This document discusses how two cancer centers, Johns Hopkins Kimmel Cancer Center and H. Lee Moffitt Cancer Center, are using analytics to increase the efficiency and effectiveness of their development and fundraising efforts. It provides an overview of how predictive modeling and analytics can help identify prospective new donors, segment existing donors, and optimize fundraising strategies. As a case study, it outlines how Moffitt Cancer Center used analytics to identify high-potential donors from their direct mail program who were overlooked by traditional screening methods, resulting in increased returns. The document advocates for incorporating analytics more fully into development practices to move towards a "Science of Development".