017 as of 08152017
Web accessible nfro 2017 as of 08152017Web accessible nfro 2017 as of 08152017
Web accessible nfro 2017 as of 08152017
 
SmartAg/Food Engineering Overview
SmartAg/Food Engineering OverviewSmartAg/Food Engineering Overview
SmartAg/Food Engineering Overview
 
The Internet of Plants
The Internet of PlantsThe Internet of Plants
The Internet of Plants
 
Digital Agriculture
Digital AgricultureDigital Agriculture
Digital Agriculture
 
A New Magnetic Resononance Imaging Biomarker for Diabetes
A New Magnetic Resononance Imaging Biomarker for DiabetesA New Magnetic Resononance Imaging Biomarker for Diabetes
A New Magnetic Resononance Imaging Biomarker for Diabetes
 
MSU Transgenic and Genome Editing Facility
MSU Transgenic and Genome Editing FacilityMSU Transgenic and Genome Editing Facility
MSU Transgenic and Genome Editing Facility
 
Intelligent and Automatic In vivo Detection and Quantification of Transplante...
Intelligent and Automatic In vivo Detection and Quantification of Transplante...Intelligent and Automatic In vivo Detection and Quantification of Transplante...
Intelligent and Automatic In vivo Detection and Quantification of Transplante...
 
Re-budgeting & Report Tracking in KC
Re-budgeting & Report Tracking in KCRe-budgeting & Report Tracking in KC
Re-budgeting & Report Tracking in KC
 
Budget Development in KC
Budget Development in KCBudget Development in KC
Budget Development in KC
 
Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...
Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...
Submitting and Editing Proposals and Tracking Proposal Activity and COI Compl...
 
Proposal Development in KC
Proposal Development in KCProposal Development in KC
Proposal Development in KC
 
Thomas D. Gregory 9 14-16
Thomas D. Gregory 9 14-16Thomas D. Gregory 9 14-16
Thomas D. Gregory 9 14-16
 
Taking an ancient path towards artificial intelligence 10-12-16
Taking an ancient path towards artificial intelligence 10-12-16Taking an ancient path towards artificial intelligence 10-12-16
Taking an ancient path towards artificial intelligence 10-12-16
 
Michigan State University coffee break: building a budget 10-20-16
Michigan State University coffee break: building a budget 10-20-16Michigan State University coffee break: building a budget 10-20-16
Michigan State University coffee break: building a budget 10-20-16
 
Domicology: Changing the CEM Paradigm
Domicology: Changing the CEM ParadigmDomicology: Changing the CEM Paradigm
Domicology: Changing the CEM Paradigm
 
Removal of Abandoned Properties Deconstruction vs.Demolition
Removal of Abandoned Properties Deconstruction vs.DemolitionRemoval of Abandoned Properties Deconstruction vs.Demolition
Removal of Abandoned Properties Deconstruction vs.Demolition
 
Advancing the Science of Domicology
Advancing the Science of DomicologyAdvancing the Science of Domicology
Advancing the Science of Domicology
 
Advancing Domicology for Sustainable Construction
Advancing Domicology for Sustainable ConstructionAdvancing Domicology for Sustainable Construction
Advancing Domicology for Sustainable Construction
 
Harnessing Microbe-Electrode Interactions for Bioenergy
Harnessing Microbe-Electrode Interactions for BioenergyHarnessing Microbe-Electrode Interactions for Bioenergy
Harnessing Microbe-Electrode Interactions for Bioenergy
 

Recently uploaded

原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样
原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样
原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样
ii2sh2v
 
CFYT Rolling Ads Dawson City Yukon Canada
CFYT Rolling Ads Dawson City Yukon CanadaCFYT Rolling Ads Dawson City Yukon Canada
CFYT Rolling Ads Dawson City Yukon Canada
pmenzies
 
快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样
快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样
快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样
yemqpj
 
2024: The FAR - Federal Acquisition Regulations, Part 41
2024: The FAR - Federal Acquisition Regulations, Part 412024: The FAR - Federal Acquisition Regulations, Part 41
2024: The FAR - Federal Acquisition Regulations, Part 41
JSchaus & Associates
 
Border towns and spaces of (in)visibility.pdf
Border towns and spaces of (in)visibility.pdfBorder towns and spaces of (in)visibility.pdf
Border towns and spaces of (in)visibility.pdf
Scalabrini Institute for Human Mobility in Africa
 
