1) Myxedema coma is a rare life-threatening condition that occurs when a patient with severe, long-standing hypothyroidism experiences physiological decompensation, usually brought on by an external precipitating event like infection. 2) It is characterized by hypothermia, unconsciousness, decreased metabolism and oxygen consumption. Patients often present with symptoms of both the underlying hypothyroidism and the precipitating condition. 3) Treatment involves supportive care, thyroid hormone replacement, glucocorticoids, and treating any underlying infections or precipitating conditions. Patients require intensive monitoring and care due to involvement of multiple organ systems.