Neoplasms of the nose and paranasal sinuses are very rare tumors. They are often diagnosed late due to similarity to benign conditions. The document discusses the epidemiology, locations, presentations, diagnostic imaging, and treatments of both benign and malignant lesions of the nose and paranasal sinuses. The treatments involve multimodality approaches including surgery, radiation therapy, and chemotherapy depending on the type and stage of cancer.
Spaces of middle ear and their surgical importanceDr Soumya Singh
one of the imp topics in ENT that should be understood very thoroughly if u want to pursue as an otologist.I tried to simplify the topic with simple diagrams and models for better understanding .
This is a presentation I used for my seminar on 'Phonosurgery' on 4th November, 2015. I hope they are useful to you. Constructive as well as Destructive criticism welcomed.
Cavity obliteration is a procedure done at the end of Mastoidectomy to get a cavity-less mastoid cavity thus solving the problem of discharging post-operative cavity.
Spaces of middle ear and their surgical importanceDr Soumya Singh
one of the imp topics in ENT that should be understood very thoroughly if u want to pursue as an otologist.I tried to simplify the topic with simple diagrams and models for better understanding .
This is a presentation I used for my seminar on 'Phonosurgery' on 4th November, 2015. I hope they are useful to you. Constructive as well as Destructive criticism welcomed.
Cavity obliteration is a procedure done at the end of Mastoidectomy to get a cavity-less mastoid cavity thus solving the problem of discharging post-operative cavity.
Pericytes are the perivascular or mural cells of micro vessels. They are of mesenchymal origin and capable of differentiating into a number of different cell lineages. They are intimately associated with endothelial cells and communicate with them via direct physical contact or through paracrine signaling pathways. These interactions are important for blood vessel maturation, remodelling, and maintenance. Pericytes are versatile and their varying morphological characteristics and distribution make them difficult to study. The lack of universal pericytes markers is a major problem. A number of different functions have been attributed to pericytes, and in some organs they have more specific roles. The role of pericytes in tumor vessels is debated, but pericytes may contribute to stability, and might protect the vessels from antiangiogenic therapy. Understanding the process of angiogenesis in angiogenesis dependent diseases role of pericytes may be of therapeutic benefit.This article gives an overview of pericytes their role in health and disease particularly in relation to oral cavity.
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Neoplasms of the nose and paranasal sinus /certified fixed orthodontic courses by Indian dental academy
1. Neoplasms of the
Nose and Paranasal
Sinus ACADEMY
INDIAN DENTAL
Leader in continuing dental education
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1
2. Neoplasms of Nose and Paranasal
Sinuses
Very rare 3%
Delay in diagnosis due to similarity to benign
conditions
Nasal cavity
½ benign
½ malignant
Paranasal Sinuses
Malignant
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3. Neoplasms of Nose and Paranasal
Sinuses
Multimodality treatment
Orbital Preservation
Minimally invasive surgical techniques
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4. Epidemiology
Predominately of older males
Exposure:
Wood, nickel-refining processes
Industrial fumes, leather tanning
Cigarette and Alcohol consumption
No significant association has been shown
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10. Inverted Papilloma
4% of sinonasal tumors
Site of Origin: lateral nasal wall
Unilateral
Malignant degeneration in 2-13% (avg 10%)
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11. Inverted Papilloma
Resection
Initially via transnasal resection:
Medial Maxillectomy via lateral rhinotomy:
50-80% recurrence
Gold Standard
10-20%
Endoscopic medial maxillectomy:
Key concepts:
Identify the origin of the papilloma
Bony removal of this region
Recurrent lesions:
Via medial maxillectomy vs. Endoscopic resection
22%
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12. Osteomas
Benign slow growing tumors of mature bone
Location:
Frontal, ethmoids, maxillary sinuses
When obstructing mucosal flow can lead to
mucocele formation
Treatment is local excision
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13. Fibrous dysplasia
Dysplastic transformation of normal bone with
collagen, fibroblasts, and osteoid material
Monostotic vs Polyostotic
Surgical excision for obstructing lesions
Malignant transformation to rhabdomyosarcoma
has been seen with radiation
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14. Neurogenic tumors
4% are found within the paranasal sinuses
Schwannomas
Neurofibromas
Treatment via surgical resection
Neurogenic Sarcomas are very aggressive and
require surgical excision with post op
chemo/XRT for residual disease.
When associated with Von Recklinghausen’s
syndrome: more aggressive (30% 5yr survival).
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16. Squamous cell carcinoma
Most common tumor (80%)
Location:
Maxillary sinus (70%)
Nasal cavity (20%)
90% have local invasion by presentation
Lymphatic drainage:
First echelon: retropharyngeal nodes
Second echelon: subdigastric nodes
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17. Treatment
88% present in advanced stages (T3/T4)
Surgical resection with postoperative radiation
Complex 3-D anatomy makes margins difficult
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18. Adenoid Cystic Carcinoma
3rd most common site is the nose/paranasal
sinuses
Perineural spread
Anterograde and retrograde
Despite aggressive surgical resection and
radiotherapy, most grow insidiously.
Neck metastasis is rare and usually a sign of local
failure
Postoperative XRT is very important
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20. Adenocarcinoma
2nd most common malignant tumor in the
maxillary and ethmoid sinuses
Present most often in the superior portions
Strong association with occupational exposures
High grade: solid growth pattern with poorly
defined margins. 30% present with metastasis
Low grade: uniform and glandular with less
incidence of perineural invasion/metastasis.