A proposed request for information on LIHTC
A proposed request for information on LIHTCA proposed request for information on LIHTC
A proposed request for information on LIHTC
Roger Valdez
 
Texas Water Development Board Updates June 2024
Texas Water Development Board Updates June 2024Texas Water Development Board Updates June 2024
Texas Water Development Board Updates June 2024
Texas Alliance of Groundwater Districts
 
PPT Item # 5 - 318 Tuxedo Ave. (sign. review)
PPT Item # 5 - 318 Tuxedo Ave. (sign. review)PPT Item # 5 - 318 Tuxedo Ave. (sign. review)
PPT Item # 5 - 318 Tuxedo Ave. (sign. review)
ahcitycouncil
 
Researching the client.pptxsxssssssssssssssssssssss
Researching the client.pptxsxssssssssssssssssssssssResearching the client.pptxsxssssssssssssssssssssss
Researching the client.pptxsxssssssssssssssssssssss
DanielOliver74
 
Item #s 8&9 -- Demolition Code Amendment
Item #s 8&9 -- Demolition Code AmendmentItem #s 8&9 -- Demolition Code Amendment
Item #s 8&9 -- Demolition Code Amendment
ahcitycouncil
 
加急办理华威大学毕业证硕士文凭证书原版一模一样
加急办理华威大学毕业证硕士文凭证书原版一模一样加急办理华威大学毕业证硕士文凭证书原版一模一样
加急办理华威大学毕业证硕士文凭证书原版一模一样
uu1psyf6
 
Milton Keynes Hospital Charity - A guide to leaving a gift in your Will
Milton Keynes Hospital Charity - A guide to leaving a gift in your WillMilton Keynes Hospital Charity - A guide to leaving a gift in your Will
Milton Keynes Hospital Charity - A guide to leaving a gift in your Will
fundraising4
 
在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样
在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样
在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样
yemqpj
 
CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054
CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054
CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054
Congressional Budget Office
 
Awaken new depths - World Ocean Day 2024, June 8th.
Awaken new depths - World Ocean Day 2024, June 8th.Awaken new depths - World Ocean Day 2024, June 8th.
Awaken new depths - World Ocean Day 2024, June 8th.
Christina Parmionova
 
2024: The FAR - Federal Acquisition Regulations, Part 39
2024: The FAR - Federal Acquisition Regulations, Part 392024: The FAR - Federal Acquisition Regulations, Part 39
2024: The FAR - Federal Acquisition Regulations, Part 39
JSchaus & Associates
 
2024: The FAR - Federal Acquisition Regulations, Part 40
2024: The FAR - Federal Acquisition Regulations, Part 402024: The FAR - Federal Acquisition Regulations, Part 40
2024: The FAR - Federal Acquisition Regulations, Part 40
JSchaus & Associates
 
在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样
在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样
在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样
9d5c8i83
 
TRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRIST
TRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRISTTRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRIST
TRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRIST
Cheong Man Keong
 
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
Christina Parmionova
 

Recently uploaded (20)

原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样
原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样
原版制作(Hope毕业证书)利物浦霍普大学毕业证文凭证书一模一样
 
CFYT Rolling Ads Dawson City Yukon Canada
CFYT Rolling Ads Dawson City Yukon CanadaCFYT Rolling Ads Dawson City Yukon Canada
CFYT Rolling Ads Dawson City Yukon Canada
 
快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样
快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样
快速办理(UVM毕业证书)佛蒙特大学毕业证学位证一模一样
 
2024: The FAR - Federal Acquisition Regulations, Part 41
2024: The FAR - Federal Acquisition Regulations, Part 412024: The FAR - Federal Acquisition Regulations, Part 41
2024: The FAR - Federal Acquisition Regulations, Part 41
 
Border towns and spaces of (in)visibility.pdf
Border towns and spaces of (in)visibility.pdfBorder towns and spaces of (in)visibility.pdf
Border towns and spaces of (in)visibility.pdf
 
A proposed request for information on LIHTC
A proposed request for information on LIHTCA proposed request for information on LIHTC
A proposed request for information on LIHTC
 
