This document summarizes efforts by the Pan American Health Organization to address noncommunicable diseases (NCDs) in the Americas from 2004 to 2012. It discusses commitments made at the UN High-Level Meeting on NCDs and advances made, including developing an NCD strategy and regional action plan with targets. It outlines objectives around multi-sector policies, risk factor reduction, health system response, and surveillance. The document also describes the CARMEN network of NCD surveillance sites and a meeting in Brasilia in 2012 around implementing the UN declaration on NCDs. It highlights policy advances, health promotion initiatives, and integrated management models to address NCDs in the Americas.