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21. Hemangiopericytoma
Pericytes of Zimmerman
Present as rubbery, pale/gray, well circumscribed
lesions resembling nasal polyps
Treatment is surgical resection with postoperative XRT
for positive margins
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22. Melanoma
0.5- 1.5% of melanoma originates from the nasal
cavity and paranasal sinus.
Anterior Septum: most common site
Treatment is wide local excision with/without
postoperative radiation therapy
END not recommended
AFIP: Poor prognosis
5yr: 11%
20yr: 0.5%
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23. Olfactory Neuroblastoma
Esthesioneuroblastoma
Originate from stem cells of neural crest origin
that differentiate into olfactory sensory cells.
Kadish Classification
A: confined to nasal cavity
B: involving the paranasal cavity
C: extending beyond these limits
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24. Olfactory Neuroblastoma
Esthesioneuroblastoma
UCLA Staging system
T1: Tumor involving nasal cavity and/or paranasal
sinus, excluding the sphenoid and superior most
ethmoids
T2: Tumor involving the nasal cavity and/or
paranasal sinus including sphenoid/cribriform plate
T3: Tumor extending into the orbit or anterior
cranial fossa
T4: Tumor involving the brain
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26. Sarcomas
Osteogenic Sarcoma
Most common primary malignancy of bone.
Mandible > Maxilla
Sunray radiographic appearance
Fibrosarcoma
Chondrosarcoma
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27. Rhabdomyosarcoma
Most common paranasal sinus malignancy in
children
Non-orbital, parameningeal
Triple therapy is often necessary
Aggressive chemo/XRT has improved survival
from 51% to 81% in patients with cranial nerve
deficits/skull/intracranial involvement.
Adults, Surgical resection with postoperative
XRT for positive margins.
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32. Staging of Maxillary Sinus Tumors
T1: limited to antral mucosa without bony erosion
T2: erosion or destruction of the infrastructure,
including the hard palate and/or middle meatus
T3: Tumor invades: skin of cheek, posterior wall of
sinus, inferior or medial wall of orbit, anterior ethmoid
sinus
T4: tumor invades orbital contents and/or: cribriform
plate, post ethmoids or sphenoid, nasopharynx, soft
palate, pterygopalatine or infratemporal fossa or base of
skull
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33. Surgery
Unresectable tumors:
Superior extension: frontal lobes
Lateral extension: cavernous sinus
Posterior extension: prevertebral fascia
Bilateral optic nerve involvement
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35. Tracheostomy
130 maxillectomies only 7.7% required
tracheostomy
Of those not receiving tracheostomy during
surgery, only 0.9% experienced postoperative
airway complications
Tracheostomy is unnecessary except in certain
circumstances (bulky packing/flaps,
mandibulectomy)
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36. Treatment of the Orbit
Before 1970’s orbital exenteration was included
in the radical resection
Preoperative radiation reduced tumor load and
allowed for orbital preservation with clear
surgical margins
Currently, the debate is centered on what
“degree” of orbital invasion is allowed.
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37. Current indications for orbital
exenteration
Involvement of the orbital apex
Involvement of the extraocular muscles
Involvement of the bulbar conjunctiva or sclera
Lid involvement beyond a reasonable hope for
reconstruction
Non-resectable full thickness invasion through
the periorbita into the retrobulbar fat
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38. Conclusions
Neoplasms of the nose and paranasal sinus are
very rare and require a high index of suspicion
for diagnosis
Most lesions present in advanced states and
require multimodality therapy
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39. Bibliography
Bhattacharyya N. Cancer of the Nasal Cavity: Survival and Factors Influencing Prognosis. Archives of OtoHNS. Vol 128(9). September 2002. Pp 1079-1083.
Bradley P, Jones N, Robertson I. Diagnosis and Management of Esthesioneuroblastoma. Current Opinion in
Oto-HNS. Vol 11(2). April 2003. Pp 112-118.
Carrau R, Segas J, Nuss D, et al. Squamous Cell Carcinoma of the Sinonasal Tract Invading the Orbit.
Laryngoscope. Vol 109 (2, part 1). February 1999. Pp 230-235.
Devaiah A, Larsen C, Tawfik O, et al. Esthesioneuroblastoma: Endoscopic Nasal and Anterior Craniotomy
Resection. Laryngoscope. Vol 113(12). December 2003. Pp2086-2090.
Han J, Smith T, Loehrl T, et al. An Evolution in the Management of Sinonasal Inverting Papilloma.
Laryngoscope. Vol 111(8). August 2001. Pp 1395-1400.
Imola M, Schramm V. Orbital Preservation in Surgical Management of Sinonasal Malignancy. Laryngoscope.
Vol 112(8). August 2002. Pp 1357-1365.
Katzenmeyer K, Pou A. Neoplasms of the Nose and Paranasal Sinus. Dr. Quinn’s Online Textbook of
Otolaryngology. June 7, 2000.
Kraft M, Simmen D, Kaufmann T, et al. Laryngoscope. Vol 113(9). September 2003. Pp 1541-1547.
McCary S, Levine P, Cantrell R. Preservation of the eye in the Treatment of Sinonasal Malignant Neoplasms
with Orbital Involvement: A Confirmation of the Original Treatise. Archives of Oto-HNS. Vol 122(6). June
1996. Pp 657-659.
Myers E, Suen J. Cancer of the Head and Neck, 3rd Edition: Neoplasms of the Nose and Paranasal Sinuses.
W.B. Saunders Company. 1996.
Myers L, Nussenbaum B, Bradford C, et al. Paranasal Sinus Malignancies: An 18-Year Single Institution
Experience. Laryngoscope. Vol 112(11). November 2002. Pp 1964-1969.
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40. Thank you
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