Texas Water Development Board Updates June 2024
Texas Water Development Board Updates June 2024Texas Water Development Board Updates June 2024
Texas Water Development Board Updates June 2024
 
PPT Item # 5 - 318 Tuxedo Ave. (sign. review)
PPT Item # 5 - 318 Tuxedo Ave. (sign. review)PPT Item # 5 - 318 Tuxedo Ave. (sign. review)
PPT Item # 5 - 318 Tuxedo Ave. (sign. review)
 
Researching the client.pptxsxssssssssssssssssssssss
Researching the client.pptxsxssssssssssssssssssssssResearching the client.pptxsxssssssssssssssssssssss
Researching the client.pptxsxssssssssssssssssssssss
 
Item #s 8&9 -- Demolition Code Amendment
Item #s 8&9 -- Demolition Code AmendmentItem #s 8&9 -- Demolition Code Amendment
Item #s 8&9 -- Demolition Code Amendment
 
加急办理华威大学毕业证硕士文凭证书原版一模一样
加急办理华威大学毕业证硕士文凭证书原版一模一样加急办理华威大学毕业证硕士文凭证书原版一模一样
加急办理华威大学毕业证硕士文凭证书原版一模一样
 
Milton Keynes Hospital Charity - A guide to leaving a gift in your Will
Milton Keynes Hospital Charity - A guide to leaving a gift in your WillMilton Keynes Hospital Charity - A guide to leaving a gift in your Will
Milton Keynes Hospital Charity - A guide to leaving a gift in your Will
 
在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样
在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样
在线办理(ISU毕业证书)爱荷华州立大学毕业证学历证书一模一样
 
CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054
CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054
CBO’s Outlook for U.S. Fertility Rates: 2024 to 2054
 
Awaken new depths - World Ocean Day 2024, June 8th.
Awaken new depths - World Ocean Day 2024, June 8th.Awaken new depths - World Ocean Day 2024, June 8th.
Awaken new depths - World Ocean Day 2024, June 8th.
 
2024: The FAR - Federal Acquisition Regulations, Part 39
2024: The FAR - Federal Acquisition Regulations, Part 392024: The FAR - Federal Acquisition Regulations, Part 39
2024: The FAR - Federal Acquisition Regulations, Part 39
 
2024: The FAR - Federal Acquisition Regulations, Part 40
2024: The FAR - Federal Acquisition Regulations, Part 402024: The FAR - Federal Acquisition Regulations, Part 40
2024: The FAR - Federal Acquisition Regulations, Part 40
 
在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样
在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样
在线办理美国乔治华盛顿大学毕业证(gwu毕业证书)学历学位证书原版一模一样
 
TRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRIST
TRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRISTTRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRIST
TRUE BOOK OF LIFE 1.15 OF TRUE JESUS CHRIST
 
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
Combined Illegal, Unregulated and Unreported (IUU) Vessel List.
 

NIH rigor and reproducibility.use of animals in research.msu 2.16

  • 1. NIH Rigor and Reproducibility: Use of Animals in Research F. Claire Hankenson, Director of CAR and Attending Veterinarian J.R. Haywood, Assistant Vice President for Regulatory Affairs
  • 3. NIH Review Criteria • Scientific Premise • Rigorous Experimental Design • Consideration of Sex and Other Relevant Biological Variables • Authentication of Key Biological and/or Chemical Resources From: NIH Notice – Enhancing Reproducibility through Rigor and Transparency (NOT-OD-15-103)
  • 5. Core Reporting Standards: Animal Studies • Randomization • Blinding • Sample size estimation • Data handling (inclusion/exclusion criteria) • Landis, et al Nature 490:187-191, 2012 • Standards • Replicates • Statistics
  • 7. General Guidelines and Standards http://www.plosbiology.org/article/fetchObject.action?uri=info:doi/10. 1371/journal.pbio.1000412&representation=PDF Institute for Laboratory Animal Research. Guidance for the Description of Animal Research in Scientific Publications. 2011. The National Academies Press
  • 8. Workshops on the Topic http://www.the- aps.org/mm/SciencePolicy/Ag ency-Policy/Reproducibility
  • 9. Workshops on the Topic http://nas-sites.org/ilar- roundtable/roundtable- activities/reproducibility/
  • 10. Discussion of parameters to be considered for in vivo work