This document discusses the challenges of collaborative development in matrix cancer centers. It provides examples from the Abramson Cancer Center and Robert H. Lurie Comprehensive Cancer Center. Some key challenges mentioned include different priorities and reporting structures between the university and health system sides, as well as managing relationships that involve multiple doctors. However, opportunities also exist through disease-focused collaborations and enhancing relationships across the university and health system. Rules of engagement for prospect management aim to increase coordination and prevent duplication of efforts between fundraising teams.