This document discusses the need for business process management (BPM) to move beyond tactical, departmental improvements and enable strategic advantages through enterprise-wide and cross-company process management. It argues that current BPM approaches are limited and that the next generation of BPM requires: 1) a universal business process management system (BPMS); 2) new process-oriented architecture and methods; 3) tools for human interaction management; 4) complex event processing; and 5) agent technology. These capabilities are needed to manage end-to-end, value chain processes in a holistic way and drive competitive advantages in today's business environment of globalization and extreme competition.